Sandro de Souza, Ph.D.

Professor & Director, Bioinformatics Multidisciplinary Environment (BioME) & Brain Institute, The Federal University of Rio Grande do Norte (Brazil)

巴西北里奥格兰德联邦大学大脑研究所主任、教授，巴西基因组学和生物信息学研究先驱和国际知名学者。在哈佛大学期间获得Pew Latin American Fellow奖项， 2009年获得世界经济论坛的“Young Global Leader”。发表140多篇论文，引用超过两千多次。

Translational opportunities for cancer/testis genes

The development of immunotherapeutic strategies has revolutionized cancer treatment. In spite of the success, one limitation is the development of resistance due to the genetic heterogeneity of tumors. This raises the need for the development of new strategies, like vaccines, involving different targets.
Cancer/testis (CT) genes are interesting targets for immunotherapeutic approaches due to their restricted expression to testis among normal tissues. In my talk I will discuss a genome-wide strategy used by us to identify and characterize hundreds of cancer/testis genes in 15 different types of tumors. Furthermore, we developed a method to associate the expression of CT genes to several clinical parameters. By associating the expression of CTs to overall survival and CD8+ infiltration, we identify promising targets for vaccines in several cancer targets. Finally, I will discuss other clinical applications of CT genes to oncology.

参考译文

癌症/睾丸基因的转化机遇

免疫治疗策略的发展革新了癌症治疗。尽管取得了成功，其受限于肿瘤的遗传异质性从而产生的耐药性。这就带来了发展新治疗手段的需求，如研究多个靶标的疫苗。
癌症/睾丸（CT）基因由于在不同正常组织中特异性的表达使其成为很有意思的免疫治疗靶标。我的报告将会讨论我们使用的基因组范围的策略在15个不同类型肿瘤中筛选和鉴定出的数百个CT基因。另外，我们建立了一个将CT基因的表达与几种临床参数关联的方法。通过将CT基因的表达关联到整体的生存和CD8+渗透实验中，我们从几种癌症靶标中筛选出了最可靠的靶标。最后，我会讨论CT基因在肿瘤学中的其他临床应用。