176 Biomarkers
ID | Biomarker | Location | Application | Reference |
---|---|---|---|---|
20 | Chromosome 18q | Colon, Rectum | Prognosis | Jen J et al. N Engl J Med. 1994 |
30 | DNA index (DI) | Colon, Rectum | Prognosis | Tomoda H et al. J Surg Oncol. 1993 |
53 | Loss of heterozygosity (LOH) | Colon, Rectum | Prognosis | Ogunbiyi OA et al. Gastroenterology. 1997 |
57 | Loss of heterozygosity (LOH) | Colon, Rectum | Prognosis | Ogunbiyi OA et al. J Clin Oncol. 1998 |
59 | DNA index (DI) | Colon, Rectum | Prognosis | Tomoda H et al. Dis Colon Rectum. 1998 |
64 | Loss of heterozygosity (LOH) | Colon, Rectum | Treatment | Mart?nez-L?pez E et al. Gastroenterology. 1998 |
72 | DNA index (DI) | Colon, Rectum | Prognosis | Yamamoto T et al. Surg Today. 1998 |
89 | Loss of heterozygosity (LOH) | Colon, Rectum | Prognosis | Jernvall P et al. Br J Cancer. 1999 |
97 | Microsatellite instability (MSI) | Colon, Rectum | Prognosis | Halling KC et al. J Natl Cancer Inst. 1999 |
99 | P16 hypermethylation | Colon, Rectum | Prognosis | Liang JT et al. Oncology. 1999 |
104 | Microvessel count (MVC) | Colon, Rectum | Prognosis | Kimura T et al. Int J Oncol. 2000 |
119 | Microsatellite instability (MSI) | Colon, Rectum | Prognosis | Hemminki A et al. Gastroenterology. 2000 |
131 | Aneuploidy index (AI) | Colon, Rectum | Prognosis | Risques RA et al. Lab Invest. 2001 |
136 | MMP-2:TIMP-2 ratio | Colon, Rectum | Diagnosis | Chan CC et al. Int J Colorectal Dis. 2001 |
149 | P16 methylation | Colon, Rectum | Diagnosis | Zou HZ et al. Clin Cancer Res. 2002 |
154 | Apoptosis | Colon, Rectum | Prognosis, Treatment | Rödel C et al. Int J Radiat Oncol Biol Phys. 2002 |
166 | Microsatellite instability (MSI) | Colon, Rectum | Prognosis | Choi SW et al. Clin Cancer Res. 2002 |
172 | Microsatellite instability (MSI) | Rectum | Prognosis | Colombino M et al. Ann Oncol. 2002 |
205 | Microsatellite instability (MSI) | Colon, Rectum | Treatment | Brueckl WM et al. Anticancer Res. 2003 |
215 | CpG island methylator phenotype (CIMP) | Colon, Rectum | Treatment | Van Rijnsoever M et al. Clin Cancer Res. 2003 |
222 | Disseminated tumor cells (DTC) | Colon, Rectum | Prognosis | Linnemann U et al. Int J Colorectal Dis. 2004 |
256 | Loss of heterozygosity (LOH) | Colon, Rectum | Prognosis | Sarli L et al. Dis Colon Rectum. 2004 |
259 | Microsatellite instability (MSI) | Colon, Rectum | Treatment | Charara M et al. Anticancer Res. 2004 |
261 | Phase angle | Colon, Rectum | Prognosis | Gupta D et al. Am J Clin Nutr. 2004 |
274 | Loss of heterozygosity (LOH) | Colon, Rectum | Prognosis | Chang SC et al. World J Gastroenterol. 2005 |
281 | Fraction of genome altered (FGA), Clinical risk score (CRS) | Colon, Rectum | Prognosis | Mehta KR et al. Clin Cancer Res. 2005 |
285 | Microsatellite instability (MSI) | Colon, Rectum | Prognosis | Kohonen-Corish MR et al. J Clin Oncol. 2005 |
297 | Microsatellite instability (MSI) | Colon, Rectum | Prognosis | Kim YH et al. World J Gastroenterol. 2005 |
298 | Soluble FAS/soluble FASL ratio | Colon, Rectum | Treatment | Nadal C et al. Clin Cancer Res. 2005 |
306 | GNAS1 T393C | Colon, Rectum | Prognosis, Treatment | Frey UH et al. Clin Cancer Res. 2005 |
317 | DNA methylation | Colon, Rectum | Treatment | Leung WK et al. Am J Gastroenterol. 2005 |
321 | Inflammatory cell response | Colon, Rectum | Prognosis | Klintrup K et al. Eur J Cancer. 2005 |
324 | MMR status | Colon, Rectum | Prognosis | Jover R et al. Gut. 2006 |
326 | Microsatellite instability (MSI) | Colon, Rectum | Prognosis | Benatti P et al. Clin Cancer Res. 2005 |
327 | Angiogenesis | Colon, Rectum | Prognosis | Georgiou L et al. J Surg Res. 2006 |
328 | Urinary nucleosides | Colon, Rectum | Diagnosis | Feng B et al. J Gastroenterol Hepatol. 2005 |
358 | Visceral adiposity | Colon, Rectum | Prognosis | Moon HG et al. Ann Surg Oncol. 2008 |
361 | P16 hypermethylation | Colon, Rectum | Prognosis | Wettergren Y et al. Mol Med. 2008 |
365 | Receptor for hyaluronic acid mediated motility (RHAMM) | Colon, Rectum | Prognosis | Zlobec I et al. Gut. 2008 |
368 | Extramural vascular invasion (EVI) | Colon, Rectum | Prognosis | Courtney ED et al. Colorectal Dis. 2009 |
373 | Apoptotic body index (ABI) | Colon, Rectum | Prognosis | El-Awady S et al. Hepatogastroenterology. 2008 |
375 | GSTP1 Ile105Val polymorphism | Colon, Rectum | Treatment | Agostini M et al. Drugs Aging. 2008 |
378 | Tumor doubling time (TDT) | Colon, Rectum | Prognosis | Tomimaru Y et al. Dig Surg. 2008 |
380 | Circulating tumor cells (CTCs) | Colon, Rectum | Prognosis | Cohen SJ et al. J Clin Oncol. 2008 |
381 | Microsatellite instability (MSI) | Colon, Rectum | Treatment | M?ller CI et al. Int J Colorectal Dis. 2008 |
386 | Microvessel density (MVD) | Colon, Rectum | Prognosis | Yodavudh S et al. J Med Assoc Thai. 2008 |
388 | TS1494del6 polymorphism | Rectum | Treatment | Stoehlmacher J et al. Cancer Lett. 2008 |
390 | CpG island methylator phenotype (CIMP), BRAF | Colon | Prognosis | Ogino S et al. Gut. 2009 |
418 | Secernin 1 (SCRN1) | NA | Prognosis | Miyoshi N et al. J Surg Oncol. 2010 |
421 | Apical node metastasis | Colon, Rectum | Prognosis | Ang CW et al. Colorectal Dis. 2011 |
430 | Carbohydrate antigen 125 (CA125) | Colon, Rectum | Prognosis | Yang XQ et al. Med Oncol. 2011 |
443 | Dermokine (DK) | NA | Diagnosis | Taqi T et al. J Gastroenterol. 2010 |
449 | γ-Catenin | Colon, Rectum | Prognosis | Nagel JM et al. Int J Colorectal Dis. 2010 |
453 | CCTζ-1 | Colon, Rectum | Prognosis | Qian-Lin Z et al. J Surg Oncol. 2010 |
473 | Osteoprotegerin (OPG) | NA | Prognosis, Treatment | Tsukamoto S et al. Clin Cancer Res. 2011 |
480 | Adrenomedullin (ADM) | Colon, Rectum | Prognosis | Uemura M et al. Anticancer Res. 2011 |
484 | Lymphopenia | Colon, Rectum | Prognosis | Cz N et al. Cancer Chemother Pharmacol. 2011 |
496 | MGb2-Ag/TRAK1 | NA | Prognosis | An Y et al. Int J Colorectal Dis. 2011 |
499 | Immune cells (iCD10) | Colon, Rectum | Prognosis | Khanh do T et al. Cancer Sci. 2011 |
516 | MSCs, CD34b LCs | NA | Diagnosis | Bellows CF et al. Cancer Epidemiol Biomarkers Prev. 2011 |
521 | Fucosylated haptoglobin (Fuc-Hpt) | NA | Prognosis | Takeda Y et al. Cancer. 2012 |
525 | Thrombocytosis | Colon, Rectum | Prognosis | Sasaki K et al. World J Surg. 2012 |
529 | Microsatellite instability (MSI) | Colon, Rectum | Prognosis | Hong SP et al. Eur J Cancer. 2012 |
532 | Onodera's prognostic nutritional index (OPNI) | Rectum | Prognosis | Nozoe T et al. Surg Today. 2012 |
537 | Serum levels of soluble E-cadherin (sE-cadherin) | NA | Prognosis | Okugawa Y et al.?J Surg Res. 2012 |
544 | Helicase-like transcription factor (HLTF), hyperplastic polyposis 1 (HPP1) | Colon, Rectum | Prognosis | Philipp AB et al. Int J Cancer. 2012 |
551 | NHLN | Colon, Rectum | Prognosis | La Torre M et al. J Surg Oncol. 2012 |
562 | Nanog | NA | Prognosis | Xu F et al. Dig Dis Sci. 2012 |
567 | Activating transcription factor 1 (ATF1) | Colon, Rectum | Prognosis | Huang GL et al. Asian Pac J Cancer Prev. 2012 |
569 | Circulating tumor cells (CTCs) | Colon, Rectum | Prognosis | Sastre J et al. Oncologist. 2012 |
577 | PIK3CA mutation, methylation | NA | Prognosis | Iida S et al. Oncol Lett. 2012 |
584 | Glasgow prognostic score (GPS) | Colon, Rectum | Prognosis | Furukawa K et al. Oncol Lett. 2012 |
587 | Phospho-ERK | NA | Prognosis | Tai CJ et al. Pol J Pathol. 2012 |
588 | XIAP (X-linked inhibitor of apoptosis) | Rectum | Prognosis | Moussata D et al. Am J Pathol. 2012 |
597 | Combination of CFD, CEA, CA19-9 | Rectum | Diagnosis | Qi J et al. Clin Biochem. 2013 |
601 | eSNPs in CD47 | Colon, Rectum | Prognosis | Lascorz J et al. Int J Colorectal Dis. 2013 |
612 | PPP1R13L rs1970764 variant | Colon, Rectum | Prognosis | Chae YS et al. J Cancer Res Clin Oncol. 2013 |
617 | Microsatellite instability (MSI) | Colon, Rectum | Prognosis | Merok MA et al. Ann Oncol. 2013 |
618 | The lymph node ratio (LNR) | NA | Prognosis | Allaix ME et al. Surg Endosc. 2013 |
622 | Bevacizumab-related proteinuria | Colon, Rectum | Diagnosis | Lwasa S et al. Anticancer Res. 2013 |
626 | Alpha 1-antitrypsin, the levels of mRNA expression of MMP7, COX-2, Upar | NA | Diagnosis | Bujanda L et al. PLoS One. 2013 |
643 | Preoperative platelets | Colon, Rectum | Prognosis | Wan S et al. J Gastrointest Cancer. 2013 |
648 | Lymph node ratio (LNR) | Rectum | Prognosis | La Torre M et al. Colorectal Dis. 2013 |
652 | Hyperphosphatemia | Colon, Rectum | Prognosis | Ye Z et al. J Gastroenterol Hepatol. 2013 |
656 | 12-LOX 261Arg > Gln polymorphism | Colon, Rectum | Prognosis | Li S et al. Fam Cancer. 2013 |
658 | MPO+ cell infiltration | NA | Prognosis | Droeser RA et al. PLoS One. 2013 |
664 | Yes-associated protein (YAP),transcriptional co-activator with PDZ-binding motif (TAZ) | Rectum | Prognosis | Wang L et al. PLoS One. 2013 |
673 | COP-NLR (COmbination of Platelet count, Neutrophil to Lymphocyte Ratio) | NA | Prognosis | Ishizuka M et al. Br J Cancer. 2013 |
677 | Carboxypeptidase E (CPE)-ΔN | Colon, Rectum | Prognosis | Zhou K et al. Tumour Biol. 2013 |
681 | Lymph node ratio (LNR) | NA | Prognosis | Nadoshan JJ et al. Asian Pac J Cancer Prev. 2013 |
683 | Neutrophil lymphocyte ratio (NLR) | NA | Prognosis | Shibutani M et al. Anticancer Res. 2013 |
692 | Slug, Vimentin | NA | Diagnosis, Prognosis | Toiyama Y et al. Carcinogenesis. 2013 |
694 | Combination of circulating tumor cells plus KRAS | Colon, Rectum | Prognosis | Sastre J et al. Clin Colorectal Cancer. 2013 |
696 | Perineural invasion (PNI) | Colon, Rectum | Prognosis | Ueno H et al. Am J Surg Pathol. 2013 |
697 | Neutropenia | NA | Prognosis | Sunaga T et al. Eur J Cancer Care (Engl). 2014 |
699 | Microsatellite instability (MSI), Chromosomal instability (CIN) | Colon, Rectum | Prognosis | Mouradov D et al. Am J Gastroenterol. 2013 |
701 | P62/sequestosome-1 | NA | Treatment | Ren F et al. Mol Cell Biochem. 2014 |
704 | Neutrophil lymphocyte ratio (NLR) | Colon, Rectum | Prognosis | Malietzis G et al. Ann Surg. 2014 |
705 | Intraoperative blood loss (IBL) | NA | Prognosis | Jiang W et al. PLoS One. 2013 |
706 | Extramural vascular invasion (EVI) | Rectum | Prognosis | Bhangu A et al. Colorectal Dis. 2013 |
708 | Peritumoral deposits (PTDs) | Colon, Rectum | Prognosis | Ueno H et al. Am J Surg. 2014 |
712 | Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) | Rectum | Prognosis | Lollert A et al. J Magn Reson Imaging. 2014 |
720 | Crohn's like lymphoid reaction (CLR) | Colon, Rectum | Prognosis | V?yrynen JP et al. Int J Cancer. 2014 |
745 | TWIST1, SNAI1 | Colon | Prognosis | Kim YH et al. Oncol Rep. 2014 |
758 | Fusobacterium nucleatum (Fn) | Colon, Rectum | Diagnosis, Prognosis | Flanagan L et al. Eur J Clin Microbiol Infect Dis. 2014 |
764 | Immunoscore | Rectum | Prognosis | Anitei MG et al. Anitei MG |
766 | P21, CD166 | NA | Prognosis | Sim SH et al. BMC Cancer. 2014 |
767 | Colon cancer-specific antigen-2 (CCSA-2) | NA | Diagnosis, Prognosis | Xue G et al. PLoS One. 2014 |
771 | Interleukin-like EMT inducer (ILEI) | Colon, Rectum | Prognosis | Gao ZH et al. Histopathology. 2014 |
774 | Neutrophil lymphocyte ratio (NLR) | NA | Prognosis | Ozdemir Y et al. Asian Pac J Cancer Prev. 2014 |
776 | Nutritional risk screening (NRS) | Colon, Rectum | Prognosis | Kwag SJ et al. Ann Surg Treat Res. 2014 |
777 | Aldh1, Survivin,, EpCAM | Colon, Rectum | Prognosis | Goossens-Beumer IJ et al. Br J Cancer. 2014 |
784 | β1-Integrin | Colon, Rectum | Prognosis | Oh BY et al. Ann Coloproctol. 2014 |
791 | Contrast-enhanced ultrasonography (CEUS) | Rectum | Prognosis | Wang Y et al. Biomed Res Int. 2014 |
792 | β-Catenin, E-Cadherin | NA | Prognosis | Bruun J et al. Front Oncol. 2014 |
797 | Vascular invasion | Colon, Rectum | Prognosis | Fujii T et al. Anticancer Res. 2014 |
798 | TAC1, SEPT9 methylation | NA | Prognosis | Tham C et al. Cancer. 2014 |
799 | Heme oxygenase-1 (HO-1)/carbon monoxide (CO) | NA | Diagnosis, Prognosis | Yin H et al. BMC Cancer. 2014 |
801 | CHFR promoter CpG island methylation | NA | Prognosis | Cleven AH et al. Clin Cancer Res. 2014 |
805 | WNT inhibitory factor 1 (WIF1), secreted frizzled related protein 1 (SFRP1) | NA | Prognosis | Huang S et al. Biomed Res Int. 2014 |
815 | Standardized uptake values of the regional lymph nodes (SUVn) | NA | Prognosis | Byun BH et al. Eur J Nucl Med Mol Imaging. 2014 |
820 | O6-methylguanine DNA methyltransferase (MGMT), CD133 | NA | Prognosis | Oliver JA et al. BMC Cancer. 2014 |
826 | IL-17, Tr1-positive cells | NA | Prognosis | Chen J et al. Med Oncol. 2014 |
827 | The lymph node ratio (LNR) | NA | Prognosis | Zeng WG et al. Asian Pac J Cancer Prev. 2014 |
829 | Histone modifications H3K4me3, H3K9me3, H4K20me3 | Colon, Rectum | Prognosis | Benard A et al. BMC Cancer. 2014 |
830 | 19 genes regulated by TREM1 or CTGF activation (TCA19) | NA | Prognosis | Kim SK et al. Mol Oncol. 2014 |
839 | Inflammatory state | NA | Prognosis | Hamilton TD et al. BMC Cancer. 2014 |
842 | Lymph node ratio (LNR) | Colon, Rectum | Prognosis | Costi R et al. J Gastrointest Surg. 2014 |
852 | Neutrophil lymphocyte ratio (NLR) | NA | Prognosis | Azab B et al. Cancer Biomark. 2014 |
860 | Integrin αvβ6, Ets-1 | Colon, Rectum | Prognosis | Peng C et al. Cell Biosci. 2014 |
875 | Circumferential resection margin involvement (R1) | NA | Prognosis | Khan MA et al. Colorectal Dis. 2015 |
877 | Circulating tumor cells (CTCs) | Rectum, Colon | Prognosis | Bork U et al. Br J Cancer. 2015 |
882 | Integrin-β1 (ITGB1) | Rectum, Colon | Prognosis | Zhou F et al. Cancer Chemother Pharmacol. 2015 |
888 | Platelet lymphocyte ratio (PLR) | Rectum, Colon | Prognosis | Ozawa T et al. Int J Colorectal Dis. 2015 |
894 | E2F1 | Rectum, Colon | Diagnosis, Prognosis | Fang Z et al. Biochem Biophys Res Commun. 2015 |
901 | Endothelial cell-specific molecule-1 (ESM-1) | Rectum, Colon | Prognosis | Jiang H et al. Genet Mol Res. 2015 |
915 | Lymphocyte to monocyte ratio (LMR) | Rectum, Colon | Prognosis | Shibutani M et al. World J Gastroenterol. 2015 |
932 | Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) | NA | Diagnosis, Prognosis | Xu W et al. Discov Med. 2015 |
935 | Serum uric acid | Colon | Prognosis | Selcukbiricik F et al. Clin Transl Oncol. 2016 |
936 | micrometastasis volume | Colon, Rectum | Prognosis | Yamamoto H et al. Clin Cancer Res. 2016 |
952 | PRKDC | NA | Prognosis, Treatment | Sun S et al. Gene. 2016 |
954 | Platelet lymphocyte ratio (PLR) | Rectum, Colon | Prognosis | Zou ZY et al. Oncol Lett. 2016 |
955 | Neutrophil lymphocyte ratio (NLR) | Rectum, Colon | Prognosis | Zou ZY et al. Oncol Lett. 2016 |
958 | Cancer susceptibility candidate 11 (CASC11) | NA | Diagnosis, Treatment | Zhang Z et al. Cancer Lett. 2016 |
959 | Sciellin (SCEL) | NA | Treatment | Chou CK et al. Oncotarget. 2016 |
968 | Lymphocyte to monocyte ratio (LMR) | Colon, Rectum | Prognosis | Chan JC et al. Ann Surg. 2017 |
973 | Tumour-associated macrophages (TAMs) | Colon, Rectum | Prognosis | Marech I et al. J Cell Mol Med. 2016 |
978 | Tumour necrosis percentage | NA | Prognosis | Vyrynen SA et al. Br J Cancer. 2016 |
979 | prognostic nutritional index (PNI) | Colon, Rectum | Prognosis | Park BK et al. J Surg Oncol. 2016 |
1009 | Lymphovascular, perineural invasion (LVI, PNI) | Colon, Rectum | Prognosis | Al-Sukhni E et al. Int J Surg. 2017 |
1015 | Fecal Bacteria | Colon | Diagnosis | Liang Q et al. Clin Cancer Res. 2017 |
1027 | CD133+, CD133+CD54+CD44+ cellular subpopulations | Colon, Rectum | Prognosis | Fang C et al. Oncotarget. 2016 |
1031 | Dieckol | NA | Prognosis | Jeong SH et al. Mol Med Rep. 2016 |
1036 | Combination of hERG1 positivity, Glut-1 negativity | Colon, Rectum | Prognosis | Muratori L et al. Onco Targets Ther. 2016 |
1039 | Fusobacterium nucleatum (Fn) | Colon | Diagnosis | Wong SH et al. Gut. 2016 |
1043 | Interleukin 23 (IL-23) | Colon, Rectum | Prognosis | Hu WH et al. J Surg Oncol. 2017 |
1049 | Total lesion glycolysis (TLG) | Colon, Rectum | Treatment | Lim Y et al. Eur J Nucl Med Mol Imaging. 2017 |
1052 | Neutrophil lymphocyte ratio (NLR) | Colon, Rectum | Prognosis | Oh SY et al. J Surg Res. 2017 |
1055 | WNT5A methylation status | Colon, Rectum | Prognosis, Treatment | Jiang G et al. Genet Test Mol Biomarkers. 2017 |
1058 | RAS/PIK3CA/BRAF mutations | Colon, Rectum | Treatment | Nakayama I et al. BMC Cancer. 2017 |
1059 | Perineural invasion (PNI) | Colon, Rectum | Prognosis | Alotaibi AM et al. Ann Surg Oncol. 2017 |
1062 | Choline | Colon, Rectum | Prognosis | Guertin KA et al. Cancer Epidemiol Biomarkers Prev. 2017 |
1064 | Circulating (CTC) or disseminated tumor cells (DTC) | Colon | Prognosis | Hinz S et al. BMC Cancer. 2017 |
1065 | The CpG island methylator phenotype (CIMP) | Colon, Rectum | Prognosis | Kim CH et al. J Gastroenterol Hepatol. 2017 |
1078 | Platelet-lymphocyte ratio (PLR) | Colon, Rectum | Prognosis | Bong TS et al. Int J Clin Oncol. 2017 |
1082 | Enterotoxigenic Bacteroides fragilis (ETBF) | Colon, Rectum | Diagnosis | Purcell RV et al. PLoS One. 2017 |
1088 | CYFRA 21-1 | Colon, Rectum | Diagnosis | Lim DH et al. J Clin Lab Anal. 2017 |
1100 | Prognostic nutritional index (PNI) | Colon, Rectum | Prognosis | Noh GT et al. J Cancer Res Clin Oncol. 2017 |
1102 | Derived neutrophil to lymphocyte ratio (dNLR) | Colon, Rectum | Prognosis | Wood G et al. Anticancer Drugs. 2017 |
1105 | Body mass index | Colon, Rectum | Prognosis | He Y et al. Dis Colon Rectum. 2017 |
1111 | Prognostic nutritional index (PNI) | Colon, Rectum | Prognosis | Cao X et al. Nutr Cancer. 2017 |
1115 | Neutrophil lymphocyte ratio (NLR) | Colon, Rectum | Prognosis | Sung S et al. PLoS One. 2017 |
1119 | Circulating tumor cells (CTCs) | Colon, Rectum | Diagnosis | Lyberopoulou A et al. Anticancer Res. 2017 |
1120 | Platelet lymphocyte ratio (PLR) | Colon, Rectum | Prognosis | Lee IH et al. Anticancer Res. 2017 |
1122 | Apparent diffusion coefficient (ADC) | Colon, Rectum | Prognosis | Schmeel FC et al. J Cancer Res Clin Oncol. 2017 |
1127 | TGFβ1 R25P | Colon, Rectum | Treatment | Smith JJ et al. Int J Radiat Oncol Biol Phys. 2017 |
176 Biomarker