POCDKB

No.	Risk name	Risk type	Surgery type	Sample size	Definition	Evaluation time	Odds ratio	P value
47	Genetic polymorphisms	Associated genes	Carotid artery stenting(CAS)/carotid endarterectomy(CEA)	142	Global scores below 1.5SD of the mean performance of the control laminectomy patients were determined to represent moderate-to-severe neurocognitive dysfunction	1month	7.82(1.09-72.0)	0.04
343	DNA repair enzyme	Associated genes	craniocerebral surgery	229	Cognitive impairment was defined as a decrease of Cognitive Assessment Montreal (MoCA)’s score in atleast two cognitive domains or any MoCA’s score of less than 26 points at the time of studycompared with baseline level.	3month		0.001
368	miRNA	Associated genes	Esophageal and gastrointestinal surgery	110	POCD was defined when the RCI score was＜-1.96 atleast on 2 tests or when the combined Z score was＜-1.96	1week	2.732(1.415-5.233)	0.002
604	Neurotrophic factor gene	Associated genes	Elective joint arthroplasty (TJA)	124	When a change score was at least 1.96 SD lower than the mean score of the matchedcontrol group after adjusting for expected change over time using controls, we considered the test “+.	1week	0.67(0.47-0.96)	0.017
605	Neurotrophic factor gene	Associated genes	Elective joint arthroplasty (TJA)	124	When a change score was at least 1.96 SD lower than the mean score of the matchedcontrol group after adjusting for expected change over time using controls, we considered the test “+.	1week	0.41(0.2-0.84)	0.015
606	Neurotrophic factor gene	Associated genes	Elective joint arthroplasty (TJA)	124	When a change score was at least 1.96 SD lower than the mean score of the matchedcontrol group after adjusting for expected change over time using controls, we considered the test “+.	3month	0.65(0.32-0.302)	0.22
635	miRNA	Associated genes	Non-cardiac surgery	47	The result was designated a Z score. When at least two Z scalesare greater than 1.96,POCD was considered	1week	0.715(0.520-0.912)	＜0.05
724	Clock gene	Associated genes	Non-cardiac surgery	279	POCD was defined as a combined Z score 1.96 or a Z score 1.96 in at least 2 of the 7 subtests as previously described.	1week		0.68
818	Chromosome telomere	Associated genes	Non-cardiac surgery	196	suffering from dNCR when they exhibited a Z score≤-1.96 on a minimum of 2 different neuropsychological tests out of 10possible tests.	1week	12.33(3.29-46.24)	＜0.001