POCDKB

No.	Risk name	Risk type	Surgery type	Sample size	Definition	Evaluation time	Odds ratio	P value
124	Insulin therapy	Medications and therapy	Cardiac Surgery	543	The neuropsychological portion of the study design followed the consensus statements on the assessment of central nervous system disorders after cardiac surgery	6month	2.4(1.8-3.1)	0.01
128	Insulin therapy	Medications and therapy	Cardiac Surgery	180	The neuropsychologic portion of the study was designed in accordance with the consensus statements on the assessment of central nervous system disorders after cardiac surgery	NA	2.1(1.4-3.5)	0.01
278	Anticholinergic or sedative-hypnotic drugs	Medications and therapy	Non-cardiac surgery	69	Z score＜1.96	3month	5.64(1.35-30.22)	0.014
412	Anticoagulant	Medications and therapy	Cardiac Surgery	300	We defined the presence of POCD when the Z score＜-1.96 on≥2 tests or the combined Z score＜-1.96.	1-3day	10.35(3.54-30.27)	＜0.001
503	Probiotics	Medications and therapy	Elective joint arthroplasty (TJA)	40	declined significantly compared to the normal range	1month		0.009
504	Probiotics	Medications and therapy	Elective joint arthroplasty (TJA)	40	declined significantly compared to the normal range	1month		0.012
505	Probiotics	Medications and therapy	Elective joint arthroplasty (TJA)	40	declined significantly compared to the normal range	1month		0.018
506	Probiotics	Medications and therapy	Elective joint arthroplasty (TJA)	40	declined significantly compared to the normal range	1month		0.025
507	Probiotics	Medications and therapy	Elective joint arthroplasty (TJA)	40	declined significantly compared to the normal range	1month		0.032
508	Probiotics	Medications and therapy	Elective joint arthroplasty (TJA)	40	declined significantly compared to the normal range	1month		0.04
559	Insulin therapy	Medications and therapy	Cardiac Surgery	124	we considered a 20% reduction incognitive function to be clinically important.	1week	1.9(1.5-2.0)	0.03
566	Insulin therapy	Medications and therapy	Cardiac Surgery	124	we considered a 20% reduction incognitive function to be clinically important.	6month	1.9(1.4-2.2)	0.04
592	Chemotherapy	Medications and therapy	Breast surgery	73	Neuropsychologic impairment was determined as follows: first,a patient who scored 2 standard deviations (SD) below the mean of the control group on a test was considered impaired on that specific test.	2year	6.4(1.5-27.6)	0.013
698	Probiotics	Medications and therapy	Elective joint arthroplasty (TJA)	106	Mild POCD and severe POCD were defined as a decreaseof 1-2 standard deviation (SD) or more than 2 SD of two ormore neuropsychological tests	1week		0.003
758	Statins	Medications and therapy	Cardiac Surgery	440	Cognitive deficit was defined as a decline of 1 SD or more inperformance on at least 1 of the 4 domains	discharge		0.67
759	Statins	Medications and therapy	Cardiac Surgery	440	Cognitive deficit was defined as a decline of 1 SD or more inperformance on at least 1 of the 4 domains	6week		0.19
824	Antibiotics	Medications and therapy	Non-cardiac surgery	13899	ICD-10	1year	1.667(1.077-2.582)	0.022