Alzheimer's Disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time.[1][2]It is the cause of 60–70% of cases of dementia.[1][2]

The most common early symptom is difficulty in remembering recent events.[1] As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, not managing self-care, and behavioural issues.[1][2] As a person's condition declines, they often withdraw from family and society.[3] Gradually, bodily functions are lost, ultimately leading to death.[10] Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years.[4][5]

[1]Burns A, Iliffe S (February 2009). "Alzheimer's disease". BMJ. 338: b158. doi:10.1136/bmj.b158. PMID 19196745
[2]"Dementia Fact sheet". World Health Organization. 12 December 2017.
[3]"About Alzheimer's Disease: Symptoms". National Institute on Aging. Archived from the original on 15 January 2012. Retrieved 28 December 2011.
[4]Querfurth HW, LaFerla FM (January 2010). "Alzheimer's disease". The New England Journal of Medicine. 362 (4): 329–44. doi:10.1056/NEJMra0909142. PMID 20107219.
[5]Todd S, Barr S, Roberts M, Passmore AP (November 2013). "Survival in dementia and predictors of mortality: a review". International Journal of Geriatric Psychiatry. 28 (11): 1109–24. doi:10.1002/gps.3946. PMID 23526458.
The search result for the NDD Category "Alzheimer's Disease"
A total of 1005 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Condition PMID
1 Alzheimer's disease human 5, 10-methylenetetrahydrofolate dehydrogenase gene (MTHFD1) RF 20217437
2 Alzheimer’s Disease human 5-HTT RF homozygous low activity genotype: ε4 alleles of the ApoE gene 9106747
3 Alzheimer's Disease human 5-LO RF A allele 20110601
5 Alzheimer’s Disease human ABCA7 RF Calculated by fixed effect model 29504051
5 Alzheimer’s Disease human ABCA7 RF 29589097
5 Alzheimer’s Disease human ABCA7 RF 29589097
5 Alzheimer’s Disease human ABCA7 RF 29589097
5 Alzheimer’s Disease human ABCA7 PF National Alzheimer’s Coordinating Center (NACC) cohort 30128317
5 Alzheimer's disease human ABCA7 RF 26795201
5 Alzheimer's disease human ABCA7 RF with both ApoEε4-carrier and aging being factors enhancing its risk 24113560
7 Alzheimer’s Disease human ACE RF 11078932
7 Alzheimer's Disease human ACE RF 21537449
7 Alzheimer's Disease human ACE RF in subjects aged 73 years and above. 19539712
7 Alzheimer's Disease human ACE RF in subjects aged 73 years and above. 19539712
8 Alzheimer's disease human ACT RF especially in Caucasians 22294107
8 Alzheimer's disease human ACT RF especially in Caucasians 22294107
8 Alzheimer's disease human ACT RF A allele carriers are associated with increased susceptibility to AD in variant populations 22272609
8 Alzheimer's disease human ACT RF A allele carriers are associated with increased susceptibility to AD in variant populations 22272609
10 Alzheimer's disease human ALDH2 RF dependent on APOE epsilon4 status in Chinese 18201725
11 Alzheimer's disease human ALOX5 RF 26944113
12 Alzheimer's disease human ANK1 RF 26611832
13 Alzheimer's Disease human APOC1 RF using logistic regression、Dataset：FHS(Framingham Heart Study) 29107063
13 Alzheimer's Disease human APOC1 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 29107063
13 Alzheimer's Disease human APOC1 RF using Cox regression、Dataset：FHS（Framingham Heart Study） 29107063
13 Alzheimer's disease human APOC1 RF 30443289
13 Alzheimer's disease human APOC1 RF not in African Americans 24498013
14 Alzheimer's Disease human APOD RF in APOEε4 (-) subgroup 23690001
15 Alzheimer's Disease human APOE RF 22712640
15 Alzheimer’s Disease human APOE RF ε4 allele 29990559
15 Alzheimer’s Disease human APOE PF ε2 allele 29990559
15 Alzheimer’s Disease human APOE PF ε3 allele 29990559
15 Alzheimer’s Disease human APOE RF Genotype/Allele: A/A 29990559
15 Alzheimer’s Disease human APOE PF Genotype/Allele: A/T 29990559
15 Alzheimer’s Disease human APOE RF Genotype/Allele: A 29990559
15 Alzheimer’s Disease human APOE PF Genotype/Allele: T 29990559
15 Alzheimer’s Disease human APOE RF ε4 allele 29592889
15 Alzheimer’s Disease human APOE RF ε4 allele 30112972
15 Alzheimer’s Disease human APOE RF ε4 allele; AD all 29703883
15 Alzheimer’s Disease human APOE RF ε4 allele; AD without depression 29703883
15 Alzheimer’s Disease human APOE RF Genotype: ?3/?4; AD all 29703883
15 Alzheimer’s Disease human APOE RF Genotype: ?3/?4; AD without depression 29703883
15 Alzheimer’s Disease human APOE RF Genotype: ?4/?4; AD without depression 29703883
15 Alzheimer’s Disease human APOE RF PENN cohort; ε2 30128317
15 Alzheimer’s Disease human APOE PF PENN cohort; ε4 30128317
15 Alzheimer’s Disease human APOE RF National Alzheimer’s Coordinating Center (NACC) cohort; ε2 30128317
15 Alzheimer’s Disease human APOE PF National Alzheimer’s Coordinating Center (NACC) cohort; ε4 30128317
15 Alzheimer’s Disease human APOE RF ε4 allele 7841371
15 Alzheimer’s Disease human APOE RF ε2 allele 7824157
15 Alzheimer’s Disease human APOE RF ε2 allele 29562509
15 Alzheimer’s Disease human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 30205398
15 Alzheimer’s Disease human APOE RF Genotype: ε4/4; adjusted for age and education, and stratified by gender 30205398
15 Alzheimer’s Disease human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 30205398
15 Alzheimer’s Disease human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 30205398
15 Alzheimer’s Disease human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 30205398
15 Alzheimer’s Disease human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 30205398
15 Alzheimer’s Disease human APOE RF Genotype: ε4/4; adjusted for age and education, and stratified by gender 30205398
15 Alzheimer’s Disease human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 30205398
15 Alzheimer’s Disease human APOE RF ε4 allele; stronger in women 30039745
15 Alzheimer’s Disease human APOE RF ε4 allele 7977635
15 Alzheimer’s Disease human APOE RF ε4 allele; associated with homozygosity 8128961
15 Alzheimer’s Disease human APOE RF ε4 allele; associated with heterozygosity 8128961
15 Alzheimer’s Disease human APOE RF at least one epsilon 4 allele 8786847
15 Alzheimer’s Disease human APOE RF Genotype: AA 10213175
15 Alzheimer’s Disease human APOE RF Carrying at least one ε4 allele 10213175
15 Alzheimer’s Disease human APOE RF Gender: female; Calculated by Step-wise model 10213175
15 Alzheimer’s Disease human APOE RF Carrying at least one ε4 allele; Calculated by Step-wise model 10213175
15 Alzheimer’s Disease human APOE RF Gender: female; Calculated by Forced entry model 10213175
15 Alzheimer’s Disease human APOE RF Carrying at least one ε4 allele; Calculated by Forced entry model 10213175
15 Alzheimer’s Disease human APOE RF 9008509
15 Alzheimer’s Disease human APOE RF 8993485
15 Alzheimer’s Disease human APOE RF 9811931
15 Alzheimer’s Disease human APOE RF ε4 allele 11376902
15 Alzheimer’s Disease human APOE RF ε4 allele 12160362
15 Alzheimer’s Disease human APOE RF 12095653
15 Alzheimer’s Disease human APOE RF 12095653
15 Alzheimer’s Disease human APOE RF Th1/E47cs polymorphism allele 12095653
15 Alzheimer’s Disease human APOE RF APOE ε4 10912224
15 Alzheimer's Disease human APOE RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 29107063
15 Alzheimer's Disease human APOE RF using logistic regression、Dataset：HRS(Health and Retirement Study) 29107063
15 Alzheimer's Disease human APOE RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 29107063
15 Alzheimer's Disease human APOE RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 29107063
15 Alzheimer's Disease human APOE RF using Cox regression、Dataset：HRS（Health and Retirement Study） 29107063
15 Alzheimer's Disease human APOE PF APOEε2ε3 25673977
15 Alzheimer's Disease human APOE RF APOE ε3ε4 25673977
15 Alzheimer's Disease human APOE RF APOE ε4ε4 25673977
15 Alzheimer's Disease human APOE RF A/A genotype 19172988
15 Alzheimer's disease human APOE RF 30991302
15 Alzheimer's disease human APOE RF 30894904
15 Alzheimer's disease human APOE RF 30890475
15 Alzheimer's disease human APOE RF 30450407
15 Alzheimer's disease human APOE RF 28461186
15 Alzheimer's disease human APOE RF 27079723
15 Alzheimer's disease human APOE RF 27033052
15 Alzheimer's disease human APOE RF 26885125
15 Alzheimer's disease human APOE RF The ε4 allele increases the risk of Alzheimer's disease by 5.114 times 26835020
15 Alzheimer's disease human APOE RF 26738348
15 Alzheimer's disease human APOE RF 24326531
15 Alzheimer's disease human APOE RF 24281128
15 Alzheimer's disease human APOE RF 24045327
15 Alzheimer's disease human APOE RF 23887281
15 Alzheimer's disease human APOE RF 23871727
15 Alzheimer's disease human APOE RF 23871727
15 Alzheimer's disease human APOE RF 22311091
15 Alzheimer's disease human APOE PF 22068907
15 Alzheimer's disease human APOE RF 22068907
15 Alzheimer's disease human APOE RF 21649613
15 Alzheimer's disease human APOE RF 21637534
15 Alzheimer's disease human APOE RF 21556001
15 Alzheimer's disease human APOE RF The rate of APOE4 carrier status and the frequency of the ε4 allele were 47% and 27% for LOAD, 50% and 31% for EOAD, 21552550
15 Alzheimer's disease human APOE RF 22737475
15 Alzheimer's disease human APOE RF 20682755
15 Alzheimer's disease human and mice APOE RF nutritional imbalance 20413864
15 Alzheimer's disease human APOE RF 20385913
15 Alzheimer's disease human APOE RF 20376800
15 Alzheimer's disease human APOE RF 20217437
15 Alzheimer's disease human APOE RF 18560129
15 Alzheimer's disease human APOE RF 18446027
15 Alzheimer's disease human APOE RF lowers age at onset of LOAD significantly 18416843
15 Alzheimer's disease human APOE RF Individuals with 2 epsilon 4 alleles had a higher risk for AD than subjects with only 1 such allele 18317248
15 Alzheimer's disease human APOE PF 18317248
15 Alzheimer's disease human APOE RF 18317248
15 Alzheimer's disease human APOE PF 18317248
15 Alzheimer's Disease human APOE RF APOE haplotypes 24596166
15 Alzheimer's Disease human ApoE RF ?4 allele 23038715
15 Alzheimer's Disease human APOE RF 19819468
16 Alzheimer's Disease human APOE ε2/ε3 PF 28846757
16 Alzheimer's Disease human APOE ε2/ε3 PF 28846757
15 Alzheimer's Disease human APOE PF ε3 allele 24632849
17 Alzheimer's Disease human APOE ε3/ε4 RF from ages 55 to 85 years 28846757
17 Alzheimer's Disease human APOE ε3/ε4 RF from ages 55 to 85 years 28846757
15 Alzheimer's Disease human APOE RF 29348964
15 Alzheimer's Disease human APOE RF 25853819
15 Alzheimer's Disease human APOE RF ε4 allele 24632849
18 Alzheimer's Disease human ApoE ε4/ε3 RF ε4/ε3 genotype 24632849
19 Alzheimer's Disease human ApoE ε4/ε4 RF ε4/ε4 genotype 24632849
20 Alzheimer’s Disease human APOE,ACT RF ACT Genotype: TT; One Copy of ε4 8993481
20 Alzheimer’s Disease human APOE,ACT RF ACT Genotype: TT; Two Copies of ε4 8993481
20 Alzheimer’s Disease human APOE,ACT RF ACT Genotype: AT; One Copy of ε4 8993481
20 Alzheimer’s Disease human APOE,ACT RF ACT Genotype: AT; Two Copies of ε4 8993481
20 Alzheimer’s Disease human APOE,ACT RF ACT Genotype: AA; One Copy of ε4 8993481
20 Alzheimer’s Disease human APOE,ACT RF ACT Genotype: AA; Two Copies of ε4 8993481
15 Alzheimer's Disease human APOE RF 29307083
24 Alzheimer's Disease human Arg972 IRS1 RF AA genotype 24589556
24 Alzheimer's Disease human Arg972 IRS1 RF GA genotype 24589556
24 Alzheimer's Disease human Arg972 IRS1 RF A Allele 24589556
25 Alzheimer's Disease human ASTN2 RF 25410587
27 Alzheimer's Disease human ATP10B RF 22950421
28 Alzheimer's Disease human ATP7B RF 22950421
29 Alzheimer's Disease human ATP8B RF 22950421
30 Alzheimer's Disease human ATP9B RF 22950421
34 Alzheimer's disease human BACE1 RF with APOEε4 carrier status 26550136
34 Alzheimer's disease human BACE1 RF in carrying the ApoE epsilon4 allele 18182766
35 Alzheimer's disease human BACE2 RF Rheumatoid arthritis (RA) RA-SNPs Association with AD 21595938
36 Alzheimer's Disease human BDNF C270T RF 26136901
37 Alzheimer’s Disease human BIN1 RF Calculated by fixed effect model 29504051
37 Alzheimer’s Disease human BIN1 RF Calculated by random effect model 29504051
37 Alzheimer’s Disease human BIN1 RF Calculated by fixed effect model 29504051
37 Alzheimer’s Disease human BIN1 RF Calculated by random effect model 29504051
37 Alzheimer’s Disease human BIN1 RF Calculated by fixed effect model 29504051
37 Alzheimer’s Disease human BIN1 PF National Alzheimer’s Coordinating Center (NACC) cohort 30128317
37 Alzheimer’s Disease human BIN1 PF National Alzheimer’s Coordinating Center (NACC) cohort 30128317
37 Alzheimer's disease human BIN1 RF 26768592
37 Alzheimer's disease human BIN1 RF 26768592
41 Alzheimer's Disease human C282Y HFE PF 19429178
45 Alzheimer's Disease human CALHM1 RF 20061624
51 Alzheimer's Disease human CD163L1 RF 29177109
52 Alzheimer's disease human CD33 PF this association was not significant in Asians 26795201
52 Alzheimer's disease human CD33 RF 22382309
52 Alzheimer's disease human CD33 PF in APOE e4 carriers 22167654
52 Alzheimer's disease human CD33 PF in APOE e4 carriers 22167654
53 Alzheimer’s Disease human CD36 RF Genotype: GG 30235742
53 Alzheimer’s Disease human CD36 RF Genotype: GG; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 30235742
53 Alzheimer’s Disease human CD36 RF Genotype: Dominant 30235742
53 Alzheimer’s Disease human CD36 RF Genotype: Dominant; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 30235742
53 Alzheimer’s Disease human CD36 RF Genotype: Recessive 30235742
53 Alzheimer’s Disease human CD36 PF Genotype: GT 30235742
53 Alzheimer’s Disease human CD36 PF Genotype: GT; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 30235742
53 Alzheimer’s Disease human CD36 PF Genotype: Dominant 30235742
53 Alzheimer’s Disease human CD36 PF Genotype: Dominant; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 30235742
54 Alzheimer's Disease human CDK5RAP2 RF 29360470
54 Alzheimer's Disease human CDK5RAP2 PF for female AA carriers 29360470
56 Alzheimer's disease human CHAT RF 27272392
56 Alzheimer's disease human CHAT RF 27272392
56 Alzheimer's disease human CHAT RF 18562794
59 Alzheimer’s Disease human CHI3L1 PF CG+GG 30223258
59 Alzheimer’s Disease human CHI3L1 PF G allele 30223258
59 Alzheimer’s Disease human CHI3L1 RF TT 30223258
59 Alzheimer’s Disease human CHI3L1 RF CT+TT 30223258
59 Alzheimer’s Disease human CHI3L1 RF T allele 30223258
62 Alzheimer's disease human chromosome 12q24.22 RF 24361131
66 Alzheimer's disease human chromosome 9p21.3 RF 20427016
66 Alzheimer's disease human chromosome 9p21.3 RF in non-APOE epsilon4 20427016
66 Alzheimer's Disease human Chromosome 9p21.3 RF C allele 19664850
67 Alzheimer's Disease human CLECL1 RF 29177109
68 Alzheimer’s Disease human CLU RF Calculated by fixed effect model 29504051
68 Alzheimer’s Disease human CLU RF Calculated by fixed effect model 29504051
68 Alzheimer’s Disease human CLU RF Calculated by fixed effect model 29504051
68 Alzheimer’s Disease human CLU RF Calculated by random effect model 29504051
68 Alzheimer's disease human CLU RF 26757186
68 Alzheimer's disease human CLU PF 26757186
71 Alzheimer's Disease human COMT Met allele RF without APOE ε4 allele carriers 24575113
71 Alzheimer's Disease human COMT Met allele RF without APOE ε4 allele carriers;in men 24575113
73 Alzheimer's Disease human COX-2 RF GG allele 20110601
73 Alzheimer's Disease human COX-2 RF G allele 20110601
74 Alzheimer’s Disease human CR1 RF Calculated by fixed effect model 29504051
74 Alzheimer’s Disease human CR1 RF Calculated by fixed effect model 29504051
74 Alzheimer’s Disease human CR1 RF Calculated by fixed effect model 29504051
74 Alzheimer’s Disease human CR1 PF PENN cohort 30128317
74 Alzheimer’s Disease human CR1 PF National Alzheimer’s Coordinating Center (NACC) cohort 30128317
76 Alzheimer’s Disease human CST3 RF CST3-A allele; APOE ε4 carrier 11711204
76 Alzheimer’s Disease human CST3 RF CST3-A allele; Non-APOE ε4 carrier 11711204
76 Alzheimer’s Disease human CST3 RF Caucasians 10993992
77 Alzheimer's Disease human CTNNA1 RF 29177109
78 Alzheimer's disease human CTSD RF 24281128
80 Alzheimer's disease human CYP17A1 PF in APOE e4 carriers 26940238
80 Alzheimer's disease human CYP17A1 RF in APOE e4 carriers 26940238
81 Alzheimer's disease human CYP19A1 RF 27583919
82 Alzheimer’s Disease human CYP2D6 RF CYP2D6B allele; in the Lewy body variant of AD 7818242
83 Alzheimer's Disease human CYP2J2 RF total;Allele T 25796175
83 Alzheimer's Disease human CYP2J2 RF total;Genotype GT + TT 25796175
84 Alzheimer’s Disease human CYP46A1 RF Overall; Genotype:TC; logistic regression model 29516283
84 Alzheimer’s Disease human CYP46A1 RF APOE ε4 carrier; Genotype:CC 29516283
84 Alzheimer’s Disease human CYP46A1 RF Overall; Genotype:TT; dominant mode 29516283
84 Alzheimer’s Disease human CYP46A1 RF APOE ε4 carrier; Genotype:TT; dominant mode 29516283
84 Alzheimer’s Disease human CYP46A1 RF APOE ε4 carrier; Genotype:CC; additive model 29516283
84 Alzheimer’s Disease human CYP46A1 RF APOE ε3/ε4; Genotype:TT; dominant mode 29516283
84 Alzheimer’s Disease human CYP46A1 RF APOE ε3/ε4; Genotype:CC; additive model 29516283
84 Alzheimer's Disease human CYP46A1 RF CYP46A1 gene variations 19286353
84 Alzheimer's disease human CYP46A1 RF 22528464
85 Alzheimer's disease human DAPK1 PF especially the homozygotes 21167819
85 Alzheimer's disease human DAPK1 RF 21167819
93 Alzheimer's Disease human DR4 PF the GA genotype 25207117
93 Alzheimer's Disease human DR4 RF GCA haplotype 25207117
93 Alzheimer's Disease human DR4 RF GCC haplotype 25207117
93 Alzheimer's Disease human DR4 PF ACA haplotype 25207117
93 Alzheimer's Disease human DR4 PF GGC haplotype 25207117
93 Alzheimer's Disease human DR4 PF GGA haplotype 25207117
99 Alzheimer's Disease human ENST00000414107 RF 29027019
102 Alzheimer's disease human ESR1 RF 20674091
102 Alzheimer's disease human ESR1 PF 20674091
102 Alzheimer's disease human ESR1 RF 20674091
103 Alzheimer's disease human ESR1 and ESR2 RF the genetic profile created with the combination of the less represented alleles of these SNPs (expressed as XPAA) 24052609
104 Alzheimer's disease human ESR2 RF predominantly Caucasian AIMS-defined ancestry 24326520
104 Alzheimer's disease human ESR2 RF predominantly Caucasian AIMS-defined ancestry 24326520
104 Alzheimer's disease human ESR2 RF predominantly Caucasian AIMS-defined ancestry 24326520
104 Alzheimer's disease human ESR2 RF predominantly Caucasian AIMS-defined ancestry 24326520
105 Alzheimer's disease human ESR3 PF 24326520
106 Alzheimer's disease human EXOC3L2 RF 28423615
106 Alzheimer's disease human EXOC3L2 PF 28423615
109 Alzheimer's disease human FRMD4A RF 22430674
111 Alzheimer's Disease human G-308A( TNF-alpha gene) RF A-allele 18992723
112 Alzheimer's Disease human GAB2 RF ApoE epsilon4 non-carriers 19276544
112 Alzheimer's disease human GAB2 PF 26770425
112 Alzheimer's disease human GAB2 PF 26770425
112 Alzheimer's disease human GAB2 RF 21285854
112 Alzheimer's disease human GAB2 RF 21285854
112 Alzheimer's disease human GAB2 RF 21285854
112 Alzheimer's disease human GAB2 RF 21285854
112 Alzheimer's disease human GAB2 RF 21108942
112 Alzheimer's disease human GAB2 RF a minor genetic determinant of AD 18272374
113 Alzheimer's Disease human GALR3 RF 29177109
117 Alzheimer's Disease human GCH1 RF 29432188
119 Alzheimer's disease human GOLPH2 RF 22167654
119 Alzheimer's disease human GOLPH2 RF 22167654
122 Alzheimer's disease human GRN RF 26820675
123 Alzheimer's disease human GSTM1 RF 22381228
123 Alzheimer's Disease human GSTM1 RF 29072550
124 Alzheimer's disease human GSTO1 RF 22100662
125 Alzheimer's disease human GSTP1 RF mainly in the presence of the apoE 4 allele 18298341
126 Alzheimer's Disease human GSTT1 RF 22813660
126 Alzheimer's Disease human GSTT1 RF 29072550
127 Alzheimer's disease human hemochromatosis (HFE) RF 27081498
129 Alzheimer’s Disease human HIF3A RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 30319691
130 Alzheimer's Disease human HLA-A24 RF 18936542
134 Alzheimer's Disease human HLA-DRB1 RF under a recessive model in the total sample 29190991
134 Alzheimer's Disease human HLA-DRB1 RF non-APOE ε4 carriers with rs9271192 genotype CC;additive model 29190991
134 Alzheimer's Disease human HLA-DRB1 RF non-APOE ε4 carriers with rs9271192 genotype CC;recessive model 29190991
137 Alzheimer’s Disease human HSP70/HSPA1A PF Genotype: A/C; AD without depression 29703883
138 Alzheimer's Disease human IL-1 beta promoter polymorphism RF APOE4 presence:No stratified 18717723
138 Alzheimer's Disease human IL-1 beta promoter polymorphism RF APOE4 presence:APOE4 yes 18717723
138 Alzheimer's Disease human IL-1 beta promoter polymorphism RF APOE4 presence:APOE4 no 18717723
139 Alzheimer's disease human IL-1 genes cluster PF 22498095
139 Alzheimer's disease human IL-1 genes cluster RF 22498095
141 Alzheimer's Disease human IL-12A PF TT genotype 25037175
142 Alzheimer's Disease human IL-12B PF GG genotype 25037175
142 Alzheimer's Disease human IL-12B PF GG/GT genotype 25037175
144 Alzheimer's disease human IL-1B RF 26768592
144 Alzheimer's disease human IL-1B RF 26768592
145 Alzheimer's disease human IL-1α RF 27014584
148 Alzheimer's disease human insulin degrading enzyme gene (IDE) RF 20880607
148 Alzheimer's disease human insulin degrading enzyme gene (IDE) RF CC genotype was significantly associated with earlier age at onset 20880607
153 Alzheimer’s Disease human ITGA4 RF Codominant; Genotype/Allele: AG; Univariate analysis 29769839
153 Alzheimer’s Disease human ITGA4 RF Dominant; Genotype/Allele: AG+GG; Univariate analysis 29769839
153 Alzheimer’s Disease human ITGA4 RF Dominant; Genotype/Allele: AG+GG; Multivariate analysis 29769839
153 Alzheimer’s Disease human ITGA4 RF Overdominant; Genotype/Allele: AG; Univariate analysis 29769839
153 Alzheimer’s Disease human ITGA4 RF Overdominant; Genotype/Allele: AG; Multivariate analysis 29769839
155 Alzheimer's Disease human KCNJ15 RF 29432188
156 Alzheimer's disease human KIBRA PF 24190487
158 Alzheimer’s Disease human LCORL RF 29860282
159 Alzheimer's disease human LDLR RF 18065781
160 Alzheimer's disease human LHCGR PF carrying an APOE epsilon4 allele 18439297
161 Alzheimer's Disease human LOC100505811 RF 29027019
161 Alzheimer's Disease human LOC100505811 RF 29027019
161 Alzheimer's Disease human LOC100505811 RF 29027019
161 Alzheimer's Disease human LOC100505811 RF 29027019
167 Alzheimer's disease human LRP2 RF 20971101
173 Alzheimer's Disease human MAPT RF 22556362
177 Alzheimer's disease human MC1R RF 28059796
179 Alzheimer's Disease human microtubule-associated protein tau (MAPT) gene PF individuals with a GG genotype of rs242557G/A 29098924
180 Alzheimer's Disease human MIEF1 RF 29177109
182 Alzheimer’s Disease human MLKL RF MLKL loss-of-function mutation 29656768
185 Alzheimer's Disease human mosaic aneuploidy in the brain RF 24602248
186 Alzheimer's disease human MS4A4E RF 26770425
187 Alzheimer’s Disease human MS4A6A RF Calculated by fixed effect model 29504051
187 Alzheimer’s Disease human MS4A6A RF Calculated by fixed effect model 29504051
187 Alzheimer’s Disease human MS4A6A RF Calculated by fixed effect model 29504051
187 Alzheimer's disease human MS4A6A PF 26770425
187 Alzheimer's disease human MS4A6A RF 22382309
188 Alzheimer's disease human MTHFD1L RF the results were influenced by APOE status 21741665
189 Alzheimer's Disease human MTHFR RF Genotype CT;P value adjusted for age, gender, educational attainment, and APOE-e4 status 25359311
189 Alzheimer's Disease human MTHFR RF AA genotype 23659764
189 Alzheimer's disease human MTHFR RF in APOE?4 or in non-APOE?4 carriers 28211809
189 Alzheimer's disease human MTHFR RF increased the odds of developing AD by 2.5 22015309
189 Alzheimer's disease human MTHFR RF without APOE epsilon4 alleles 20600372
192 Alzheimer’s Disease human MTNR1A RF 29982836
195 Alzheimer's disease human NEP gene (MME) RF 22493749
196 Alzheimer's disease human neprilysin (NEP) RF 20376800
197 Alzheimer's disease human NINJ2 PF 21674003
197 Alzheimer's disease human NINJ2 PF 21674003
197 Alzheimer's disease human NINJ2 PF 21674003
201 Alzheimer's disease human NOS3 RF 20505439
201 Alzheimer's disease human NOS3 RF in the APOE epsilon 4 noncarriers 18183499
201 Alzheimer's disease human NOS3 RF in the APOE epsilon 4 noncarriers 18183499
202 Alzheimer's disease human NQO1 PF significant difference in the APOE epsilon4 non-carriers 18253865
202 Alzheimer's disease human NQO1 RF 18253865
203 Alzheimer’s Disease human NT-3 RF homozygotes or heterozygotes for the mutated type (Glu[-63]) 9502217
204 Alzheimer's disease human NTF-3 PF in patients lacking the ApoE-?4 allele 26814132
204 Alzheimer's disease human NTF-3 RF 24174922
204 Alzheimer's disease human NTF-3 RF 24174922
204 Alzheimer's disease human NTF-3 PF 24174922
207 Alzheimer's disease human OX2R RF A allele may be a susceptible factor for AD 30955315
207 Alzheimer's disease human OX2R RF A allele may be a susceptible factor for AD 30955315
208 Alzheimer's disease human oxidized LDL receptor 1(OLR1) RF 21709374
208 Alzheimer's disease human oxidized LDL receptor 1(OLR1) RF 21709374
218 Alzheimer's disease human PEMT RF 21881829
220 Alzheimer’s Disease human PICALM RF PENN cohort 30128317
220 Alzheimer’s Disease human PICALM RF PENN cohort 30128317
220 Alzheimer's Disease human PICALM RF Genotype GG;P value adjusted for age, gender, educational attainment, and APOE-e4 status 25359311
222 Alzheimer's disease human PLA2G3 RF 20930276
224 Alzheimer's Disease human PLEKHG5 RF 29177109
225 Alzheimer’s Disease human PM20D1 PF in a particular genetic background 29736028
230 Alzheimer's Disease human presence of one or more APOE ε4 alleles RF in females 26343475
232 Alzheimer’s Disease human PS-1 RF 8930979
232 Alzheimer’s Disease human PS-1 RF 9298817
232 Alzheimer’s Disease human PS-1 RF APOE ε4 10581373
233 Alzheimer’s Disease human PS-2 RF APOE ε4 10581373
234 Alzheimer's Disease human PSEN1 RF 25104557
235 Alzheimer's Disease human PSEN2 RF 25104557
235 Alzheimer's Disease human PSEN2 RF 24927704
236 Alzheimer’s Disease human PTK2B PF National Alzheimer’s Coordinating Center (NACC) cohort 30128317
237 Alzheimer’s Disease human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 30319691
237 Alzheimer’s Disease human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 30319691
237 Alzheimer’s Disease human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 30319691
237 Alzheimer's Disease human PVRL2 RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 29107063
237 Alzheimer's Disease human PVRL2 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 29107063
237 Alzheimer's Disease human PVRL2 RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 29107063
237 Alzheimer's Disease human PVRL2 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 29107063
238 Alzheimer's Disease human RAB10 PF 29183403
239 Alzheimer's Disease human RCAN1 RF 26497675
239 Alzheimer's Disease human RCAN1 RF 26497675
240 Alzheimer's Disease human reduced DYRK1A expression RF 25116835
241 Alzheimer's disease human reduced folate carrier gene (RFC1) RF especially for female individuals 18258338
241 Alzheimer's disease human reduced folate carrier gene (RFC1) RF especially for female individuals 18258338
247 Alzheimer's disease human SERPINE1 RF women were at an increased risk over their male genotype counterparts 28466654
247 Alzheimer's disease human SERPINE1 RF women were at an increased risk over their male genotype counterparts 28466654
248 Alzheimer's disease human SHARPIN RF 31216982
249 Alzheimer's disease human SIRT2 RF APOEε4 noncarriers 24139700
249 Alzheimer's disease human SIRT2 RF 24139700
251 Alzheimer’s Disease human SLC6A4/5-HTT PF S allele; AD with depression 29703883
258 Alzheimer's Disease human SOD1 gene PF After Bonferroni correction；recessive model 25440013
258 Alzheimer's Disease human SOD1 gene PF After Bonferroni correction；additive model 25440013
258 Alzheimer's Disease human SOD1 gene PF Logistic regression analysis controlled for age, genderand APOE carrier status；recessive model 25440013
258 Alzheimer's Disease human SOD1 gene PF Logistic regression analysis controlled for age, genderand APOE carrier status；additive model 25440013
259 Alzheimer's Disease human SORL1 RF with the A allele 25450149
259 Alzheimer’s Disease human SORL1 PF 30009200
259 Alzheimer's Disease human SORL1 RF 26303663
259 Alzheimer's Disease human SORL1 RF when restricting the analysis to the 205 cases with a positive family history 26303663
259 Alzheimer's Disease human SORL1 RF adjusted for age and gender 25881907
259 Alzheimer's Disease human SORL1 RF adjusted foe age, gender, APOE 4 25881907
259 Alzheimer's Disease human SORL1 RF 19368828
259 Alzheimer's disease human SORL1 RF 24486888
259 Alzheimer's disease human SORL1 PF 18407551
260 Alzheimer's disease human SORT1 PF 27392867
263 Alzheimer’s Disease human SREBF2 RF significant dual associations with LOAD pathological biomarkers and gene expression levels 29503034
264 Alzheimer's Disease human SRR RF 29338921
265 Alzheimer's disease human STARD6 RF in combination with the APOE ε4 allele 30666118
266 Alzheimer's disease human STH RF especially in caucasian population, late‐onset AD subjects and studies with high quality 28211174
270 Alzheimer's disease human SUMO1 RF 27084229
271 Alzheimer's disease human SUMO2 RF 27084229
271 Alzheimer's disease human SUMO2 RF 27084229
273 Alzheimer’s Disease human SYMPK RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 30319691
279 Alzheimer's disease human TFAM RF 18430995
280 Alzheimer's Disease human TGF-β1 RF Genotype AC 26327336
280 Alzheimer's Disease human TGF-β1 RF allele C 26327336
280 Alzheimer's Disease human TGF-β1 RF Genotype TG 26327336
280 Alzheimer's Disease human TGF-β1 RF allele G 26327336
280 Alzheimer's Disease human TGF-β1 RF without the ApoE ε4 allele;AC 26327336
280 Alzheimer's Disease human TGF-β1 RF without the ApoE ε4allele;C 26327336
280 Alzheimer's Disease human TGF-β1 RF without the ApoE ε4 allele;TG 26327336
280 Alzheimer's Disease human TGF-β1 RF without the ApoE ε4 allele;G 26327336
280 Alzheimer's Disease human TGF-β1 RF AC+ CC vs AA 26327336
282 Alzheimer's Disease human THBS2 RF 29177109
285 Alzheimer's disease human TLR2 PF 26738351
286 Alzheimer's disease human TLR4 PF when incorporated into a haplotype with rs10759930, the strongest association was detected 22272615
287 Alzheimer's disease human TMEM106B RF APOE interact 24166182
288 Alzheimer's disease human TMP21 RF 28233271
289 Alzheimer's disease human TNFRSF1A, CDH1, CASP7, LRP1B and TG RF 26621834
290 Alzheimer's disease human TNF-α RF in the APOE epsilon4 non-carriers 18396294
290 Alzheimer's disease human TNF-α RF in the APOE epsilon4 non-carriers 18396294
291 Alzheimer's Disease human TNF-α -308 RF A vs. G allele 25647294
291 Alzheimer's Disease human TNF-α -308 RF AA + AG vs. GG (dominant) 25647294
291 Alzheimer's Disease human TNF-α -308 RF AA vs. AG + GG (recessive) 25647294
291 Alzheimer's Disease human TNF-α -308 RF AA vs. GG 25647294
291 Alzheimer's Disease human TNF-α -308 RF AA vs. AG 25647294
292 Alzheimer’s Disease human TOMM40 RF 29797398
292 Alzheimer’s Disease human TOMM40 RF 29797398
292 Alzheimer's Disease human TOMM40 RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 29107063
292 Alzheimer's Disease human TOMM40 RF using logistic regression、Dataset：FHS(Framingham Heart Study) 29107063
292 Alzheimer's Disease human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 29107063
292 Alzheimer's Disease human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 29107063
292 Alzheimer's Disease human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 29107063
292 Alzheimer's Disease human TOMM40 RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 29107063
292 Alzheimer's Disease human TOMM40 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 29107063
292 Alzheimer's Disease human TOMM40 RF using Cox regression、Dataset：FHS（Framingham Heart Study） 29107063
292 Alzheimer's Disease human TOMM40 RF using Cox regression、Dataset：HRS（Health and Retirement Study） 29107063
292 Alzheimer's Disease human TOMM40 RF using Cox regression、Dataset：HRS（Health and Retirement Study） 29107063
292 Alzheimer's disease human TOMM40 RF 30443289
292 Alzheimer's disease human TOMM40 RF the association between the Asian and Caucasian groups was significantly different 26795201
292 Alzheimer's disease human TOMM40 PF the association between the Asian and Caucasian groups was significantly different 26795201
293 Alzheimer’s Disease human TREM2 RF 30222607
293 Alzheimer’s Disease human TREM2 RF 29794134
293 Alzheimer's Disease human TREM2 RF 26037549
293 Alzheimer's Disease human TREM2 RF 25936935
293 Alzheimer's Disease human TREM2 RF the T allele of the rs75932628 variant of TREM2 25260849
293 Alzheimer's Disease human TREM2 RF 25160042
293 Alzheimer's disease human TREM2 RF 24439484
293 Alzheimer's disease human TREM2 RF 24041969
293 Alzheimer's disease human TREM2 RF 24041969
293 Alzheimer's disease human TREM2 RF 23855982
293 Alzheimer's Disease human TREM2 RF 23380991
295 Alzheimer's disease human TREML2 PF 24439484
296 Alzheimer's disease human TYROBP RF 27658901
298 Alzheimer's disease human ubiquilin 1 gene (UBQLN1) RF This effect was stronger in a group of LOAD patients without APOE4 allele 18340109
309 Alzheimer's disease human 25(OH)D deficiency PF 28522216
310 Alzheimer's Disease human a decrease in LRP10 function RF 22734645
312 Alzheimer’s Disease human A priori occupations RF Printers, mechanics, garage workers, oilers, painters, auto body workers, wood finishers, shoemakers, and dry cleaners (as one of two longest held occupations). 7771442
313 Alzheimer’s Disease human Activities of daily living assistance RF after Hemodialysis Initiation 30093374
318 Alzheimer's disease human African ancestry RF 28369008
319 Alzheimer's Disease human Age RF in females 26343475
319 Alzheimer's Disease human Age RF 22976076
319 Alzheimer’s Disease human Age RF 30103328
319 Alzheimer’s Disease human Age RF after Hemodialysis Initiation 30093374
319 Alzheimer’s Disease human Age RF after Hemodialysis Initiation 30093374
319 Alzheimer’s Disease human Age RF after Hemodialysis Initiation 30093374
319 Alzheimer’s Disease human Age RF after Hemodialysis Initiation 30093374
319 Alzheimer's Disease human Age RF 25624416
319 Alzheimer's Disease human Age RF 25401488
319 Alzheimer's Disease human Age RF 20016220
319 Alzheimer's disease human Age RF 31058682
319 Alzheimer's disease human Age RF 24489845
319 Alzheimer's disease human Age RF 22526079
319 Alzheimer's Disease human Age RF 28806610
319 Alzheimer's disease human Age RF people with mild cognitive impairment (MCI) 21518614
319 Alzheimer's disease human Age RF in patients after spine surgery 20375503
324 Alzheimer’s Disease human age in first degree relatives RF age of 90 in first degree relatives 8411049
327 Alzheimer's disease human age-associated decline in health status RF the nontraditional risk factors index [FI-NTRF] was constructed for predict Alzheimer disease and dementia 21753161
332 Alzheimer's disease human Air pollution RF 30741678
334 Alzheimer’s Disease human Alcohol dependence PF after Hemodialysis Initiation 30093374
336 Alzheimer’s Disease human amnestic mild cognitive impairment (aMCI) RF 30199883
337 Alzheimer's Disease human an increase in K(+) intake PF 26391254
342 Alzheimer's disease human anemia RF 24419041
343 Alzheimer’s Disease human Anxiety RF Calculated by fixed effect model 30339108
343 Alzheimer’s Disease human Anxiety RF Calculated by random effect model 30339108
343 Alzheimer's Disease human Anxiety RF Model 1: Main effect unadjusted 29077487
343 Alzheimer's Disease human Anxiety RF Model 2: Main effects adjusted for sex, education, age, and race. 29077487
343 Alzheimer's Disease human Anxiety RF Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 29077487
343 Alzheimer's Disease human Anxiety RF Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 29077487
343 Alzheimer's disease human anxiety RF people with mild cognitive impairment (MCI) 21518614
343 Alzheimer's disease human Anxiety RF Clinically significant anxiety,not subclinical anxiety 30825716
346 Alzheimer’s Disease human Arthritis PF 2146525
347 Alzheimer’s Disease human Atherosclerotic heart disease PF after Hemodialysis Initiation 30093374
348 Alzheimer's Disease human atrial fibrillation (AF) RF 24825565
354 Alzheimer's Disease human beliefs about stress RF 28605999
355 Alzheimer’s Disease human Benzene, toluene exposure RF 7771442
357 Alzheimer's disease human Better sleep consolidation attenuate PF in APOE e4 carriers 24145819
358 Alzheimer's disease human Bilingualism PF 30475769
363 Alzheimer's Disease human blood pressure variability (BPV) RF 28784823
367 Alzheimer’s Disease human Body mass index RF after Hemodialysis Initiation; <18.5 30093374
367 Alzheimer’s Disease human Body mass index RF after Hemodialysis Initiation; 18.5–25.0 30093374
367 Alzheimer’s Disease human Body mass index RF after Hemodialysis Initiation; 25.0–30.0 30093374
367 Alzheimer’s Disease human Body mass index RF extrinsic epigenetic age acceleration 30167451
367 Alzheimer’s Disease human Body mass index RF intrinsic epigenetic age acceleration 30167451
368 Alzheimer's disease human bone mineral density (BMD) RF low bone mineral density (BMD) 21187587
369 Alzheimer's disease rabbit Caffeine PF even very low doses of caffeine might protect against sporadic AD 20638472
369 Alzheimer's disease human Caffeine PF coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life 20182054
372 Alzheimer’s Disease human Cancer PF after Hemodialysis Initiation 30093374
372 Alzheimer's disease human Cancer PF 30906403
372 Alzheimer's disease human Cancer PF Cancer History(Cancer survivors) 28035936
373 Alzheimer's disease human Cardiorespiratory fitness (CRF) PF 28293467
374 Alzheimer’s Disease human cardiovascular disease (CaVD) RF 30149459
375 Alzheimer's Disease human carotid atherosclerosis RF 28810593
376 Alzheimer’s Disease human Cataract PF 2146525
377 Alzheimer’s Disease human cerebrovascular disease RF Cerebrovascular Alterations 30355253
377 Alzheimer's Disease human cerebrovascular disease RF 28806610
378 Alzheimer's disease human characteristics of anxiety RF people with mild cognitive impairment (MCI) 21518614
379 Alzheimer’s Disease human childhood stress RF 30020441
379 Alzheimer’s Disease human childhood stress RF adjusted for age, education, income and other covariates 30020441
381 Alzheimer's disease mice Chronic low-dose-rate ionising radiation RF chronic low-dose-rate radiation exposure (1 mGy/day or 20 mGy/day) 27708245
383 Alzheimer's Disease human chronic periodontitis (CP) RF 10-year CP exposure 28784164
385 Alzheimer's disease mice Chronic Sleep Deprivation(SD) RF 26757041
388 Alzheimer's Disease human coffee consumption RF per one cup a day 29212772
389 Alzheimer's Disease human cognitive impairment RF 23254639
390 Alzheimer’s Disease human Congestive heart failure PF after Hemodialysis Initiation 30093374
391 Alzheimer’s Disease human constipation RF colorectal cancer and AD have similar epidemiologic feature 30323761
395 Alzheimer's disease human covariant associated with social status RF 26893902
400 Alzheimer's Disease human Depression RF clinically significant depressive symptoms at baseline 26343475
400 Alzheimer’s Disease human Depression RF 29606955
400 Alzheimer’s Disease human Depression RF fundamental shift in depression-related monoaminergic systems (including serotonin and noradrenaline) 29685068
400 Alzheimer's Disease human depression RF 28731429
400 Alzheimer's Disease human Depression RF 25401488
400 Alzheimer's Disease human depression RF 18603262
400 Alzheimer's Disease human Depression RF clinician verified;Model 1: Main effect unadjusted 29077487
400 Alzheimer's Disease human Depression RF clinician verified;Model 2: Main effects adjusted for sex, education, age, and race. 29077487
400 Alzheimer's Disease human Depression RF clinician verified;Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 29077487
400 Alzheimer's Disease human Depression RF clinician verified;Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 29077487
400 Alzheimer's Disease human Depression RF Model 1: Main effect unadjusted 29077487
400 Alzheimer's Disease human Depression RF Model 2: Main effects adjusted for sex, education, age, and race. 29077487
400 Alzheimer's Disease human Depression RF Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 29077487
400 Alzheimer's Disease human Depression RF Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 29077487
400 Alzheimer’s Disease human Depression RF Depressive disorder in last 10 years 2146525
400 Alzheimer's Disease human Depression RF 28605999
400 Alzheimer's disease human Depression RF HAM:Hamilton Depression Rating Scale 18327871
400 Alzheimer's disease mice Depression RF 27837334
400 Alzheimer's Disease human Depression RF Late-onset MD(major episode) with DEDS;after adjustment by age, gender, marital status, education, cognitive impairment, executive function and stroke history 22588687
400 Alzheimer's Disease human Depression RF Late-onset MDDIS(minor depressive disorders) with DEDS;after adjustment by age, gender, marital status, education, cognitive impairment, executive function and stroke history 22588687
400 Alzheimer's Disease human Depression RF late-onset MD with DEDS 22588687
400 Alzheimer's Disease human Depression RF late-onset MDDIS with DEDS 22588687
400 Alzheimer's Disease human Depression RF unadjusted 28560728
400 Alzheimer's Disease human Depression RF adjusteda without ε4 carrier status Hazard ratio 28560728
400 Alzheimer's Disease human Depression RF adjusted with ε4 carrier status Hazard ratio 28560728
400 Alzheimer's Disease human Depression RF personal history of depression 24596166
400 Alzheimer's Disease human Depression RF recent depression last 2 years;unadjusted 28560728
400 Alzheimer's Disease human Depression RF recent depression last 2 years;adjusteda without ε4 carrier status Hazard ratio 28560728
400 Alzheimer's Disease human Depression RF recent depression last 2 years;adjusted with ε4 carrier status Hazard ratio 28560728
400 Alzheimer's Disease human Depression RF recent depression last 2 years;adjusted with ε4 carrier status and AD Medication use Hazard ratio 28560728
400 Alzheimer's Disease human Depression RF Model 1: Main effect unadjusted 29077487
400 Alzheimer's Disease human Depression RF Model 2: Main effects adjusted for sex, education, age, and race. 29077487
400 Alzheimer's Disease human Depression RF Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 29077487
400 Alzheimer's Disease human Depression RF Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 29077487
400 Alzheimer's Disease human Depression RF Severe depression 23791538
401 Alzheimer’s Disease human Diabetes RF 29971140
401 Alzheimer’s Disease human Diabetes RF 30103328
401 Alzheimer’s Disease human Diabetes RF after Hemodialysis Initiation 30093374
401 Alzheimer's Disease human diabetes RF 28806610
401 Alzheimer's disease human Diabetes RF 28503814
401 Alzheimer's disease human diabetes RF people with mild cognitive impairment (MCI) 21518614
401 Alzheimer's disease human Diabetes PF with APOE4 genotype in AD population 18189240
401 Alzheimer’s Disease human Diabetes RF 30149459
401 Alzheimer’s Disease human Diabetes RF 29606955
401 Alzheimer’s Disease human Diabetes RF 7473847
401 Alzheimer’s Disease human Diabetes RF 15148141
401 Alzheimer's Disease human Diabetes RF 26495049
401 Alzheimer's disease human Diabetes RF 24489845
401 Alzheimer's disease human Diabetes RF people with mild memory impairment/no dementia (MMI/ND) 21205364
402 Alzheimer's Disease human dieldrin RF 22904031
403 Alzheimer's Disease human Dietary AGEs(dietary advanced glycation end products) RF 25633677
405 Alzheimer’s Disease human Dietary Risk PF Dietary sources that contain high amounts of DHA in phospholipid form 30289748
406 Alzheimer's disease mice dietary sugar or sucrose RF controlling the consumption of sugar-sweetened beverages may be an effective way to curtail the risk of developing AD 17942401
409 Alzheimer’s Disease human Disorders in a 1st-degree relative RF Dementia 2146525
409 Alzheimer’s Disease human Disorders in a 1st-degree relative RF Probable AD 2146525
409 Alzheimer’s Disease human Disorders in a 1st-degree relative RF Down’s syndrome 2146525
409 Alzheimer’s Disease human Disorders in a 1st-degree relative PF Thyroid disorders 2146525
410 Alzheimer’s Disease human Dispersion and Disengaged Lifestyle RF 31162439
411 Alzheimer's disease human disseminated mycoses RF 24452965
413 Alzheimer's disease human dread fullness RF people with mild cognitive impairment (MCI) 21518614
414 Alzheimer's disease human Drinking RF Daily drinking 21187587
414 Alzheimer’s Disease human Drinking PF 12707449
422 Alzheimer's disease human dyslipidemia RF 30894904
425 Alzheimer's Disease human education PF a higher number of school years 25624416
425 Alzheimer's Disease human education PF 20016220
425 Alzheimer's disease human education RF 31058682
425 Alzheimer's disease human education PF in PSEN1 E280A mutation carriers 26902171
425 Alzheimer's disease human education PF people with mild cognitive impairment (MCI) 21518614
425 Alzheimer's Disease human education PF per year of education completed 29212772
425 Alzheimer's Disease human education PF per unit higher log odds of having completed college/university 29212772
425 Alzheimer's disease human education RF lower education 18446027
425 Alzheimer's disease human education RF Lower levels of education 30425786
425 Alzheimer's Disease human education RF Lack of formal education 25401488
425 Alzheimer's Disease human education RF Low Education 26495049
425 Alzheimer’s Disease human education RF Low educational attainent 29606955
427 Alzheimer’s Disease human Employment status PF after Hemodialysis Initiation; Employed 30093374
427 Alzheimer’s Disease human Employment status RF after Hemodialysis Initiation; Other 30093374
428 Alzheimer's Disease human endothelial dysfunction RF specifically loss of endothelial NO 23745722
429 Alzheimer's disease human environmental exposure to cadmium RF high cadmium levels (>0.6 μg/L) 27301955
433 Alzheimer's disease mice excess zinc exposure RF 21179415
435 Alzheimer's Disease human experienced appreciable weight loss RF 18835864
438 Alzheimer's Disease human Exposure to Lead RF Cigarette smoking 29089568
440 Alzheimer’s Disease human Exposure to N2O RF 29991368
445 Alzheimer’s Disease human Exposure to PM2.5 RF 29935448
456 Alzheimer's Disease human family history of cardiovascular diseases RF 24596166
458 Alzheimer's disease human Family history of dementia (FH) RF 26531229
459 Alzheimer's disease human family history of dementia (within third-degree relatives) RF people with mild memory impairment/no dementia (MMI/ND) 21205364
460 Alzheimer's disease human farming PF 31239120
460 Alzheimer's disease human farming PF 31239120
315 Alzheimer's Disease human Obesity RF being obese (BMI ≥30) at age 30, 40, or 45 years and jointly centrally obese (waist circumference ≥80th percentile) at age 30, 35, or 50 years 18835864
465 Alzheimer's Disease human Formaldehyde (FA) RF 24766729
469 Alzheimer's Disease human Gender RF 28806610
469 Alzheimer's Disease human Gender RF 25624416
469 Alzheimer's Disease human Gender RF 20016220
469 Alzheimer's disease human Gender RF 27105335
469 Alzheimer's disease human Gender RF 24489845
469 Alzheimer's disease human Gender RF 22526079
469 Alzheimer’s Disease human Gender RF after Hemodialysis Initiation 30093374
473 Alzheimer's disease human Having a first-degree relative or a parent with dementia RF 26531229
477 Alzheimer’s Disease human head circumference (HC) RF within the lowest quintile of HC for women 9222166
478 Alzheimer’s Disease human Head injury RF 10746604
478 Alzheimer’s Disease human Head injury RF 12707449
478 Alzheimer’s Disease human Head injury RF 12707449
479 Alzheimer's disease human Healthy diet PF in late life 22163237
483 Alzheimer's disease Heavy metals toxicity:Cadmium (Cd) RF 24557150
488 Alzheimer’s Disease human High blood pressure RF intrinsic epigenetic age acceleration 30167451
489 Alzheimer's Disease human High consumption of aluminum RF 19064650
491 Alzheimer's disease human High occupational attainment RF mild cognitive impairment(MCI) patient 27662289
491 Alzheimer's disease human High occupational attainment PF 27662289
493 Alzheimer's disease human higher age among senior citizens in urban communities RF 31286894
494 Alzheimer's Disease human higher body mass index RF 24596166
495 Alzheimer's Disease human higher CDR-SB scores RF in male 26343475
496 Alzheimer's disease human Higher leptin level PF 21187587
497 Alzheimer's Disease human higher levels of estrogen exposure RF 24968011
498 Alzheimer's Disease human higher levels of prenatal testosterone exposure RF 24968011
500 Alzheimer's disease human history of depressive episodes RF 18446027
503 Alzheimer's disease human Hypercholesterolemia RF 27921357
504 Alzheimer's Disease human hyperhomocysteinemia RF 24656904
504 Alzheimer's disease human Hyperhomocysteinemia RF 23833960
505 Alzheimer's disease human hyperlipidemia RF people with mild cognitive impairment (MCI) 21518614
505 Alzheimer’s Disease human hyperlipidemia RF 29971140
505 Alzheimer's Disease human hyperlipidemia RF 28806610
506 Alzheimer's Disease human hypertension RF 25624416
506 Alzheimer’s Disease human hypertension RF 29971140
506 Alzheimer’s Disease human hypertension RF 30149459
506 Alzheimer’s Disease human Hypertension RF after Hemodialysis Initiation 30093374
506 Alzheimer’s Disease human hypertension RF 7473847
506 Alzheimer's Disease human hypertension RF 20016220
506 Alzheimer's disease human hypertension RF 30894904
506 Alzheimer's disease human hypertension RF 24489845
506 Alzheimer's disease human hypertension RF people with mild cognitive impairment (MCI) 21518614
506 Alzheimer’s Disease human hypertension RF 29606955
506 Alzheimer's Disease human hypertension RF 26495049
507 Alzheimer’s Disease human hypertension and diabetes RF 29971140
508 Alzheimer’s Disease human hypertension and hyperlipidemia RF 29971140
509 Alzheimer’s Disease human hypertension, diabetes and hyperlipidemia RF 29971140
510 Alzheimer's disease human hypertensive RF 18288934
512 Alzheimer’s Disease human Illiteracy RF < 1 year at school 12212789
512 Alzheimer's Disease human Illiteracy RF 25401488
514 Alzheimer's disease human Improving cardiovascular functions PF mean velocity of the BA 28505975
514 Alzheimer's disease human Improving cardiovascular functions PF mean velocity of the LTICA 28505975
514 Alzheimer's disease human Improving cardiovascular functions PF Ejection fraction 28505975
515 Alzheimer’s Disease human Inability to ambulate RF after Hemodialysis Initiation 30093374
522 Alzheimer's Disease human infectious burden:C. pneumoniae RF 24910016
523 Alzheimer's Disease human infectious burden:cytomegalovirus (CMV) RF 24910016
525 Alzheimer’s Disease human institutionalization RF after Hemodialysis Initiation 30093374
526 Alzheimer's Disease human Insulin resistance (IR) RF 20031276
526 Alzheimer's disease human insulin resistance (IR) RF 27079723
527 Alzheimer's disease human intellectual work PF people with mild cognitive impairment (MCI) 21518614
528 Alzheimer's disease human introvert characteristics RF people with mild cognitive impairment (MCI) 21518614
529 Alzheimer's Disease human ionizing radiation RF 28671130
530 Alzheimer’s Disease human Job description only RF Exposure to printing/printer's ink, coal tar/creosote, oils, glues/resins/waxes, rubber production, or paints. 7771442
531 Alzheimer’s Disease human Jobs as seamstress, dressmaker and tailor RF 7677130
531 Alzheimer’s Disease human Jobs as seamstress, dressmaker and tailor RF 7677130
534 Alzheimer’s Disease human Ketones exposure RF 7771442
535 Alzheimer's disease human lack of sports RF people with mild cognitive impairment (MCI) 21518614
540 Alzheimer's Disease human light-moderate alcohol drinker RF 28806610
543 Alzheimer's disease human loneliness RF people with mild cognitive impairment (MCI) 21518614
545 Alzheimer’s Disease human low education/rural residence RF 10636132
546 Alzheimer’s Disease human Malaria RF 2146525
552 Alzheimer's disease human Maternal breastfeeding history PF Women who breastfed had lower AD risk than women who did not breastfeed(p = 0.017) 23948914
557 Alzheimer’s Disease mice maternal transmission RF Tg2576 female mice 29691440
562 Alzheimer’s Disease human monozygotic(MZ) twins RF twins born in Finland before 1958 with both co-twins alive in 1967 8596319
566 Alzheimer's disease human Native American ancestry PF 28369008
568 Alzheimer's disease human no chronic use of nonsteroidal anti-inflammatory drugs PF 18446027
572 Alzheimer's Disease human Nonmarried RF 25401488
573 Alzheimer's disease human nonstroke cardiovascular disease (CVD) RF in carriers of the ApoE4 allele 20473139
574 Alzheimer's disease human normal tension glaucoma (NTG) RF Among patients with NTG, none of the glaucoma eye drops used significantly changed the risk of subsequent AD. 30397009
315 Alzheimer’s Disease human Obesity RF 29606955
315 Alzheimer's Disease human Obesity RF 26495049
315 Alzheimer's Disease human Obesity RF 26324099
315 Alzheimer's disease Obesity RF 31191220
315 Alzheimer's disease human obesity RF 30792733
583 Alzheimer's disease human often taking part in recreational activities PF people with mild cognitive impairment (MCI) 21518614
584 Alzheimer's Disease human okra RF particularly in people carrying a H63D polymorphism 26170247
588 Alzheimer’s Disease human Other solvents exposure RF 7771442
592 Alzheimer's disease human Parental death during childhood RF with strength of these associations attenuated by remarriage of the widowed parent. 21873837
599 Alzheimer’s Disease human Peripheral vascular disease PF after Hemodialysis Initiation 30093374
600 Alzheimer's Disease human personal experience with AD RF 28605999
602 Alzheimer’s Disease human Phenols, alcohols exposure RF 7771442
603 Alzheimer's disease human phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) RF 24067654
605 Alzheimer’s Disease human Physical inactivity RF 29606955
605 Alzheimer's Disease human Physical Inactivity RF 26495049
606 Alzheimer’s Disease human Physically underactive RF 2146525
606 Alzheimer’s Disease human Physically underactive RF 2146525
613 Alzheimer’s Disease human pregnancy RF pregnant 5xFAD transgenic mice 29855361
615 Alzheimer's Disease human prenatal estrogen exposure RF lower levels of prenatal estrogen exposure 24968011
618 Alzheimer's Disease human prenatal testosterone exposure RF lower levels of prenatal testosterone exposure 24968011
621 Alzheimer’s Disease human Probable solvent exposure RF Any above-named solvent or "job description." 7771442
621 Alzheimer’s Disease human Probable solvent exposure RF Any above-named solvent or "job description." 7771442
625 Alzheimer's disease human Proton pump inhibitors (PPIs) RF Chronic consumption of PPIs 20456731
628 Alzheimer’s Disease human Race RF after Hemodialysis Initiation 30093374
628 Alzheimer’s Disease human Race RF after Hemodialysis Initiation 30093374
629 Alzheimer's Disease human Reading RF reading occasionally 28806610
629 Alzheimer's disease human Reading PF people with mild cognitive impairment (MCI) 21518614
630 Alzheimer's disease human regular "mind-body" religious meditative activities(or kowtow) PF 26757186
638 Alzheimer's Disease human Rural residency RF 25401488
644 Alzheimer's Disease human serum cholesterol RF 22904031
646 Alzheimer's Disease human severe OSA(obstructive sleep apnea) RF ≥30 vs. <5 apnea-hypopnea events/hour;using adjudicated outcomes 28738188
648 Alzheimer's Disease human severe PWMH RF in male 26343475
650 Alzheimer's Disease human Sleep disturbance RF Model 1: Main effect unadjusted 29077487
650 Alzheimer's Disease human Sleep disturbance RF Model 2: Main effects adjusted for sex, education, age, and race. 29077487
650 Alzheimer's Disease human Sleep disturbance RF Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 29077487
650 Alzheimer's Disease human Sleep disturbance RF Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 29077487
651 Alzheimer's disease Sleep-wake regulation RF 30649520
652 Alzheimer's disease human Smoking RF Current smokers 21187587
652 Alzheimer's Disease human Smoking RF current smoking 28806610
652 Alzheimer's Disease human Smoking RF in Mongolian males aged over 55 years 25657695
652 Alzheimer's Disease human Smoking RF 23422663
652 Alzheimer’s Disease human Smoking PF 30103328
652 Alzheimer’s Disease human Smoking RF 29606955
652 Alzheimer’s Disease human Smoking RF 2754163
652 Alzheimer’s Disease human Smoking PF Light smoker 9346343
652 Alzheimer’s Disease human Smoking RF Daily smoker 9346343
652 Alzheimer's Disease human Smoking RF 26495049
652 Alzheimer's Disease human Smoking RF 24596166
652 Alzheimer's disease human Smoking PF 30792733
652 Alzheimer's disease human Smoking RF smoking more than 2 packs a day 20975015
652 Alzheimer's disease human Smoking RF in APOE e4 carriers 20847559
652 Alzheimer’s Disease human Smoking RF intrinsic epigenetic age acceleration; current smoker (N=939); former smoker, stopped within past 12 months (N=158); former smoker, stopped more than 12 months ago (N=1309); never smoker (N=2533), and not coded (N=62). 30167451
655 Alzheimer’s Disease human Socioeconomic status (SIMD, SD) RF intrinsic epigenetic age acceleration 30167451
656 Alzheimer’s Disease human Solvent exposure RF Any positive response to a named solvent group 7771442
656 Alzheimer’s Disease human Solvent exposure RF Any positive response to a named solvent group. 7771442
658 Alzheimer's disease human soy food products RF 24440006
661 Alzheimer's disease human statin use PF 20533968
662 Alzheimer's Disease human stress RF chronic stress 20044001
663 Alzheimer's disease human stroke RF previous stroke history 24489845
663 Alzheimer's disease human stroke RF mediated the association between selected CV risk factors and LOAD 27533593
663 Alzheimer's disease human stroke RF mediated the association between selected CV risk factors and LOAD 27533593
664 Alzheimer’s Disease human Stroke/transient ischemic attack RF after Hemodialysis Initiation 30093374
673 Alzheimer’s Disease human Total:HDL cholesterol (ratio) RF extrinsic epigenetic age acceleration 30167451
678 Alzheimer's Disease human Traumatic brain injury (TBI) RF 26401777
679 Alzheimer's Disease human traumatic brain injury (TBI) with reported loss of consciousness (LOC) RF 29389151
680 Alzheimer's Disease human treadmill exercise PF 25960981
684 Alzheimer's disease human type 2 diabetes mellitus (T2DM) RF a risk factor for MCI progressing into AD 27729793
687 Alzheimer's Disease human underweight RF at age 30, 40, or 45 years 18835864
688 Alzheimer's disease human urbanization status RF 24489845
694 Alzheimer's Disease human vascular risk RF 20164563
695 Alzheimer's disease human vascular risk factors(hypertension, diabetes, cerebrovascular diseases, and hypercholesterolemia) RF people with mild cognitive impairment (MCI) 21490316
697 Alzheimer's disease human vitamin D insufficiency RF 22306846
698 Alzheimer's disease mice Vulnerability to stress RF pharmacological treatment with venlafaxine may represent a therapeutic strategy for the treatment of stress-related disorders, including AD 21797840
699 Alzheimer’s Disease human Wandering RF exhibit wandering in the middle or late stages 8422268
701 Alzheimer's Disease human weight gain RF between 30 and 50 years for any 5-year interval 18835864
705 Alzheimer’s Disease human Years of education PF 30103328
706 Alzheimer’s Disease human Yemenite origin RF 30103328
708 Alzheimer's Disease human β- hexachlorocyclohexane RF 22904031
709 Alzheimer's Disease human anti-AT1R RF 26401573
711 Alzheimer's Disease human free copper RF 23760784
714 Alzheimer's Disease human the lowest folate tertile RF 28698453
715 Alzheimer's Disease human a protective response to proteostatic stress, directed by the NRF1-sMAF complex RF people carrying the risk (A) allele of rs667897 29179108
716 Alzheimer's Disease human accumulation of p16(INK4a)-positive senescent astrocytes RF 22984612
719 Alzheimer's disease mice age-related increase in chemokine CCL11 RF antagonizing CCR3 may bring therapeutic benefits to?AD 27878757
720 Alzheimer's Disease human Albuminuria RF Model 1:adjusted for age and sex 29353232
720 Alzheimer's Disease human Albuminuria RF Model 2:adjusted for Model 1 plus educational level, history of stroke, systolic blood pressure, the use of antihypertensive agents, diabetes mellitus, total cholesterol, body mass index, smoking habits, alcohol intake, and regular exercise 29353232
720 Alzheimer's Disease Albuminuria RF Model 3:adjusted for Model 2 plus eGFR 29353232
720 Alzheimer's Disease human Albuminuria RF Model 1:adjusted for age and sex 29353232
720 Alzheimer's Disease Albuminuria RF Model 2:adjusted for Model 1 plus educational level, history of stroke, systolic blood pressure, the use of antihypertensive agents, diabetes mellitus, total cholesterol, body mass index, smoking habits, alcohol intake, and regular exercise 29353232
720 Alzheimer's Disease human Albuminuria RF Model 3:adjusted for Model 2 plus eGFR 29353232
722 Alzheimer’s Disease human Aluminum RF 7507666
722 Alzheimer’s Disease rat Aluminum RF 18-day fetal rats 8537015
723 Alzheimer's disease Amyloid-β (Aβ)(42) RF 21955816
724 Alzheimer's Disease human annexin A5 RF 23576984
727 Alzheimer’s Disease human apoE protein activity RF 7672107
729 Alzheimer’s Disease human Apolipoprotein E (APOE)-epsilon4 RF 29605385
732 Alzheimer’s Disease human benzodiazepine and related drug (BZDR) RF 29851063
733 Alzheimer’s Disease human beta-amyloid (Abeta) accumulation RF 29592889
734 Alzheimer’s Disease human beta-amyloid precursor protein (APP) processing RF 9041854
735 Alzheimer’s Disease Caenorhabditis elegans betaine PF both the presence and absence of 1 mM homocysteine; independent of the remethylation pathway but requires the transsulfuration pathway mediated by cystathionine-β-synthase 30065790
736 Alzheimer's disease human Bleomycin hydrolase (BLH) RF 20308784
737 Alzheimer’s Disease human Blood levels of alpha-1-antichymotrypsin(ACT) RF 10629358
738 Alzheimer’s Disease human Branched-chain amino acids (BCAAs) RF 29802157
739 Alzheimer’s Disease mice CB1 receptor desensitization RF Seven-month-old male 3xTg-AD mice 29865071
740 Alzheimer's Disease human cerebral hypoperfusion RF 23295908
741 Alzheimer's disease human coexistence of the APOE-ε4 allele and 3 SNPs in the BCHE gene RF 30914707
742 Alzheimer's disease human combine Rate of brain aging and APOE ε4 RF interventions that slow aging may substantially reduce risk of neurological disease and decline even in the presence of APOE ε4. 31133613
743 Alzheimer’s Disease human Complement Receptor 1 (CR1) Density RF 30044434
746 Alzheimer’s Disease human CSF AβPET(amyloid beta brain PET imaging) RF Associated with AD progression 29982466
747 Alzheimer’s Disease human CSF Tau(cerebrospinal fluid tau) and P-tau(phosphorylated tau) RF Associated with AD progression 29982466
748 Alzheimer's disease human decreased 25-hydroxyvitamin D(25OHD) level RF 27856775
749 Alzheimer's disease human decreased expression of FERMT2 RF 27215977
751 Alzheimer’s Disease human decreasing Aβ1-42 rates RF 30250861
752 Alzheimer’s Disease human depression-related monoaminergic systems RF including serotonin and noradrenaline 29685068
755 Alzheimer's disease human Dysfunction of the mTOR pathway RF is independent of the ApoE status of the patients 24252508
757 Alzheimer's disease human Elevated blood plasma levels of α7(1-208) nAChR-specific antibodies RF 21593571
758 Alzheimer's disease human Elevated Low-density Lipoprotein Cholesterol Levels(LDL-C) RF 31135820
759 Alzheimer's disease human elevated malondialdehyde levels RF The elevated malondialdehyde levels increases the risk of Alzheimer's disease by 9.342. 26835020
760 Alzheimer’s Disease human elevated midlife total cholesterol level RF 12160362
762 Alzheimer’s Disease human Estrogen-replacement therapy PF postmenopausal women 9566385
765 Alzheimer's Disease human fasting plasma glucose (FPG) RF Model I: adjusted for age and sex 28705834
765 Alzheimer's Disease human fasting plasma glucose (FPG) RF Model II: adjusted for age, sex, FPG,HbA1c, insured amount and insured unit (see Table 1), smoking, alcohol consumption, duration of diabetes, type of hypoglycemic drug, hypertension drug treatment, and obesity 28705834
765 Alzheimer's Disease human fasting plasma glucose (FPG) RF Model III: adjusted for CAD, CHF, stroke, cancer, hyperlipidemia, hypertension, atrial fibrillation, chronic hepatitis, COPD, and hypoglycemia along with all other confounders in model II 28705834
765 Alzheimer's Disease human fasting plasma glucose (FPG) RF Model IV: adjusted for PFG CV and HbA1c CV along with all other confounders in model III 28705834
766 Alzheimer's disease mice glucose regulation PF 31034991
767 Alzheimer's Disease human glycated hemoglobin (HbA1c) RF Model I: adjusted for age and sex 28705834
767 Alzheimer's Disease human glycated hemoglobin (HbA1c) RF Model II: adjusted for age, sex, FPG,HbA1c, insured amount and insured unit (see Table 1), smoking, alcohol consumption, duration of diabetes, type of hypoglycemic drug, hypertension drug treatment, and obesity 28705834
767 Alzheimer's Disease human glycated hemoglobin (HbA1c) RF Model III: adjusted for CAD, CHF, stroke, cancer, hyperlipidemia, hypertension, atrial fibrillation, chronic hepatitis, COPD, and hypoglycemia along with all other confounders in model II 28705834
767 Alzheimer's Disease human glycated hemoglobin (HbA1c) RF Model IV: adjusted for PFG CV and HbA1c CV along with all other confounders in model III 28705834
768 Alzheimer’s Disease human H4K16ac enrichment RF related to aging 29507413
769 Alzheimer's disease human high blood lipids and insulin resistance RF 21033433
770 Alzheimer’s Disease human High CSF(cerebrospinal fluid) MCP-1(monocyte chemoattractant protein 1) RF Associated with AD progression 29982466
772 Alzheimer's disease high level of Dkk1 RF 26880631
774 Alzheimer’s Disease human high midlife systolic blood pressure RF 12160362
775 Alzheimer's Disease human high plasma clusterin levels RF 26402636
777 Alzheimer’s Disease human High thiamine diphosphate level PF 29718773
778 Alzheimer’s Disease human IL-17A/IL-23 axis RF 30081688
779 Alzheimer’s Disease human increased cholesterol or blood pressure RF 30112972
780 Alzheimer's disease human increased expression of NUP160 PF 27215977
781 Alzheimer's disease human increased fibrillar amyloid-{beta} RF individuals with a family history of late-onset Alzheimer's;particularly in persons with an AD mother 20231448
782 Alzheimer's disease human increased gene dosage of MIR138-2 RF 30909216
783 Alzheimer's disease human Increased levels of specific sub-fractions of LDL cholesterol RF 17982892
784 Alzheimer's disease human increased plasma adiponectin levels RF 22213409
785 Alzheimer’s Disease human increased platelet membrane fluidity RF first-degree relatives of probands with Alzheimer's disease 8610834
786 Alzheimer's disease human increased skeletal muscle mass PF 30700801
787 Alzheimer's disease mice inhibition of angiotensin-converting enzyme (ACE) activity RF 31072831
526 Alzheimer’s Disease human Insulin resistance (IR) RF 30112972
788 Alzheimer's disease human intracellular iron accumulation RF 24199959
789 Alzheimer's disease ischemia/HIF-1α RF 24478626
790 Alzheimer's disease human levels of homocysteine RF 20885792
791 Alzheimer's disease human lifetime-acquired loss of chromosome Y (LOY) RF in blood cells 27231129
794 Alzheimer’s Disease human Longitudinal Changes in Serum Glucose Levels RF 29480176
797 Alzheimer's Disease human low NAA/MI(N-Acetyl Aspartate/Myo-Inositol)ratios RF 28968236
799 Alzheimer's disease human low serum paraoxonase activity RF 20980077
800 Alzheimer's Disease human lower plasma apoE levels RF in middle age 19720974
801 Alzheimer's Disease human lower serum leptin levels RF 26425011
802 Alzheimer's disease human lower serum level of folate PF 18446027
804 Alzheimer’s Disease mice mammalian target of rapamycin (mTOR) RF Tg2576 mice 29729422
806 Alzheimer's disease human Manganese (Mn) deficiency RF 28273828
807 Alzheimer’s Disease mice meningeal lymphatics RF wild-type mice (C57BL/6J background) 30046111
808 Alzheimer’s Disease human menopause transition (MT) RF decreased metabolic activity and increased brain amyloid-beta deposition 30298180
809 Alzheimer’s Disease human Methionine synthase RF 12876480
809 Alzheimer’s Disease human Methionine synthase RF 12876480
809 Alzheimer’s Disease human Methionine synthase RF 12876480
809 Alzheimer’s Disease human Methionine synthase RF 12876480
810 Alzheimer's Disease human microglia RF 29207277
811 Alzheimer's disease mice microglial functions(specifically microglial plaque coverage) RF APOE4 genotype 31113487
812 Alzheimer's Disease human Midlife serum total cholesterol RF Model 1 is unadjusted 19648749
812 Alzheimer's Disease human Midlife serum total cholesterol RF Model 2 is adjusted for age (as time scale), sex, education, race/ethnic group, midlife BMI, diabetes and hypertension; for AD, the model is additionally adjusted for late-life stroke. 19648749
813 Alzheimer's disease human mtDNA sub-haplogroup H5 RF in particular for females and independently from the APOE genotype 20700462
815 Alzheimer’s Disease human Myeloperoxidase(MPO) polymorphism RF 9918702
817 Alzheimer’s Disease human NO(Nitric Oxide) bioavailability and cortical, extracranial, and peripheral circulation RF 29593548
819 Alzheimer’s Disease mice Pantoea agglomerans-derived lipopolysaccharide (LPSp) PF fed a high-fat diet, oral administration of LPSp at 0.3 or 1 mg/kg body weight.day for 18 weeks 29856882
820 Alzheimer’s Disease human pathogenic mutations in CSF1R TK domain RF in concert with TREM2, TYROBP, and GRN 29544907
822 Alzheimer's Disease human plasma ApoE levels RF 25547651
823 Alzheimer's disease human Plasma clusterin levels RF elderly persons 27453932
823 Alzheimer's disease human Plasma clusterin levels PF younger participants 27453932
825 Alzheimer's disease human plasma total homocysteine RF 27031476
827 Alzheimer’s Disease mice plasmin (PL) RF Tg6799 transgenic mice (referred to as AD mice) are double-transgenic for human APP/Presenilin 1 30254165
828 Alzheimer's disease human reduced 25-hydroxyvitamin D (25[OH]D) RF 23871764
830 Alzheimer’s Disease rabbit royal jelly (RJ) PF male White Hair and Black Eyes (WHBE) rabbits (3–4 months old, 1.8–2.0 kg) 29556189
831 Alzheimer's disease human self-assembly of the Apolipoprotein E4 RF impacts on ε4/ε4 individuals more severely than those with ε3/ε4 31051176
832 Alzheimer's Disease human serum Ang-1 RF 23094194
833 Alzheimer's disease human Serum apoE RF 26876448
835 Alzheimer’s Disease human serum folate RF 9823829
837 Alzheimer's Disease human serum sEPCR levels RF 25588409
839 Alzheimer's disease human telomere length (TL) RF shorter telomeres in AD patients 27091133
840 Alzheimer’s Disease human tHcy level RF 9823829
842 Alzheimer's Disease human The highest Hcy RF 28698453
843 Alzheimer's Disease human Triggering receptor expressed in myeloid cells-2 (TREM2) RF in Down Syndrome 29278889
844 Alzheimer’s Disease human Type 2 diabetes (T2D) RF 30112972
845 Alzheimer's Disease human Type 2 diabetic RF 23478310
846 Alzheimer’s Disease human vitamin B12 RF 9823829
849 Alzheimer's disease human White matter hyperintensities(WMH) load RF 30678723
850 Alzheimer's disease human α-synuclein rs356182 variants PF 30598082
851 Alzheimer's Disease Human BuChE-K variant and ApoE allele RF 29254094
852 Alzheimer's Disease Human Depressed 2 years + sleep disturbance RF Model 1: Main effect unadjusted 29077487
852 Alzheimer's Disease Human Depressed 2 years + sleep disturbance RF Model 2: Main effects adjusted for sex, education, age, and race 29077487
852 Alzheimer's Disease Human Depressed 2 years + sleep disturbance RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 29077487
852 Alzheimer's Disease Human Depressed 2 years + sleep disturbance RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 29077487
853 Alzheimer's Disease Human Depression lifetime + sleep disturbance RF Model 1: Main effect unadjusted 29077487
853 Alzheimer's Disease Human Depression lifetime + sleep disturbance RF Model 2: Main effects adjusted for sex, education, age, and race 29077487
853 Alzheimer's Disease Human Depression lifetime + sleep disturbance RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 29077487
853 Alzheimer's Disease Human Depression lifetime + sleep disturbance RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 29077487
854 Alzheimer's Disease Human Clinician-verified depression + sleep disturbance RF Model 1: Main effect unadjusted 29077487
854 Alzheimer's Disease Human Clinician-verified depression + sleep disturbance RF Model 2: Main effects adjusted for sex, education, age, and race 29077487
854 Alzheimer's Disease Human Clinician-verified depression + sleep disturbance RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 29077487
854 Alzheimer's Disease Human Clinician-verified depression + sleep disturbance RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 29077487
855 Alzheimer's Disease Human Sleep Disturbance + anxiety RF Model 1: Main effect unadjusted 29077487
855 Alzheimer's Disease Human Sleep Disturbance + anxiety RF Model 2: Main effects adjusted for sex, education, age, and race 29077487
855 Alzheimer's Disease Human Sleep Disturbance + anxiety RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 29077487
855 Alzheimer's Disease Human Sleep Disturbance + anxiety RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 29077487
856 Alzheimer's Disease Human Depressed 2 years + anxiety RF Model 1: Main effect unadjusted 29077487
856 Alzheimer's Disease Human Depressed 2 years + anxiety RF Model 2: Main effects adjusted for sex, education, age, and race 29077487
856 Alzheimer's Disease Human Depressed 2 years + anxiety RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 29077487
856 Alzheimer's Disease Human Depressed 2 years + anxiety RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 29077487
857 Alzheimer's Disease Human Depression lifetime + anxiety RF Model 1: Main effect unadjusted 29077487
857 Alzheimer's Disease Human Depression lifetime + anxiety RF Model 2: Main effects adjusted for sex, education, age, and race 29077487
857 Alzheimer's Disease Human Depression lifetime + anxiety RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 29077487
857 Alzheimer's Disease Human Depression lifetime + anxiety RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 29077487
858 Alzheimer's Disease Human Clinician-verified depression + anxiety RF Model 1: Main effect unadjusted 29077487
858 Alzheimer's Disease Human Clinician-verified depression + anxiety RF Model 2: Main effects adjusted for sex, education, age, and race 29077487
858 Alzheimer's Disease Human Clinician-verified depression + anxiety RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 29077487
858 Alzheimer's Disease Human Clinician-verified depression + anxiety RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 29077487
859 Alzheimer's Disease Human APOE e4 and GSTM1 null deletion RF 29072550
860 Alzheimer's Disease Human APOE4 and woman RF 24623176
861 Alzheimer's Disease Human the genotypes GG and APOEε4 RF 24575113
862 Alzheimer's Disease Human COMT (Val158 Met) polymorphism with APOE epsilon4 allele RF GG allele 19793392
863 Alzheimer's Disease Human COMT (Val158 Met) polymorphism with APOE epsilon5 allele RF AG allele 19793392
864 Alzheimer's Disease Human The combined effects of TNFa, IL-6 and IL-10 variant alleles RF 19744138
865 Alzheimer's Disease Human female and the APOE ε3/ε4 genotype RF between the ages of 65 and 75 years 28846757
866 Alzheimer's Disease Human male and the APOE ε3/ε4 genotype RF between the ages of 65 and 75 years 28846757
867 Alzheimer's disease human interaction between a GRS comprised of AD SNPs and midlife triglyceride levels RF rs11218343 and APOE?4 30412497
868 Alzheimer's disease human combine TGG haplotype and APOEε4 RF 27188425
869 Alzheimer's disease human combine SUMO1 rs12472035 CT genotype,SUMO2 rs35271045 GA genotype and SUMO2 rs9913676 TC genotype RF 27084229
870 Alzheimer's disease human combine levels of leptin, adiponectin and insulin RF 26906354
871 Alzheimer's disease human combine SOD2 gene rs4880-T genotype and APOEε4 genotype RF 26696693
872 Alzheimer's disease human combine APOC1 insertion mutation and APOE ε4 RF 24498013
873 Alzheimer's disease human carriers of the CTSD T and APOE ε4 alleles RF 24281128
874 Alzheimer's disease human Higher estrone (E1) levels and carrying the APOE ε4 allele RF 21211518
875 Alzheimer's disease human MTHFR 677 T allele and APOE epsilon4 allele RF 18258338
885 Alzheimer’s Disease rat combination of risk factor hHcy(Hyperhomocysteinemia) with IRI(ischemia-reperfusion injury) RF Adult male Wistar rats 5–6 months old and weighing 300–400 g 30003389
886 Alzheimer's disease human combination therapy with insulin RF 24489845
888 Alzheimer's disease human combine Type 2 diabetes and diabetic ketoacidosis (DKA) RF 30481578
890 Alzheimer’s Disease human diabetes and hyperlipidemia RF 29971140
892 Alzheimer's Disease human MDFK（mineral turpentine, diesel oil, fuel oil and kerosene） RF adjusted for age, education and sex, using logistic regression;Model 1 25028582
892 Alzheimer's Disease human MDFK（mineral turpentine, diesel oil, fuel oil and kerosene） RF adjusted for age, education and sex, using logistic regression;Model 2 25028582
892 Alzheimer's Disease human MDFK（mineral turpentine, diesel oil, fuel oil and kerosene） RF adjusted for age, education and sex, using logistic regression;Model 3 25028582
893 Alzheimer's disease Mercury (Hg) and lead (Pb) RF 30603762
894 Alzheimer's Disease human APOE and gender RF 29278785
894 Alzheimer's Disease human APOE and gender RF 29278785
895 Alzheimer’s Disease human ApoE + deposition of β-amyloid (Aβ) RF 29527500
896 Alzheimer’s Disease human Depression + depression-related monoaminergic systems RF including serotonin and noradrenaline 29685068
897 Alzheimer’s Disease human APOE ε4 allele + family history RF family history of late-onset AD (FH) 30134963
898 Alzheimer’s Disease human CHD5 rs11121295 + drinking RF 29861839
898 Alzheimer’s Disease human CHD5 rs11121295 + drinking RF 29861839
899 Alzheimer’s Disease human ApoE + ApoE protein RF effect the formation of protein polymers and fibrilization through interaction with tau and Abeta 7695621
900 Alzheimer’s Disease human Traumatic brain injury (TBI) + S100A9 protein RF S100A9-driven amyloid-neurodegenerative cascade 30150640
901 Alzheimer’s Disease human APOE ε4 allele + alpha 1-antichymotrypsin polymorphism RF 7670501
902 Alzheimer’s Disease human APOE ε4 allele + Herpes simplex virus type 1(HSV1) RF Frontal lobe 9014911
902 Alzheimer’s Disease human APOE ε4 allele + Herpes simplex virus type 1(HSV1) RF Temporal lobe 9014911
902 Alzheimer’s Disease human APOE ε4 allele + Herpes simplex virus type 1(HSV1) RF Overall 9014911
52 Alzheimer's disease human CD33 RF 31611055
15 Alzheimer's disease human APOE RF 32979926
15 Alzheimer's disease human APOE RF 32979926
15 Alzheimer's disease human APOE RF 32979926
15 Alzheimer's disease human APOE RF 32979926
912 Alzheimer's disease human Ig γ marker (GM) allotypes RF encoded by highly polymorphic IGHG genes on chromosome 14q32 33006184
920 Alzheimer's disease human Aβ misfolding(measured in blood plasma) RF 33138082
921 Alzheimer's disease human body mass index [BMI] PF 33138082
922 Alzheimer's disease human diastolic blood pressure [DBP] RF 33138082
422 Alzheimer's disease human Dyslipidemia RF 31771063
422 Alzheimer's disease human Dyslipidemia RF (a higher LDL cholesterol level) 32903761
923 Alzheimer's disease human Fasting glucose RF 32043803
924 Alzheimer's disease human high-density lipoprotein cholesterol [HDL-C] RF 32767997
924 Alzheimer's disease human high-density lipoprotein cholesterol [HDL-C] RF 32647856
925 Alzheimer's disease human indices of HbA1c variability RF 33021140
926 Alzheimer's disease human low-density lipoprotein cholesterol [LDL-C] RF 33021140
926 Alzheimer's disease human low-density lipoprotein cholesterol [LDL-C] RF 33168078
927 Alzheimer's disease human pulse pressure [PP] PF 33070529
928 Alzheimer's disease human systolic blood pressure [SBP] PF 32949544
929 Alzheimer's disease human total cholesterol [TC] RF 32949544
929 Alzheimer's disease human total cholesterol [TC] RF 32949544
930 Alzheimer's disease human triglycerides [TG] RF 20154673
931 Alzheimer's disease human Multiple vascular risk factors (VRFs) RF especially in APOE ε4 carriers 31587263
932 Alzheimer's disease human Depressive symptoms RF for pre-frailty and frailty in patients with AD 32335425
400 Alzheimer's disease human depression RF 33126696
933 Alzheimer's disease human diabetes mellitus RF 33126696
934 Alzheimer's disease human older age RF 33126696
935 Alzheimer's disease human treated dyslipidemia PF 33126696
936 Alzheimer's disease human Male sex RF 32043803
400 Alzheimer's disease human Depression RF 32043803
937 Alzheimer's disease human polypharmacy RF 32251456
938 Alzheimer's disease human inappropriate use anti-dementia drugs RF 32251456
939 Alzheimer's disease human irregular medication use anti-dementia drugs RF 32251456
940 Alzheimer's disease human number of functional tooth units (FTU) RF 32116259
941 Alzheimer's disease human Statin therapy PF 32753051
942 Alzheimer's disease human coronavirus disease 2019 (COVID-19) RF 32715280
943 Alzheimer's disease human age at baseline RF 32485802
944 Alzheimer's disease human daytime napping PF 33150399
425 Alzheimer's disease human education PF higher education;more likely to consume colorful fruits and vegetables 32970519
945 Alzheimer's disease human Severe periodontitis with tooth loss RF 33124208
946 Alzheimer's disease human increasing years of schooling PF 33177243
947 Alzheimer's disease human pulse pressure (PP) RF 32960784
400 Alzheimer's disease human Depression RF 32003417
948 Alzheimer's disease human severe hypoglycaemia RF 32870568
401 Alzheimer's disease human Diabetes RF 32767997
480 Alzheimer's disease human Heart disease RF 32767997
663 Alzheimer's disease human Stroke RF 32767997
949 Alzheimer's disease human Delirium RF 32767997
950 Alzheimer's disease human moderate depression RF healthy-to-MCI/dementia 33088897
506 Alzheimer's disease human hypertension PF MCI-to-dementia 33088897
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