Alzheimer's Disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time.[1][2]It is the cause of 60–70% of cases of dementia.[1][2]

The most common early symptom is difficulty in remembering recent events.[1] As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, not managing self-care, and behavioural issues.[1][2] As a person's condition declines, they often withdraw from family and society.[3] Gradually, bodily functions are lost, ultimately leading to death.[10] Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years.[4][5]

[1]Burns A, Iliffe S (February 2009). "Alzheimer's disease". BMJ. 338: b158. doi:10.1136/bmj.b158. PMID 19196745
[2]"Dementia Fact sheet". World Health Organization. 12 December 2017.
[3]"About Alzheimer's Disease: Symptoms". National Institute on Aging. Archived from the original on 15 January 2012. Retrieved 28 December 2011.
[4]Querfurth HW, LaFerla FM (January 2010). "Alzheimer's disease". The New England Journal of Medicine. 362 (4): 329–44. doi:10.1056/NEJMra0909142. PMID 20107219.
[5]Todd S, Barr S, Roberts M, Passmore AP (November 2013). "Survival in dementia and predictors of mortality: a review". International Journal of Geriatric Psychiatry. 28 (11): 1109–24. doi:10.1002/gps.3946. PMID 23526458.
The search result for the NDD Category "Alzheimer's Disease"
A total of 1809 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Phase Condition Year PMID
3543 Alzheimer's Disease Human the assessment of oxidative stress and function parameters in peripheral blood cells,isolated neutrophils and mononuclear cells RF 2018 29375582
2204 Alzheimer's Disease Human TMEM RF APOE-?2 2021 33576571
876 Alzheimer's Disease mice restoring vascular functions(microvascular injury) PF 2021 33892818
3757 Alzheimer's Disease Human progressive brain energy decline RF 2021 33186671
4064 Alzheimer's Disease Human Occupational types RF Diagnosis 2003 12541276
1780 Alzheimer's Disease Human non-cancer chronic pain conditions (NCPCs) RF 2021 34351824
453 Alzheimer's Disease Human Healthy Eating Index PF Diagnosis 2022 35697505
462 Alzheimer's Disease Human Healthy Eating Index PF Diagnosis 2022 35697505
3899 Alzheimer's Disease mice Endogenous melatonin reduction (EMR) RF Diagnosis 2023 35619714
1540 Alzheimer's Disease Human Diabetic retinopathy (DR) RF Diagnosis persons with diabetes 2022 35068460
1839 Alzheimer's Disease Human MT-ND2 RF Diagnosis 2023 34854014
1840 Alzheimer's Disease Human MT-ND5 RF Diagnosis 2023 34854014
902 Alzheimer's Disease Human Glucagon-like peptide 1 (GLP-1) agonists PF Prognosis 2023 35128745
442 Alzheimer's Disease Human metformin PF Diagnosis Type 2 diabetes mellitus (T2DM) 2022 36109050
920 Alzheimer's Disease Human gut metabolites PF Diagnosis 2022 35275534
1068 Alzheimer's Disease Human Physical activity (PA) PF Diagnosis 2009 19671904
914 Alzheimer's Disease Human Physical activity (PA) PF Diagnosis without dementia 2022 35871345
1037 Alzheimer's Disease Human Physical activity (PA) PF Prognosis mild-to- moderate AD(Clinical Dementia Rating (CDR) scale score of 2 or less) 2018 30282355
2145 Alzheimer's Disease Human Physical activity (PA) RF 2021 33718584
418 Alzheimer's Disease Human Physical activity (PA) PF 2021 33435977
4044 Alzheimer's Disease Human Physical activity (PA) RF Prognosis 2014 24646035
3006 Alzheimer's Disease Human Physical activity (PA) RF Diagnosis subjective cognitive decline (SCD) 2022 35587456
1067 Alzheimer's Disease Human Physical activity (PA) PF Diagnosis 2009 19671904
913 Alzheimer's Disease Human Physical activity (PA) PF Prognosis Individuals Without Dementia 2022 35068452
1059 Alzheimer's Disease Human Physical activity (PA) PF Prognosis 2010 20414564
457 Alzheimer's Disease Human Physical activity (PA) PF Diagnosis 2022 35697505
1038 Alzheimer's Disease Human Physical activity (PA) PF Prognosis 2018 29527551
1612 Alzheimer's Disease Human Physical activity (PA) RF Diagnosis 2022 36049961
907 Alzheimer's Disease Human Physical activity (PA) PF Prognosis 2023 36502318
3945 Alzheimer's Disease Human multimorbidity RF Diagnosis 2023 37950963
3942 Alzheimer's Disease Human West Nile virus (WNV) RF Diagnosis 2023 37734269
2921 Alzheimer's Disease Human chronic stress and depression RF Diagnosis 2023 37779209
918 Alzheimer's Disease Human absence of impairment with prior daily functioning PF Diagnosis 2023 37454558
917 Alzheimer's Disease Human non-Hispanic White PF Diagnosis 2023 37454558
3940 Alzheimer's Disease Human impaired patient ability in the use of telephone RF Diagnosis 2023 37454558
3939 Alzheimer's Disease Human hearing impairment RF Diagnosis 2023 37454558
807 Alzheimer's Disease Human cardioembolic stroke [CES] PF Diagnosis 2023 37665672
403 Alzheimer's Disease Human with 4 or 5 healthy factors PF Prognosis 2022 35418416
1552 Alzheimer's Disease Human with 4 or 5 healthy factors RF Prognosis 2022 35418416
411 Alzheimer's Disease Human with 4 or 5 healthy factors PF Prognosis 2022 35418416
426 Alzheimer's Disease Human with 2 or 3 healthy factors PF Prognosis 2022 35418416
428 Alzheimer's Disease Human with 2 or 3 healthy factors PF Prognosis 2022 35418416
1509 Alzheimer's Disease Human with 2 or 3 healthy factors RF Prognosis 2022 35418416
446 Alzheimer's Disease Human with 2 or 3 healthy factors PF Prognosis 2022 35418416
3938 Alzheimer's Disease Human MYO15A RF Diagnosis 2023 36788216
3937 Alzheimer's Disease Human COX7C RF Diagnosis 2023 36788216
916 Alzheimer's Disease Human Hypericin PF Diagnosis 2023 37183545
3093 Alzheimer's Disease Human cognitive decline RF Prognosis 2022 35850031
3933 Alzheimer's Disease mice body temperature RF Diagnosis 2022 35851831
3936 Alzheimer's Disease Human ABCA1 RF Diagnosis 2023 36788216
2264 Alzheimer's Disease Human ABCA1 RF Diagnosis 2022 36411364
2118 Alzheimer's Disease Human ATP8B4 RF Diagnosis 2022 36411364
1349 Alzheimer's Disease Human Radon exposure RF Diagnosis 2023 36495187
3932 Alzheimer's Disease Human glucose RF Diagnosis 2023 35319157
1549 Alzheimer's Disease Human napping RF Prognosis 2022 34109847
1591 Alzheimer's Disease Human Long sleep RF Prognosis 2022 34109847
3930 Alzheimer's Disease Human IDE RF Diagnosis 2022 35236268
3931 Alzheimer's Disease mice Sepsis RF Diagnosis 2023 37452088
1470 Alzheimer's Disease Human insulin and pioglitazone RF Diagnosis Type 2 diabetes mellitus (T2DM) 2023 37095270
1458 Alzheimer's Disease Human insulin RF Diagnosis Type 2 diabetes mellitus (T2DM) 2023 37095270
1465 Alzheimer's Disease Human Pioglitazone RF Diagnosis Type 2 diabetes mellitus (T2DM) 2023 37095270
544 Alzheimer's Disease Human social support PF Diagnosis 2023 37182880
2799 Alzheimer's Disease Human social support RF Prognosis 2022 35850031
912 Alzheimer's Disease Human Acai Berry PF Diagnosis Acai aqueous extracts contain nutraceutical components with anti-cholinesterase and antioxidant capabilities 2022 35956841
3926 Alzheimer's Disease Human Hsa-miR-320a RF Diagnosis related to AD and depression 2022 36040555
3925 Alzheimer's Disease Human Hsa-miR-451a RF Diagnosis related to AD and depression 2022 36040555
3924 Alzheimer's Disease Human Hsa-miR-27a-3p RF Diagnosis related to AD and depression 2022 36040555
3923 Alzheimer's Disease Human Hsa-miR-664a-3p RF Diagnosis related to AD and depression 2022 36040555
3922 Alzheimer's Disease Human Hsa-miR-181c-5p RF Diagnosis related to AD and depression 2022 36040555
3920 Alzheimer's Disease Human Hsa-miR-497-5p RF Diagnosis related to AD and education 2022 36040555
3919 Alzheimer's Disease Human Hsa-miR-20a-5p RF Diagnosis related to AD and education 2022 36040555
3921 Alzheimer's Disease Human Hsa-miR-185-5p RF Diagnosis related to AD and depression 2022 36040555
3918 Alzheimer's Disease Human Hsa-miR-185-5p RF Diagnosis related to AD and education 2022 36040555
1435 Alzheimer's Disease Human Difficulty Upper and Lower Body RF Diagnosis 2022 36031903
1425 Alzheimer's Disease Human Difficulty Upper Body RF Diagnosis 2022 36031903
1430 Alzheimer's Disease Human Difficulty Climbing Stairs RF Diagnosis 2022 36031903
409 Alzheimer's Disease Human Cataract surgery PF Diagnosis 2023 35940935
429 Alzheimer's Disease Human Cataract surgery PF Prognosis 2021 34870676
1586 Alzheimer's Disease Human Nonsurgical cataract RF Diagnosis 2023 35940935
3912 Alzheimer's Disease Human Spicy food RF Diagnosis only in older adults with low physical activity 2023 37193785
1420 Alzheimer's Disease Human limitation in physical function RF Diagnosis Main exposure variables were difficulty with activities of daily living, mobility, large muscle strength, gross motor and upper limb activities. 2022 35441254
3911 Alzheimer's Disease mice Knee osteoarthritis (OA) RF Diagnosis 2023 36593507
483 Alzheimer's Disease Human inpatient status PF Prognosis 2022 35196953
484 Alzheimer's Disease Human anxiolytics PF Prognosis 2022 35196953
1831 Alzheimer's Disease Human hypertension medication RF Diagnosis 2022 35196953
1836 Alzheimer's Disease Human antipsychotics RF Diagnosis 2022 35196953
1610 Alzheimer's Disease Human Fructose consumption RF Diagnosis 2023 36946445
911 Alzheimer's Disease Human omega-3 (ω-3) supplementation PF Prognosis APOE ε4 carriers 2022 34710256
437 Alzheimer's Disease Human Dietary patterns PF Diagnosis APOE ε4 non-carriers 2022 34632537
908 Alzheimer's Disease Human socially activities PF Prognosis 2023 36502318
3909 Alzheimer's Disease Human Gait and/or balance disturbances RF Diagnosis 2023 37386779
1779 Alzheimer's Disease Human Muscle relaxant RF Diagnosis 2022 36641664
1775 Alzheimer's Disease Human Muscle relaxant RF Diagnosis 2022 36641664
1778 Alzheimer's Disease Human Muscle relaxant RF Diagnosis 2022 36641664
1508 Alzheimer's Disease Human residential density RF Diagnosis 2023 36894118
1618 Alzheimer's Disease Human self-perceived health (SPH) RF Diagnosis 2022 35025095
1908 Alzheimer's Disease Human Thyroid dysfunction RF Diagnosis 2022 35321339
1958 Alzheimer's Disease Human Thyroid dysfunction RF Diagnosis 2022 35321339
1900 Alzheimer's Disease Human Thyroid dysfunction RF Diagnosis 2022 35321339
3904 Alzheimer's Disease Human NOTCH2 RF Diagnosis 2023 37355909
3903 Alzheimer's Disease Human chronic vascular lesions RF Diagnosis Traumatic brain injury (TBI) 2022 34966025
3902 Alzheimer's Disease Human post-traumatic amnesia RF Diagnosis Traumatic brain injury (TBI) 2022 34966025
3901 Alzheimer's Disease Human Transgender Adults RF Diagnosis 2022 35324265
493 Alzheimer's Disease Human Education level + low genetic risk PF Diagnosis 2023 37663829
2604 Alzheimer's Disease Human Nutritional impairment (NI) RF Prognosis 2022 34657824
2715 Alzheimer's Disease Human working status RF Diagnosis 2022 36479845
2516 Alzheimer's Disease Human working status RF Diagnosis 2022 36479845
2291 Alzheimer's Disease Human working status RF Diagnosis 2022 36479845
905 Alzheimer's Disease Human Health Coaching PF Diagnosis 2022 35543001
2254 Alzheimer's Disease Human social isolation RF Diagnosis 2022 35700125
2250 Alzheimer's Disease Human social isolation RF Diagnosis 2022 35700125
2249 Alzheimer's Disease Human thyroid diseases RF Diagnosis 2022 35700125
2253 Alzheimer's Disease Human Thyroid diseases RF Diagnosis 2022 35700125
903 Alzheimer's Disease mice fasting-mimicking diet (FMD) PF Diagnosis 2022 36170815
3897 Alzheimer's Disease mice Myelin dysfunction RF Diagnosis 2023 37258678
3896 Alzheimer's Disease Human total tau (t-tau) RF Diagnosis 2023 34494715
3895 Alzheimer's Disease Human plasma glial fibrillary acidic protein (GFAP) RF Diagnosis 2023 34494715
2220 Alzheimer's Disease Human 5, 10-methylenetetrahydrofolate dehydrogenase gene (MTHFD1) RF 2010 20217437
2267 Alzheimer's Disease Human 5-HTT RF homozygous low activity genotype: ε4 alleles of the ApoE gene 1997 9106747
2305 Alzheimer's Disease Human 5-LO RF A allele 2010 20110601
3148 Alzheimer's Disease Human ABCA7 RF 2018 29589097
3150 Alzheimer's Disease Human ABCA7 RF with both ApoEε4-carrier and aging being factors enhancing its risk 2014 24113560
1974 Alzheimer's Disease Human ABCA7 RF Calculated by fixed effect model 2018 29504051
1942 Alzheimer's Disease Human ABCA7 RF 2016 26795201
721 Alzheimer's Disease Human ABCA7 PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
3149 Alzheimer's Disease Human ABCA7 RF 2018 29589097
2972 Alzheimer's Disease Human ABCA7 RF 2018 29589097
2986 Alzheimer's Disease Human ABCA8 RF APOE-?2 2021 33576571
2900 Alzheimer's Disease Human ABCA8 RF APOE-?2 2021 33576571
2349 Alzheimer's Disease Human ACAT1 RF 2021 33057949
546 Alzheimer's Disease Human ACAT1 PF 2021 33057949
3153 Alzheimer's Disease Human ACE RF in subjects aged 73 years and above. 2009 19539712
3152 Alzheimer's Disease Human ACE RF in subjects aged 73 years and above. 2009 19539712
2495 Alzheimer's Disease Human ACE RF 2000 11078932
3151 Alzheimer's Disease Human ACE RF 2010 21537449
1894 Alzheimer's Disease Human ACT RF A allele carriers are associated with increased susceptibility to AD in variant populations 2013 22272609
1897 Alzheimer's Disease Human ACT RF A allele carriers are associated with increased susceptibility to AD in variant populations 2013 22272609
1976 Alzheimer's Disease Human ACT RF especially in Caucasians 2012 22294107
1896 Alzheimer's Disease Human ACT RF especially in Caucasians 2012 22294107
512 Alzheimer's Disease Human ADH1C PF 2021 33551739
1951 Alzheimer's Disease Human AKNAD1 RF APOE-?3 2021 33576571
756 Alzheimer's Disease Human AKNAD1 PF APOE-?3 2021 33576571
2337 Alzheimer's Disease Human AKNAD1 RF APOE-?2 2021 33576571
2803 Alzheimer's Disease Human ALDH2 RF dependent on APOE epsilon4 status in Chinese 2008 18201725
691 Alzheimer's Disease Human ALDH5A1 PF APOE-?3 2021 33576571
3155 Alzheimer's Disease Human ALOX5 RF 2016 26944113
2325 Alzheimer's Disease Human ANK1 RF 2016 26611832
2536 Alzheimer's Disease Human APOC1 RF using logistic regression、Dataset：FHS(Framingham Heart Study) 2018 29107063
3156 Alzheimer's Disease Human APOC1 RF 2018 30443289
1656 Alzheimer's Disease Human APOC1 RF using Cox regression、Dataset：FHS（Framingham Heart Study） 2018 29107063
1670 Alzheimer's Disease Human APOC1 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 2018 29107063
3157 Alzheimer's Disease Human APOC1 RF not in African Americans 2014 24498013
3158 Alzheimer's Disease Human APOD RF in APOEε4 (-) subgroup 2013 23690001
1669 Alzheimer's Disease Human APOE RF 2021 33397450
3168 Alzheimer's Disease Human APOE RF 1996 8993485
2938 Alzheimer's Disease Human APOE RF 2014 23871727
3169 Alzheimer's Disease Human APOE RF 1998 9811931
2348 Alzheimer's Disease Human APOE RF 2008 18446027
2847 Alzheimer's Disease Human APOE RF Th1/E47cs polymorphism allele 2002 12095653
3175 Alzheimer's Disease Human APOE RF 2015 26885125
3695 Alzheimer's Disease Human APOE RF 2021 34336000
527 Alzheimer's Disease Human APOE PF National Alzheimer’s Coordinating Center (NACC) cohort; ε4 2018 30128317
3180 Alzheimer's Disease Human APOE RF 2011 21637534
3015 Alzheimer's Disease Human APOE RF Carrying at least one ε4 allele 1999 10213175
3159 Alzheimer's Disease Human APOE RF 2012 22712640
2755 Alzheimer's Disease Human APOE RF National Alzheimer’s Coordinating Center (NACC) cohort; ε2 2018 30128317
3185 Alzheimer's Disease Human APOE RF 2008 18560129
2976 Alzheimer's Disease Human APOE RF ε4 allele; AD without depression 2018 29703883
1572 Alzheimer's Disease Human APOE RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 2018 29107063
2646 Alzheimer's Disease Human APOE RF 2011 22311091
3164 Alzheimer's Disease Human APOE RF ε2 allele 2018 29562509
1771 Alzheimer's Disease Human APOE RF 2018 30450407
3082 Alzheimer's Disease Human APOE RF 2002 12095653
2339 Alzheimer's Disease Human APOE RF 2010 19819468
1722 Alzheimer's Disease Human APOE RF 2011 21649613
2717 Alzheimer's Disease Human APOE RF Genotype: AA 1999 10213175
2087 Alzheimer's Disease Human APOE RF Genotype/Allele: A 2018 29990559
2898 Alzheimer's Disease Human APOE RF Individuals with 2 epsilon 4 alleles had a higher risk for AD than subjects with only 1 such allele 2008 18317248
822 Alzheimer's Disease Human APOE PF 2012 22068907
3044 Alzheimer's Disease Human APOE RF PENN cohort; ε2 2018 30128317
3171 Alzheimer's Disease Human APOE RF 2019 30890475
602 Alzheimer's Disease Human APOE PF ε2 allele 2018 29990559
2350 Alzheimer's Disease Human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 2018 30205398
3177 Alzheimer's Disease Human APOE RF 2015 26738348
625 Alzheimer's Disease Human APOE PF Genotype/Allele: A/T 2018 29990559
705 Alzheimer's Disease Human APOE PF 2008 18317248
2113 Alzheimer's Disease Human APOE RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 2018 29107063
1762 Alzheimer's Disease Human APOE RF 2020 32485802
3182 Alzheimer's Disease Human APOE RF The rate of APOE4 carrier status and the frequency of the ε4 allele were 47% and 27% for LOAD, 50% and 31% for EOAD, 2011 21552550
2522 Alzheimer's Disease Human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 2018 30205398
3161 Alzheimer's Disease Human APOE RF ε4 allele 2018 30112972
719 Alzheimer's Disease Human APOE PF Genotype/Allele: T 2018 29990559
2929 Alzheimer's Disease Human APOE RF 2014 23871727
2654 Alzheimer's Disease Human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 2018 30205398
2823 Alzheimer's Disease Human APOE RF at least one epsilon 4 allele 1995 8786847
3191 Alzheimer's Disease Human APOE RF ?4 allele 2015 23038715
500 Alzheimer's Disease Human APOE PF PENN cohort; ε4 2018 30128317
2982 Alzheimer's Disease Human APOE RF ε4 allele; associated with homozygosity 1994 8128961
3167 Alzheimer's Disease Human APOE RF 1997 9008509
2894 Alzheimer's Disease Human APOE RF ε4 allele; AD all 2018 29703883
3023 Alzheimer's Disease Human APOE RF Genotype: ε4/4; adjusted for age and education, and stratified by gender 2018 30205398
2140 Alzheimer's Disease Human APOE RF 2008 18317248
2936 Alzheimer's Disease Human APOE RF 2010 20217437
3089 Alzheimer's Disease Human APOE RF ε4 allele 2018 29990559
2774 Alzheimer's Disease Human APOE RF Genotype: ?4/?4; AD without depression 2018 29703883
3139 Alzheimer's Disease Human APOE RF lowers age at onset of LOAD significantly 2008 18416843
2844 Alzheimer's Disease Human APOE RF Carrying at least one ε4 allele; Calculated by Forced entry model 1999 10213175
571 Alzheimer's Disease Human APOE PF ε3 allele 2014 24632849
3174 Alzheimer's Disease Human APOE RF 2016 27033052
1331 Alzheimer's Disease Human APOE RF 2010 20376800
1643 Alzheimer's Disease Human APOE RF 2020 32767997
2857 Alzheimer's Disease Human APOE RF 2011 20682755
2260 Alzheimer's Disease Human APOE RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 2018 29107063
697 Alzheimer's Disease Human APOE PF APOEε2ε3 2015 25673977
3179 Alzheimer's Disease Human APOE RF 2013 23887281
1620 Alzheimer's Disease Human APOE RF using Cox regression、Dataset：HRS（Health and Retirement Study） 2018 29107063
3014 Alzheimer's Disease Human APOE RF Genotype: ?3/?4; AD without depression 2018 29703883
3667 Alzheimer's Disease Human APOE RF 2020 32116259
2807 Alzheimer's Disease Human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 2018 30205398
3184 Alzheimer's Disease Human APOE RF 2010 20385913
2463 Alzheimer's Disease Human APOE RF Diagnosis 2022 35135450
3163 Alzheimer's Disease Human APOE RF ε2 allele 1994 7824157
2592 Alzheimer's Disease Human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 2018 30205398
1848 Alzheimer's Disease Human APOE RF 2012 22068907
2829 Alzheimer's Disease Human APOE RF 2019 30894904
2897 Alzheimer's Disease Human APOE RF Genotype: ?3/?4; AD all 2018 29703883
3042 Alzheimer's Disease Human APOE RF Genotype: ε4/4; adjusted for age and education, and stratified by gender 2018 30205398
2433 Alzheimer's Disease Human APOE RF 2002 12095653
2601 Alzheimer's Disease Human APOE RF A/A genotype 2009 19172988
3170 Alzheimer's Disease Human APOE RF 2019 30991302
2906 Alzheimer's Disease Human APOE RF ε4 allele 2014 24632849
3176 Alzheimer's Disease Human APOE RF The ε4 allele increases the risk of Alzheimer's disease by 5.114 times 2016 26835020
532 Alzheimer's Disease Human APOE PF ε3 allele 2018 29990559
2356 Alzheimer's Disease Human APOE RF Gender: female; Calculated by Forced entry model 1999 10213175
1761 Alzheimer's Disease Human APOE RF 2021 33397450
3115 Alzheimer's Disease Human APOE RF Diagnosis 2022 35135450
3181 Alzheimer's Disease Human APOE RF 2011 21556001
542 Alzheimer's Disease Human APOE PF 2008 18317248
2366 Alzheimer's Disease Human APOE RF Gender: female; Calculated by Step-wise model 1999 10213175
3160 Alzheimer's Disease Human APOE RF ε4 allele 2018 29592889
3190 Alzheimer's Disease Human APOE RF APOE haplotypes 2014 24596166
1717 Alzheimer's Disease Human APOE RF 2014 24045327
2375 Alzheimer's Disease Human APOE RF APOE ε3ε4 2015 25673977
3166 Alzheimer's Disease Human APOE RF ε4 allele 1994 7977635
3086 Alzheimer's Disease Human APOE RF ε4 allele 2001 11376902
2480 Alzheimer's Disease Human APOE RF APOE ε4 2000 10912224
3172 Alzheimer's Disease Human APOE RF 2017 28461186
2298 Alzheimer's Disease Human APOE RF Genotype/Allele: A/A 2018 29990559
2675 Alzheimer's Disease Human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 2018 30205398
2855 Alzheimer's Disease Human APOE RF Carrying at least one ε4 allele; Calculated by Step-wise model 1999 10213175
2734 Alzheimer's Disease Human APOE RF Diagnosis with APOE*4?allele 2023 36528961
2912 Alzheimer's Disease Human APOE RF Diagnosis 2022 35135450
3178 Alzheimer's Disease Human APOE RF 2014 24326531
2449 Alzheimer's Disease Human APOE RF APOE ε4ε4 2015 25673977
2957 Alzheimer's Disease Human APOE RF 2018 29307083
2505 Alzheimer's Disease Human APOE RF ε4 allele 2002 12160362
2864 Alzheimer's Disease Human APOE RF ε4 allele; associated with heterozygosity 1994 8128961
3666 Alzheimer's Disease Human APOE RF 2020 32043803
3065 Alzheimer's Disease Human APOE RF 2011 22737475
2750 Alzheimer's Disease Human APOE RF 2014 24281128
3183 Alzheimer's Disease human and mice APOE RF nutritional imbalance 2010 20413864
2368 Alzheimer's Disease Human APOE RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
3162 Alzheimer's Disease Human APOE RF ε4 allele 1994 7841371
3080 Alzheimer's Disease Human APOE RF 2017 29348964
732 Alzheimer's Disease Human APOE ε2/ε3 PF 2017 28846757
620 Alzheimer's Disease Human APOE ε2/ε3 PF 2017 28846757
2828 Alzheimer's Disease Human APOE ε3/ε4 RF from ages 55 to 85 years 2017 28846757
2794 Alzheimer's Disease Human APOE ε3/ε4 RF from ages 55 to 85 years 2017 28846757
2793 Alzheimer's Disease Human ApoE ε4/ε3 RF ε4/ε3 genotype 2014 24632849
2435 Alzheimer's Disease Human ApoE ε4/ε4 RF ε4/ε4 genotype 2014 24632849
3114 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: AT; Two Copies of ε4 1996 8993481
2811 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: TT; Two Copies of ε4 1996 8993481
2946 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: AA; One Copy of ε4 1996 8993481
2915 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: AA; Two Copies of ε4 1996 8993481
2657 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: TT; One Copy of ε4 1996 8993481
2813 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: AT; One Copy of ε4 1996 8993481
869 Alzheimer's Disease Human APOE?2 PF substantially attenuated among Black people 2021 34334408
3731 Alzheimer's Disease Human APOE?4 RF 2021 33686543
2666 Alzheimer's Disease Human APOE?4 RF Diagnosis 2023 37182880
3705 Alzheimer's Disease Human APOE?4 RF 2021 34214049
3756 Alzheimer's Disease Human APOE?4 RF 2021 33196771
2956 Alzheimer's Disease Human APOE?4 RF 2021 33732104
3697 Alzheimer's Disease Human APOE?4 RF 2021 34266503
3009 Alzheimer's Disease Human APOE?4 RF 2021 33541779
3694 Alzheimer's Disease Human APOE?4 RF substantially attenuated among Black people 2021 34334408
3917 Alzheimer's Disease Human APOE?4 RF Diagnosis 2022 36226340
3749 Alzheimer's Disease Human APOE?4 RF 2021 33009037
3555 Alzheimer's Disease Human Apolipoprotein E (APOE)-epsilon4 RF 2018 29605385
871 Alzheimer's Disease Human apolipoprotein E ?3 PF 2021 34258926
3914 Alzheimer's Disease Human APP RF Diagnosis 2023 37145212
1808 Alzheimer's Disease Human Arg972 IRS1 RF GA genotype 2014 24589556
1800 Alzheimer's Disease Human Arg972 IRS1 RF A Allele 2014 24589556
1819 Alzheimer's Disease Human Arg972 IRS1 RF AA genotype 2014 24589556
513 Alzheimer's Disease Human ARHGAP33 PF APOE-?3 2021 33576571
3196 Alzheimer's Disease Human ASTN2 RF 2015 25410587
2580 Alzheimer's Disease Human ATP10B RF 2013 22950421
2640 Alzheimer's Disease Human ATP6V0E2 RF APOE-?2 2021 33576571
2142 Alzheimer's Disease Human ATP7B RF 2013 22950421
2177 Alzheimer's Disease Human ATP8B RF 2013 22950421
2284 Alzheimer's Disease Human ATP9B RF 2013 22950421
2323 Alzheimer's Disease Human AZU1 RF APOE-?2 2021 33576571
659 Alzheimer's Disease Human B3GAT2 PF APOE-?3 2021 33576571
2107 Alzheimer's Disease Human BACE1 RF with APOEε4 carrier status 2015 26550136
2413 Alzheimer's Disease Human BACE1 RF in carrying the ApoE epsilon4 allele 2008 18182766
1935 Alzheimer's Disease Human BACE2 RF Rheumatoid arthritis (RA) RA-SNPs Association with AD 2011 21595938
592 Alzheimer's Disease Human BCL2L13 PF APOE-?2 2021 33576571
2353 Alzheimer's Disease Human BDNF C270T RF 2015 26136901
1920 Alzheimer's Disease Human BIN1 RF Calculated by fixed effect model 2018 29504051
3205 Alzheimer's Disease Human BIN1 RF 2017 26768592
682 Alzheimer's Disease Human BIN1 PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
1916 Alzheimer's Disease Human BIN1 RF Calculated by random effect model 2018 29504051
3067 Alzheimer's Disease Human BIN1 RF 2021 33732104
3204 Alzheimer's Disease Human BIN1 RF 2017 26768592
1906 Alzheimer's Disease Human BIN1 RF Calculated by random effect model 2018 29504051
1891 Alzheimer's Disease Human BIN1 RF Calculated by fixed effect model 2018 29504051
714 Alzheimer's Disease Human BIN1 PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
1910 Alzheimer's Disease Human BIN1 RF Calculated by fixed effect model 2018 29504051
744 Alzheimer's Disease Human BMS1 PF APOE-?3 2021 33576571
2441 Alzheimer's Disease Human C1orf185 RF APOE-?2 2021 33576571
828 Alzheimer's Disease Human C282Y HFE PF 2009 19429178
2751 Alzheimer's Disease Human C9orf72 RF 2021 33935096
1954 Alzheimer's Disease Human CALHM1 RF 2010 20061624
3100 Alzheimer's Disease Human CALHM2 RF APOE-?3 2021 33576571
2926 Alzheimer's Disease Human CCDC60 RF APOE-?2 2021 33576571
3212 Alzheimer's Disease Human CD163L1 RF 2017 29177109
3664 Alzheimer's Disease Human CD33 RF 2020 32647856
3213 Alzheimer's Disease Human CD33 RF 2012 22382309
2162 Alzheimer's Disease Human CD33 RF Diagnosis 2022 35408990
593 Alzheimer's Disease Human CD33 PF in APOE e4 carriers 2012 22167654
563 Alzheimer's Disease Human CD33 PF in APOE e4 carriers 2012 22167654
815 Alzheimer's Disease Human CD33 PF this association was not significant in Asians 2016 26795201
2389 Alzheimer's Disease Human CD36 RF Genotype: Dominant 2018 30235742
664 Alzheimer's Disease Human CD36 PF Genotype: Dominant; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 2018 30235742
2477 Alzheimer's Disease Human CD36 RF Genotype: GG; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 2018 30235742
641 Alzheimer's Disease Human CD36 PF Genotype: GT 2018 30235742
681 Alzheimer's Disease Human CD36 PF Genotype: Dominant 2018 30235742
630 Alzheimer's Disease Human CD36 PF Genotype: GT; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 2018 30235742
2247 Alzheimer's Disease Human CD36 RF Genotype: Dominant; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 2018 30235742
2598 Alzheimer's Disease Human CD36 RF Genotype: GG 2018 30235742
2221 Alzheimer's Disease Human CD36 RF Genotype: Recessive 2018 30235742
3214 Alzheimer's Disease Human CHAT RF 2008 18562794
2236 Alzheimer's Disease Human CHAT RF 2016 27272392
2203 Alzheimer's Disease Human CHAT RF 2016 27272392
2200 Alzheimer's Disease Human CHI3L1 RF CT+TT 2019 30223258
680 Alzheimer's Disease Human CHI3L1 PF CG+GG 2019 30223258
2551 Alzheimer's Disease Human CHI3L1 RF TT 2019 30223258
687 Alzheimer's Disease Human CHI3L1 PF G allele 2019 30223258
2127 Alzheimer's Disease Human CHI3L1 RF T allele 2019 30223258
3217 Alzheimer's Disease Human chromosome 12q24.22 RF 2014 24361131
2336 Alzheimer's Disease Human chromosome 9p21.3 RF 2010 20427016
2096 Alzheimer's Disease Human chromosome 9p21.3 RF in non-APOE epsilon4 2010 20427016
1991 Alzheimer's Disease Human chromosome 9p21.3 RF C allele 2011 19664850
3227 Alzheimer's Disease Human CLECL1 RF 2017 29177109
502 Alzheimer's Disease Human CLU PF 2016 26757186
1859 Alzheimer's Disease Human CLU RF Calculated by fixed effect model 2018 29504051
1856 Alzheimer's Disease Human CLU RF Calculated by random effect model 2018 29504051
1858 Alzheimer's Disease Human CLU RF Calculated by fixed effect model 2018 29504051
1860 Alzheimer's Disease Human CLU RF Calculated by fixed effect model 2018 29504051
2969 Alzheimer's Disease Human CLU RF 2016 26757186
2922 Alzheimer's Disease Human CLU RF Diagnosis 2022 35135450
2684 Alzheimer's Disease Human CNGB1 RF APOE-?2 2021 33576571
2410 Alzheimer's Disease Human CNGB1 RF APOE-?2 2021 33576571
2683 Alzheimer's Disease Human CNGB1 RF APOE-?2 2021 33576571
2326 Alzheimer's Disease Human CNGB1 RF APOE-?2 2021 33576571
3767 Alzheimer's Disease Human CNR1 RF 2021 33523009
3564 Alzheimer's Disease Human coexistence of the APOE-ε4 allele and 3 SNPs in the BCHE gene RF 2019 30914707
2868 Alzheimer's Disease Human COMT RF 2021 33900525
3002 Alzheimer's Disease Human COMT RF without APOE ε4 allele carriers;in men 2014 24575113
2324 Alzheimer's Disease Human COMT RF without APOE ε4 allele carriers 2014 24575113
3005 Alzheimer's Disease Human COMT RF 2021 33900525
673 Alzheimer's Disease Human COX11 PF APOE-?2 2021 33576571
2100 Alzheimer's Disease Human COX-2 RF GG allele 2010 20110601
2125 Alzheimer's Disease Human COX-2 RF G allele 2010 20110601
2403 Alzheimer's Disease Human CPT1B RF APOE-?2 2021 33576571
1905 Alzheimer's Disease Human CR1 RF Calculated by fixed effect model 2018 29504051
1899 Alzheimer's Disease Human CR1 RF Calculated by fixed effect model 2018 29504051
1979 Alzheimer's Disease Human CR1 RF Calculated by fixed effect model 2018 29504051
747 Alzheimer's Disease Human CR1 PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
633 Alzheimer's Disease Human CR1 PF PENN cohort 2018 30128317
688 Alzheimer's Disease Human CRTC3 PF APOE-?2 2021 33576571
2572 Alzheimer's Disease Human CST3 RF CST3-A allele; APOE ε4 carrier 2001 11711204
2532 Alzheimer's Disease Human CST3 RF Caucasians 2000 10993992
3081 Alzheimer's Disease Human CST3 RF CST3-A allele; Non-APOE ε4 carrier 2001 11711204
3229 Alzheimer's Disease Human CTNNA1 RF 2017 29177109
2485 Alzheimer's Disease Human CTSB RF APOE-?2 2021 33576571
2632 Alzheimer's Disease Human CTSD RF 2014 24281128
3732 Alzheimer's Disease Human CXCL12 RF 2021 33687622
3232 Alzheimer's Disease Human CYP19A1 RF 2016 27583919
2211 Alzheimer's Disease Human CYP2B6 RF APOE-?2 2021 33576571
1919 Alzheimer's Disease Human CYP2B6 RF APOE-?3 2021 33576571
3233 Alzheimer's Disease Human CYP2D6 RF CYP2D6B allele; in the Lewy body variant of AD 1995 7818242
2687 Alzheimer's Disease Human CYP2J2 RF total;Allele T 2015 25796175
2710 Alzheimer's Disease Human CYP2J2 RF total;Genotype GT + TT 2015 25796175
2136 Alzheimer's Disease Human CYP46A1 RF Overall; Genotype:TC; logistic regression model 2018 29516283
2594 Alzheimer's Disease Human CYP46A1 RF APOE ε3/ε4; Genotype:CC; additive model 2018 29516283
3120 Alzheimer's Disease Human CYP46A1 RF APOE ε4 carrier; Genotype:CC 2018 29516283
2636 Alzheimer's Disease Human CYP46A1 RF APOE ε4 carrier; Genotype:CC; additive model 2018 29516283
2665 Alzheimer's Disease Human CYP46A1 RF APOE ε3/ε4; Genotype:TT; dominant mode 2018 29516283
3234 Alzheimer's Disease Human CYP46A1 RF CYP46A1 gene variations 2009 19286353
2137 Alzheimer's Disease Human CYP46A1 RF Overall; Genotype:TT; dominant mode 2018 29516283
2259 Alzheimer's Disease Human CYP46A1 RF 2012 22528464
2688 Alzheimer's Disease Human CYP46A1 RF APOE ε4 carrier; Genotype:TT; dominant mode 2018 29516283
2034 Alzheimer's Disease Human DAPK1 RF 2011 21167819
753 Alzheimer's Disease Human DAPK1 PF especially the homozygotes 2011 21167819
629 Alzheimer's Disease Human DDIT4L PF APOE-?2 2021 33576571
1783 Alzheimer's Disease Human DHCR7 RF Chinese population 2021 33692822
3724 Alzheimer's Disease Human DLD gene RF 2021 33917565
648 Alzheimer's Disease Human DR4 PF GGA haplotype 2013 25207117
2076 Alzheimer's Disease Human DR4 RF GCA haplotype 2013 25207117
504 Alzheimer's Disease Human DR4 PF GGC haplotype 2013 25207117
830 Alzheimer's Disease Human DR4 PF the GA genotype 2013 25207117
581 Alzheimer's Disease Human DR4 PF ACA haplotype 2013 25207117
2384 Alzheimer's Disease Human DR4 RF GCC haplotype 2013 25207117
2222 Alzheimer's Disease Human ENST00000414107 RF 2018 29027019
2062 Alzheimer's Disease Human EPHA7 RF APOE-?3 2021 33576571
549 Alzheimer's Disease Human EPHA7 PF APOE-?2 2021 33576571
2239 Alzheimer's Disease Human ESR1 RF 2012 20674091
653 Alzheimer's Disease Human ESR1 PF 2012 20674091
1999 Alzheimer's Disease Human ESR1 RF 2012 20674091
3017 Alzheimer's Disease Human ESR1 and ESR2 RF the genetic profile created with the combination of the less represented alleles of these SNPs (expressed as XPAA) 2013 24052609
2372 Alzheimer's Disease Human ESR2 RF predominantly Caucasian AIMS-defined ancestry 2014 24326520
2195 Alzheimer's Disease Human ESR2 RF predominantly Caucasian AIMS-defined ancestry 2014 24326520
2371 Alzheimer's Disease Human ESR2 RF predominantly Caucasian AIMS-defined ancestry 2014 24326520
2194 Alzheimer's Disease Human ESR2 RF predominantly Caucasian AIMS-defined ancestry 2014 24326520
678 Alzheimer's Disease Human ESR3 PF 2014 24326520
814 Alzheimer's Disease Human EXOC3L2 PF 2017 28423615
1925 Alzheimer's Disease Human EXOC3L2 RF 2017 28423615
3021 Alzheimer's Disease Human FAM107B RF APOE-?2 2021 33576571
703 Alzheimer's Disease Human FAM47E PF 2021 33654092
2584 Alzheimer's Disease Human FAM71E2 RF APOE-?3 2021 33576571
2294 Alzheimer's Disease Human FOXN1 RF APOE-?2 2021 33576571
2246 Alzheimer's Disease Human FRMD4A RF 2013 22430674
3759 Alzheimer's Disease Human FZD3 RF 2021 32966694
2685 Alzheimer's Disease Human G-308A( TNF-alpha gene) RF A-allele 2008 18992723
3127 Alzheimer's Disease Human GAB2 RF a minor genetic determinant of AD 2008 18272374
785 Alzheimer's Disease Human GAB2 PF 2015 26770425
3246 Alzheimer's Disease Human GAB2 RF ApoE epsilon4 non-carriers 2009 19276544
2471 Alzheimer's Disease Human GAB2 RF 2011 21285854
2032 Alzheimer's Disease Human GAB2 RF 2011 21108942
3248 Alzheimer's Disease Human GAB2 RF 2011 21285854
3097 Alzheimer's Disease Human GAB2 RF 2011 21285854
792 Alzheimer's Disease Human GAB2 PF 2015 26770425
3247 Alzheimer's Disease Human GAB2 RF 2011 21285854
3249 Alzheimer's Disease Human GALR3 RF 2017 29177109
2043 Alzheimer's Disease Human GAMT RF APOE-?3 2021 33576571
2518 Alzheimer's Disease Human GAMT RF APOE-?2 2021 33576571
2293 Alzheimer's Disease Human GCH1 RF 2018 29432188
3761 Alzheimer's Disease Human GOLGA8B RF 2021 32966694
2066 Alzheimer's Disease Human GOLPH2 RF 2012 22167654
2065 Alzheimer's Disease Human GOLPH2 RF 2012 22167654
3107 Alzheimer's Disease Human GORASP2 RF APOE-?2 2021 33576571
601 Alzheimer's Disease Human GPIHBP1 PF APOE-?2 2021 33576571
3047 Alzheimer's Disease Human GPR37 RF APOE-?2 2021 33576571
1934 Alzheimer's Disease Human GRN RF 2017 26820675
3018 Alzheimer's Disease Human GSN RF APOE-?2 2021 33576571
2867 Alzheimer's Disease Human GSTM1 RF 2018 29072550
2498 Alzheimer's Disease Human GSTM1 RF 2012 22381228
3264 Alzheimer's Disease Human GSTP1 RF mainly in the presence of the apoE 4 allele 2008 18298341
2225 Alzheimer's Disease Human GSTT1 RF 2018 29072550
591 Alzheimer's Disease Human HAP1 PF APOE-?3 2021 33576571
587 Alzheimer's Disease Human HAP1 PF APOE-?3 2021 33576571
3265 Alzheimer's Disease Human hemochromatosis (HFE) RF 2014 27081498
3268 Alzheimer's Disease Human HIF3A RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
1437 Alzheimer's Disease Human HLA-A24 RF 2008 18936542
2488 Alzheimer's Disease Human HLA-DRB1 RF under a recessive model in the total sample 2017 29190991
1931 Alzheimer's Disease Human HLA-DRB1 RF non-APOE ε4 carriers with rs9271192 genotype CC;additive model 2017 29190991
2667 Alzheimer's Disease Human HLA-DRB1 RF non-APOE ε4 carriers with rs9271192 genotype CC;recessive model 2017 29190991
554 Alzheimer's Disease Human HSP70/HSPA1A PF Genotype: A/C; AD without depression 2018 29703883
2934 Alzheimer's Disease Human Ig γ marker (GM) allotypes RF encoded by highly polymorphic IGHG genes on chromosome 14q32 2020 32709662
2628 Alzheimer's Disease Human IGFALS RF APOE-?3 2021 33576571
2691 Alzheimer's Disease Human IL-1 beta promoter polymorphism RF APOE4 presence:APOE4 yes 2008 18717723
2063 Alzheimer's Disease Human IL-1 beta promoter polymorphism RF APOE4 presence:No stratified 2008 18717723
2205 Alzheimer's Disease Human IL-1 beta promoter polymorphism RF APOE4 presence:APOE4 no 2008 18717723
831 Alzheimer's Disease Human IL-1 genes cluster PF 2012 22498095
3270 Alzheimer's Disease Human IL-1 genes cluster RF 2012 22498095
3274 Alzheimer's Disease Human IL-1B RF 2017 26768592
3275 Alzheimer's Disease Human IL-1B RF 2017 26768592
3276 Alzheimer's Disease Human IL-1α RF 2016 27014584
628 Alzheimer's Disease Human INO80D PF APOE-?2 2021 33576571
3738 Alzheimer's Disease mice INPP5D RF 2021 33631273
2280 Alzheimer's Disease Human insulin degrading enzyme gene (IDE) RF 2012 20880607
2997 Alzheimer's Disease Human insulin degrading enzyme gene (IDE) RF CC genotype was significantly associated with earlier age at onset 2012 20880607
1932 Alzheimer's Disease Human ITGA2B RF APOE-?3 2021 33576571
2256 Alzheimer's Disease Human ITGA4 RF Dominant; Genotype/Allele: AG+GG; Multivariate analysis 2018 29769839
2334 Alzheimer's Disease Human ITGA4 RF Overdominant; Genotype/Allele: AG; Univariate analysis 2018 29769839
2302 Alzheimer's Disease Human ITGA4 RF Dominant; Genotype/Allele: AG+GG; Univariate analysis 2018 29769839
2360 Alzheimer's Disease Human ITGA4 RF Codominant; Genotype/Allele: AG; Univariate analysis 2018 29769839
2242 Alzheimer's Disease Human ITGA4 RF Overdominant; Genotype/Allele: AG; Multivariate analysis 2018 29769839
2181 Alzheimer's Disease Human KCNJ15 RF 2018 29432188
574 Alzheimer's Disease Human KIBRA PF 2013 24190487
2215 Alzheimer's Disease Human LAMA2 RF APOE-?2 2021 33576571
535 Alzheimer's Disease Human LAMA2 PF APOE-?2 2021 33576571
3124 Alzheimer's Disease Human LAMA2 RF APOE-?3 2021 33576571
3279 Alzheimer's Disease Human LCORL RF 2018 29860282
2108 Alzheimer's Disease Human LDLR RF 2008 18065781
489 Alzheimer's Disease Human LHCGR PF carrying an APOE epsilon4 allele 2008 18439297
2149 Alzheimer's Disease Human LOC100505811 RF 2018 29027019
2183 Alzheimer's Disease Human LOC100505811 RF 2018 29027019
2180 Alzheimer's Disease Human LOC100505811 RF 2018 29027019
2091 Alzheimer's Disease Human LOC100505811 RF 2018 29027019
2418 Alzheimer's Disease Human LPA RF APOE-?2 2021 33576571
2052 Alzheimer's Disease Human LRP2 RF 2011 20971101
783 Alzheimer's Disease Human LRRC17 PF APOE-?3 2021 33576571
656 Alzheimer's Disease Human LRRC17 PF APOE-?2 2021 33576571
2005 Alzheimer's Disease Human LRRC17 RF APOE-?3 2021 33576571
2098 Alzheimer's Disease Human LRRC2 RF APOE-?2 2021 33576571
3711 Alzheimer's Disease Human LRRK2 RF 2021 34135785
2801 Alzheimer's Disease Human LTBP1 RF APOE-?2 2021 33576571
631 Alzheimer's Disease Human LTBP1 PF APOE-?3 2021 33576571
2800 Alzheimer's Disease Human LTBP1 RF APOE-?2 2021 33576571
2568 Alzheimer's Disease Human MAPT RF 2012 22556362
2411 Alzheimer's Disease Human MC1R RF 2017 28059796
3712 Alzheimer's Disease Human MEF2C RF 2021 34163341
3048 Alzheimer's Disease Human MGME1 RF APOE-?2 2021 33576571
768 Alzheimer's Disease Human MIA2 PF APOE-?3 2021 33576571
573 Alzheimer's Disease Human MIA2 PF APOE-?3 2021 33576571
796 Alzheimer's Disease Human microtubule-associated protein tau (MAPT) gene PF individuals with a GG genotype of rs242557G/A 2018 29098924
3289 Alzheimer's Disease Human MIEF1 RF 2017 29177109
3290 Alzheimer's Disease Human MLKL RF MLKL loss-of-function mutation 2018 29656768
3292 Alzheimer's Disease Human mosaic aneuploidy in the brain RF 2014 24602248
1888 Alzheimer's Disease Human MS4A4E RF 2015 26770425
1861 Alzheimer's Disease Human MS4A6A RF Calculated by fixed effect model 2018 29504051
3293 Alzheimer's Disease Human MS4A6A RF 2012 22382309
1857 Alzheimer's Disease Human MS4A6A RF Calculated by fixed effect model 2018 29504051
1862 Alzheimer's Disease Human MS4A6A RF Calculated by fixed effect model 2018 29504051
802 Alzheimer's Disease Human MS4A6A PF 2015 26770425
2331 Alzheimer's Disease Human MTHFD1L RF the results were influenced by APOE status 2011 21741665
3294 Alzheimer's Disease Human MTHFR RF increased the odds of developing AD by 2.5 2012 22015309
1937 Alzheimer's Disease Human MTHFR RF in APOE?4 or in non-APOE?4 carriers 2017 28211809
2771 Alzheimer's Disease Human MTHFR RF AA genotype 2013 23659764
1992 Alzheimer's Disease Human MTHFR RF without APOE epsilon4 alleles 2010 20600372
3295 Alzheimer's Disease Human MTNR1A RF 2018 29982836
3773 Alzheimer's Disease mice MUTYH RF Treatment 2021 34970419
2402 Alzheimer's Disease Human MYEOV RF APOE-?2 2021 33576571
3758 Alzheimer's Disease Human MYH11 RF 2021 32966694
2071 Alzheimer's Disease Human NEP gene (MME) RF 2012 22493749
1330 Alzheimer's Disease Human neprilysin (NEP) RF 2010 20376800
541 Alzheimer's Disease Human NINJ2 PF 2011 21674003
537 Alzheimer's Disease Human NINJ2 PF 2011 21674003
575 Alzheimer's Disease Human NINJ2 PF 2011 21674003
762 Alzheimer's Disease Human NOP56 PF APOE-?3 2021 33576571
672 Alzheimer's Disease Human NOP56 PF APOE-?2 2021 33576571
1332 Alzheimer's Disease Human NOS3 RF in the APOE epsilon 4 noncarriers 2008 18183499
3299 Alzheimer's Disease Human NOS3 RF 2010 20505439
1333 Alzheimer's Disease Human NOS3 RF in the APOE epsilon 4 noncarriers 2008 18183499
1966 Alzheimer's Disease Human NQO1 RF 2008 18253865
711 Alzheimer's Disease Human NQO1 PF significant difference in the APOE epsilon4 non-carriers 2008 18253865
2304 Alzheimer's Disease Human NT-3 RF homozygotes or heterozygotes for the mutated type (Glu[-63]) 1998 9502217
599 Alzheimer's Disease Human NTF-3 PF in patients lacking the ApoE-?4 allele 2015 26814132
2652 Alzheimer's Disease Human NUMA1 RF APOE-?2 2021 33576571
2626 Alzheimer's Disease Human NUMA1 RF APOE-?2 2021 33576571
2475 Alzheimer's Disease Human OPRD1 RF APOE-?2 2021 33576571
2286 Alzheimer's Disease Human OPRD1 RF APOE-?3 2021 33576571
2273 Alzheimer's Disease Human OR1S2 RF APOE-?2 2021 33576571
2216 Alzheimer's Disease Human OR1S2 RF APOE-?2 2021 33576571
2036 Alzheimer's Disease Human OR2B2 RF 2021 33654092
640 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
657 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
671 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
649 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
652 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
3301 Alzheimer's Disease Human OX2R RF A allele may be a susceptible factor for AD 2019 30955315
3300 Alzheimer's Disease Human OX2R RF A allele may be a susceptible factor for AD 2019 30955315
3126 Alzheimer's Disease Human oxidized LDL receptor 1(OLR1) RF 2011 21709374
3137 Alzheimer's Disease Human oxidized LDL receptor 1(OLR1) RF 2011 21709374
3718 Alzheimer's Disease Human paraoxonase 1 (PON1) RF can be ameliorated by B-vitamins in individuals with MCI 2021 33935094
572 Alzheimer's Disease Human PELO PF APOE-?2 2021 33576571
638 Alzheimer's Disease Human PELO PF APOE-?3 2021 33576571
2103 Alzheimer's Disease Human PEMT RF 2012 21881829
2760 Alzheimer's Disease Human PGP RF APOE-?2 2021 33576571
2352 Alzheimer's Disease Human PICALM RF PENN cohort 2018 30128317
2508 Alzheimer's Disease Human PICALM RF PENN cohort 2018 30128317
3311 Alzheimer's Disease Human PLA2G3 RF 2010 20930276
3313 Alzheimer's Disease Human PLEKHG5 RF 2017 29177109
832 Alzheimer's Disease Human PM20D1 PF in a particular genetic background 2018 29736028
695 Alzheimer's Disease Human POMT1 PF APOE-?2 2021 33576571
2631 Alzheimer's Disease Human PRAME RF APOE-?2 2021 33576571
1699 Alzheimer's Disease Human presence of one or more APOE ε4 alleles RF in females 2015 26343475
746 Alzheimer's Disease Human PRKAG3 PF APOE-?3 2021 33576571
2588 Alzheimer's Disease Human PRKAG3 RF APOE-?2 2021 33576571
3022 Alzheimer's Disease Human PRPH RF APOE-?2 2021 33576571
2161 Alzheimer's Disease Human PRSS48 RF APOE-?2 2021 33576571
3317 Alzheimer's Disease Human PS-1 RF 1996 8930979
2415 Alzheimer's Disease Human PS-1 RF APOE ε4 1999 10581373
3318 Alzheimer's Disease Human PS-1 RF 1997 9298817
3105 Alzheimer's Disease Human PS-2 RF APOE ε4 1999 10581373
3319 Alzheimer's Disease Human PSEN1 RF 2014 25104557
3321 Alzheimer's Disease Human PSEN2 RF 2014 25104557
3928 Alzheimer's Disease Human PSEN2 RF Diagnosis 2022 36362122
3322 Alzheimer's Disease Human PSEN2 RF 2014 24927704
2233 Alzheimer's Disease Human PSMB7 RF APOE-?2 2021 33576571
3101 Alzheimer's Disease Human PTBP1 RF APOE-?3 2021 33576571
642 Alzheimer's Disease Human PTCH1 PF APOE-?2 2021 33576571
763 Alzheimer's Disease Human PTK2B PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
2261 Alzheimer's Disease Human PVRL2 RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 2018 29107063
2064 Alzheimer's Disease Human PVRL2 RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 2018 29107063
3323 Alzheimer's Disease Human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
3325 Alzheimer's Disease Human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
1573 Alzheimer's Disease Human PVRL2 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 2018 29107063
2114 Alzheimer's Disease Human PVRL2 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
3324 Alzheimer's Disease Human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
3091 Alzheimer's Disease Human QPCTL RF APOE-?2 2021 33576571
3326 Alzheimer's Disease Human RCAN1 RF 2015 26497675
3327 Alzheimer's Disease Human RCAN1 RF 2015 26497675
2019 Alzheimer's Disease Human reduced folate carrier gene (RFC1) RF especially for female individuals 2009 18258338
2058 Alzheimer's Disease Human reduced folate carrier gene (RFC1) RF especially for female individuals 2009 18258338
2378 Alzheimer's Disease Human RIPK2 RF APOE-?2 2021 33576571
3003 Alzheimer's Disease Human SCAF11 RF APOE-?3 2021 33576571
558 Alzheimer's Disease Human SCAF11 PF APOE-?2 2021 33576571
3019 Alzheimer's Disease Human SEMA6A RF APOE-?2 2021 33576571
2965 Alzheimer's Disease Human SERPINE1 RF women were at an increased risk over their male genotype counterparts 2017 28466654
3106 Alzheimer's Disease Human SERPINE1 RF women were at an increased risk over their male genotype counterparts 2017 28466654
2925 Alzheimer's Disease Human SERPINE2 RF APOE-?2 2021 33576571
2309 Alzheimer's Disease Human SFTPB RF APOE-?2 2021 33576571
2763 Alzheimer's Disease Human SH3D19 RF APOE-?3 2021 33576571
3052 Alzheimer's Disease Human SHARPIN RF 2019 31216982
3707 Alzheimer's Disease Human SIGLEC14 RF 2021 34208838
3332 Alzheimer's Disease Human SIRT2 RF 2014 24139700
2227 Alzheimer's Disease Human SIRT2 RF APOEε4 noncarriers 2014 24139700
595 Alzheimer's Disease Human SLC35G6 PF APOE-?2 2021 33576571
617 Alzheimer's Disease Human SLC35G6 PF APOE-?2 2021 33576571
578 Alzheimer's Disease Human SLC6A4/5-HTT PF S allele; AD with depression 2018 29703883
2330 Alzheimer's Disease Human SMPD4 RF APOE-?3 2021 33576571
621 Alzheimer's Disease Human SMTNL1 PF APOE-?2 2021 33576571
733 Alzheimer's Disease Human SMTNL1 PF APOE-?3 2021 33576571
2419 Alzheimer's Disease Human SNX27 RF APOE-?2 2021 33576571
589 Alzheimer's Disease Human SOD1 gene PF Logistic regression analysis controlled for age, genderand APOE carrier status；additive model 2014 25440013
637 Alzheimer's Disease Human SOD1 gene PF After Bonferroni correction；recessive model 2014 25440013
590 Alzheimer's Disease Human SOD1 gene PF Logistic regression analysis controlled for age, genderand APOE carrier status；recessive model 2014 25440013
627 Alzheimer's Disease Human SOD1 gene PF After Bonferroni correction；additive model 2014 25440013
3760 Alzheimer's Disease Human SORCS3 RF 2021 32966694
3916 Alzheimer's Disease Human SORL1 RF Diagnosis 2022 35457051
3337 Alzheimer's Disease Human SORL1 RF with the A allele 2015 25450149
3908 Alzheimer's Disease Human SORL1 RF Diagnosis 2022 35456392
2053 Alzheimer's Disease Human SORL1 RF adjusted foe age, gender, APOE 4 2015 25881907
3915 Alzheimer's Disease Human SORL1 RF Diagnosis 2022 35457051
834 Alzheimer's Disease Human SORL1 PF 2008 18407551
3108 Alzheimer's Disease Human SORL1 RF when restricting the analysis to the 205 cases with a positive family history 2016 26303663
2059 Alzheimer's Disease Human SORL1 RF adjusted for age and gender 2015 25881907
3338 Alzheimer's Disease Human SORL1 RF 2009 19368828
3706 Alzheimer's Disease Human SORL1 RF 2021 34214049
823 Alzheimer's Disease Human SORL1 PF 2018 30009200
2404 Alzheimer's Disease Human SORL1 RF 2014 24486888
3010 Alzheimer's Disease Human SORL1 RF 2016 26303663
674 Alzheimer's Disease Human SORT1 PF 2016 27392867
3341 Alzheimer's Disease Human SREBF2 RF significant dual associations with LOAD pathological biomarkers and gene expression levels 2018 29503034
2529 Alzheimer's Disease Human STARD6 RF in combination with the APOE ε4 allele 2019 30666118
559 Alzheimer's Disease Human STEAP1B PF APOE-?2 2021 33576571
1987 Alzheimer's Disease Human STH RF especially in caucasian population, late‐onset AD subjects and studies with high quality 2017 28211174
3344 Alzheimer's Disease Human SYMPK RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
2858 Alzheimer's Disease Human SYTL2 RF APOE-?2 2021 33576571
650 Alzheimer's Disease Human SYTL2 PF APOE-?2 2021 33576571
639 Alzheimer's Disease Human SYTL2 PF APOE-?2 2021 33576571
2376 Alzheimer's Disease Human SYTL2 RF APOE-?3 2021 33576571
596 Alzheimer's Disease Human SYTL2 PF APOE-?2 2021 33576571
667 Alzheimer's Disease Human SYTL2 PF APOE-?2 2021 33576571
2147 Alzheimer's Disease Human SYTL2 RF APOE-?3 2021 33576571
3927 Alzheimer's Disease Human tau RF Diagnosis 2022 35348036
2971 Alzheimer's Disease Human TBC1D4 RF APOE-?2 2021 33576571
2367 Alzheimer's Disease Human TCF7 RF APOE-?2 2021 33576571
2535 Alzheimer's Disease Human TESK2 RF APOE-?2 2021 33576571
2381 Alzheimer's Disease Human TFAM RF 2008 18430995
2472 Alzheimer's Disease Human TGF-β1 RF Genotype AC 2016 26327336
2081 Alzheimer's Disease Human TGF-β1 RF allele G 2016 26327336
2160 Alzheimer's Disease Human TGF-β1 RF without the ApoE ε4allele;C 2016 26327336
2229 Alzheimer's Disease Human TGF-β1 RF Genotype TG 2016 26327336
2713 Alzheimer's Disease Human TGF-β1 RF AC+ CC vs AA 2016 26327336
2363 Alzheimer's Disease Human TGF-β1 RF without the ApoE ε4 allele;TG 2016 26327336
2238 Alzheimer's Disease Human TGF-β1 RF allele C 2016 26327336
2311 Alzheimer's Disease Human TGF-β1 RF without the ApoE ε4 allele;G 2016 26327336
2270 Alzheimer's Disease Human TGF-β1 RF without the ApoE ε4 allele;AC 2016 26327336
3350 Alzheimer's Disease Human THBS2 RF 2017 29177109
2490 Alzheimer's Disease Human THG1L RF APOE-?2 2021 33576571
643 Alzheimer's Disease Human TLR2 PF 2015 26738351
835 Alzheimer's Disease Human TLR4 PF when incorporated into a haplotype with rs10759930, the strongest association was detected 2012 22272615
3353 Alzheimer's Disease Human TMEM106B RF APOE interact 2014 24166182
3354 Alzheimer's Disease Human TMP21 RF 2018 28233271
3733 Alzheimer's Disease Human TNFRSF13C RF 2021 33687622
3355 Alzheimer's Disease Human TNFRSF1A, CDH1, CASP7, LRP1B and TG RF 2015 26621834
1329 Alzheimer's Disease Human TNF-α RF in the APOE epsilon4 non-carriers 2008 18396294
1334 Alzheimer's Disease Human TNF-α RF in the APOE epsilon4 non-carriers 2008 18396294
2295 Alzheimer's Disease Human TNF-α -308 RF A vs. G allele 2015 25647294
2770 Alzheimer's Disease Human TNF-α -308 RF AA vs. GG 2015 25647294
2104 Alzheimer's Disease Human TNF-α -308 RF AA + AG vs. GG (dominant) 2015 25647294
2452 Alzheimer's Disease Human TNF-α -308 RF AA vs. AG 2015 25647294
2766 Alzheimer's Disease Human TNF-α -308 RF AA vs. AG + GG (recessive) 2015 25647294
2896 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
690 Alzheimer's Disease Human TOMM40 PF the association between the Asian and Caucasian groups was significantly different 2016 26795201
3358 Alzheimer's Disease Human TOMM40 RF 2018 30443289
1621 Alzheimer's Disease Human TOMM40 RF using Cox regression、Dataset：FHS（Framingham Heart Study） 2018 29107063
2116 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
2184 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
2885 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
1588 Alzheimer's Disease Human TOMM40 RF using Cox regression、Dataset：HRS（Health and Retirement Study） 2018 29107063
2564 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 2018 29107063
2862 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 2018 29107063
2440 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
2735 Alzheimer's Disease Human TOMM40 RF the association between the Asian and Caucasian groups was significantly different 2016 26795201
2964 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
3357 Alzheimer's Disease Human TOMM40 RF 2018 29797398
2115 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
2445 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
3696 Alzheimer's Disease Human TOMM40 RF 2021 34336000
2935 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
1673 Alzheimer's Disease Human TOMM40 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 2018 29107063
1589 Alzheimer's Disease Human TOMM40 RF using Cox regression、Dataset：HRS（Health and Retirement Study） 2018 29107063
2565 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：FHS(Framingham Heart Study) 2018 29107063
3356 Alzheimer's Disease Human TOMM40 RF 2018 29797398
2585 Alzheimer's Disease Human TOX RF APOE-?2 2021 33576571
594 Alzheimer's Disease Human TRAF3IP2 PF APOE-?2 2021 33576571
739 Alzheimer's Disease Human TRAF3IP2 PF APOE-?3 2021 33576571
2383 Alzheimer's Disease Human TREM2 RF 2014 24439484
2907 Alzheimer's Disease Human TREM2 RF APOE-?3 2021 33576571
3360 Alzheimer's Disease Human TREM2 RF 2018 29794134
3076 Alzheimer's Disease Human TREM2 RF APOE-?2 2021 33576571
2704 Alzheimer's Disease Human TREM2 RF 2015 25936935
2933 Alzheimer's Disease Human TREM2 RF 2014 24041969
2849 Alzheimer's Disease Human TREM2 RF 2013 23855982
3359 Alzheimer's Disease Human TREM2 RF 2018 30222607
2928 Alzheimer's Disease Human TREM2 RF 2013 23380991
2534 Alzheimer's Disease Human TREM2 RF 2014 25160042
2427 Alzheimer's Disease Human TREM2 RF the T allele of the rs75932628 variant of TREM2 2015 25260849
2703 Alzheimer's Disease Human TREM2 RF 2015 26037549
2932 Alzheimer's Disease Human TREM2 RF 2014 24041969
811 Alzheimer's Disease Human TREML2 PF 2014 24439484
2804 Alzheimer's Disease Human TTC38 RF APOE-?2 2021 33576571
2359 Alzheimer's Disease Human TTLL13 RF APOE-?2 2021 33576571
2328 Alzheimer's Disease Human TTLL13 RF APOE-?2 2021 33576571
2987 Alzheimer's Disease Human TXNRD3NB RF APOE-?2 2021 33576571
3368 Alzheimer's Disease Human TYROBP RF 2016 27658901
2232 Alzheimer's Disease Human UBASH3B RF APOE-?2 2021 33576571
738 Alzheimer's Disease Human UGT3A1 PF APOE-?3 2021 33576571
663 Alzheimer's Disease Human UGT3A1 PF APOE-?2 2021 33576571
3762 Alzheimer's Disease Human vascular apoE RF 2021 33321072
3020 Alzheimer's Disease Human VSTM5 RF APOE-?2 2021 33576571
797 Alzheimer's Disease Human WDR60 PF APOE-?3 2021 33576571
622 Alzheimer's Disease Human YDJC PF APOE-?2 2021 33576571
2182 Alzheimer's Disease Human ZAR1 RF APOE-?3 2021 33576571
2638 Alzheimer's Disease Human ZAR1 RF APOE-?2 2021 33576571
584 Alzheimer's Disease Human ZCCHC9 PF APOE-?2 2021 33576571
2616 Alzheimer's Disease Human ZNF596 RF APOE-?2 2021 33576571
2599 Alzheimer's Disease Human ZNF778 RF APOE-?2 2021 33576571
2385 Alzheimer's Disease Human ZNF804B RF APOE-?3 2021 33576571
2493 Alzheimer's Disease Human ZNF90 RF APOE-?2 2021 33576571
3443 Alzheimer's Disease Human family history of cardiovascular diseases RF 2014 24596166
2705 Alzheimer's Disease Human Family history of dementia (FH) RF 2016 26531229
3445 Alzheimer's Disease Human family history of dementia (within third-degree relatives) RF people with mild memory impairment/no dementia (MMI/ND) 2011 21205364
2743 Alzheimer's Disease Human Having a first-degree relative or a parent with dementia RF 2016 26531229
1032 Alzheimer's Disease Human Alcohol + Smoking PF Diagnosis 2010 20164550
4043 Alzheimer's Disease Human Education + Occupational attainment RF Diagnosis 1994 8139057
4042 Alzheimer's Disease Human Rural residence + Education RF Diagnosis Education:Low(<= 6 years); high(>= 7 years) 2000 10636132
1031 Alzheimer's Disease Human Smoking + family history of dementia PF Diagnosis 1997 9152711
4041 Alzheimer's Disease Human Smoking + APOE ε4 carriers RF Diagnosis 2010 20847559
4040 Alzheimer's Disease Human Obesity associated gene (FTO) RF Diagnosis In a genome wide association study (GWAS), the fat mass and obesity associated gene (FTO) was found to be associated with increased body mass index (BMI) in both childhood and midlife. 2011 21098976
1030 Alzheimer's Disease Mice Dietary polyphenols + Exercise PF Prognosis 2015 25318545
1029 Alzheimer's Disease Mice Exercise + Probiotic treatment PF Prognosis 2019 30529024
1027 Alzheimer's Disease Mice Resveratrol + Exercise PF Prognosis 2019 31114160
1028 Alzheimer's Disease Mice Resveratrol + Exercise PF Prognosis 2019 30717730
3653 Alzheimer's Disease rat combination of risk factor hHcy(Hyperhomocysteinemia) with IRI(ischemia-reperfusion injury) RF Adult male Wistar rats 5–6 months old and weighing 300–400 g 2018 30003389
1665 Alzheimer's Disease Human combination therapy with insulin RF 2014 24489845
1640 Alzheimer's Disease Human combine Type 2 diabetes and diabetic ketoacidosis (DKA) RF 2019 30481578
1485 Alzheimer's Disease Human depression + cerebrovascular disease(CVD) RF 2021 33726788
3659 Alzheimer's Disease Human Depression + depression-related monoaminergic systems RF including serotonin and noradrenaline 2019 29685068
2861 Alzheimer's Disease Human diabetes and hyperlipidemia RF 2018 29971140
2007 Alzheimer's Disease Human MDFK（mineral turpentine, diesel oil, fuel oil and kerosene） RF adjusted for age, education and sex, using logistic regression;Model 3 2014 25028582
1936 Alzheimer's Disease Human MDFK（mineral turpentine, diesel oil, fuel oil and kerosene） RF adjusted for age, education and sex, using logistic regression;Model 2 2014 25028582
2006 Alzheimer's Disease Human MDFK（mineral turpentine, diesel oil, fuel oil and kerosene） RF adjusted for age, education and sex, using logistic regression;Model 1 2014 25028582
3657 Alzheimer's Disease Human Mercury (Hg) and lead (Pb) RF 2019 30603762
3662 Alzheimer's Disease Human Traumatic brain injury (TBI) + S100A9 protein RF S100A9-driven amyloid-neurodegenerative cascade 2018 30150640
3751 Alzheimer's Disease Human Mild cognitive decline(MCI) and APOE?4 RF 2021 33009037
3565 Alzheimer's Disease Human combine Rate of brain aging and APOE ε4 RF interventions that slow aging may substantially reduce risk of neurological disease and decline even in the presence of APOE ε4. 2019 31133613
1739 Alzheimer's Disease Human Clinician-verified depression + anxiety RF Model 1: Main effect unadjusted 2018 29077487
1745 Alzheimer's Disease Human Clinician-verified depression + anxiety RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 2018 29077487
1735 Alzheimer's Disease Human Clinician-verified depression + anxiety RF Model 2: Main effects adjusted for sex, education, age, and race 2018 29077487
1743 Alzheimer's Disease Human Clinician-verified depression + anxiety RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 2018 29077487
1729 Alzheimer's Disease Human Clinician-verified depression + sleep disturbance RF Model 1: Main effect unadjusted 2018 29077487
1738 Alzheimer's Disease Human Clinician-verified depression + sleep disturbance RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 2018 29077487
1727 Alzheimer's Disease Human Clinician-verified depression + sleep disturbance RF Model 2: Main effects adjusted for sex, education, age, and race 2018 29077487
1737 Alzheimer's Disease Human Clinician-verified depression + sleep disturbance RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 2018 29077487
3641 Alzheimer's Disease Human APOE e4 and GSTM1 null deletion RF 2018 29072550
3660 Alzheimer's Disease Human APOE ε4 allele + family history RF family history of late-onset AD (FH) 2018 30134963
3640 Alzheimer's Disease Human BuChE-K variant and ApoE allele RF 2018 29254094
3055 Alzheimer's Disease Human carriers of the CTSD T and APOE ε4 alleles RF 2014 24281128
2716 Alzheimer's Disease Human combine APOC1 insertion mutation and APOE ε4 RF 2014 24498013
3648 Alzheimer's Disease Human combine SOD2 gene rs4880-T genotype and APOEε4 genotype RF 2015 26696693
3045 Alzheimer's Disease Human COMT (Val158 Met) polymorphism with APOE epsilon4 allele RF GG allele 2009 19793392
3071 Alzheimer's Disease Human COMT (Val158 Met) polymorphism with APOE epsilon5 allele RF AG allele 2009 19793392
3136 Alzheimer's Disease Human MTHFR 677 T allele and APOE epsilon4 allele RF 2009 18258338
3644 Alzheimer's Disease Human The combined effects of TNFa, IL-6 and IL-10 variant alleles RF 2009 19744138
3643 Alzheimer's Disease Human the genotypes GG and APOEε4 RF 2014 24575113
3661 Alzheimer's Disease Human ApoE + ApoE protein RF effect the formation of protein polymers and fibrilization through interaction with tau and Abeta 1995 7695621
3658 Alzheimer's Disease Human ApoE + deposition of β-amyloid (Aβ) RF 2018 29527500
3064 Alzheimer's Disease Human APOE and gender RF 2018 29278785
2462 Alzheimer's Disease Human APOE and gender RF 2018 29278785
3663 Alzheimer's Disease Human APOE ε4 allele + alpha 1-antichymotrypsin polymorphism RF 1995 7670501
2916 Alzheimer's Disease Human APOE ε4 allele + Herpes simplex virus type 1(HSV1) RF Temporal lobe 1997 9014911
2453 Alzheimer's Disease Human APOE ε4 allele + Herpes simplex virus type 1(HSV1) RF Overall 1997 9014911
2768 Alzheimer's Disease Human APOE ε4 allele + Herpes simplex virus type 1(HSV1) RF Frontal lobe 1997 9014911
3726 Alzheimer's Disease Human APOE ε4 gene + AD-promoting pathogens RF The interaction of APOE ε4 gene and the AD-promoting pathogens 2021 33732104
3642 Alzheimer's Disease Human APOE4 and woman RF 2014 24623176
1354 Alzheimer's Disease Human CHD5 rs11121295 + drinking RF 2018 29861839
1353 Alzheimer's Disease Human CHD5 rs11121295 + drinking RF 2018 29861839
3647 Alzheimer's Disease Human combine levels of leptin, adiponectin and insulin RF 2016 26906354
2955 Alzheimer's Disease Human female and the APOE ε3/ε4 genotype RF between the ages of 65 and 75 years 2017 28846757
3649 Alzheimer's Disease Human Higher estrone (E1) levels and carrying the APOE ε4 allele RF 2011 21211518
3645 Alzheimer's Disease Human interaction between a GRS comprised of AD SNPs and midlife triglyceride levels RF rs11218343 and APOE?4 2018 30412497
2805 Alzheimer's Disease Human male and the APOE ε3/ε4 genotype RF between the ages of 65 and 75 years 2017 28846757
1750 Alzheimer's Disease Human Depressed 2 years + anxiety RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 2018 29077487
1755 Alzheimer's Disease Human Depressed 2 years + anxiety RF Model 1: Main effect unadjusted 2018 29077487
1491 Alzheimer's Disease Human Depressed 2 years + anxiety RF Model 2: Main effects adjusted for sex, education, age, and race 2018 29077487
1751 Alzheimer's Disease Human Depressed 2 years + anxiety RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 2018 29077487
1748 Alzheimer's Disease Human Depressed 2 years + sleep disturbance RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 2018 29077487
1753 Alzheimer's Disease Human Depressed 2 years + sleep disturbance RF Model 2: Main effects adjusted for sex, education, age, and race 2018 29077487
1747 Alzheimer's Disease Human Depressed 2 years + sleep disturbance RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 2018 29077487
1754 Alzheimer's Disease Human Depressed 2 years + sleep disturbance RF Model 1: Main effect unadjusted 2018 29077487
1715 Alzheimer's Disease Human Depression lifetime + anxiety RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 2018 29077487
1721 Alzheimer's Disease Human Depression lifetime + anxiety RF Model 1: Main effect unadjusted 2018 29077487
1723 Alzheimer's Disease Human Depression lifetime + anxiety RF Model 2: Main effects adjusted for sex, education, age, and race 2018 29077487
1714 Alzheimer's Disease Human Depression lifetime + anxiety RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 2018 29077487
1720 Alzheimer's Disease Human Depression lifetime + sleep disturbance RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 2018 29077487
1711 Alzheimer's Disease Human Depression lifetime + sleep disturbance RF Model 2: Main effects adjusted for sex, education, age, and race 2018 29077487
1716 Alzheimer's Disease Human Depression lifetime + sleep disturbance RF Model 1: Main effect unadjusted 2018 29077487
1718 Alzheimer's Disease Human Depression lifetime + sleep disturbance RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 2018 29077487
1741 Alzheimer's Disease Human Sleep Disturbance + anxiety RF Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status 2018 29077487
1744 Alzheimer's Disease Human Sleep Disturbance + anxiety RF Model 2: Main effects adjusted for sex, education, age, and race 2018 29077487
1749 Alzheimer's Disease Human Sleep Disturbance + anxiety RF Model 1: Main effect unadjusted 2018 29077487
1740 Alzheimer's Disease Human Sleep Disturbance + anxiety RF Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. 2018 29077487
3720 Alzheimer's Disease Human lower BMI + higher polygenic risk RF 2021 33880516
3544 Alzheimer's Disease Human a protective response to proteostatic stress, directed by the NRF1-sMAF complex RF people carrying the risk (A) allele of rs667897 2018 29179108
3545 Alzheimer's Disease Human accumulation of p16(INK4a)-positive senescent astrocytes RF 2012 22984612
3548 Alzheimer's Disease mice age-related increase in chemokine CCL11 RF antagonizing CCR3 may bring therapeutic benefits to?AD 2017 27878757
3741 Alzheimer's Disease Human amyloid beta (Aβ) misfolding RF 2021 33614887
2537 Alzheimer's Disease Human Amyloid-β (Aβ)(42) RF 2012 21955816
3551 Alzheimer's Disease Human annexin A5 RF 2013 23576984
3540 Alzheimer's Disease Human anti-AT1R RF 2015 26401573
3554 Alzheimer's Disease Human apoE protein activity RF 1995 7672107
3132 Alzheimer's Disease Human Aβ misfolding(measured in blood plasma) RF 2020 31611055
3558 Alzheimer's Disease Human beta-amyloid (Abeta) accumulation RF 2018 29592889
2296 Alzheimer's Disease Human beta-amyloid precursor protein (APP) processing RF 1997 9041854
858 Alzheimer's Disease Caenorhabditis elegans betaine PF both the presence and absence of 1 mM homocysteine; independent of the remethylation pathway but requires the transsulfuration pathway mediated by cystathionine-β-synthase 2018 30065790
3559 Alzheimer's Disease Human Bleomycin hydrolase (BLH) RF 2010 20308784
3561 Alzheimer's Disease Human Branched-chain amino acids (BCAAs) RF 2018 29802157
3562 Alzheimer's Disease mice CB1 receptor desensitization RF Seven-month-old male 3xTg-AD mice 2018 29865071
3709 Alzheimer's Disease mice CD22 RF 2021 34140954
482 Alzheimer's Disease Human cerebrospinal fluid (CSF) Aβ42 PF patients with negative amyloid PET 2021 33667602
481 Alzheimer's Disease Human cerebrospinal fluid (CSF) Aβ42 PF patients with negative amyloid PET 2021 33667602
3566 Alzheimer's Disease Human Complement Receptor 1 (CR1) Density RF 2018 30044434
1868 Alzheimer's Disease Human C-reactive protein (CRP) RF Diagnosis 2023 34538509
3571 Alzheimer's Disease Human CSF AβPET(amyloid beta brain PET imaging) RF Associated with AD progression 2018 29982466
3572 Alzheimer's Disease Human CSF Tau(cerebrospinal fluid tau) and P-tau(phosphorylated tau) RF Associated with AD progression 2018 29982466
3573 Alzheimer's Disease Human decreased expression of FERMT2 RF 2016 27215977
1752 Alzheimer's Disease Human decreasing Aβ1-42 rates RF 2018 30250861
3575 Alzheimer's Disease Human depression-related monoaminergic systems RF including serotonin and noradrenaline 2019 29685068
883 Alzheimer's Disease Human Fibroblast Growth Factor 21 (FGF21) PF 2021 33131010
2346 Alzheimer's Disease Human Fibroblast Growth Factor 21 (FGF21) RF 2021 33850218
3541 Alzheimer's Disease Human free copper RF 2013 23760784
859 Alzheimer's Disease mice glucose regulation PF 2019 31034991
1576 Alzheimer's Disease Human glycated hemoglobin (HbA1c) RF Model III: adjusted for CAD, CHF, stroke, cancer, hyperlipidemia, hypertension, atrial fibrillation, chronic hepatitis, COPD, and hypoglycemia along with all other confounders in model II 2017 28705834
1611 Alzheimer's Disease Human glycated hemoglobin (HbA1c) RF Model I: adjusted for age and sex 2017 28705834
1557 Alzheimer's Disease Human glycated hemoglobin (HbA1c) RF Model IV: adjusted for PFG CV and HbA1c CV along with all other confounders in model III 2017 28705834
1581 Alzheimer's Disease Human glycated hemoglobin (HbA1c) RF Model II: adjusted for age, sex, FPG,HbA1c, insured amount and insured unit (see Table 1), smoking, alcohol consumption, duration of diabetes, type of hypoglycemic drug, hypertension drug treatment, and obesity 2017 28705834
3583 Alzheimer's Disease Human H4K16ac enrichment RF related to aging 2018 29507413
3585 Alzheimer's Disease Human High CSF(cerebrospinal fluid) MCP-1(monocyte chemoattractant protein 1) RF Associated with AD progression 2018 29982466
3590 Alzheimer's Disease Human IL-17A/IL-23 axis RF 2018 30081688
861 Alzheimer's Disease Human increased expression of NUP160 PF 2016 27215977
3592 Alzheimer's Disease Human increased fibrillar amyloid-{beta} RF individuals with a family history of late-onset Alzheimer's;particularly in persons with an AD mother 2010 20231448
3593 Alzheimer's Disease Human increased gene dosage of MIR138-2 RF 2019 30909216
3675 Alzheimer's Disease Human indices of HbA1c variability RF 2020 32870568
3596 Alzheimer's Disease mice inhibition of angiotensin-converting enzyme (ACE) activity RF 2019 31072831
3598 Alzheimer's Disease Human intracellular iron accumulation RF 2014 24199959
887 Alzheimer's Disease mice Irisin PF Treatment 2021 33768561
3599 Alzheimer's Disease Human ischemia/HIF-1α RF 2014 24478626
1765 Alzheimer's Disease Human lifetime-acquired loss of chromosome Y (LOY) RF in blood cells 2016 27231129
3609 Alzheimer's Disease mice mammalian target of rapamycin (mTOR) RF Tg2576 mice 2018 29729422
2656 Alzheimer's Disease Human Methionine synthase RF 2003 12876480
2795 Alzheimer's Disease Human Methionine synthase RF 2003 12876480
2699 Alzheimer's Disease Human Methionine synthase RF 2003 12876480
2718 Alzheimer's Disease Human Methionine synthase RF 2003 12876480
2341 Alzheimer's Disease Human mtDNA sub-haplogroup H5 RF in particular for females and independently from the APOE genotype 2010 20700462
3739 Alzheimer's Disease Human MWF; an in vivo marker of myelin content RF 2021 33638111
3617 Alzheimer's Disease Human Myeloperoxidase(MPO) polymorphism RF 1999 9918702
885 Alzheimer's Disease mice Non-saponin fraction with rich polysaccharide (NFP) PF 2021 33422674
864 Alzheimer's Disease mice Pantoea agglomerans-derived lipopolysaccharide (LPSp) PF fed a high-fat diet, oral administration of LPSp at 0.3 or 1 mg/kg body weight.day for 18 weeks 2018 29856882
3620 Alzheimer's Disease Human pathogenic mutations in CSF1R TK domain RF in concert with TREM2, TYROBP, and GRN 2018 29544907
3700 Alzheimer's Disease mice perfluorooctane sulfonate (PFOS) RF 2021 34224775
3753 Alzheimer's Disease Human perfluorooctane sulfonate (PFOS) RF in older adults with normal kidney function 2021 33068581
3765 Alzheimer's Disease Human plasma phosphorylated tau181 (p-tau181) RF 2021 33419453
3624 Alzheimer's Disease mice plasmin (PL) RF Tg6799 transgenic mice (referred to as AD mice) are double-transgenic for human APP/Presenilin 1 2018 30254165
882 Alzheimer's Disease rat propylparaben (PPB) PF traumatic brain injury (TBI) 2021 33185606
3626 Alzheimer's Disease Human self-assembly of the Apolipoprotein E4 RF impacts on ε4/ε4 individuals more severely than those with ε3/ε4 2019 31051176
772 Alzheimer's Disease Human Trunk fat‐free mass PF 2021 33718584
3692 Alzheimer's Disease Human White matter hyperintensities (WMH) RF All patients were Aβ-positive (Aβpos-AD) 2021 34322985
3639 Alzheimer's Disease Human White matter hyperintensities(WMH) load RF 2019 30678723
694 Alzheimer's Disease Human α-synuclein rs356182 variants PF 2018 30598082
2792 Alzheimer's Disease Human hypertension and diabetes RF 2018 29971140
2870 Alzheimer's Disease Human hypertension and hyperlipidemia RF 2018 29971140
2998 Alzheimer's Disease Human hypertension, diabetes and hyperlipidemia RF 2018 29971140
2159 Alzheimer's Disease Human African ancestry RF 2017 28369008
1512 Alzheimer's Disease Human Age RF 2014 24489845
1943 Alzheimer's Disease Human Age RF 2015 25624416
1584 Alzheimer's Disease Human Age RF after Hemodialysis Initiation 2018 30093374
1704 Alzheimer's Disease Human Age RF 2017 28806610
1530 Alzheimer's Disease Human Age RF 2020 32485802
3374 Alzheimer's Disease Human Age RF 2015 25401488
1660 Alzheimer's Disease Human Age RF after Hemodialysis Initiation 2018 30093374
1878 Alzheimer's Disease Human Age RF 2021 33850218
3748 Alzheimer's Disease Human Age RF 2021 33009037
3376 Alzheimer's Disease Human Age RF 2011 22526079
3730 Alzheimer's Disease Human Age RF 2021 33686543
1929 Alzheimer's Disease Human Age RF 2010 20016220
3745 Alzheimer's Disease Human Age RF 2021 32852053
3768 Alzheimer's Disease Human Age RF 2021 34499125
1832 Alzheimer's Disease Human Age RF Diagnosis 2022 35196953
1507 Alzheimer's Disease Human Age RF in females 2015 26343475
1639 Alzheimer's Disease Human Age RF after Hemodialysis Initiation 2018 30093374
1921 Alzheimer's Disease Human Age RF in patients after spine surgery 2010 20375503
1440 Alzheimer's Disease Human Age RF people with mild cognitive impairment (MCI) 2011 21518614
3375 Alzheimer's Disease Human Age RF 2019 31058682
1663 Alzheimer's Disease Human Age RF after Hemodialysis Initiation 2018 30093374
1879 Alzheimer's Disease Human Age RF 2013 22976076
2721 Alzheimer's Disease Human age in first degree relatives RF age of 90 in first degree relatives 1993 8411049
795 Alzheimer's Disease Human Asian ethnic PF 2021 33554910
2033 Alzheimer's Disease Human Black ethnic RF 2021 33554910
1539 Alzheimer's Disease Human Gender RF 2014 24489845
2901 Alzheimer's Disease Human Gender RF 2015 25624416
1517 Alzheimer's Disease Human Gender RF after Hemodialysis Initiation 2018 30093374
3449 Alzheimer's Disease Human Gender RF 2011 22526079
1634 Alzheimer's Disease Human Gender RF 2017 28806610
2789 Alzheimer's Disease Human Gender RF 2010 20016220
3448 Alzheimer's Disease Human Gender RF 2016 27105335
3769 Alzheimer's Disease Human female sex RF 2021 34499125
3457 Alzheimer's Disease Human higher age among senior citizens in urban communities RF 2019 31286894
1342 Alzheimer's Disease Human Male sex RF 2021 33681711
1344 Alzheimer's Disease Human Male sex RF 2021 33681711
1343 Alzheimer's Disease Human Male sex RF 2021 33681711
1345 Alzheimer's Disease Human Male sex RF 2021 33681711
3677 Alzheimer's Disease Human Male sex RF 2020 32043803
754 Alzheimer's Disease Human Native American ancestry PF 2017 28369008
1768 Alzheimer's Disease Human Nonmarried RF 2015 25401488
1913 Alzheimer's Disease Human older age RF 2020 33126696
2883 Alzheimer's Disease Human older age RF Prognosis 2022 35850031
1946 Alzheimer's Disease Human older age RF Diagnosis 2023 37182880
3746 Alzheimer's Disease Human Race RF 2021 31948505
1626 Alzheimer's Disease Human Race RF after Hemodialysis Initiation 2018 30093374
1628 Alzheimer's Disease Human Race RF after Hemodialysis Initiation 2018 30093374
647 Alzheimer's Disease Human Arthritis PF 1990 2146525
454 Alzheimer's Disease Human Atherosclerotic heart disease PF after Hemodialysis Initiation 2018 30093374
444 Alzheimer's Disease Human Cancer PF after Hemodialysis Initiation 2018 30093374
723 Alzheimer's Disease Human Cancer PF Cancer History(Cancer survivors) 2017 28035936
425 Alzheimer's Disease Human Cancer PF 2018 30906403
3393 Alzheimer's Disease Human cardiovascular disease (CVD) RF 2018 30149459
635 Alzheimer's Disease Human Cataract PF 1990 2146525
1480 Alzheimer's Disease Human cerebrovascular disease RF 2021 33726788
3395 Alzheimer's Disease Human cerebrovascular disease RF Cerebrovascular Alterations 2018 30355253
1692 Alzheimer's Disease Human cerebrovascular disease RF 2017 28806610
1351 Alzheimer's Disease Human coronary heart disease (CHD) RF 2021 33742562
3680 Alzheimer's Disease Human coronavirus disease 2019 (COVID-19) RF 2020 32715280
3752 Alzheimer's Disease Human cytomegalovirus (CMV) RF 2021 33094810
1475 Alzheimer's Disease Human depression or cerebrovascular disease(CVD) RF 2021 33726788
1377 Alzheimer's Disease Human Diabetes RF 2018 29606955
2561 Alzheimer's Disease Human Diabetes RF 2018 29971140
1616 Alzheimer's Disease Human Diabetes RF 2004 15148141
3007 Alzheimer's Disease Human Diabetes RF a risk factor for MCI progressing into AD 2016 27729793
3635 Alzheimer's Disease Human Diabetes RF 2018 30112972
3414 Alzheimer's Disease Human Diabetes RF 1995 7473847
1447 Alzheimer's Disease Human Diabetes RF people with mild cognitive impairment (MCI) 2011 21518614
1367 Alzheimer's Disease Human Diabetes RF 2015 26495049
1633 Alzheimer's Disease Human Diabetes RF 2017 28806610
1498 Alzheimer's Disease Human Diabetes RF 2021 32996171
2458 Alzheimer's Disease Human Diabetes RF Diagnosis 2022 35587456
1406 Alzheimer's Disease Human Diabetes RF Diagnosis 2022 35532912
3894 Alzheimer's Disease Human Diabetes RF Diagnosis 2023 35128745
2719 Alzheimer's Disease Human Diabetes RF 2020 33126696
2093 Alzheimer's Disease Human Diabetes RF Diagnosis 2022 34806607
2245 Alzheimer's Disease Human Diabetes RF 2017 28503814
1603 Alzheimer's Disease Human Diabetes RF 2020 32767997
3413 Alzheimer's Disease Human Diabetes RF 2018 30149459
1497 Alzheimer's Disease Human Diabetes RF after Hemodialysis Initiation 2018 30093374
3636 Alzheimer's Disease Human Diabetes RF 2013 23478310
1627 Alzheimer's Disease Human Diabetes RF 2014 24489845
3415 Alzheimer's Disease Human Diabetes RF people with mild memory impairment/no dementia (MMI/ND) 2011 21205364
510 Alzheimer's Disease Human Diabetes PF with APOE4 genotype in AD population 2008 18189240
1700 Alzheimer's Disease Human Diabetes RF Diagnosis 2023 37563765
1383 Alzheimer's Disease Human Diabetes RF 2021 33435977
3929 Alzheimer's Disease Human Diabetes RF Prognosis 2023 36453775
2871 Alzheimer's Disease Human Disorders in a 1st-degree relative RF Dementia 1990 2146525
2431 Alzheimer's Disease Human Disorders in a 1st-degree relative RF Down’s syndrome 1990 2146525
577 Alzheimer's Disease Human Disorders in a 1st-degree relative PF Thyroid disorders 1990 2146525
2945 Alzheimer's Disease Human Disorders in a 1st-degree relative RF Probable AD 1990 2146525
3419 Alzheimer's Disease Human disseminated mycoses RF 2014 24452965
1604 Alzheimer's Disease Human heart disease RF 2020 32767997
3744 Alzheimer's Disease Human heart disease RF 2021 33527694
3008 Alzheimer's Disease Human High blood pressure RF Diagnosis 2022 35587456
3454 Alzheimer's Disease Human High blood pressure RF intrinsic epigenetic age acceleration 2018 30167451
2497 Alzheimer's Disease Human history of depressive episodes RF 2008 18446027
423 Alzheimer's Disease Human history of hypercholesterolemia PF 2021 33967045
1456 Alzheimer's Disease Human Hospital-treated infectious diseases RF 2021 34166620
2674 Alzheimer's Disease Human infection RF Diagnosis 2022 36107840
1918 Alzheimer's Disease Human infection RF Diagnosis 2022 36107840
2619 Alzheimer's Disease Human infectious burden:C. pneumoniae RF 2015 24910016
2587 Alzheimer's Disease Human infectious burden:cytomegalovirus (CMV) RF 2015 24910016
1877 Alzheimer's Disease Human infectious disease burden RF 2021 33780369
1889 Alzheimer's Disease Human inflammatory bowel disease (IBD) RF Diagnosis 2023 35470286
2830 Alzheimer's Disease Human inflammatory bowel disease (IBD) RF Diagnosis 2023 35470286
2578 Alzheimer's Disease Human inflammatory bowel disease (IBD) RF Diagnosis 2023 35470286
1455 Alzheimer's Disease Human inflammatory bowel disease (IBD) RF 2021 34499125
2784 Alzheimer's Disease Human Malaria RF 1990 2146525
3477 Alzheimer's Disease mice maternal transmission RF Tg2576 female mice 2018 29691440
3676 Alzheimer's Disease Human Multiple vascular risk factors (VRFs) RF especially in APOE ε4 carriers 2020 31587263
1380 Alzheimer's Disease Human myocardial infraction (MI) RF 2021 33742562
488 Alzheimer's Disease Human Neoplasms PF 2021 33718584
3728 Alzheimer's Disease mice Nonalcoholic fatty liver disease (NAFLD) RF 2021 33681678
1678 Alzheimer's Disease Human nonstroke cardiovascular disease (CVD) RF in carriers of the ApoE4 allele 2010 20473139
1597 Alzheimer's Disease Human normal tension glaucoma (NTG) RF Among patients with NTG, none of the glaucoma eye drops used significantly changed the risk of subsequent AD. 2018 30397009
450 Alzheimer's Disease Human Peripheral vascular disease PF after Hemodialysis Initiation 2018 30093374
3491 Alzheimer's Disease Human phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) RF 2013 24067654
3531 Alzheimer's Disease Human vascular risk RF 2010 20164563
3532 Alzheimer's Disease Human vascular risk factors(hypertension, diabetes, cerebrovascular diseases, and hypercholesterolemia) RF people with mild cognitive impairment (MCI) 2011 21490316
3057 Alzheimer's Disease Human A priori occupations RF Printers, mechanics, garage workers, oilers, painters, auto body workers, wood finishers, shoemakers, and dry cleaners (as one of two longest held occupations). 1995 7771442
2048 Alzheimer's Disease Human Air pollution RF Diagnosis 2023 36521347
3723 Alzheimer's Disease Human Air pollution RF higher levels of CO, NO2, PM10, and SO2 exposure were associated with increased risk of AD cognitive deterioration;high SO2 exposure has the greatest impact while O3 has a neutral effect on AD cognitive deterioration 2021 33882496
1545 Alzheimer's Disease Human Air pollution RF Diagnosis 2023 36373950
1864 Alzheimer's Disease Human Air pollution RF Diagnosis 2023 36521347
3704 Alzheimer's Disease Human Air pollution RF 2021 34258378
1570 Alzheimer's Disease Human Air pollution RF 2021 33749652
3382 Alzheimer's Disease Human Air pollution RF 2019 30741678
3701 Alzheimer's Disease Human Air pollution RF in Latin America and the Caribbean (LAC) 2021 34367051
3770 Alzheimer's Disease Human Air pollution RF Diagnosis cognitively unimpaired adults with increased risk of AD 2021 34537521
1926 Alzheimer's Disease Human Air pollution RF Diagnosis 2023 36521347
3703 Alzheimer's Disease Human Air pollution RF 2021 34258378
2903 Alzheimer's Disease Human Benzene, toluene exposure RF 1995 7771442
3397 Alzheimer's Disease mice Chronic low-dose-rate ionising radiation RF chronic low-dose-rate radiation exposure (1 mGy/day or 20 mGy/day) 2016 27708245
3766 Alzheimer's Disease mice chronic noise RF 2021 33407614
422 Alzheimer's Disease Human Employment status PF after Hemodialysis Initiation; Employed 2018 30093374
1500 Alzheimer's Disease Human Employment status RF after Hemodialysis Initiation; Other 2018 30093374
1730 Alzheimer's Disease Human environmental exposure to cadmium RF high cadmium levels (>0.6 μg/L) 2016 27301955
3429 Alzheimer's Disease mice excess zinc exposure RF 2010 21179415
3432 Alzheimer's Disease Human Exposure to Lead RF Cigarette smoking 2017 29089568
3435 Alzheimer's Disease Human Exposure to N2O RF 2019 29991368
3438 Alzheimer's Disease Human Exposure to PM2.5 RF 2018 29935448
404 Alzheimer's Disease Human farming PF 2019 31239120
416 Alzheimer's Disease Human farming PF 2019 31239120
3714 Alzheimer's Disease Human fine particulate matter (PM 2.5) RF 2021 34044832
3446 Alzheimer's Disease Human Formaldehyde (FA) RF 2014 24766729
3453 Alzheimer's Disease Human Heavy metals toxicity:Cadmium (Cd) RF 2014 24557150
1636 Alzheimer's Disease Human High occupational attainment RF mild cognitive impairment(MCI) patient 2017 27662289
849 Alzheimer's Disease Human High occupational attainment PF 2017 27662289
3459 Alzheimer's Disease Human higher levels of estrogen exposure RF 2014 24968011
3460 Alzheimer's Disease Human higher levels of prenatal testosterone exposure RF 2014 24968011
363 Alzheimer's Disease Human intellectual work PF people with mild cognitive impairment (MCI) 2011 21518614
3474 Alzheimer's Disease Human ionizing radiation RF 2017 28671130
2466 Alzheimer's Disease Human Job description only RF Exposure to printing/printer's ink, coal tar/creosote, oils, glues/resins/waxes, rubber production, or paints. 1995 7771442
2365 Alzheimer's Disease Human Job involves mainly walking or standing RF 2021 33718584
2781 Alzheimer's Disease Human Jobs as seamstress, dressmaker and tailor RF 1995 7677130
2891 Alzheimer's Disease Human Jobs as seamstress, dressmaker and tailor RF 1995 7677130
3090 Alzheimer's Disease Human Ketones exposure RF 1995 7771442
886 Alzheimer's Disease Human living in an urban area PF 2021 34499125
3719 Alzheimer's Disease Human living in the most highly disadvantaged neighborhoods RF 2021 33853894
2042 Alzheimer's Disease Human long-term exposures to ambient particulate matter 2.5 (PM2.5) RF in North Carolina (NC) 2021 34242242
1410 Alzheimer's Disease Human Low-frequency electromagnetic fields RF 2021 33435977
3702 Alzheimer's Disease rat Methamphetamine (METH) RF 2021 34224806
65 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
52 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
57 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
4065 Alzheimer's Disease Human Occupational exposure RF Diagnosis 1995 7771442
62 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
54 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
59 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
4067 Alzheimer's Disease Human Occupational exposure RF Diagnosis 2013 22899726
64 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
51 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1996 8837919
56 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
61 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
4069 Alzheimer's Disease Human Occupational exposure RF Diagnosis 2013 22899726
53 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
1074 Alzheimer's Disease Human Occupational exposure PF Diagnosis 2001 11416089
58 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
4066 Alzheimer's Disease Human Occupational exposure RF Diagnosis 1995 7771442
63 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
55 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
60 Alzheimer's Disease Human Occupational exposure Not Related Diagnosis 1997 9071441
4068 Alzheimer's Disease Human Occupational exposure RF Diagnosis 2013 22899726
2947 Alzheimer's Disease Human Other solvents exposure RF 1995 7771442
2999 Alzheimer's Disease Human Phenols, alcohols exposure RF 1995 7771442
3496 Alzheimer's Disease Human prenatal estrogen exposure RF lower levels of prenatal estrogen exposure 2014 24968011
3497 Alzheimer's Disease Human prenatal testosterone exposure RF lower levels of prenatal testosterone exposure 2014 24968011
2468 Alzheimer's Disease Human Probable solvent exposure RF Any above-named solvent or job description. 1995 7771442
2660 Alzheimer's Disease Human Probable solvent exposure RF Any above-named solvent or job description. 1995 7771442
872 Alzheimer's Disease Human Residential exposure to green spaces PF 2021 34258378
1654 Alzheimer's Disease Human Rural residency RF 2015 25401488
2701 Alzheimer's Disease Human Solvent exposure RF Any positive response to a named solvent group 1995 7771442
3072 Alzheimer's Disease Human Solvent exposure RF Any positive response to a named solvent group. 1995 7771442
3747 Alzheimer's Disease mice traffic noise RF 2021 33096582
1558 Alzheimer's Disease Human urbanization status RF 2014 24489845
2432 Alzheimer's Disease Human β- hexachlorocyclohexane RF 2012 22904031
1776 Alzheimer's Disease Human benzodiazepine and related drug (BZDR) RF 2018 29851063
870 Alzheimer's Disease mice dexibuprofen (DXI) PF 2021 34294142
519 Alzheimer's Disease Human Estrogen-replacement therapy PF postmenopausal women 1998 9566385
432 Alzheimer's Disease Human Hearing aid PF hearing-impaired adults 2021 33614893
2733 Alzheimer's Disease Human inappropriate use anti-dementia drugs RF 2020 32251456
2155 Alzheimer's Disease Human irregular medication use anti-dementia drugs RF 2020 32251456
566 Alzheimer's Disease Human no chronic use of nonsteroidal anti-inflammatory drugs PF 2008 18446027
392 Alzheimer's Disease Human Non-aspirin NSAIDS PF 2021 33435977
3499 Alzheimer's Disease Human Proton pump inhibitors (PPIs) RF Chronic consumption of PPIs 2010 20456731
469 Alzheimer's Disease Human Statin therapy PF 2020 32753051
817 Alzheimer's Disease Human statin use PF 2021 33804752
398 Alzheimer's Disease Human statin use PF 2010 20533968
1580 Alzheimer's Disease Human Underwent Surgery under Neuraxial Anesthesia RF Diagnosis 2021 34945858
3900 Alzheimer's Disease mice gut microbiota RF Diagnosis 2023 35619714
3947 Alzheimer's Disease Human gut microbiota RF Diagnosis 2022 35275534
3898 Alzheimer's Disease Human gut microbiota RF Diagnosis 2023 37002253
1651 Alzheimer's Disease Human higher CDR-SB scores RF in male 2015 26343475
850 Alzheimer's Disease Human Maternal breastfeeding history PF Women who breastfed had lower AD risk than women who did not breastfeed(p = 0.017) 2013 23948914
3613 Alzheimer's Disease Human menopause transition (MT) RF decreased metabolic activity and increased brain amyloid-beta deposition 2018 30298180
464 Alzheimer's Disease Human 25(OH)D deficiency PF 2017 28522216
3373 Alzheimer's Disease Human a decrease in LRP10 function RF 2012 22734645
2407 Alzheimer's Disease Human abnormal serum Hcy elevation RF 2021 33907404
1607 Alzheimer's Disease Human Albuminuria RF Model 3:adjusted for Model 2 plus eGFR 2018 29353232
1609 Alzheimer's Disease Human Albuminuria RF Model 2:adjusted for Model 1 plus educational level, history of stroke, systolic blood pressure, the use of antihypertensive agents, diabetes mellitus, total cholesterol, body mass index, smoking habits, alcohol intake, and regular exercise 2018 29353232
1625 Alzheimer's Disease Human Albuminuria RF Model 3:adjusted for Model 2 plus eGFR 2018 29353232
1593 Alzheimer's Disease Human Albuminuria RF Model 1:adjusted for age and sex 2018 29353232
1619 Alzheimer's Disease Human Albuminuria RF Model 1:adjusted for age and sex 2018 29353232
1624 Alzheimer's Disease Human Albuminuria RF Model 2:adjusted for Model 1 plus educational level, history of stroke, systolic blood pressure, the use of antihypertensive agents, diabetes mellitus, total cholesterol, body mass index, smoking habits, alcohol intake, and regular exercise 2018 29353232
776 Alzheimer's Disease Human Basal metabolic rate PF 2021 33718584
3560 Alzheimer's Disease Human Blood levels of alpha-1-antichymotrypsin(ACT) RF 2018 10629358
731 Alzheimer's Disease Human blood levels of Selenium (μg/dL) PF Diagnosis 2022 35742553
2602 Alzheimer's Disease Human blood levels of chromium RF Diagnosis 2022 35742553
3693 Alzheimer's Disease Human blood lipid levels RF 2021 34340865
1481 Alzheimer's Disease Human bone mineral density (BMD) RF low bone mineral density (BMD) 2011 21187587
456 Alzheimer's Disease Human Cardiorespiratory fitness (CRF) PF Diagnosis 2023 36946469
873 Alzheimer's Disease Human Cardiorespiratory fitness (CRF) PF 2021 34268447
843 Alzheimer's Disease Human Cardiorespiratory fitness (CRF) PF 2017 28293467
433 Alzheimer's Disease Human Cardiorespiratory fitness (CRF) PF Diagnosis 2023 36946469
441 Alzheimer's Disease Human Cardiorespiratory fitness (CRF) PF Diagnosis 2023 36946469
420 Alzheimer's Disease Human Cardiorespiratory fitness (CRF) PF Diagnosis 2023 36946469
436 Alzheimer's Disease Human carotid distensibility PF 2021 33870735
1541 Alzheimer's Disease Human carotid intima-media thickness RF 2021 33870735
3755 Alzheimer's Disease Human cholesterol levels RF 2021 32996171
1973 Alzheimer's Disease Human decreased 25-hydroxyvitamin D(25OHD) level RF 2017 27856775
1513 Alzheimer's Disease Human diastolic blood pressure [DBP] RF 2020 32979926
884 Alzheimer's Disease Human diastolic blood pressure [DBP] PF 2021 32996171
1703 Alzheimer's Disease Human dyslipidemia RF 2020 32485802
1773 Alzheimer's Disease Human dyslipidemia RF (a higher LDL cholesterol level) 2020 32753051
2556 Alzheimer's Disease Human dyslipidemia RF 2019 30894904
3579 Alzheimer's Disease Human Elevated blood plasma levels of α7(1-208) nAChR-specific antibodies RF 2011 21593571
3580 Alzheimer's Disease Human Elevated Low-density Lipoprotein Cholesterol Levels(LDL-C) RF 2019 31135820
3581 Alzheimer's Disease Human elevated malondialdehyde levels RF The elevated malondialdehyde levels increases the risk of Alzheimer's disease by 9.342. 2016 26835020
2720 Alzheimer's Disease Human elevated midlife total cholesterol level RF 2002 12160362
2004 Alzheimer's Disease Human fasting plasma glucose (FPG) RF 2020 33177243
1613 Alzheimer's Disease Human fasting plasma glucose (FPG) RF Model I: adjusted for age and sex 2017 28705834
1563 Alzheimer's Disease Human fasting plasma glucose (FPG) RF Model III: adjusted for CAD, CHF, stroke, cancer, hyperlipidemia, hypertension, atrial fibrillation, chronic hepatitis, COPD, and hypoglycemia along with all other confounders in model II 2017 28705834
1544 Alzheimer's Disease Human fasting plasma glucose (FPG) RF Model IV: adjusted for PFG CV and HbA1c CV along with all other confounders in model III 2017 28705834
1569 Alzheimer's Disease Human fasting plasma glucose (FPG) RF Model II: adjusted for age, sex, FPG,HbA1c, insured amount and insured unit (see Table 1), smoking, alcohol consumption, duration of diabetes, type of hypoglycemic drug, hypertension drug treatment, and obesity 2017 28705834
2744 Alzheimer's Disease Human head circumference (HC) RF within the lowest quintile of HC for women 1997 9222166
3587 Alzheimer's Disease Human high level of Dkk1 RF 2016 26880631
2659 Alzheimer's Disease Human high midlife systolic blood pressure RF 2002 12160362
3588 Alzheimer's Disease Human high plasma clusterin levels RF 2015 26402636
816 Alzheimer's Disease Human High thiamine diphosphate level PF 2018 29718773
3674 Alzheimer's Disease Human high-density lipoprotein cholesterol (HDL-C) RF 2020 32979926
720 Alzheimer's Disease Human high-density lipoprotein cholesterol (HDL-C) PF 2020 33177243
3715 Alzheimer's Disease Human Higher homocysteine level RF 2021 34057086
399 Alzheimer's Disease Human Higher leptin level PF 2011 21187587
1341 Alzheimer's Disease Human homocysteine (Hcy) RF elevated plasma Hcy levels 2021 34122042
757 Alzheimer's Disease Human Improving cardiovascular functions PF Ejection fraction 2017 28505975
810 Alzheimer's Disease Human Improving cardiovascular functions PF mean velocity of the LTICA 2017 28505975
784 Alzheimer's Disease Human Improving cardiovascular functions PF mean velocity of the BA 2017 28505975
3591 Alzheimer's Disease Human increased cholesterol or blood pressure RF 2018 30112972
3594 Alzheimer's Disease Human Increased levels of specific sub-fractions of LDL cholesterol RF 2007 17982892
1490 Alzheimer's Disease Human increased plasma adiponectin levels RF 2012 22213409
3595 Alzheimer's Disease Human increased platelet membrane fluidity RF first-degree relatives of probands with Alzheimer's disease 1996 8610834
862 Alzheimer's Disease Human increased skeletal muscle mass PF 2019 30700801
909 Alzheimer's Disease Human Intelligence PF Prognosis 2023 36502318
737 Alzheimer's Disease Human Intelligence PF 2021 33718584
1537 Alzheimer's Disease Human interadventitial diameter RF 2021 33870735
1712 Alzheimer's Disease Human Leukocyte telomere length (LTL) RF short rLTL 2021 34266503
3131 Alzheimer's Disease Human Leukocyte telomere length (LTL) RF shorter telomere length 2021 33679878
3600 Alzheimer's Disease Human levels of homocysteine RF 2010 20885792
3602 Alzheimer's Disease Human Longitudinal Changes in Serum Glucose Levels RF 2018 29480176
3604 Alzheimer's Disease Human low NAA/MI(N-Acetyl Aspartate/Myo-Inositol)ratios RF 2017 28968236
3606 Alzheimer's Disease Human low serum paraoxonase activity RF 2012 20980077
1515 Alzheimer's Disease Human low-density lipoprotein cholesterol (LDL-C) RF 2020 32979926
1933 Alzheimer's Disease Human low-density lipoprotein cholesterol (LDL-C) RF 2020 33177243
413 Alzheimer's Disease Human low-density lipoprotein cholesterol (LDL-C) PF 2021 32766741
3607 Alzheimer's Disease Human lower plasma apoE levels RF in middle age 2009 19720974
1655 Alzheimer's Disease Human lower serum leptin levels RF 2015 26425011
812 Alzheimer's Disease Human lower serum level of folate PF 2008 18446027
3611 Alzheimer's Disease Human Manganese (Mn) deficiency RF 2017 28273828
3612 Alzheimer's Disease mice meningeal lymphatics RF wild-type mice (C57BL/6J background) 2018 30046111
3615 Alzheimer's Disease mice microglial functions(specifically microglial plaque coverage) RF APOE4 genotype 2019 31113487
1617 Alzheimer's Disease Human Midlife serum total cholesterol RF Model 1 is unadjusted 2009 19648749
1605 Alzheimer's Disease Human Midlife serum total cholesterol RF Model 2 is adjusted for age (as time scale), sex, education, race/ethnic group, midlife BMI, diabetes and hypertension; for AD, the model is additionally adjusted for late-life stroke. 2009 19648749
3619 Alzheimer's Disease Human NO(Nitric Oxide) bioavailability and cortical, extracranial, and peripheral circulation RF 2018 29593548
3679 Alzheimer's Disease Human number of functional tooth units (FTU) RF 2020 32116259
3710 Alzheimer's Disease Human Palmitic acid (PA) RF 2021 34151811
3622 Alzheimer's Disease Human plasma ApoE levels RF 2015 25547651
415 Alzheimer's Disease Human Plasma clusterin levels PF younger participants 2016 27453932
1763 Alzheimer's Disease Human Plasma clusterin levels RF elderly persons 2016 27453932
1487 Alzheimer's Disease Human plasma high-density lipoprotein (HDL) RF 2021 33964140
915 Alzheimer's Disease Human plasma high-density lipoprotein (HDL) PF Diagnosis 2023 35319157
3717 Alzheimer's Disease Human plasma membrane cholesterol RF 2021 33967735
2831 Alzheimer's Disease Human plasma total homocysteine RF 2016 27031476
3681 Alzheimer's Disease Human pulse pressure (PP) RF 2020 32960784
452 Alzheimer's Disease Human pulse pressure (PP) PF 2020 32979926
1543 Alzheimer's Disease Human reduced 25-hydroxyvitamin D (25[OH]D) RF 2014 23871764
3627 Alzheimer's Disease Human serum Ang-1 RF 2012 23094194
1594 Alzheimer's Disease Human Serum apoE RF 2016 26876448
1915 Alzheimer's Disease Human serum cholesterol RF 2012 22904031
3629 Alzheimer's Disease Human serum folate RF 1998 9823829
3630 Alzheimer's Disease Human serum sEPCR levels RF 2015 25588409
3725 Alzheimer's Disease Human serum uric acid (UA) RF Low concentrations of UA 2021 33716713
395 Alzheimer's Disease Human serum uric acid (UA) PF 2021 33435977
396 Alzheimer's Disease Human Serum vitamin D PF 2021 33435977
799 Alzheimer's Disease Human Standing height PF 2021 33718584
445 Alzheimer's Disease Human systolic blood pressure (SBP) PF 2020 32979926
1606 Alzheimer's Disease Human systolic blood pressure (SBP) RF 2021 33860609
1602 Alzheimer's Disease Human systolic blood pressure (SBP) RF 2021 33860609
3632 Alzheimer's Disease Human telomere length (TL) RF shorter telomeres in AD patients 2016 27091133
1524 Alzheimer's Disease Human Testosterone RF 2021 32602403
2973 Alzheimer's Disease Human tHcy level RF 1998 9823829
1818 Alzheimer's Disease Human The highest Hcy RF 2017 28698453
1815 Alzheimer's Disease Human the lowest folate tertile RF 2017 28698453
1501 Alzheimer's Disease Human total cholesterol [TC] RF 2020 32979926
2013 Alzheimer's Disease Human total cholesterol [TC] RF 2020 33177243
1822 Alzheimer's Disease Human total homocysteine (tHcy) RF Diagnosis 2021 34720990
3524 Alzheimer's Disease Human Total:HDL cholesterol (ratio) RF extrinsic epigenetic age acceleration 2018 30167451
588 Alzheimer's Disease Human treated dyslipidemia PF 2020 33126696
1521 Alzheimer's Disease Human triglyceride glucose (TyG) index RF 2021 33402193
1504 Alzheimer's Disease Human triglycerides [TG] RF 2020 32979926
1510 Alzheimer's Disease Human visual rating scale (CVRS) score RF high CVRS score 2021 33715339
2949 Alzheimer's Disease Human vitamin B12 RF 1998 9823829
3764 Alzheimer's Disease Human Vitamin D levels RF 2021 33406925
679 Alzheimer's Disease Human Vitamin D levels PF 2021 33718584
3763 Alzheimer's Disease Human Vitamin D levels RF 2021 33406925
906 Alzheimer's Disease Human Age at natural menopause PF Diagnosis 2023 37357294
2321 Alzheimer's Disease Human monozygotic(MZ) twins RF twins born in Finland before 1958 with both co-twins alive in 1967 1996 8596319
3495 Alzheimer's Disease Human pregnancy RF pregnant 5xFAD transgenic mice 2018 29855361
3384 Alzheimer's Disease Human amnestic mild cognitive impairment (aMCI) RF 2018 30199883
1681 Alzheimer's Disease Human anemia RF 2014 24419041
2426 Alzheimer's Disease Human Blood-Stasis RF 2021 33907404
3394 Alzheimer's Disease Human carotid atherosclerosis RF 2017 28810593
3563 Alzheimer's Disease Human cerebral hypoperfusion RF 2013 23295908
3771 Alzheimer's Disease Human chronic corticosterone consumption RF Diagnosis 2021 34923495
1622 Alzheimer's Disease Human chronic periodontitis (CP) RF 10-year CP exposure 2017 28784164
2501 Alzheimer's Disease Human cognitive impairment RF Prognosis 2022 34657824
3402 Alzheimer's Disease Human cognitive impairment RF 2013 23254639
451 Alzheimer's Disease Human Congestive heart failure PF after Hemodialysis Initiation 2018 30093374
3403 Alzheimer's Disease Human constipation RF colorectal cancer and AD have similar epidemiologic feature 2018 30323761
3750 Alzheimer's Disease Human diagnosis of mild cognitive decline (MCI) RF 2021 33009037
3426 Alzheimer's Disease Human endothelial dysfunction RF specifically loss of endothelial NO 2013 23745722
3754 Alzheimer's Disease Human Frailty RF These risk effects were present and similar in both carriers and non-carriers of the?APOE?ε4 allele. 2021 33188132
3740 Alzheimer's Disease Human Frailty RF 2021 33586645
1548 Alzheimer's Disease Human Hearing loss (HL) RF 2021 32959064
1473 Alzheimer's Disease Human Hearing loss (HL) RF increase the risk of dementia 2021 34305572
1368 Alzheimer's Disease Human Hearing loss (HL) RF Diagnosis 2022 35532912
2421 Alzheimer's Disease Human Hearing loss (HL) RF Diagnosis 2022 35587456
3772 Alzheimer's Disease Human hemodynamic deficits RF Diagnosis 2021 34953303
3584 Alzheimer's Disease Human high blood lipids and insulin resistance RF 2010 21033433
3463 Alzheimer's Disease Human Hypercholesterolemia RF 2017 27921357
3464 Alzheimer's Disease Human hyperhomocysteinemia RF 2013 23833960
1914 Alzheimer's Disease Human hyperhomocysteinemia RF 2014 24656904
1429 Alzheimer's Disease Human hyperlipidemia RF people with mild cognitive impairment (MCI) 2011 21518614
1641 Alzheimer's Disease Human hyperlipidemia RF 2017 28806610
2876 Alzheimer's Disease Human hyperlipidemia RF 2018 29971140
1355 Alzheimer's Disease Human Hypertension RF Diagnosis 2022 35532912
3708 Alzheimer's Disease Human Hypertension RF 2021 34218735
430 Alzheimer's Disease Human Hypertension PF Diagnosis FOXO3 rs2802292 longevity genotype (TG/GG) 2023 37483002
868 Alzheimer's Disease Human Hypertension PF MCI-to-dementia 2020 33088897
2275 Alzheimer's Disease Human Hypertension RF 2008 18288934
1579 Alzheimer's Disease Human Hypertension RF 2021 33967045
2297 Alzheimer's Disease Human Hypertension RF 2015 25624416
3467 Alzheimer's Disease Human Hypertension RF 1995 7473847
2492 Alzheimer's Disease Human Hypertension RF 2010 20016220
1394 Alzheimer's Disease Human Hypertension RF 2018 29606955
1442 Alzheimer's Disease Human Hypertension RF people with mild cognitive impairment (MCI) 2011 21518614
2248 Alzheimer's Disease Human Hypertension RF Diagnosis 2022 35700125
3466 Alzheimer's Disease Human Hypertension RF 2018 30149459
1522 Alzheimer's Disease Human Hypertension RF after Hemodialysis Initiation 2018 30093374
2563 Alzheimer's Disease Human Hypertension RF 2018 29971140
2252 Alzheimer's Disease Human Hypertension RF Diagnosis 2022 35700125
1551 Alzheimer's Disease Human Hypertension RF 2014 24489845
2351 Alzheimer's Disease Human Hypertension RF 2019 30894904
1395 Alzheimer's Disease Human Hypertension RF 2015 26495049
3597 Alzheimer's Disease Human Insulin resistance (IR) RF 2018 30112972
3735 Alzheimer's Disease Human Insulin resistance (IR) RF In non-diabetic AD 2021 33597002
3472 Alzheimer's Disease Human Insulin resistance (IR) RF 2011 20031276
3729 Alzheimer's Disease mice liver dysfunction RF 2021 33681678
2615 Alzheimer's Disease Human medication difficulty RF 2021 33037589
2979 Alzheimer's Disease Human medication difficulty RF 2021 33037589
1689 Alzheimer's Disease Human metabolic syndrome (MetS) RF 2021 33849249
3892 Alzheimer's Disease Human metabolic syndrome (MetS) RF Diagnosis 2022 36744341
1535 Alzheimer's Disease Human metabolic syndrome (MetS) RF 2021 33849249
2425 Alzheimer's Disease Human Phlegm-Dampness RF 2021 33907404
3682 Alzheimer's Disease Human severe hypoglycaemia RF 2020 32870568
1404 Alzheimer's Disease Human severe OSA(obstructive sleep apnea) RF ≥30 vs. <5 apnea-hypopnea events/hour;using adjudicated outcomes 2018 28738188
1454 Alzheimer's Disease Human Severe periodontitis with tooth loss RF 2020 33124208
1767 Alzheimer's Disease Human severe PWMH RF in male 2015 26343475
3518 Alzheimer's Disease Human Stroke RF mediated the association between selected CV risk factors and LOAD 2016 27533593
485 Alzheimer's Disease Human Stroke PF Prognosis 2022 35196953
1674 Alzheimer's Disease Human Stroke RF 2020 32767997
1630 Alzheimer's Disease Human Stroke RF previous stroke history 2014 24489845
3519 Alzheimer's Disease Human Stroke RF mediated the association between selected CV risk factors and LOAD 2016 27533593
1547 Alzheimer's Disease Human Stroke/transient ischemic attack RF after Hemodialysis Initiation 2018 30093374
3713 Alzheimer's Disease Human Vascular Inflammation:blood-brain barrier(BBB) RF 2021 34041783
3910 Alzheimer's Disease Human visual impairment (VI) RF Prognosis 2023 36502318
1903 Alzheimer's Disease Human Glioma RF 2021 33718584
2983 Alzheimer's Disease Human Head injury RF 2000 10746604
2740 Alzheimer's Disease Human Head injury RF 2003 12707449
2574 Alzheimer's Disease Human Head injury RF 2003 12707449
3525 Alzheimer's Disease Human traumatic brain injury (TBI) RF 2015 26401777
2067 Alzheimer's Disease Human traumatic brain injury (TBI) RF 2021 33435977
1363 Alzheimer's Disease Human traumatic brain injury (TBI) RF 2021 34320558
1756 Alzheimer's Disease Human traumatic brain injury (TBI) RF Diagnosis in veteran/nonveteran males 2023 36854141
3527 Alzheimer's Disease Human traumatic brain injury (TBI) with reported loss of consciousness (LOC) RF 2018 29389151
2131 Alzheimer's Disease Human Polypharmacy RF 2020 32251456
1082 Alzheimer's Disease Human Music therapy PF Treatment 2009 19628939
1081 Alzheimer's Disease Human Cognitive stimulation therapy PF Treatment 2010 20713437
1076 Alzheimer's Disease Human Atorvastatin PF Prognosis 2005 15974900
68 Alzheimer's Disease Human Simvastatin Not Related Prognosis 2011 21795660
67 Alzheimer's Disease Human NSAIDs Not Related Diagnosis 1998 10192221
66 Alzheimer's Disease Human NSAIDs Not Related Diagnosis 2008 18519870
378 Alzheimer's Disease Human Statin PF 2021 33435977
1078 Alzheimer's Disease Human Statin PF Diagnosis 2009 18931004
1075 Alzheimer's Disease Human Statin PF Prognosis 2015 25408208
1080 Alzheimer's Disease Human Statin PF Diagnosis 2006 19595865
1077 Alzheimer's Disease Human Statin PF Diagnosis 2004 14739574
1079 Alzheimer's Disease Human Statin PF Diagnosis 2010 20533968
1496 Alzheimer's Disease Human PM2.5 RF Diagnosis male, with old age, with low education levels, used to work as farmers or blue-collar workers before retirement, overweight and obese were associated with a higher effect of PM2.5 2022 36447194
3913 Alzheimer's Disease Human PM2.5 RF Diagnosis 2023 35436383
3943 Alzheimer's Disease Human Manganese RF Diagnosis APOE e4 allele 2023 37579537
2420 Alzheimer's Disease Human Dieldrin RF 2012 22904031
3941 Alzheimer's Disease mice Lead RF Diagnosis 2023 38091880
443 Alzheimer's Disease Human Alcohol consumption PF Diagnosis 2022 35697505
379 Alzheimer's Disease Human Alcohol consumption PF 2021 33435977
440 Alzheimer's Disease Human Alcohol dependence PF after Hemodialysis Initiation 2018 30093374
839 Alzheimer's Disease Human an increase in K(+) intake PF 2015 26391254
3698 Alzheimer's Disease mice Cadmium (Cd) RF 2021 34248598
463 Alzheimer's Disease Human caffeine intake PF Diagnosis 2023 35288978
1577 Alzheimer's Disease Human caffeine intake RF Diagnosis 2023 35288978
1983 Alzheimer's Disease Human Coffee consumption RF per one cup a day 2017 29212772
380 Alzheimer's Disease Human Coffee consumption PF 2021 33435977
381 Alzheimer's Disease Human Coffee consumption PF 2021 33435977
3416 Alzheimer's Disease Human Dietary AGEs(dietary advanced glycation end products) RF 2015 25633677
3417 Alzheimer's Disease mice Dietary Risk RF controlling the consumption of sugar-sweetened beverages may be an effective way to curtail the risk of developing AD 2007 17942401
844 Alzheimer's Disease Human Dietary Risk PF Dietary sources that contain high amounts of DHA in phospholipid form 2018 30289748
1443 Alzheimer's Disease Human dread fullness RF people with mild cognitive impairment (MCI) 2011 21518614
782 Alzheimer's Disease Human Drinking PF 2003 12707449
2416 Alzheimer's Disease Human Drinking RF Diagnosis subjective cognitive decline (SCD) 2022 35587456
1467 Alzheimer's Disease Human Drinking RF Daily drinking 2011 21187587
1534 Alzheimer's Disease Human excessive total sugar intake RF Diagnosis 2022 34328409
1533 Alzheimer's Disease Human excessive total sugar intake RF lactose had a stronger impact on AD risk 2022 34328409
550 Alzheimer's Disease Human having breakfast PF 2021 33435416
3455 Alzheimer's Disease Human High consumption of aluminum RF 2009 19064650
3699 Alzheimer's Disease mice high fat/cholesterol diet (HFCD) RF 2021 34219714
427 Alzheimer's Disease Human Meat consumption PF 2021 33748832
1596 Alzheimer's Disease Human Meat consumption RF 2021 33748832
3484 Alzheimer's Disease Human okra RF particularly in people carrying a H63D polymorphism 2015 26170247
866 Alzheimer's Disease rabbit royal jelly (RJ) PF male White Hair and Black Eyes (WHBE) rabbits (3–4 months old, 1.8–2.0 kg) 2018 29556189
3515 Alzheimer's Disease Human soy food products RF 2014 24440006
448 Alzheimer's Disease Human tea drinking PF Diagnosis 2022 35474192
447 Alzheimer's Disease Human tea drinking PF Diagnosis 2022 35474192
518 Alzheimer's Disease Human Time Restricted Feeding(TRF) PF 2021 33435416
3533 Alzheimer's Disease Human vitamin D insufficiency RF 2012 22306846
389 Alzheimer's Disease Human Vitamin E dietary intake PF 2021 33435977
3774 Alzheimer's Disease Human vitamins RF Diagnosis 2021 33998538
1566 Alzheimer's Disease Human western diet (WD) RF Diagnosis APOE ε4 carriers 2022 34632537
3722 Alzheimer's Disease mice western diet (WD) RF 2021 33867971
3935 Alzheimer's Disease mice western diet (WD) RF Diagnosis 2022 35563135
840 Alzheimer's Disease Human Bilingualism PF 2018 30475769
881 Alzheimer's Disease Human Education level PF 2021 33009037
727 Alzheimer's Disease Human Education level PF Diagnosis 2023 37663829
1419 Alzheimer's Disease Human Education level RF 2021 33435977
713 Alzheimer's Disease Human Education level PF 2021 33718584
880 Alzheimer's Disease Human Education level PF diminish in ε4 carriers 2021 32314201
524 Alzheimer's Disease Human Education level PF 2021 33850218
877 Alzheimer's Disease Human Education level PF 2021 33686543
517 Alzheimer's Disease Human Education level PF 2021 33718584
3742 Alzheimer's Disease Human Education level RF 2021 33527694
569 Alzheimer's Disease Human Education level PF 2021 33718584
2776 Alzheimer's Disease Human Illiteracy RF < 1 year at school 2002 12212789
1733 Alzheimer's Disease Human Illiteracy RF 2021 33787634
1759 Alzheimer's Disease Human Illiteracy RF 2015 25401488
710 Alzheimer's Disease Human increasing years of schooling PF 2020 33177243
3061 Alzheimer's Disease Human low education/rural residence RF 2000 10636132
421 Alzheimer's Disease Human Better sleep consolidation attenuate PF in APOE e4 carriers 2013 24145819
3398 Alzheimer's Disease mice Chronic Sleep Deprivation(SD) RF 2016 26757041
3406 Alzheimer's Disease Human covariant associated with social status RF 2016 26893902
722 Alzheimer's Disease Human daytime napping PF 2021 33150399
725 Alzheimer's Disease Human daytime napping PF 2021 33150399
3418 Alzheimer's Disease Human Dispersion and Disengaged Lifestyle RF 2018 31162439
1706 Alzheimer's Disease Human Exposure to secondhand smoke RF 2021 34101793
1785 Alzheimer's Disease Human Insomnia RF Diagnosis 2023 37269705
1336 Alzheimer's Disease Human Insomnia RF 2021 34025548
1672 Alzheimer's Disease Human light-moderate alcohol drinker RF 2017 28806610
910 Alzheimer's Disease Human sleep quality PF Treatment ABCA7 rs115550680 G allele carriers 2023 37212111
3743 Alzheimer's Disease Human sedentary lifestyle RF 2021 33527694
3716 Alzheimer's Disease mice Sleep deprivation (SD) RF 2021 34087256
888 Alzheimer's Disease Human sleep efficiency PF Diagnosis 2021 34130902
824 Alzheimer's Disease Human sleep efficiency PF 2021 34130902
438 Alzheimer's Disease Human sleep efficiency PF Diagnosis 2022 35697505
434 Alzheimer's Disease Human sleep efficiency PF Diagnosis 2022 35697505
3721 Alzheimer's Disease Human sleep efficiency RF especially in the presence of β-amyloid (Aβ) accumulation 2021 33912975
3506 Alzheimer's Disease Human Sleep-wake regulation RF 2019 30649520
3727 Alzheimer's Disease Human social networks RF 2021 33749650
3535 Alzheimer's Disease Human Wandering RF exhibit wandering in the middle or late stages 1993 8422268
874 Alzheimer's Disease Human healthier lifestyle PF 2021 34061824
1505 Alzheimer's Disease Human institutionalization RF after Hemodialysis Initiation 2018 30093374
3490 Alzheimer's Disease Human personal experience with AD RF 2017 28605999
1516 Alzheimer's Disease Human Activities of daily living assistance RF after Hemodialysis Initiation 2018 30093374
366 Alzheimer's Disease Human often taking part in recreational activities PF people with mild cognitive impairment (MCI) 2011 21518614
1418 Alzheimer's Disease Human Physical inactivity RF 2015 26495049
1391 Alzheimer's Disease Human Physical inactivity RF Diagnosis 2022 35532912
1417 Alzheimer's Disease Human Physical inactivity RF 2018 29606955
2853 Alzheimer's Disease Human Physically underactive RF 1990 2146525
3056 Alzheimer's Disease Human Physically underactive RF 1990 2146525
875 Alzheimer's Disease Human regular moderate and high intensity exercise PF 2021 33925348
3379 Alzheimer's Disease Human age-associated decline in health status RF the nontraditional risk factors index [FI-NTRF] was constructed for predict Alzheimer disease and dementia 2011 21753161
3391 Alzheimer's Disease Human BMI(Body Mass Index) RF intrinsic epigenetic age acceleration 2018 30167451
1553 Alzheimer's Disease Human BMI(Body Mass Index) RF after Hemodialysis Initiation; <18.5 2018 30093374
1562 Alzheimer's Disease Human BMI(Body Mass Index) RF after Hemodialysis Initiation; 18.5–25.0 2018 30093374
458 Alzheimer's Disease Human BMI(Body Mass Index) PF 2020 32979926
3390 Alzheimer's Disease Human BMI(Body Mass Index) RF extrinsic epigenetic age acceleration 2018 30167451
3458 Alzheimer's Disease Human BMI(Body Mass Index) RF 2014 24596166
1538 Alzheimer's Disease Human BMI(Body Mass Index) RF after Hemodialysis Initiation; 25.0–30.0 2018 30093374
1659 Alzheimer's Disease Human experienced appreciable weight loss RF 2008 18835864
808 Alzheimer's Disease Human Height PF 2021 33718584
1499 Alzheimer's Disease Human Inability to ambulate RF after Hemodialysis Initiation 2018 30093374
1426 Alzheimer's Disease Human lack of sports RF people with mild cognitive impairment (MCI) 2011 21518614
1416 Alzheimer's Disease Human Midlife BMI RF 2021 33435977
1770 Alzheimer's Disease Human self-rated health RF poorer self-rated health 2021 34311955
1760 Alzheimer's Disease Human underweight RF at age 30, 40, or 45 years 2008 18835864
1726 Alzheimer's Disease Human weight gain RF between 30 and 50 years for any 5-year interval 2008 18835864
3734 Alzheimer's Disease Human Weight loss RF 2021 33597012
3029 Alzheimer's Disease Human Yang-Deficient RF 2021 33907404
1812 Alzheimer's Disease Human adverse childhood experiences RF Prognosis in later adulthood 2021 34957876
3388 Alzheimer's Disease Human beliefs about stress RF 2017 28605999
1449 Alzheimer's Disease Human characteristics of anxiety RF people with mild cognitive impairment (MCI) 2011 21518614
1638 Alzheimer's Disease Human childhood stress RF 2018 30020441
1648 Alzheimer's Disease Human childhood stress RF adjusted for age, education, income and other covariates 2018 30020441
1694 Alzheimer's Disease Human Cynical hostility (CH) RF 2021 33849668
1769 Alzheimer's Disease Human Delirium RF 2020 32767997
3134 Alzheimer's Disease Human Depressive symptoms RF for pre-frailty and frailty in patients with AD 2020 32335425
1427 Alzheimer's Disease Human introvert characteristics RF people with mild cognitive impairment (MCI) 2011 21518614
3133 Alzheimer's Disease Human loneliness RF middle-income countries (LMICs)(China, Ghana, India, Mexico, Russia and South Africa) 2021 33606886
3944 Alzheimer's Disease Human loneliness RF Diagnosis 2023 38008386
1422 Alzheimer's Disease Human loneliness RF people with mild cognitive impairment (MCI) 2011 21518614
1575 Alzheimer's Disease Human loneliness RF Diagnosis 2023 36482759
2144 Alzheimer's Disease Human loneliness RF middle-income countries (LMICs)(China, Ghana, India, Mexico, Russia and South Africa) 2021 33606886
405 Alzheimer's Disease Human loneliness PF 2021 33760348
1645 Alzheimer's Disease Human loneliness RF 2021 33760348
3683 Alzheimer's Disease Human moderate depression RF healthy-to-MCI/dementia 2020 33088897
3486 Alzheimer's Disease Human Parental death during childhood RF with strength of these associations attenuated by remarriage of the widowed parent. 2011 21873837
506 Alzheimer's Disease Human regular mind-body religious meditative activities(or kowtow) PF 2016 26757186
3534 Alzheimer's Disease mice Vulnerability to stress RF pharmacological treatment with venlafaxine may represent a therapeutic strategy for the treatment of stress-related disorders, including AD 2012 21797840
2622 Alzheimer's Disease Human Stress RF Diagnosis 2023 37779209
3517 Alzheimer's Disease Human Stress RF chronic stress 2010 20044001
1073 Alzheimer's Disease Human Openness PF Diagnosis 2011 20973606
3736 Alzheimer's Disease Human neuroticism RF 2021 33627625
4063 Alzheimer's Disease Human Neuroticism RF Diagnosis 2011 20973606
4062 Alzheimer's Disease Human Distress proneness RF Diagnosis Distress proneness was assessed with 6 items (item No. 1, 6, 21, 36, 41, 51; e.g. I often feel tense and jittery) from the standard 12- item Neuroticism scale of the NEO Five-Factor Inventory. 2006 16974109
4060 Alzheimer's Disease Human Anxiety RF Diagnosis 2019 30825716
1598 Alzheimer's Disease Human Anxiety RF Calculated by random effect model 2018 30339108
1713 Alzheimer's Disease Human Anxiety RF Model 2: Main effects adjusted for sex, education, age, and race. 2018 29077487
1725 Alzheimer's Disease Human Anxiety RF Model 1: Main effect unadjusted 2018 29077487
2557 Alzheimer's Disease Human Anxiety RF 2021 34023748
1732 Alzheimer's Disease Human Anxiety RF Clinically significant anxiety,not subclinical anxiety 2019 30825716
4059 Alzheimer's Disease Human Anxiety RF Diagnosis 2018 29077487
1708 Alzheimer's Disease Human Anxiety RF Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 2018 29077487
1444 Alzheimer's Disease Human Anxiety RF people with mild cognitive impairment (MCI) 2011 21518614
4061 Alzheimer's Disease Human Anxiety RF Diagnosis 2017 27805724
1502 Alzheimer's Disease Human Anxiety RF Calculated by fixed effect model 2018 30339108
1479 Alzheimer's Disease Human Anxiety RF Diagnosis 2023 36597404
1695 Alzheimer's Disease Human Anxiety RF Diagnosis 2023 36597404
1707 Alzheimer's Disease Human Anxiety RF Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 2018 29077487
2600 Alzheimer's Disease Human Depression RF 2020 32003417
1697 Alzheimer's Disease Human Depression RF clinician verified;Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 2018 29077487
1675 Alzheimer's Disease Human Depression RF Model 1: Main effect unadjusted 2018 29077487
2951 Alzheimer's Disease Human Depression RF Depressive disorder in last 10 years 1990 2146525
1462 Alzheimer's Disease Human Depression RF recent depression last 2 years;adjusted with ε4 carrier status and AD Medication use Hazard ratio 2018 28560728
1644 Alzheimer's Disease Human Depression RF 2021 32959064
1682 Alzheimer's Disease Human Depression RF Model 2: Main effects adjusted for sex, education, age, and race. 2018 29077487
3408 Alzheimer's Disease Human Depression RF 2017 28731429
1478 Alzheimer's Disease Human Depression RF recent depression last 2 years;adjusteda without ε4 carrier status Hazard ratio 2018 28560728
1403 Alzheimer's Disease Human Depression RF 2021 33435977
2251 Alzheimer's Disease Human Depression RF Diagnosis 2022 35700125
1381 Alzheimer's Disease Human Depression RF Diagnosis 2022 35532912
1492 Alzheimer's Disease Human Depression RF HAM:Hamilton Depression Rating Scale 2008 18327871
4057 Alzheimer's Disease Human Depression RF Diagnosis 2018 29077487
1684 Alzheimer's Disease Human Depression RF Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 2018 29077487
1600 Alzheimer's Disease Human Depression RF Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 2018 29077487
3411 Alzheimer's Disease mice Depression RF 2017 27837334
1690 Alzheimer's Disease Human Depression RF clinician verified;Model 2: Main effects adjusted for sex, education, age, and race. 2018 29077487
1461 Alzheimer's Disease Human Depression RF adjusted with ε4 carrier status Hazard ratio 2018 28560728
1590 Alzheimer's Disease Human Depression RF Model 2: Main effects adjusted for sex, education, age, and race. 2018 29077487
1494 Alzheimer's Disease Human Depression RF late-onset MD with DEDS 2013 22588687
1561 Alzheimer's Disease Human Depression RF unadjusted 2018 28560728
3407 Alzheimer's Disease Human Depression RF fundamental shift in depression-related monoaminergic systems (including serotonin and noradrenaline) 2019 29685068
2583 Alzheimer's Disease Human Depression RF Diagnosis 2023 37779209
1402 Alzheimer's Disease Human Depression RF 2018 29606955
3678 Alzheimer's Disease Human Depression RF 2020 32043803
1693 Alzheimer's Disease Human Depression RF clinician verified;Model 1: Main effect unadjusted 2018 29077487
1484 Alzheimer's Disease Human Depression RF Late-onset MDDIS(minor depressive disorders) with DEDS;after adjustment by age, gender, marital status, education, cognitive impairment, executive function and stroke history 2013 22588687
1411 Alzheimer's Disease Human Depression RF 2021 33435977
1698 Alzheimer's Disease Human Depression RF clinician verified;Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 2018 29077487
4056 Alzheimer's Disease Human Depression RF Diagnosis 2018 29077487
1676 Alzheimer's Disease Human Depression RF 2021 32959064
2255 Alzheimer's Disease Human Depression RF Diagnosis 2022 35700125
1463 Alzheimer's Disease Human Depression RF adjusteda without ε4 carrier status Hazard ratio 2018 28560728
1705 Alzheimer's Disease Human Depression RF clinically significant depressive symptoms at baseline 2015 26343475
1556 Alzheimer's Disease Human Depression RF Model 1: Main effect unadjusted 2018 29077487
1734 Alzheimer's Disease Human Depression RF 2015 25401488
1683 Alzheimer's Disease Human Depression RF Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 2018 29077487
2457 Alzheimer's Disease Human Depression RF Diagnosis 2022 35587456
1599 Alzheimer's Disease Human Depression RF Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 2018 29077487
3410 Alzheimer's Disease Human Depression RF 2017 28605999
1837 Alzheimer's Disease Human Depression RF Diagnosis 2023 37104247
1746 Alzheimer's Disease Human Depression RF Severe depression 2015 23791538
1486 Alzheimer's Disease Human Depression RF Late-onset MD(major episode) with DEDS;after adjustment by age, gender, marital status, education, cognitive impairment, executive function and stroke history 2013 22588687
2438 Alzheimer's Disease Human Depression RF 2020 33126696
1493 Alzheimer's Disease Human Depression RF late-onset MDDIS with DEDS 2013 22588687
4058 Alzheimer's Disease Human Depression RF Diagnosis 2018 29077487
1680 Alzheimer's Disease Human Depression RF recent depression last 2 years;unadjusted 2018 28560728
1476 Alzheimer's Disease Human Depression RF recent depression last 2 years;adjusted with ε4 carrier status Hazard ratio 2018 28560728
2524 Alzheimer's Disease Human Depression RF 2009 18603262
3412 Alzheimer's Disease Human Depression RF personal history of depression 2014 24596166
1657 Alzheimer's Disease Human Depression RF significant among women only(HR = 2.3; 95%CI, 1.7-3.1) 2021 33455858
4055 Alzheimer's Disease Human Occupational attainment RF Diagnosis 1994 8139057
3514 Alzheimer's Disease Human Socioeconomic status (SES) RF intrinsic epigenetic age acceleration 2018 30167451
4054 Alzheimer's Disease Human Socioeconomic status (SES) RF Diagnosis 2004 14718220
1529 Alzheimer's Disease Human Socioeconomic status (SES) RF Prognosis 2022 35905220
1072 Alzheimer's Disease Human Socioeconomic status (SES) PF Diagnosis SES: low(<=2000DM);The CAS was calculated as the sum score of the five items (range: 0–10 points). Participants were classified as poorly (≤ 3 points), moderately (4–7 points) or highly (≥ 8 points) cognitively active at t1. 2012 22390831
1536 Alzheimer's Disease Human Socioeconomic status (SES) RF Prognosis 2022 35905220
402 Alzheimer's Disease Human Socioeconomic status (SES) PF Diagnosis 2023 37926784
1525 Alzheimer's Disease Human Socioeconomic status (SES) RF Prognosis 2022 35905220
1070 Alzheimer's Disease Human Religious meditative activities PF Diagnosis 2016 26757186
1069 Alzheimer's Disease Human Religious meditative activities PF Diagnosis 2016 26757186
4053 Alzheimer's Disease Human Religious meditative activities RF Diagnosis 2016 26757186
1071 Alzheimer's Disease Human Religious meditative activities PF Diagnosis 2016 26757186
4052 Alzheimer's Disease Mice Prolonged stress RF Prognosis 2007 17499446
4051 Alzheimer's Disease Mice Chronic mild stress RF Diagnosis 2012 22045482
4050 Alzheimer's Disease rat Chronic psychosocial stress RF Prognosis 2009 18849021
4049 Alzheimer's Disease rat Chronic psychosocial stress RF Diagnosis 2011 21854392
50 Alzheimer's Disease Human Genetic and hence lifelong low BMI Not Related Diagnosis 2017 28609829
4047 Alzheimer's Disease Human Overweight in midlife RF Diagnosis To gain statistical power, we therefore applied a slightly different categorization with BMI dichotomized into two categories with the top 25% of the distribution defined as overweight (BMI ≥ 26.5; coded as 1) and all others defined as normal weight (coded as 0). 2009 19506566
4046 Alzheimer's Disease Human Obesity at midlife RF Diagnosis 2005 16216938
1390 Alzheimer's Disease Human Obesity at midlife RF Diagnosis 2022 35532912
655 Alzheimer's Disease Human Obesity PF CARTPT was identified to be shared by the anti-obesity drug targets and AD susceptibility genes 2021 33523009
2694 Alzheimer's Disease Human Obesity RF 2019 30792733
1392 Alzheimer's Disease Human Obesity RF 2018 29606955
3483 Alzheimer's Disease Human Obesity RF 2019 31191220
1764 Alzheimer's Disease Human Obesity RF being obese (BMI ≥30) at age 30, 40, or 45 years and jointly centrally obese (waist circumference ≥80th percentile) at age 30, 35, or 50 years 2008 18835864
3482 Alzheimer's Disease Human Obesity RF 2016 26324099
2917 Alzheimer's Disease Human Obesity RF Diagnosis 2022 35587456
1393 Alzheimer's Disease Human Obesity RF 2015 26495049
4048 Alzheimer's Disease Human Obesity RF Diagnosis 2019 30792733
2030 Alzheimer's Disease Human Obesity RF CARTPT was identified to be shared by the anti-obesity drug targets and AD susceptibility genes 2021 33523009
4045 Alzheimer's Disease Human Obesity RF Diagnosis 2019 30792733
904 Alzheimer's Disease Human Yoga PF Diagnosis 2023 35275541
1065 Alzheimer's Disease Human Cognitive activity PF Diagnosis 2012 22390831
1066 Alzheimer's Disease Human Cognitive activity PF Diagnosis 2002 12499482
1064 Alzheimer's Disease Human Moderate exercise PF Prognosis Cases: People depressed with AD 2005 15717340
1062 Alzheimer's Disease Human Leisure-time physical activity at midlife PF Diagnosis 2005 16239176
855 Alzheimer's Disease Human Treadmill exercise PF 2015 25960981
1049 Alzheimer's Disease Mice Treadmill exercise PF Prognosis 2014 25426461
1048 Alzheimer's Disease Mice Running exercise PF Prognosis 2015 25543023
1047 Alzheimer's Disease Human Physical activity training PF Prognosis 2015 25884637
1046 Alzheimer's Disease Human Elastic band resistance exercise PF Prognosis 2015 26180356
1044 Alzheimer's Disease Human Moderate-to-high intensity exercise PF Prognosis 2016 26682695
1042 Alzheimer's Disease Human Physical Exercise PF Prognosis 2016 27403134
1045 Alzheimer's Disease Human Aerobic exercise PF Prognosis 2015 26556080
1052 Alzheimer's Disease Human Aerobic exercise PF Prognosis 2015 24652914
1041 Alzheimer's Disease Human Aerobic exercise PF Prognosis 2017 28187125
1043 Alzheimer's Disease Human Aerobic exercise PF Prognosis 2016 27344641
1040 Alzheimer's Disease Human Treadmill walking exercise PF Prognosis 2016 28479898
1035 Alzheimer's Disease Human Exercise PF Prognosis Fall rates were 1.48 (95% confidence interval (CI)=1.26-1.73) per person-year in the intervention group and 2.87 (95% CI=2.43-3.35) in the control group. 2018 30320427
1058 Alzheimer's Disease Mice Exercise PF Prognosis 2011 20969897
1063 Alzheimer's Disease Mice Exercise PF Prognosis 2005 15858047
1050 Alzheimer's Disease Human Exercise PF Prognosis 2015 25408208
1055 Alzheimer's Disease Mice Exercise PF Prognosis 2013 23307759
1060 Alzheimer's Disease Mice Exercise PF Prognosis 2008 18813861
1034 Alzheimer's Disease Mice Exercise PF Prognosis 2019 30717730
1057 Alzheimer's Disease Human Exercise PF Prognosis 2012 21564154
1039 Alzheimer's Disease rat Exercise PF Prognosis 2018 29232315
3046 Alzheimer's Disease Human Exercise RF Prognosis 2022 35850031
1054 Alzheimer's Disease rat Exercise PF Prognosis 2013 23627709
1036 Alzheimer's Disease Human Exercise PF Prognosis 2018 30315403
1051 Alzheimer's Disease Mice Exercise PF Prognosis 2015 25318545
1033 Alzheimer's Disease Mice Exercise PF Prognosis 2019 31114160
1056 Alzheimer's Disease Human Exercise PF Prognosis 2013 22686565
1061 Alzheimer's Disease Human Exercise PF Prognosis 2008 29213577
1053 Alzheimer's Disease Human Exercise PF Prognosis 2013 24219193
1629 Alzheimer's Disease Human Reading RF reading occasionally 2017 28806610
365 Alzheimer's Disease Human Reading PF people with mild cognitive impairment (MCI) 2011 21518614
455 Alzheimer's Disease Human Smoking status PF Diagnosis 2022 35697505
449 Alzheimer's Disease Human Smoking status PF Diagnosis 2022 35697505
1026 Alzheimer's Disease Human Conscientiousness PF Diagnosis 2011 20973606
1688 Alzheimer's Disease Human Sleep disturbance RF Model 2: Main effects adjusted for sex, education, age, and race. 2018 29077487
4039 Alzheimer's Disease Human Sleep disturbance RF Diagnosis 2018 29077487
1696 Alzheimer's Disease Human Sleep disturbance RF Model 1: Main effect unadjusted 2018 29077487
1687 Alzheimer's Disease Human Sleep disturbance RF Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status 2018 29077487
1686 Alzheimer's Disease Human Sleep disturbance RF Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia 2018 29077487
3509 Alzheimer's Disease Human Smoking RF 2013 23422663
4037 Alzheimer's Disease Human Smoking RF Diagnosis 1998 9652667
1387 Alzheimer's Disease Human Smoking RF 2015 26495049
1471 Alzheimer's Disease Human Smoking RF Current smokers 2011 21187587
3511 Alzheimer's Disease Human Smoking RF 2014 24596166
49 Alzheimer's Disease Human Smoking Not Related Diagnosis 1992 1550089
2446 Alzheimer's Disease Human Smoking RF Diagnosis subjective cognitive decline (SCD) 2022 35587456
1024 Alzheimer's Disease Human Smoking PF Diagnosis 2019 30792733
1623 Alzheimer's Disease Human Smoking RF current smoking 2017 28806610
3507 Alzheimer's Disease Human Smoking RF in Mongolian males aged over 55 years 2012 25657695
1451 Alzheimer's Disease Human Smoking RF in APOE e4 carriers 2010 20847559
1369 Alzheimer's Disease Human Smoking RF Diagnosis 2022 35532912
4036 Alzheimer's Disease Human Smoking RF Diagnosis 2006 16493200
1386 Alzheimer's Disease Human Smoking RF 2018 29606955
1477 Alzheimer's Disease Human Smoking RF smoking more than 2 packs a day 2011 20975015
2288 Alzheimer's Disease Human Smoking RF Daily smoker 1997 9346343
3510 Alzheimer's Disease Human Smoking RF 1989 2754163
820 Alzheimer's Disease Human Smoking PF 2019 30792733
48 Alzheimer's Disease Human Smoking Not Related Diagnosis 1992 1550089
1023 Alzheimer's Disease Human Smoking PF Diagnosis 2019 30792733
4038 Alzheimer's Disease Human Smoking RF Diagnosis 1994 7969962
496 Alzheimer's Disease Human Smoking PF Light smoker 1997 9346343
3512 Alzheimer's Disease Human Smoking RF intrinsic epigenetic age acceleration; current smoker (N=939); former smoker, stopped within past 12 months (N=158); former smoker, stopped more than 12 months ago (N=1309); never smoker (N=2533), and not coded (N=62). 2018 30167451
4035 Alzheimer's Disease Human Smoking RF Diagnosis 2011 20975015
1025 Alzheimer's Disease Human Smoking PF Diagnosis 1997 9152711
4027 Alzheimer's Disease Human Education RF Prognosis 2006 16484637
4032 Alzheimer's Disease Human Education RF Prognosis 1995 7755353
47 Alzheimer's Disease Human Education Not Related Diagnosis 1995 7675231
1022 Alzheimer's Disease Human Education PF Diagnosis 2015 26402761
364 Alzheimer's Disease Human Education PF people with mild cognitive impairment (MCI) 2011 21518614
699 Alzheimer's Disease Human Education PF 2021 32996171
748 Alzheimer's Disease Human Education PF per unit higher log odds of having completed college/university 2017 29212772
4029 Alzheimer's Disease Human Education RF Diagnosis 2001 11522804
1019 Alzheimer's Disease Human Education PF Diagnosis 2012 22233764
4034 Alzheimer's Disease Human Education RF Diagnosis 1994 7969962
1389 Alzheimer's Disease Human Education RF Low educational attainent 2018 29606955
846 Alzheimer's Disease Human Education PF in PSEN1 E280A mutation carriers 2016 26902171
4026 Alzheimer's Disease Human Education RF Prognosis 2007 19595922
4031 Alzheimer's Disease Human Education RF Prognosis 1999 10599762
3424 Alzheimer's Disease Human Education RF Lower levels of education 2018 30425786
1021 Alzheimer's Disease Human Education PF Diagnosis 1998 9810959
867 Alzheimer's Disease Human Education PF higher education;more likely to consume colorful fruits and vegetables 2020 32970519
1653 Alzheimer's Disease Human Education RF Lack of formal education 2015 25401488
804 Alzheimer's Disease Human Education PF per year of education completed 2017 29212772
4028 Alzheimer's Disease Human Education RF Diagnosis Education(Low:2-7 years; Intermediate:8-10 years; High:>10 years) 2004 14718220
2082 Alzheimer's Disease Human Education RF lower education 2008 18446027
1018 Alzheimer's Disease Human Education PF Diagnosis High education:low(< 10 years) 2012 22390831
4033 Alzheimer's Disease Human Education RF Diagnosis 1994 8139057
1388 Alzheimer's Disease Human Education RF Low Education 2015 26495049
4025 Alzheimer's Disease Human Education RF Prognosis 2008 18042993
4030 Alzheimer's Disease Human Education RF Diagnosis Education:Low(<= 7years); middle(8-11 years); High(>= 12 years) 2000 10873130
781 Alzheimer's Disease Human Education PF a higher number of school years 2015 25624416
3421 Alzheimer's Disease Human Education RF 2019 31058682
1020 Alzheimer's Disease Human Education PF Diagnosis 2008 18484674
1424 Alzheimer's Disease Human Education RF Diagnosis 2022 35532912
536 Alzheimer's Disease Human Education PF Diagnosis 2023 37182880
755 Alzheimer's Disease Human Education PF 2010 20016220
1017 Alzheimer's Disease Human Educational PF Diagnosis 2012 25657695
1016 Alzheimer's Disease Human Educational PF Diagnosis 2012 25657695
3737 Alzheimer's Disease mice Zinc RF zinc status is linked to inflammatory reactivity 2021 33597269
879 Alzheimer's Disease Human Tomato PF 2021 33577362
1015 Alzheimer's Disease Human Juices PF Diagnosis 2006 16945610
1014 Alzheimer's Disease Human Silica PF Diagnosis 2000 10901330
3549 Alzheimer's Disease Human Aluminum RF 1994 7507666
4024 Alzheimer's Disease Human Aluminum RF Diagnosis 2000 10901330
4023 Alzheimer's Disease Human Aluminum RF Diagnosis Daily aluminum consumption from drinking water 2009 19064650
3550 Alzheimer's Disease rat Aluminum RF 18-day fetal rats 1995 8537015
46 Alzheimer's Disease Human Cooked fruit and vegetables Not Related Diagnosis 2019 30883348
45 Alzheimer's Disease Human Cooked fruit and vegetables Not Related Diagnosis 2019 30883348
44 Alzheimer's Disease Human Raw vegetables Not Related Diagnosis 2019 30883348
43 Alzheimer's Disease Human Raw vegetables Not Related Diagnosis 2019 30883348
42 Alzheimer's Disease Human Raw fruit Not Related Diagnosis 2019 30883348
41 Alzheimer's Disease Human Raw fruit Not Related Diagnosis 2019 30883348
1013 Alzheimer's Disease Human Meat PF Diagnosis Low meat consumption (≤1 time/week) was associated with an increased risk of dementia and AD compared with regular consumption (≥4 times/week) 2019 30883348
1009 Alzheimer's Disease Human Total n-3 fatty acids PF Diagnosis 2003 12873849
39 Alzheimer's Disease Human Fish Not Related Diagnosis 2019 30883348
1008 Alzheimer's Disease Human Fish PF Diagnosis 2003 12873849
38 Alzheimer's Disease Human Fish Not Related Diagnosis 2019 30883348
40 Alzheimer's Disease Human Fish Not Related Diagnosis 2019 30883348
37 Alzheimer's Disease Human Eggs Not Related Diagnosis 2017 28052883
36 Alzheimer's Disease Human Cholesterol Not Related Diagnosis 2017 28052883
4022 Alzheimer's Disease Human Saturatedfatty acids (SFA) RF Diagnosis 2006 16710090
1004 Alzheimer's Disease Human Polyunsaturated fats PF Diagnosis 2006 16710090
424 Alzheimer's Disease Human Dietary cholesterol PF Diagnosis 2023 37874096
35 Alzheimer's Disease Human Dietary cholesterol Not Related Diagnosis 2003 12580703
34 Alzheimer's Disease Human Animal fat Not Related Diagnosis 2003 12580703
33 Alzheimer's Disease Human Total fat Not Related Diagnosis 2003 12580703
1003 Alzheimer's Disease Human Vegetable fats PF Diagnosis 2003 12580703
1002 Alzheimer's Disease Human ω-6 polyunsaturated fats PF Diagnosis 2003 12580703
1001 Alzheimer's Disease Mice Aged?garlic?extract PF Prognosis 2007 17380553
998 Alzheimer's Disease rat Alcohol extracts from G. lucidum PF Prognosis 2019 30971923
996 Alzheimer's Disease Mice Resveratrol supplements PF Prognosis 2013 23129026
994 Alzheimer's Disease Rabbit Caffeine PF Diagnosis 2010 20638472
842 Alzheimer's Disease Human Caffeine PF coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life 2010 20182054
385 Alzheimer's Disease Human Caffeine PF 2021 33435977
995 Alzheimer's Disease Mice Caffeine PF Treatment 2009 19581722
841 Alzheimer's Disease rabbit Caffeine PF even very low doses of caffeine might protect against sporadic AD 2010 20638472
992 Alzheimer's Disease Mice Green tea catechin (GTC) PF Treatment 2013 23333093
991 Alzheimer's Disease Human Green tea PF Prognosis 2016 27757204
989 Alzheimer's Disease Human Acetyl-L-carnitine hydrochloride (ALCAR) PF Treatment Subjects with mild to moderate probable AD, aged 50 or older 1996 8797468
988 Alzheimer's Disease Human Acety-L-carnitine (ALC) PF Prognosis 1998 9677506
990 Alzheimer's Disease Human Acety-L-carnitine (ALC) PF Treatment 1990 2178869
987 Alzheimer's Disease rat Curcuminoids PF Prognosis 2010 20538041
29 Alzheimer's Disease Human Vitamin B6 (S) Not Related Diagnosis 2009 19924351
28 Alzheimer's Disease Human Folic acid(S) Not Related Diagnosis 2009 19924351
27 Alzheimer's Disease Human Vitamin B6(D) Not Related Diagnosis 2009 19924351
32 Alzheimer's Disease Human Vitamin B6(D) Not Related Diagnosis 2006 16917153
26 Alzheimer's Disease Human Vitamin B12(D) Not Related Diagnosis 2009 19924351
31 Alzheimer's Disease Human Vitamin B12(D) Not Related Diagnosis 2006 16917153
24 Alzheimer's Disease Human Vitamin D2 Not Related Prognosis 2011 21694461
984 Alzheimer's Disease Human Vitamin D PF Diagnosis Being in the highest quintile of vitamin D dietary intakes was associated with a lower risk of AD compared with the lower 4 quintiles combined 2012 22503994
983 Alzheimer's Disease Human Folic acid + Vitamin B6 + Vitamin B12 PF Treatment 2013 23690582
982 Alzheimer's Disease Human Vitamin?E (alpha tocopherol) PF Prognosis 2014 24381967
23 Alzheimer's Disease Human Vitamin E(S) Not Related Prognosis 2018 30174138
22 Alzheimer's Disease Human Folic acid(S) + Vitamin B6(S) + Vitamin B12(S) Not Related Treatment 2007 18042476
978 Alzheimer's Disease Human DHA-enriched Omega-3 FA supplement PF Prognosis 2009 19054188
977 Alzheimer's Disease rat Organoselenium dietary supplementation PF Treatment 2013 22959057
976 Alzheimer's Disease Mice Triheptanoin-rich ketogenic diet?(TKD) PF Treatment 2013 23131121
974 Alzheimer's Disease Mice Figs PF Prognosis 2014 25050360
973 Alzheimer's Disease Human Macular carotenoids (MZ, Z, and L) PF Prognosis 2015 25408222
972 Alzheimer's Disease Mice Pomegranate PF Prognosis 2015 25441596
971 Alzheimer's Disease Human Nutritional supplementation PF Diagnosis 2015 25524956
1011 Alzheimer's Disease Mice Folic acid PF Prognosis 3xTg mice 2018 29068127
970 Alzheimer's Disease Human Folic acid PF Prognosis MMSE score 3.0–26.0 points(AD of mild to moderate severity) 2016 27340344
25 Alzheimer's Disease Human Folic acid Not Related Diagnosis 2009 19924351
30 Alzheimer's Disease Human Folic acid Not Related Diagnosis 2006 16917153
1012 Alzheimer's Disease Human Folic acid PF Diagnosis Recommended Dietary Allowance (RDA) 2005 19595811
969 Alzheimer's Disease Human Probiotic PF Prognosis 2016 27891089
968 Alzheimer's Disease Mice Dietary supplementation of choline during fetal development and early postnatal life PF Diagnosis 2017 28103298
967 Alzheimer's Disease Mice Selenium-enriched yeast (Se-yeast) PF Prognosis 2017 28578584
966 Alzheimer's Disease Human Probiotic and selenium co-supplementation PF Prognosis 2018 30642737
979 Alzheimer's Disease Mice Vitamin D(S) PF Prognosis 2018 29318446
981 Alzheimer's Disease Human Vitamin D(S) PF Prognosis 2014 25153973
965 Alzheimer's Disease Human Vitamin D(S) PF Prognosis 2019 31296588
980 Alzheimer's Disease Human Vitamin D(S) PF Prognosis 2015 26571990
999 Alzheimer's Disease Human Alcohol PF Diagnosis 2010 20164550
21 Alzheimer's Disease Human Alcohol Not Related Diagnosis 1992 1550089
4021 Alzheimer's Disease Human Alcohol RF Prognosis 2016 27628432
993 Alzheimer's Disease Human Alcohol PF Diagnosis 2018 29966314
1000 Alzheimer's Disease Human Alcohol PF Diagnosis 2010 20164550
4020 Alzheimer's Disease Human Alcohol RF Diagnosis 2018 29966314
997 Alzheimer's Disease Human Alcohol PF Prognosis MMSE:24 (22–26) 2015 26656463
964 Alzheimer's Disease Mice Dietary polyphenols PF Prognosis 2015 25318545
963 Alzheimer's Disease Human Fruit PF Prognosis 2015 25408208
962 Alzheimer's Disease Human Fruit PF Prognosis 2015 25408208
961 Alzheimer's Disease Mice Resveratrol PF Prognosis 2019 30717730
960 Alzheimer's Disease Mice Resveratrol PF Prognosis 2019 31114160
956 Alzheimer's Disease Mice Polyphenols PF Prognosis 2012 22119712
878 Alzheimer's Disease Human Ketogenic diet(KD) PF a 12-week modified ketogenic diet to AD patients 2021 33622392
945 Alzheimer's Disease Human Ketogenic diet(KD) PF Prognosis 2017 29955649
955 Alzheimer's Disease Mice Ketogenic diet(KD) PF Prognosis 2013 24069439
1010 Alzheimer's Disease Human Ketogenic diet(KD) PF Prognosis 2019 31336463
4019 Alzheimer's Disease Mice WFD(Whole-food diet) RF Prognosis The WFD contained skinless freeze-dried Atlantic salmon (prepared by Guelph Food Technology Centre, Guelph, Ontario, Canada) and a proprietary mixture of powdered, freeze-dried vegetables and fruits (BerryGreen, New Chapter, Brattleboro, VT, USA). The 3 most abundant ingredients of this mixture were 2015 25212462
958 Alzheimer's Disease Human Mediterranean diet(MeDi) PF Diagnosis 2006 16622828
1006 Alzheimer's Disease Human Mediterranean diet(MeDi) PF Diagnosis MeDi (0- to 10-point scale with higher scores indicating higher adherence) 2006 17030648
368 Alzheimer's Disease Human Mediterranean diet(MeDi) PF 2021 33435977
957 Alzheimer's Disease Human Mediterranean diet(MeDi) PF Prognosis We followed the most commonly described method to construct the MeDi score as described in our previous reports. Individuals were assigned a value of 1 for each beneficial component (fruits, vegetables, legumes, cereals, and fish) whose caloric-adjusted consumption was at or above the gender-specifi 2010 20847399
1005 Alzheimer's Disease Human Mediterranean diet(MeDi) PF Diagnosis MeDi (0- to 9-point scale with higher scores indicating higher adherence) 2006 17030648
461 Alzheimer's Disease Human Mediterranean diet(MeDi) PF associated with dementia incidence after accounting for major cardiovascular risk factors;Every 2-point increase of the rMED score was associated with an 8% and 6% lower risk of dementia and AD 2021 33671575
954 Alzheimer's Disease Human Mediterranean diet(MeDi) PF Diagnosis The MedDiet Score was computed based on scoring described by Panagiotakos and colleagues.11 The scoring uses serving quantities of the traditional Greek Mediterranean diet as the comparison metric. It includes 11 dietary components each scored 0 to 5 that are summed for a total score ranging from 0 2015 25681666
367 Alzheimer's Disease Human Mediterranean diet(MeDi) PF 2021 33435977
959 Alzheimer's Disease Human Mediterranean diet(MeDi) PF Diagnosis 2006 16622828
1007 Alzheimer's Disease Human Mediterranean diet(MeDi) PF Diagnosis The diet score was analyzed either in tertiles (low adherence range, 0–3; middle adherence range, 4–5; high adherence range, 6–9) or in a median split (low adherence range, 0–4; high adherence range, 5–9). 2009 19671904
953 Alzheimer's Disease Human DASH diet PF Diagnosis The DASH diet scoring,10 was based on 7 food groups and 3 dietary components (total fat, saturated fat and sodium), each scored 0, 0.5, or 1, and summed for a total score ranging from 0 (lowest) to 10 (highest) diet concordance. Total DASH score : 10 2015 25681666
951 Alzheimer's Disease Human MIND diet PF Diagnosis MIND diet( Mediterranean-DASH(Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay;Total MIND score: 10 2015 25681666
952 Alzheimer's Disease Human MIND diet PF Diagnosis MIND diet( Mediterranean-DASH(Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay;Total MIND score: 10 2015 25681666
950 Alzheimer's Disease Mice Diet rich in date palm fruits PF Prognosis 2015 26167001
949 Alzheimer's Disease Mice Diet rich in date palm fruits PF Diagnosis 2015 26167001
948 Alzheimer's Disease Mice White wine polyphenols-enriched diet PF Prognosis 2018 29525608
947 Alzheimer's Disease Mice Quercetin enrich diet PF Prognosis 2018 29736217
946 Alzheimer's Disease Mice Pantoea agglomerans-derived lipopolysaccharide PF Diagnosis Alzheimer's disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet. 2018 29856882
975 Alzheimer's Disease Mice Walnut Supplementation PF Diagnosis Morris water maze (for spatial memory and learning ability), T maze (for position discrimination learning ability), rotarod (for psychomotor coordination), and elevated plus maze (for anxiety-related behavior) 2014 25024344
944 Alzheimer's Disease Mice Walnut Supplementation PF Prognosis From 4 months of age, experimental AD-tg mice were fed diets containing 6% (T6) or 9% walnuts (T9) (equivalent to 1 or 1.5 oz, of walnuts per day in humans) for 5, 10, or 15 months. The control groups, i.e., AD-tg (T0) and wild-type (Wt) mice, were fed diets without walnuts. 2018 30040727
943 Alzheimer's Disease Human Coconut Oil Enriched Mediterranean Diet PF Prognosis After intervention with coconut oil, improvements in episodic, temporal orientation, and semantic memory were observed, and it seems that the positive effect is more evident in women with mild-moderate state, although other improvements in males and severe state were also shown. 2018 30056419
941 Alzheimer's Disease Mice he Ethyl Acetate Extract of Leaves of Ugni molinae Turcz PF Prognosis 2018 30400089
4018 Alzheimer's Disease Mice High-fat diet RF Prognosis They were fed with either normal diet (ND: 10% fat) or high-fat diet (HFD: 60% fat) for 16 weeks with free access to water 2017 28865961
942 Alzheimer's Disease Mice High-fat diet PF Prognosis 2018 30079520
4017 Alzheimer's Disease Mice High-fat diet RF Prognosis Control diet(3.85 kcal/g; 10 kcal% fat [4.4 kcal% lard], 20 kcal% protein, and 70 kcal% carbohydrate [35 kcal% sucrose and 31 kcal% cornstarch]) 2016 27412896
3934 Alzheimer's Disease mice High-fat diet RF Diagnosis 2022 34864680
19 Alzheimer's Disease Human Vitamins C and/or E Not Related Diagnosis 2005 16227448
20 Alzheimer's Disease Human Vitamins C and/or E Not Related Diagnosis 2005 16227448
940 Alzheimer's Disease Human Vitamin E+Vitamin C PF Diagnosis 2004 14732624
939 Alzheimer's Disease Human Vitamin E+Vitamin C PF Diagnosis 2004 14732624
938 Alzheimer's Disease Human Sulfurous water PF Prognosis 2015 25939976
16 Alzheimer's Disease Human Vitamin E(D+S) Not Related Diagnosis Compared with the lowest quartiles of intakes(4 IU/d) 2003 12580704
18 Alzheimer's Disease Human Vitamin E(D+S) Not Related Diagnosis Compared with the lowest quartiles of intakes(4 IU/d) 2003 12580704
17 Alzheimer's Disease Human Vitamin E(D+S) Not Related Diagnosis Compared with the lowest quartiles of intakes(4 IU/d) 2003 12580704
13 Alzheimer's Disease Human Vitamin C(D+S) Not Related Diagnosis Compared with the lowest quartiles of intakes(79 mg/d) 2003 12580704
15 Alzheimer's Disease Human Vitamin C(D+S) Not Related Diagnosis Compared with the lowest quartiles of intakes(79 mg/d) 2003 12580704
14 Alzheimer's Disease Human Vitamin C(D+S) Not Related Diagnosis Compared with the lowest quartiles of intakes(79 mg/d) 2003 12580704
11 Alzheimer's Disease Human Vitamin E(D) Not Related Diagnosis Compared with the lowest quartiles of intakes(4 IU/d) 2003 12580704
10 Alzheimer's Disease Human Vitamin E(D) Not Related Diagnosis Compared with the lowest quartiles of intakes(4 IU/d) 2003 12580704
12 Alzheimer's Disease Human Vitamin E(D) Not Related Diagnosis Compared with the lowest quartiles of intakes(4 IU/d) 2003 12580704
8 Alzheimer's Disease Human Vitamin C(D) Not Related Diagnosis Compared with the lowest quartiles of intakes(66 mg/d) 2003 12580704
7 Alzheimer's Disease Human Vitamin C(D) Not Related Diagnosis Compared with the lowest quartiles of intakes(66 mg/d) 2003 12580704
9 Alzheimer's Disease Human Vitamin C(D) Not Related Diagnosis Compared with the lowest quartiles of intakes(66 mg/d) 2003 12580704
6 Alzheimer's Disease Human Carotenoids Not Related Diagnosis Compared with the lowest quartiles of intakes(65 IU/d) 2003 12580704
5 Alzheimer's Disease Human Carotenoids Not Related Diagnosis Compared with the lowest quartiles of intakes(65 IU/d) 2003 12580704
4 Alzheimer's Disease Human Carotenoids Not Related Diagnosis Compared with the lowest quartiles of intakes(65 IU/d) 2003 12580704
3 Alzheimer's Disease Human Vitamin C+Vitamin E Not Related Diagnosis Participants were asked at baseline and during biennial follow-up interviews whether they had taken vitamin C, vitamin E, or multivitamins (MVIs) for at least 1 week during the previous month. People were considered to be vitamin E users if they reported taking vitamin E supplements (excluding MVIs) 2008 18047492
1 Alzheimer's Disease Human Vitamin C Not Related Diagnosis Participants were asked at baseline and during biennial follow-up interviews whether they had taken vitamin C, vitamin E, or multivitamins (MVIs) for at least 1 week during the previous month. People were considered to be vitamin E users if they reported taking vitamin E supplements (excluding MVIs) 2008 18047492
933 Alzheimer's Disease rat Vitamin C PF Prognosis 2017 28192749
935 Alzheimer's Disease Human Vitamin C PF Diagnosis 1998 9772012
932 Alzheimer's Disease Human Vitamin C PF Diagnosis 2017 27708183
936 Alzheimer's Disease Human Vitamin C PF Diagnosis 2002 12076218
937 Alzheimer's Disease Human Vitamin E PF Diagnosis 2002 12076218
2 Alzheimer's Disease Human Vitamin E Not Related Diagnosis Participants were asked at baseline and during biennial follow-up interviews whether they had taken vitamin C, vitamin E, or multivitamins (MVIs) for at least 1 week during the previous month. People were considered to be vitamin E users if they reported taking vitamin E supplements (excluding MVIs) 2008 18047492
934 Alzheimer's Disease Human Vitamin E PF Diagnosis 1998 9772012
931 Alzheimer's Disease Human Vitamin E PF Diagnosis 2017 27708183
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