|
|
|||||||||||||||||||||||||||||||||||
| 1. Aim of the NDDRF Knowledgebase | |||||||||||||||||||||||||||||||||||
|
Neurodegenerative diseases (NDDs) are chronic diseases that lead to progressive loss of neuronal structure or function. The complex etiologies of many NDDs remain unclear, and prevention and early prediction of NDD are critical.
Since a systematic analysis of the diverse risk factors for NDDs would facilitate prevention and personalized medicine, we aim to build a knowledge base related to NDD risk factors.
Before collecting data, we discussed with clinicians, biostatisticians and others what needed to be collected and how to classify risk factors, as well as determining the requirements of potential users. In the end, we had completed a scientific and effective comprehensive data collection program, and defined the classification criteria for the risk factors of NDDs. We have now constructed a knowledge base of NDDs risk factors, NDDRF, by manually collecting risk factors from literature published between 1975 and 2023.
NDDRF contains 1971 single or combined risk factors, 4379 records and 1071 articles relevant to the 20 most common NDD. Single risk factors are classified into five categories, epidemiological factors (882), genetic factors (517), lifestyle factors (444), combination facotors (120) and non-risk factors (128). Among these factors, 1803 are positive and protective and 631 are negative.
This knowledge base will be curated and updated for the systematic understanding and future prevention of NDDs. | |||||||||||||||||||||||||||||||||||
|
|
|||||||||||||||||||||||||||||||||||
| 2. How to search the database | |||||||||||||||||||||||||||||||||||
|
Click on the image or link of the risk factor on the homepage to view the classification table corresponding to the risk factor, which can help users understand the content of NDDRF. Furthermore, users can click on the category link in the table to query the detailed information of the risk factor of that category in the database.
The search function includes both basic and advanced searches. The basic search facility mainly allows ‘fuzzy’ queries and is most suitable for direct queries of risk factor names. When users enter the keywords of a risk factor in the search box, we have added a keyword association function that will display a list of the top ten related suggestions for the keywords below the search box, which will greatly help users to search for risk factors. After the keyword is selected, clicking the search button will take the user to the page that displays all the search results, which shows basic information (ID, disease name, species, name, association, condition and PMID) for the risk factors searched by the keywords. Users can click on the item they want to view to see the details of the risk factor. Detailed information of risk factors, including risk factor information, reference information and experimental information, is presented in tables and all the results of the data collection are displayed in this module. If users want to know more about this risk factor, they can click on the PMID in the reference, and we have provided a hyperlink so that users can view the original article. The advanced search facility allows combined searches. On this page, we have provided a variety of drop-down lists for different types of queries based on different catetories of risk factor(includes epidemiological factors, genetic factors and lifestyle factors): phase category drop-down list (includes diagnosis, prognosis and treatment), association drop-down list (includes risk factors, protective factors and not related factors), disease name drop-down list (includes the 20 types of NDD recorded in the NDDRF), species drop-down list (human and animal) and literature year (from 1984 to 2023), group drop-down list (includes the different countries, regions and ethnic groups recorded in the NDDRF), class drop-down list (different classes are included according to different risk factor categories). Users can thus search terms individually or in combination, according to their needs. |
|||||||||||||||||||||||||||||||||||
|
|
|||||||||||||||||||||||||||||||||||
3. Items in the database |
|||||||||||||||||||||||||||||||||||
Attributes |
Description |
RF_ID: |
Risk factor ID |
RF_category: |
risk factor category,such as genetic factor |
RF_Group: |
Population of risk factor,such as Han Chinese population |
RF_Condition: |
Prerequisites for becoming a risk factor |
RF_Association: |
Risk factor of Protective factor |
Pubmed ID: |
Pubmed ID |
Year: |
Year of article |
RF_name: |
Risk factor name |
Comorbidity: |
Comorbidity,such as Gaucher disease. |
Famliy history: |
Famliy history,such as non-hereditary idiopathic PD |
Key sentence: |
Concluding key sentences in the article |
Polymorphisms Category: |
such as SNP |
Gene_name: |
Gene name |
Case: |
Case information(number,gender,age) |
Control: |
Control information(number,gender,age) |
Life style: |
such as creatine 5 grams twice daily or to placebo for 5 years;caffeine intake during the prior week |
Gender: |
Gender of risk factor |
