NDDRF knowledgebase

Neurodegenerative Disease

Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.

Our knowledge base covers and integrates Risk factors for more than ten neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Lewy body dementia (LBD), Creutzfeldt-Jakob disease (CJD) and frontotemporal lobe degeneration (FTLD). We have 5 types of risk factors, genetic factors (genes, mutations, family history, etc.), epidemiological factors (age, gender, race, disease, drugs, exposure to the environment, etc.), lifestyle factors (diet, education, habit, physical activity, etc.), non-risk factors and the combination factors, the NDDRF knowledge base also includes NDD-related knowledge, providing a personalized search method, making it a powerful search tool in the field. It also provides great convenience for further analysis, diagnosis, treatment and prognosis of the researchers.

Risk Factors

Lifestyle Factors	Epidemiological Factors	Genetic Factors
Combination Factors	Non-Risk Factors Research	Risk Models

(Click the IMAGE to view detail Risk Factors)

In epidemiology,risk factors are variables which are bound up with an increased risk of disease or infection,Protective factors are also risk factors,on the contrary, protective factors are variables which are associated with an decreased risk of disease or infection.

In this knowledgebase,NDD's risk factors are mainly divided into five categories:Epidemiological factors, Genetic factors, Lifestyle factors, Combination factors and Non-risk factors

Disease Category

• Parkinson's disease

• Alzheimer’s Disease

• Amyotrophic Lateral Sclerosis

• Creutzfeldt-Jakob disease

• Frontotemporal Lobar Degeneration

• Frontotemporal Dementia

• Lewy body dementia

• Motor Neuron Disease

• Multiple System Atrophy

• Progressive Supranuclear Palsy

• Tuberous sclerosis complex

• Tourette Syndrome

• Chronic Traumatic Encephalopathy

• Bovine Spongiform Encephalopathy

• Fatal familial insomnia

• Charcot-Marie-Tooth disease

• Spinal muscular atrophy

• Prion disease

• Huntington's disease

• Hereditary Motor and Sensory Neuropathy






Links

• PDGene
• Alzforum
• Neurodegenerative Diseases Variation Database (NDDVD)
• Sichuan University
• Institutes for Systems Genetics, West China Hospital