Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis(ALS) is a specific disease that causes the death of neurons controlling voluntary muscles.[4][9]

ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.[2] It may begin with weakness in the arms or legs, or with difficulty speaking or swallowing.[10] About half of the people affected develop at least mild difficulties with thinking and behavior and most people experience pain.[11][12] Most eventually lose the ability to walk, use their hands, speak, swallow, and breathe.[5]


[4]"Amyotrophic Lateral Sclerosis (ALS) Fact Sheet". National Institute of Neurological Disorders and Stroke. 19 September 2014. Archived from the original on 5 January 2017. Retrieved 2 January 2015.
[9]"Motor neurone disease". NHS Choices. Archived from the original on 29 December 2014. Retrieved 2 January 2015.
[2]"Motor Neuron Diseases Fact Sheet". National Institute of Neurological Disorders and Stroke. Archived from the original on 13 April 2014. Retrieved 7 November 2010.
[10]Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH (October 2017). "Amyotrophic lateral sclerosis". Nature Reviews. Disease Primers. 3 (17071): 17071. doi:10.1038/nrdp.2017.71. PMID 28980624.
[11]van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, van den Berg LH (November 2017). "Amyotrophic lateral sclerosis". Lancet. 390 (10107): 2084–2098. doi:10.1016/S0140-6736(17)31287-4. PMID 28552366.
[12]Chiò A, Mora G, Lauria G (February 2017). "Pain in amyotrophic lateral sclerosis". The Lancet. Neurology. 16 (2): 144–57. arXiv:1607.02870. doi:10.1016/S1474-4422(16)30358-1. PMID 27964824.
[5]Hobson EV, McDermott CJ (September 2016). "Supportive and symptomatic management of amyotrophic lateral sclerosis". Nature Reviews. Neurology. 12 (9): 526–38. doi:10.1038/nrneurol.2016.111. PMID 27514291.

The search result for the NDD Category "Amyotrophic Lateral Sclerosis"
A total of 475 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Condition PMID
4 Amyotrophic Lateral Sclerosis human A90V TDP-43 variant RF 18505686
22 Amyotrophic Lateral Sclerosis human APOE-2 PF 15657798
26 Amyotrophic Lateral Sclerosis human ATAXIN2 RF ≥ 31 CAG-repeat length 22425256
31 Amyotrophic lateral sclerosis human ATRN RF 27455347
32 Amyotrophic lateral sclerosis human ATXN1 RF 25023141
33 Amyotrophic lateral sclerosis human ATXN2 RF 30847648
33 Amyotrophic lateral sclerosis human ATXN2 RF 26208502
33 Amyotrophic lateral sclerosis human ATXN2 RF 23197749
33 Amyotrophic Lateral Sclerosis human ATXN2 RF ATXN2 polyQ repeat expansions greater than 27 21741123
33 Amyotrophic Lateral Sclerosis human ATXN2 RF ATXN2 high-length alleles (≥29 CAG repeats) 21670397
33 Amyotrophic Lateral Sclerosis human ATXN2 RF ATXN2 high-length alleles (≥29 CAG repeats) 21670397
38 Amyotrophic lateral sclerosis human BIRC6 RF 27455347
40 Amyotrophic lateral sclerosis human C1QTNF7 RF 27455347
43 Amyotrophic lateral sclerosis human C7orf57 RF 25023141
44 Amyotrophic lateral sclerosis human C9orf72 RF 25023141
44 Amyotrophic lateral sclerosis human C9orf72 RF 29528390
44 Amyotrophic Lateral Sclerosis human C9orf72 RF 20801718
58 Amyotrophic Lateral Sclerosis human CHGB RF 20007371
58 Amyotrophic Lateral Sclerosis human CHGB RF 20007371
61 Amyotrophic lateral sclerosis human CHRNA4 RF 22873564
75 Amyotrophic lateral sclerosis human CREB3L2 RF 27455347
79 Amyotrophic lateral sclerosis human CX3CR1 RF 24806473
79 Amyotrophic lateral sclerosis human CX3CR1 RF 24806473
79 Amyotrophic lateral sclerosis human CX3CR1 RF 24806473
86 Amyotrophic lateral sclerosis human DCC RF 27455347
89 Amyotrophic lateral sclerosis human DISC1 RF 25023141
91 Amyotrophic lateral sclerosis human DPP6 RF 25023141
92 Amyotrophic lateral sclerosis human DPYSL3(CRMP4) RF 23568759
101 Amyotrophic lateral sclerosis human ERp57/PDIA3 RF 25913742
110 Amyotrophic lateral sclerosis human FUS RF 28054830
114 Amyotrophic lateral sclerosis human GARS RF 30661401
128 Amyotrophic Lateral Sclerosis human HFE RF Genotype:GC 20642794
128 Amyotrophic Lateral Sclerosis human HFE RF Genotype:GC/GG 20642794
128 Amyotrophic Lateral Sclerosis human HFE RF Genotype:G allele frequency 20642794
133 Amyotrophic Lateral Sclerosis human HLA-DRA/HLA-DRB5 RF the AA genotype at rs9268856 28131168
149 Amyotrophic Lateral Sclerosis human Intergenic RF The estimations using the proposed method (unadjusted estimates) 19740415
149 Amyotrophic Lateral Sclerosis human Intergenic RF The estimations using the proposed method (adjusted estimates) 19740415
150 Amyotrophic Lateral Sclerosis human Intergenic and SHROOM3 RF The estimations using the proposed method (unadjusted estimates) 19740415
151 Amyotrophic Lateral Sclerosis human Intergenic and SHROOM4 RF The estimations using the proposed method (adjusted estimates) 19740415
154 Amyotrophic lateral sclerosis human ITPR2 RF 25023141
157 Amyotrophic lateral sclerosis human KIF5A RF 27455347
163 Amyotrophic Lateral Sclerosis human LOC107987057 RF 20801718
163 Amyotrophic Lateral Sclerosis human LOC107987057 RF 20801717
163 Amyotrophic Lateral Sclerosis human LOC107987057 RF In the joint analysis 20801717
164 Amyotrophic Lateral Sclerosis human LOC107987057,LOC112268043 RF 20801717
164 Amyotrophic Lateral Sclerosis human LOC107987057,LOC112268043 RF In the joint analysis 20801717
165 Amyotrophic Lateral Sclerosis human LOC112268043,LOC107987057 RF 20801718
169 Amyotrophic Lateral Sclerosis human M1(C/C) RF 17503480
170 Amyotrophic Lateral Sclerosis human M5(A/A) PF 17503480
171 Amyotrophic Lateral Sclerosis human M6(T/T) RF 17503480
183 Amyotrophic lateral sclerosis human MOB3B RF 25023141
183 Amyotrophic Lateral Sclerosis human MOB3B RF 20801718
190 Amyotrophic Lateral Sclerosis human MTHFR(T677T) RF 22385294
191 Amyotrophic Lateral Sclerosis human MTHFR(T677T/A1298A) RF 22385294
194 Amyotrophic lateral sclerosis human NEK1 RF 27455347
194 Amyotrophic lateral sclerosis human NEK1 RF 27455347
194 Amyotrophic lateral sclerosis human NEK1 RF 27455347
194 Amyotrophic lateral sclerosis human NEK1 RF 27455347
198 Amyotrophic Lateral Sclerosis human NIPA1 RF 22378146
210 Amyotrophic lateral sclerosis human P4HB/PDIA1 RF 25913742
217 Amyotrophic lateral sclerosis human PEAK1 RF 27455347
219 Amyotrophic lateral sclerosis human PFN1 RF 24309268
227 Amyotrophic Lateral Sclerosis human PON1 Q192R(major allele is Q) RF Recessive (RR vs other) 16822965
227 Amyotrophic Lateral Sclerosis human PON1 Q192R(major allele is Q) RF Additive 16822965
227 Amyotrophic Lateral Sclerosis human PON1 Q192R(major allele is Q) RF Dominant (RR and QR vs QQ) 16822965
228 Amyotrophic Lateral Sclerosis human PON2 C311S (major allele is S) RF Additive 16822965
228 Amyotrophic Lateral Sclerosis human PON2 C311S (major allele is S) RF Dominant (CC and CS vs SS) 16822965
253 Amyotrophic Lateral Sclerosis human SMN1 RF one copy 16931506
253 Amyotrophic Lateral Sclerosis human SMN1 RF three copies 16931506
253 Amyotrophic Lateral Sclerosis human SMN1 RF one or three copies of SMN1 gene were pooled 16931506
253 Amyotrophic Lateral Sclerosis human SMN1 RF abnormal SMN1 copy numbers 19922137
254 Amyotrophic Lateral Sclerosis human SMN2 RF 22187232
257 Amyotrophic Lateral Sclerosis human SOD1 RF Expression of N19S-SOD1, an SOD1 Mutant 16035108
257 Amyotrophic lateral sclerosis human SOD1 RF 24591609
261 Amyotrophic Lateral Sclerosis human SPG4 RF 16009903
262 Amyotrophic lateral sclerosis human SQSTM1 RF 22972638
268 Amyotrophic lateral sclerosis human STX12 RF 27455347
272 Amyotrophic lateral sclerosis human SUN3, HUS1 RF 25023141
274 Amyotrophic lateral sclerosis human TARDBP RF 25023141
284 Amyotrophic lateral sclerosis human TIAM1 RF 25023141
284 Amyotrophic Lateral Sclerosis human TIAM1 RF 20801718
293 Amyotrophic lateral sclerosis human TREM2 RF 24535663
300 Amyotrophic Lateral Sclerosis human UNC12A RF 22118904
301 Amyotrophic lateral sclerosis human UNC13A RF especially in Caucasian and European subjects 31201598
301 Amyotrophic Lateral Sclerosis human UNC13A RF 22118904
302 Amyotrophic lateral sclerosis mouse VAPB RF 23446633
302 Amyotrophic lateral sclerosis zebrafish VAPB RF 23446633
306 Amyotrophic lateral sclerosis human WDR49 RF 27455347
307 Amyotrophic lateral sclerosis human ZSCAN5B RF 27455347
308 Amyotrophic lateral sclerosis human 20% continuous increase of any agricultural land or specific crop type RF Total agricultural land 28851431
308 Amyotrophic lateral sclerosis human 20% continuous increase of any agricultural land or specific crop type RF Orchards 28851431
308 Amyotrophic lateral sclerosis human 20% continuous increase of any agricultural land or specific crop type RF Olive groves 28851431
311 Amyotrophic Lateral Sclerosis human A high intake of carbohydrate RF 17852010
319 Amyotrophic lateral sclerosis rat Age RF 30873018
320 Amyotrophic Lateral Sclerosis human Age at cessation of smoking RF 16963407
321 Amyotrophic lateral sclerosis human Age at first trauma leading to functional disability RF <35 years 29063790
321 Amyotrophic lateral sclerosis human Age at first trauma leading to functional disability RF 35–54 years 29063790
321 Amyotrophic lateral sclerosis human Age at first trauma leading to functional disability RF 35–54 years 29063790
326 Amyotrophic lateral sclerosis human Age of sport activity onset PF 24706338
326 Amyotrophic lateral sclerosis human Age of sport activity onset PF Significant adjusted OR 24706338
326 Amyotrophic lateral sclerosis human Age of sport activity onset PF 24706338
328 Amyotrophic Lateral Sclerosis human Agricultural chemicals RF 20012543
329 Amyotrophic lateral sclerosis human Agricultural chemicals (pesticides) RF 29681882
330 Amyotrophic Lateral Sclerosis human agricultural work RF 15995797
331 Amyotrophic lateral sclerosis human Air Force RF Adjusted for matching factors and socioeconomic status (SES) 26583610
332 Amyotrophic lateral sclerosis human Air pollution RF the nitrogen oxides NO2 and NOx 29483062
332 Amyotrophic Lateral Sclerosis human Air pollution RF Air Pollution Exposure( NOx concentrations) 29989551
332 Amyotrophic Lateral Sclerosis human Air pollution RF Air Pollution Exposure(NO2) 29989551
332 Amyotrophic Lateral Sclerosis human Air pollution RF Air Pollution Exposure(PM2.5) 29989551
335 Amyotrophic lateral sclerosis human Amateur sport activity PF 24706338
338 Amyotrophic lateral sclerosis human an IQR increase of CO RF 30622072
339 Amyotrophic lateral sclerosis human an IQR increase of PM10 RF 30622072
340 Amyotrophic lateral sclerosis human an IQR increase of PM2.5 RF 30622072
341 Amyotrophic lateral sclerosis human an IQR increase of SO2 RF 30622072
344 Amyotrophic lateral sclerosis human Military work RF Adjusted for matching factors and socioeconomic status (SES) 26583610
346 Amyotrophic lateral sclerosis human Arthritis PF 27065942
350 Amyotrophic lateral sclerosis human Average daily adulthood PA(Physical Activity) RF 26998882
351 Amyotrophic lateral sclerosis human Average daily PA(Physical Activity) in last 5–15 years RF 26998882
352 Amyotrophic lateral sclerosis human AVM(arteriovenous malformation) RF all 26260352
352 Amyotrophic lateral sclerosis human AVM(arteriovenous malformation) RF cerebral vessels 26260352
353 Amyotrophic lateral sclerosis human Bank tellers RF worked or were unemployed at 1991 Italian census, and were still resident in Turin at the beginning of 1996 28201634
359 Amyotrophic lateral sclerosis human blood levels of Copper (μg/dL) RF Adjusted for age, gender and race/ethnicity. 27085208
360 Amyotrophic lateral sclerosis human blood levels of Manganese (μg/dL) RF Adjusted for age, gender and race/ethnicity. 27085208
361 Amyotrophic lateral sclerosis human blood levels of Selenium (μg/dL) PF Adjusted for age, gender and race/ethnicity. 27085208
361 Amyotrophic lateral sclerosis human blood levels of Selenium (μg/dL) PF Adjusted for age, gender and race/ethnicity. 27085208
361 Amyotrophic lateral sclerosis human blood levels of Selenium (μg/dL) PF Adjusted for age, gender and race/ethnicity. 27085208
361 Amyotrophic lateral sclerosis human blood levels of Selenium (μg/dL) PF Adjusted for age, gender and race/ethnicity. 27085208
362 Amyotrophic lateral sclerosis human blood levels of Zinc (μg/dL) PF Adjusted for age, gender and race/ethnicity. 27085208
362 Amyotrophic lateral sclerosis human blood levels of Zinc (μg/dL) PF Adjusted for age, gender and race/ethnicity. 27085208
364 Amyotrophic lateral sclerosis human BMI history RF OR controlled for age, sex, duration of school education, and smoking status 28975435
364 Amyotrophic lateral sclerosis human BMI history RF OR controlled for age, sex, duration of school education, and smoking status 28975435
364 Amyotrophic lateral sclerosis human BMI history RF OR controlled for age, sex, duration of school education, and smoking status 28975435
364 Amyotrophic lateral sclerosis human BMI history PF OR controlled for age, sex, duration of school education, and smoking status 28975435
365 Amyotrophic lateral sclerosis human BMI(Body Mass Index) RF Low BMI(Body Mass Index) 31155341
366 Amyotrophic lateral sclerosis human Boat, sail, or kayak RF residents of New England or the bordering New York region at the time of enrollment 28122372
387 Amyotrophic lateral sclerosis mouse Circadian rhythm dysfunction (CRD) RF Transgenic mice overexpressing human SOD1 were obtained from the Nanjing Biomedical Research Institute of Nanjing University 29740382
392 Amyotrophic lateral sclerosis human construction work RF 27124833
392 Amyotrophic Lateral Sclerosis human construction work RF 19750102
393 Amyotrophic lateral sclerosis human COPD(chronic obstructive pulmonary disease) PF 27065942
397 Amyotrophic lateral sclerosis human current proximity to any agricultural land or specific crop type within 100m from residence RF Total agricultural land 28851431
398 Amyotrophic lateral sclerosis human Defense NEC(Not Elsewhere Classified) RF Adjusted for matching factors and socioeconomic status (SES) 26583610
401 Amyotrophic lateral sclerosis human Diabetes PF Unadjusted 26030836
401 Amyotrophic lateral sclerosis human Diabetes PF Adjusted for socioeconomic status, prior chronic obstructive pulmonary disease, marital status, and residence at amyotrophic lateral sclerosis diagnosis. 26030836
401 Amyotrophic lateral sclerosis human Diabetes PF Adjusted for socioeconomic status, prior chronic obstructive pulmonary disease, marital status, and residence at amyotrophic lateral sclerosis diagnosis, with diabetes and obesity simultaneously included in the model. 26030836
404 Amyotrophic Lateral Sclerosis human Dietary habits:Cold cuts RF all cases 19922125
404 Amyotrophic Lateral Sclerosis human Dietary habits:Cold cuts RF Bulbar cases 19922125
412 Amyotrophic lateral sclerosis human Distance agricultural areas RF 100m300m 29852480
414 Amyotrophic lateral sclerosis human Drinking RF 31155341
414 Amyotrophic lateral sclerosis human Drinking PF 22791740
419 Amyotrophic lateral sclerosis human Duration of OCP(oral contraceptive) use (per year) PF female 28835399
420 Amyotrophic lateral sclerosis human Duration of physical activity PF 24706338
420 Amyotrophic lateral sclerosis human Duration of physical activity PF Significant adjusted OR 24706338
420 Amyotrophic lateral sclerosis human Duration of physical activity PF 24706338
420 Amyotrophic lateral sclerosis human Duration of physical activity PF 24706338
420 Amyotrophic lateral sclerosis human Duration of physical activity PF 24706338
421 Amyotrophic lateral sclerosis human Duration of sport activity PF 24706338
421 Amyotrophic lateral sclerosis human Duration of sport activity PF Significant adjusted OR 24706338
421 Amyotrophic lateral sclerosis human Duration of sport activity PF 24706338
421 Amyotrophic lateral sclerosis human Duration of sport activity PF 24706338
425 Amyotrophic lateral sclerosis human education PF Exposure in the last 30 years 24979055
425 Amyotrophic lateral sclerosis human education PF Exposure in the last 10 years 24979055
425 Amyotrophic lateral sclerosis human education PF Exposure in the period from 30 years ago to 10 years ago 24979055
425 Amyotrophic lateral sclerosis human education PF Continuous Exposure in the last 30 years 24979055
425 Amyotrophic Lateral Sclerosis human education RF Elementary school(Crude OR) 17923612
425 Amyotrophic lateral sclerosis human education PF Exposure Ever Happened in Entire Occupational History 27159543
425 Amyotrophic lateral sclerosis human education PF Exposure Ever Happened in Last 10 years 27159543
425 Amyotrophic lateral sclerosis human education PF Exposure Ever Happened 10-30 years Ago 27159543
425 Amyotrophic lateral sclerosis human education PF Exposure Ever Happened >30 years Ago 27159543
425 Amyotrophic Lateral Sclerosis human education RF 31011473
425 Amyotrophic lateral sclerosis human education PF Longer duration of education 31155341
426 Amyotrophic lateral sclerosis human Electric current injuries RF 27124833
426 Amyotrophic lateral sclerosis human Electric current injuries RF 29681882
430 Amyotrophic lateral sclerosis human Environmental toxins RF organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs) 27231185
432 Amyotrophic lateral sclerosis human Ever worked in US Armed Forces RF Exposure Ever Happened 10-30 years Ago 27159543
438 Amyotrophic lateral sclerosis human Exposure to Lead RF residents of New England or the bordering New York region at the time of enrollment 28122372
438 Amyotrophic lateral sclerosis human Exposure to Lead RF residents of New England or the bordering New York region at the time of enrollment 28122372
438 Amyotrophic Lateral Sclerosis human Exposure to Lead RF 19750102
438 Amyotrophic Lateral Sclerosis human Exposure to Lead RF Ever had a job with lead exposure 16909025
438 Amyotrophic Lateral Sclerosis human Exposure to Lead RF Lifetime days of lead exposure:2,000+ 16909025
444 Amyotrophic lateral sclerosis human Exposure to Pesticide RF residents of New England or the bordering New York region at the time of enrollment 28122372
444 Amyotrophic lateral sclerosis human Exposure to Pesticide RF residents of New England or the bordering New York region at the time of enrollment 28122372
444 Amyotrophic Lateral Sclerosis human Exposure to Pesticide RF In a conditional logistic regression model 20847462
446 Amyotrophic lateral sclerosis human Exposure to Solvents RF residents of New England or the bordering New York region at the time of enrollment 28122372
447 Amyotrophic lateral sclerosis human Exposure to the highest quartiles of PM10 RF 30622072
448 Amyotrophic lateral sclerosis human Exposure to the highest quartiles of PM2.5 RF 30622072
450 Amyotrophic lateral sclerosis human Exposure to welding or soldering materials RF 27124833
463 Amyotrophic Lateral Sclerosis human Fire fighting occupations RF 20698805
463 Amyotrophic Lateral Sclerosis human Fire fighting occupations RF 20698805
466 Amyotrophic lateral sclerosis human Fractures RF all 28316249
466 Amyotrophic lateral sclerosis human Fractures RF osteoporotic 28316249
466 Amyotrophic lateral sclerosis human Fractures RF non-osteoporotic 28316249
466 Amyotrophic lateral sclerosis human Fractures RF traumatic 28316249
466 Amyotrophic lateral sclerosis human Fractures RF non-traumatic 28316249
468 Amyotrophic lateral sclerosis human Fungal infection RF 25892962
469 Amyotrophic lateral sclerosis human Gender PF 27065942
470 Amyotrophic lateral sclerosis human General practitioners RF worked or were unemployed at 1991 Italian census, and were still resident in Turin at the beginning of 1996 28201634
474 Amyotrophic Lateral Sclerosis human having a past history of CS/SSM RF 17538776
475 Amyotrophic Lateral Sclerosis human having surgical treatment for CS/SSM RF 17538776
478 Amyotrophic Lateral Sclerosis human Head injury RF all cases 19922125
478 Amyotrophic Lateral Sclerosis human Head injury RF Bulbar cases 19922125
478 Amyotrophic Lateral Sclerosis human head injury RF Age at last injury (years)≥29 20129626
478 Amyotrophic Lateral Sclerosis human head injury RF Years between last injury and reference date <=24 years 20129626
478 Amyotrophic Lateral Sclerosis human head injury RF Years between last injury and reference date <=15 years 20129626
478 Amyotrophic lateral sclerosis human head injury RF 31155341
478 Amyotrophic lateral sclerosis human head injury RF 2+ Trauma 29063790
478 Amyotrophic lateral sclerosis human head injury RF 25059395
478 Amyotrophic lateral sclerosis human head injury RF Head trauma leading to functional disability 29063790
481 Amyotrophic Lateral Sclerosis human heavy metals RF 6538286
482 Amyotrophic lateral sclerosis human Heavy metals (lead) RF 29681882
486 Amyotrophic Lateral Sclerosis human Herbicides/Pesticides RF with the total SALS group 16946624
486 Amyotrophic Lateral Sclerosis human Herbicides/Pesticides RF with male SALS patients 16946624
503 Amyotrophic lateral sclerosis human Hypercholesterolemia PF 25059395
505 Amyotrophic lateral sclerosis human Hyperlipidemia PF 27065942
505 Amyotrophic lateral sclerosis human Hyperlipidemia RF 30723964
506 Amyotrophic lateral sclerosis human Hypertension PF 31155341
506 Amyotrophic lateral sclerosis human Hypertension PF 27065942
513 Amyotrophic lateral sclerosis human Immunosuppressive drugs PF 25059395
516 Amyotrophic lateral sclerosis human industrial chemicals RF residents of New England or the bordering New York region at the time of enrollment 28122372
516 Amyotrophic lateral sclerosis human industrial chemicals RF residents of New England or the bordering New York region at the time of enrollment 28122372
517 Amyotrophic lateral sclerosis human Industry in accommodation or food services PF Exposure Ever Happened in Entire Occupational History 27159543
517 Amyotrophic lateral sclerosis human Industry in accommodation or food services PF Exposure Ever Happened >30 years Ago 27159543
518 Amyotrophic lateral sclerosis human Industry in health care or social assistance PF Exposure Ever Happened in Entire Occupational History 27159543
519 Amyotrophic lateral sclerosis human Industry in ublic administration PF Exposure Ever Happened in Entire Occupational History 27159543
519 Amyotrophic lateral sclerosis human Industry in ublic administration PF Exposure Ever Happened 10-30 years Ago 27159543
524 Amyotrophic Lateral Sclerosis human inhalation of BMAA, DAB, and other aerosolized cyanotoxins RF 19929742
532 Amyotrophic lateral sclerosis human Jobs as workers or farmers RF 31155341
536 Amyotrophic lateral sclerosis human Leisure time activity RF 23418211
537 Amyotrophic Lateral Sclerosis human Level of Herbicide/Pesticide Exposure RF the total SALS group 16946624
537 Amyotrophic Lateral Sclerosis human Level of Herbicide/Pesticide Exposure RF male SALS patients 16946624
538 Amyotrophic Lateral Sclerosis human Lifestyle factors RF Vigorous physical activity 19342254
538 Amyotrophic Lateral Sclerosis human Lifestyle factors RF self reported stress:high 19342254
538 Amyotrophic Lateral Sclerosis human Lifestyle factors RF Behavior pattern:Type A 19342254
538 Amyotrophic Lateral Sclerosis human Lifestyle factors RF Intake of green-yellow vegetables:Less 19342254
538 Amyotrophic Lateral Sclerosis human Lifestyle factors RF combination Type A behavior and Intake of green-yellow vegetables 19342254
539 Amyotrophic lateral sclerosis human Lifetime endogenous estrogen exposure (per year) RF 28835399
541 Amyotrophic Lateral Sclerosis human Living in rural environment RF Region of living more than 5 years before disease onset 31011473
548 Amyotrophic Lateral Sclerosis human Market-oriented skilled agricultural workers RF 20012543
559 Amyotrophic lateral sclerosis human medical service work RF 27124833
560 Amyotrophic lateral sclerosis human metals as Al, Cd, Hg, Mn and Pb RF 26671079
344 Amyotrophic lateral sclerosis human Military work RF born between 1945 and 1985 26468494
561 Amyotrophic lateral sclerosis human Moderate trauma RF 29063790
567 Amyotrophic lateral sclerosis human Neurological PF 27065942
569 Amyotrophic lateral sclerosis human Non Vigorous Physical Activities RF 28413696
577 Amyotrophic lateral sclerosis human O2?tension RF low O2?tension 30863976
315 Amyotrophic lateral sclerosis human Obesity PF Unadjusted 26030836
315 Amyotrophic lateral sclerosis human Obesity RF 27065942
578 Amyotrophic Lateral Sclerosis human Occupation RF Craft and related trades workers(Crude OR) 17923612
578 Amyotrophic Lateral Sclerosis human Occupation RF primary industrial occupations(at disease onset) 17538776
578 Amyotrophic Lateral Sclerosis human Occupation RF secondary industrial occupations(at disease onset) 17538776
578 Amyotrophic Lateral Sclerosis human Occupation PF tertiary industrial occupations(at disease onset) 17538776
578 Amyotrophic lateral sclerosis human Occupation RF Occupations in contact with customer;sworked or were unemployed at 1991 Italian census, and were still resident in Turin at the beginning of 1996 28201634
578 Amyotrophic lateral sclerosis human Occupation RF Primary occupation involves industrial chemicals;residents of New England or the bordering New York region at the time of enrollment 28122372
578 Amyotrophic lateral sclerosis human Occupation RF Primary occupation involves industrial chemicals;residents of New England or the bordering New York region at the time of enrollment 28122372
579 Amyotrophic lateral sclerosis human Occupational Exposure PF Occupational exposure to lead;Exposure Ever Happened in Entire Occupational History 27159543
579 Amyotrophic lateral sclerosis human Occupational Exposure RF Occupational exposure to pesticide;Exposure in the last 30 years 24979055
579 Amyotrophic lateral sclerosis human Occupational Exposure RF Occupational exposure to pesticide;Exposure Ever Happened in Entire Occupational History 27159543
579 Amyotrophic lateral sclerosis human Occupational Exposure RF Occupational exposure to pesticide;Exposure Ever Happened in Last 10 years 27159543
579 Amyotrophic lateral sclerosis human Occupational Exposure RF Occupational exposure to pesticide;Exposure Ever Happened 10-30 years Ago 27159543
580 Amyotrophic Lateral Sclerosis human Occupational history RF Occupational history:Building and construction sector of economic activity;Spinal cases 19922125
580 Amyotrophic Lateral Sclerosis human Occupational history RF Occupational history:Exposure to building and construction materials;Spinal cases 19922125
580 Amyotrophic Lateral Sclerosis human Occupational history RF Occupational history:Exposure to metals and metal fumes;Spinal cases 19922125
581 Amyotrophic lateral sclerosis human OCP(oral contraceptive) PF female 28835399
582 Amyotrophic lateral sclerosis human office work RF 27124833
585 Amyotrophic lateral sclerosis human Organic solvents RF 29681882
586 Amyotrophic lateral sclerosis human Organized sport activity PF 24706338
586 Amyotrophic lateral sclerosis human Organized sport activity PF Significant adjusted OR 24706338
589 Amyotrophic lateral sclerosis human overall muscle strength RF Low overall muscle strength 29285652
590 Amyotrophic Lateral Sclerosis human pack-years RF Bulbar cases 19922125
593 Amyotrophic lateral sclerosis human particulate matter RF PM2.5, PM10, and PMcoarse 29483062
594 Amyotrophic lateral sclerosis human particulate matter absorption RF PM2.5absorption 29483062
604 Amyotrophic lateral sclerosis human Physical activity PF 24706338
604 Amyotrophic lateral sclerosis human Physical activity PF Significant adjusted OR 24706338
609 Amyotrophic Lateral Sclerosis human playing professional football RF >5 years 15634730
612 Amyotrophic Lateral Sclerosis human precision metal workers RF 19750102
622 Amyotrophic lateral sclerosis human Professional sports RF 29681882
628 Amyotrophic lateral sclerosis human Race RF AA 27065942
628 Amyotrophic lateral sclerosis human Race PF other 27065942
629 Amyotrophic lateral sclerosis human Reading PF 31155341
635 Amyotrophic lateral sclerosis human Retirement or unemployment PF 31155341
639 Amyotrophic lateral sclerosis human SAH(subarachnoid haemorrhage) RF Transient ischaemic attack 26260352
640 Amyotrophic lateral sclerosis human Sales representatives RF worked or were unemployed at 1991 Italian census, and were still resident in Turin at the beginning of 1996 28201634
643 Amyotrophic Lateral Sclerosis human selenium overexposure RF 21215776
647 Amyotrophic lateral sclerosis human Severe physical activities PF 31155341
652 Amyotrophic Lateral Sclerosis human Smoking RF current smokers 22791740
652 Amyotrophic Lateral Sclerosis human Smoking RF Ever smoker(Adjustment for education) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Current smoker(Adjustment for education) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Ever smoker(Adjustment for education and alcohol consumption) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Current smoker(Adjustment for education and alcohol consumption) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Duration of smoking ≥20 years(Adjustment for education) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Duration of smoking ≥20 years(Adjustment for education and alcohol consumption) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Cumulative pack-years<20 pack-years(Adjustment for education) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Cumulative pack-years≥20 pack-years(Adjustment for education) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Cumulative pack-years<20 pack-years(Adjustment for education and alcohol consumption) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Cumulative pack-years≥20 pack-years(Adjustment for education and alcohol consumption) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Combination recency and dose:Current, <20 pack years(Adjustment for education) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Combination recency and dose:Current, ≥20 pack-years(Adjustment for education and alcohol consumption) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Combination recency and dose:Current, <20 pack years(Adjustment for education) 10645818
652 Amyotrophic Lateral Sclerosis human Smoking RF Combination recency and dose:Current, ≥20 pack-years(Adjustment for education and alcohol consumption) 10645818
652 Amyotrophic lateral sclerosis human Smoking RF 31155341
652 Amyotrophic lateral sclerosis human Smoking RF 30786056
652 Amyotrophic Lateral Sclerosis human Smoking RF Former smokers (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Current smokers (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Ever smokers (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked ≤20 (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked 21-35 (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked > 35 (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Former smokers (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Ever smokers (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked ≤20 (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked 21-35 (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked > 35 (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Former smokers (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Ever smokers (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked 21-35 (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Former smokers (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Ever smokers (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked 21-35 (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Former smokers (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Ever smokers (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked ≤20 (Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked >35(Adjusted for Age) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Former smokers (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Ever smokers (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked ≤20 (Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Pack-years smoked >35(Adjusted for Age, Body Mass Index, Physical Activity, and Education) 21320987
652 Amyotrophic Lateral Sclerosis human Smoking RF Current(Crude OR) 17923612
652 Amyotrophic Lateral Sclerosis human Smoking RF Current(Adj. OR) 17923612
652 Amyotrophic Lateral Sclerosis human Smoking RF Current smokers 19399866
652 Amyotrophic Lateral Sclerosis human Smoking RF Time spent smoking≥30years 19399866
652 Amyotrophic Lateral Sclerosis human Smoking RF Bulbar cases 19922125
652 Amyotrophic Lateral Sclerosis human Smoking RF Bulbar cases 19922125
657 Amyotrophic Lateral Sclerosis human Solvents/Chemicals RF with the total SALS group 16946624
657 Amyotrophic Lateral Sclerosis human Solvents/Chemicals RF with male patients 16946624
657 Amyotrophic Lateral Sclerosis human Solvents/Chemicals RF with female patients 16946624
659 Amyotrophic Lateral Sclerosis human spatial locations RF 18573277
660 Amyotrophic lateral sclerosis human Sport activity PF 24706338
663 Amyotrophic lateral sclerosis human Stroke RF all 26260352
663 Amyotrophic lateral sclerosis human Stroke RF Haemorrhagic 26260352
663 Amyotrophic lateral sclerosis human Stroke RF Ischaemic 26260352
663 Amyotrophic lateral sclerosis human Stroke RF Unspecified 26260352
668 Amyotrophic lateral sclerosis human The widespread distribution of dioxins, PCBs and PAHs RF 28476168
670 Amyotrophic lateral sclerosis human Thyroid PF 27065942
671 Amyotrophic lateral sclerosis human toenail mercury levels RF 29314106
674 Amyotrophic Lateral Sclerosis human Toxin exposure RF 16963407
676 Amyotrophic lateral sclerosis human Trauma RF Previous trauma 29681882
676 Amyotrophic lateral sclerosis human Trauma RF 25059395
676 Amyotrophic Lateral Sclerosis human Trauma RF At least one traumatic event(All traumatic event) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Number of events reported:1(All traumatic event) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Number of events reported:3+(All traumatic event) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Worst traumatic event reported:Moderate(All traumatic event) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Worst traumatic event reported:Severe(All traumatic event) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Number of events requiring hospitalization:1(All traumatic event) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Number of events leading to disability:1(All traumatic event) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF At least one traumatic event(Old traumatic events) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Number of events reported:2(Old traumatic events) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Number of events reported::3+(Old traumatic events) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Worst traumatic event reported:Moderate(Old traumatic events) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Worst traumatic event reported:Severe(Old traumatic events) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Number of events requiring hospitalization:2+(Old traumatic events) 22537412
676 Amyotrophic Lateral Sclerosis human Trauma RF Number of events leading to disability:2+(Old traumatic events) 22537412
677 Amyotrophic lateral sclerosis human Trauma leading to disability RF 29063790
677 Amyotrophic lateral sclerosis human Trauma leading to disability RF 29063790
677 Amyotrophic lateral sclerosis human Trauma leading to disability RF 1 Trauma 29063790
677 Amyotrophic lateral sclerosis human Trauma leading to disability RF 1 Trauma 29063790
677 Amyotrophic lateral sclerosis human Trauma leading to disability RF 2+ Trauma 29063790
677 Amyotrophic lateral sclerosis human Trauma leading to disability RF 2+ Trauma 29063790
685 Amyotrophic Lateral Sclerosis human Type of Herbicide/Pesticide Exposure RF Industrial exposure to herbicides/pesticides 16946624
685 Amyotrophic Lateral Sclerosis human Type of Herbicide/Pesticide Exposure RF Industrial exposure to herbicides/pesticides 16946624
685 Amyotrophic Lateral Sclerosis human Type of Herbicide/Pesticide Exposure RF industrial exposure being occasional 16946624
685 Amyotrophic Lateral Sclerosis human Type of Herbicide/Pesticide Exposure RF industrial exposure being occasional 16946624
685 Amyotrophic Lateral Sclerosis human Type of Herbicide/Pesticide Exposure RF industrial exposure being regular 16946624
685 Amyotrophic Lateral Sclerosis human Type of Herbicide/Pesticide Exposure RF industrial exposure being regular 16946624
685 Amyotrophic Lateral Sclerosis human Type of Herbicide/Pesticide Exposure RF Exposure to herbicides/pesticides through regular gardening 16946624
685 Amyotrophic Lateral Sclerosis human Type of Herbicide/Pesticide Exposure RF Exposure to herbicides/pesticides through regular gardening 16946624
690 Amyotrophic lateral sclerosis human Use of chemicals in job or hobby RF residents of New England or the bordering New York region at the time of enrollment 28122372
690 Amyotrophic lateral sclerosis human Use of chemicals in job or hobby RF residents of New England or the bordering New York region at the time of enrollment 28122372
692 Amyotrophic lateral sclerosis human Use of statins PF 25059395
693 Amyotrophic lateral sclerosis human Using fertilizer to treat gardens RF Exposure in the period from 30 years ago to 10 years ago 24979055
700 Amyotrophic lateral sclerosis human Water-Ski RF residents of New England or the bordering New York region at the time of enrollment 28122372
703 Amyotrophic lateral sclerosis human Work PF 24706338
703 Amyotrophic lateral sclerosis human Work PF Significant adjusted OR 24706338
704 Amyotrophic lateral sclerosis human Work & Sport PF 24706338
704 Amyotrophic lateral sclerosis human Work & Sport PF Significant adjusted OR 24706338
712 Amyotrophic lateral sclerosis human high amounts of PC(phycocyanin concentration) exposure RF 28470570
717 Amyotrophic lateral sclerosis human Aerosolization of cyanobacteria RF 23246360
718 Amyotrophic lateral sclerosis mice age-related decreases in ADAR2(adenosine deaminase acting on RNA 2) activity RF 22916266
726 Amyotrophic Lateral Sclerosis human APOE(protein) RF 11940705
731 Amyotrophic Lateral Sclerosis human Ataxin-2 intermediate-length polyglutamine expansions RF 21292779
750 Amyotrophic lateral sclerosis human decreased SOD1 stability and increased protein aggregation RF 28558143
756 Amyotrophic lateral sclerosis human dysregulation modulation of proteasome activity RF 24450587
761 Amyotrophic lateral sclerosis human ER(endoplasmic reticulum) proteostasis imbalance RF 26869642
763 Amyotrophic Lateral Sclerosis human Expanded glutamine repeats of the ataxin-2 (ATXN2) protein RF CAG repeat length >26 21610160
764 Amyotrophic Lateral Sclerosis human Expanded glutamine repeats of the ataxin-2 (ATXN3) protein RF CAG repeat length >30 21610160
771 Amyotrophic lateral sclerosis human high HbA1c(Hemoglobin A1c) levels RF 28934974
814 Amyotrophic Lateral Sclerosis human mutations in neurofilaments RF 16084104
816 Amyotrophic lateral sclerosis human neuronal apoptosis inhibitory protein RF 29311650
821 Amyotrophic lateral sclerosis human perturbations of the ER proteostasis network RF 25913742
834 Amyotrophic Lateral Sclerosis human Serum Ferritin RF 19452011
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Controlled for age and sex. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Controlled for age and sex. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Also adjusted for educational attainment, smoking, occupational work intensity, and family history of amyotrophic lateral sclerosis. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Also adjusted for educational attainment, smoking, occupational work intensity, and family history of amyotrophic lateral sclerosis. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Controlled for age and sex and also adjusted for body mass index and self-reported diabetes. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Controlled for age and sex and also adjusted for body mass index and self-reported diabetes. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Adjusted for educational attainment, smoking, occupational work intensity, and family history of amyotrophic lateral sclerosis and also adjusted for estimated glomerular filtration rate. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Adjusted for educational attainment, smoking, occupational work intensity, and family history of amyotrophic lateral sclerosis and also adjusted for estimated glomerular filtration rate. 29482216
876 Amyotrophic Lateral Sclerosis Human SNP(combination SNP1 and SNP2) RF The estimations using the proposed method (unadjusted estimates) 19740415
876 Amyotrophic Lateral Sclerosis Human SNP(combination SNP1 and SNP2) RF The estimations using the proposed method (adjusted estimates) 19740415
877 Amyotrophic Lateral Sclerosis Human SNP(combination SNP1 and SNP3) RF The estimations using the proposed method (unadjusted estimates) 19740415
877 Amyotrophic Lateral Sclerosis Human SNP(combination SNP1 and SNP3) RF The estimations using the proposed method (adjusted estimates) 19740415
191 Amyotrophic Lateral Sclerosis Human MTHFR(T677T/A1298A) RF 22385294
878 Amyotrophic Lateral Sclerosis Human SMN1(one or three copies of SMN1 gene were pooled) RF 16931506
879 Amyotrophic Lateral Sclerosis Human combination of multiple genetic and environmental factors RF 18421219
880 Amyotrophic Lateral Sclerosis Human high intakes of carbohydrate and low intakes of fat and some kinds of fatty acids(when combined) RF 17852010
881 Amyotrophic Lateral Sclerosis Human Multivariate analysis (with covariates age, smoking, education, and occupation) RF 17923612
882 Amyotrophic Lateral Sclerosis Human Lifestyle factors(combination Type A behavior and Intake of green-yellow vegetables) RF 19342254
880 Amyotrophic Lateral Sclerosis human high intakes of carbohydrate and low intakes of fat and some kinds of fatty acids(when combined) RF 17852010
891 Amyotrophic lateral sclerosis human joint contribution of genetics and environmental exposures RF 28355414
881 Amyotrophic Lateral Sclerosis human Multivariate analysis (with covariates age, smoking, education, and occupation) RF 17923612
178 Amyotrophic lateral sclerosis human MFSD8 RF 32485802
44 Amyotrophic lateral sclerosis human C9orf72 RF 33177243
44 Amyotrophic lateral sclerosis human C9orf72 RF 33177243
906 Amyotrophic lateral sclerosis human CACNA1H RF 33177243
914 Amyotrophic lateral sclerosis human LRP10 RF rare, pathogenic variants in LRP10 33006184
916 Amyotrophic lateral sclerosis human SPG7 mutations RF 33138082
919 Amyotrophic lateral sclerosis human intermediate-length alleles when present in both alleles RF Carriership of two intermediate-length alleles was associated with ALS, when the longer allele was ≥ 17 repeats 33021140
919 Amyotrophic lateral sclerosis human intermediate-length alleles when present in both alleles RF Carriership of two intermediate-length alleles was associated with ALS, when the longer allele was ≥ 21 repeats 33021140
924 Amyotrophic lateral sclerosis human high-density lipoprotein cholesterol [HDL-C] RF Higher levels of HDL-C 32172343
951 Amyotrophic lateral sclerosis human lead exposure RF environmental/occupational 31578652
333 Amyotrophic lateral sclerosis human alcohol consumption RF 32196748
952 Amyotrophic lateral sclerosis human head trauma RF 32019087
953 Amyotrophic lateral sclerosis human electric shock RF 32019087
954 Amyotrophic lateral sclerosis human use of private wells for drinking water RF 32019087
955 Amyotrophic lateral sclerosis human use of herbicides during gardening RF 32019087
956 Amyotrophic lateral sclerosis human overall fish consumption PF 32019087
957 Amyotrophic lateral sclerosis human history of occupation in the agricultural sector RF 32331298
957 Amyotrophic lateral sclerosis human history of occupation in the agricultural sector RF 32331298
958 Amyotrophic lateral sclerosis human occupational exposure to Solvents(thinners) RF 32331298
959 Amyotrophic lateral sclerosis human occupational exposure to Solvents(paint removers) RF 32331298
960 Amyotrophic lateral sclerosis human occupational exposure to electromagnetic fields RF 32331298
961 Amyotrophic lateral sclerosis human environmental exposure to electromagnetic fields RF 32331298
962 Amyotrophic lateral sclerosis human exposure to pesticides RF Occupational but not environmental exposure,particularly fungicides 32331298
439 Amyotrophic lateral sclerosis human exposure to metals RF particularly mercur yand selenium 32331298
438 Amyotrophic lateral sclerosis human Exposure to Lead RF 32331298
963 Amyotrophic lateral sclerosis human antidiabetics PF 32097525
692 Amyotrophic lateral sclerosis human Use of statins RF 32097525
429 Amyotrophic lateral sclerosis human environmental exposure to cadmium RF 33068316
429 Amyotrophic lateral sclerosis human environmental exposure to cadmium RF 33068316
438 Amyotrophic lateral sclerosis human Exposure to Lead RF 33068316
438 Amyotrophic lateral sclerosis human Exposure to Lead RF 33068316
964 Amyotrophic lateral sclerosis human Zinc PF 33068316
964 Amyotrophic lateral sclerosis human Zinc PF 33068316
663 Amyotrophic lateral sclerosis human stroke RF 32266542
965 Amyotrophic lateral sclerosis human lower BMI RF 32266542
966 Amyotrophic lateral sclerosis human regular physical activity RF 32266542
967 Amyotrophic lateral sclerosis human gut microbiota RF/PF butyrate-producing bacteria are less abundant in the gastrointestinal tracts of people with ALS (PALS) 33135936
676 Amyotrophic lateral sclerosis human trauma RF 33130429
968 Amyotrophic lateral sclerosis human solvents RF 33130429
969 Amyotrophic lateral sclerosis human diesel/CVD interaction RF 33130429
970 Amyotrophic lateral sclerosis human trauma/solvents interaction PF 33130429
968 Amyotrophic lateral sclerosis human solvents RF 33130429
676 Amyotrophic lateral sclerosis human trauma RF 33130429
438 Amyotrophic lateral sclerosis human Exposure to Lead RF 33130429
971 Amyotrophic lateral sclerosis human CVD RF 33130429
972 Amyotrophic lateral sclerosis human lead/solvents interaction PF 33130429
973 Amyotrophic lateral sclerosis human Vitamin A RF higher serum Vitamin A 32625160
974 Amyotrophic lateral sclerosis human Vitamin B2 PF higher serum Vitamin B2 32625160
975 Amyotrophic lateral sclerosis human Vitamin B9 PF higher serum Vitamin B9 32625160
277 Amyotrophic lateral sclerosis human Vitamin C PF higher serum Vitamin C 32625160
848 Amyotrophic lateral sclerosis human Vitamin E RF higher serum Vitamin E 32625160
976 Amyotrophic lateral sclerosis human Exposure to extremely low frequency magnetic fields (ELF-MF) RF 32946420
952 Amyotrophic lateral sclerosis human Head trauma RF with significantly greater effects for injuries occurring 10 or more years prior to symptom onset 33006184
977 Amyotrophic lateral sclerosis human severe electrical burns RF 33006184
978 Amyotrophic lateral sclerosis human Hobbies involving lead RF Exposures to lead 20 or more years prior to diagnosis had larger effect sizes compared to those occurring more recently. 33006184
979 Amyotrophic lateral sclerosis human Physicians RF 32687038