Creutzfeldt-Jakob Disease

Creutzfeldt–Jakob disease (CJD) also known as classic Creutzfeldt–Jakob disease, is a fatal degenerative brain disorder.[4][1]

Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances.[4] Later symptoms include dementia, involuntary movements, blindness, weakness, and coma.[4] About 70% of people die within a year of diagnosis.[4] CJD is caused by a protein known as a prion.[5] Infectious prions are misfolded proteins that can cause normally folded proteins to become misfolded.[4] Most cases occur spontaneously, while about 7.5% of cases are inherited from a person's parents in an autosomal dominant manner.[4] Exposure to brain or spinal tissue from an infected person may also result in spread.[4] There is no evidence that it can spread between people via normal contact or blood transfusions.[4] Diagnosis involves ruling out other potential causes.[4] An electroencephalogram, spinal tap, or magnetic resonance imaging may support the diagnosis.[4]


[4]"Creutzfeldt–Jakob Disease Fact Sheet | National Institute of Neurological Disorders and Stroke". NINDS. March 2003. Archived from the original on 4 July 2017. Retrieved 16 July 2017.
[1]"Creutzfeldt-Jakob Disease, Classic (CJD)". CDC. 2 October 2018. Retrieved 21 November 2018.
[5]"Creutzfeldt-Jakob Disease, Classic (CJD) | Prion Diseases | CDC". www.cdc.gov. 1 February 2019. Retrieved 17 June 2019. Classic CJD is a human prion disease
The search result for the NDD Category "Creutzfeldt-Jakob Disease"
A total of 68 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Condition PMID
15 Creutzfeldt-Jakob disease human APOE RF ε4 allele 7968026
15 Creutzfeldt-Jakob disease human APOE RF ε4 allele 7968026
15 Creutzfeldt-Jakob disease human APOE RF ε4 allele 7968026
45 Creutzfeldt-Jakob disease human CALHM1 RF Genotype:GG 22874670
45 Creutzfeldt-Jakob disease human CALHM1 PF 22874670
60 Creutzfeldt-Jakob disease human CHN2 RF 22210626
78 Creutzfeldt-Jakob disease human CTSD RF Genotype:CC 18426579
78 Creutzfeldt-Jakob disease human CTSD RF Genotype:CT 18426579
231 Creutzfeldt-Jakob disease human PRNP RF APOE?ε4 carriers 21799773
231 Creutzfeldt-Jakob disease human PRNP RF BACE1?C-allele carriers 22952813
231 Creutzfeldt-Jakob disease human PRNP RF BACE1?C-allele carriers 22952813
231 Creutzfeldt-Jakob disease human PRNP RF Codon 129: Val homozygosity 8707291
231 Creutzfeldt-Jakob disease human PRNP RF 19081515
231 Creutzfeldt-Jakob disease human PRNP RF 19081515
231 Creutzfeldt-Jakob disease human PRNP RF 22210626
399 Creutzfeldt-Jakob disease human Dementia in family RF 3066847
405 Creutzfeldt-Jakob disease human Dietary Risk RF Hot Dogs 24977122
405 Creutzfeldt-Jakob disease human Dietary Risk RF Sausage 24977122
405 Creutzfeldt-Jakob disease human Dietary Risk RF Pepperoni 24977122
405 Creutzfeldt-Jakob disease human Dietary Risk RF Kielbasa 24977122
405 Creutzfeldt-Jakob disease human Dietary Risk RF “Other” Canned Meat 24977122
405 Creutzfeldt-Jakob disease human Dietary Risk RF kidneys,ever 19144172
405 Creutzfeldt-Jakob disease human Dietary Risk RF consumption of raw meat 9660576
405 Creutzfeldt-Jakob disease human Dietary Risk RF consumption of brain 9660576
414 Creutzfeldt-Jakob disease human Drinking PF Current alcohol 3066847
416 Creutzfeldt-Jakob disease human Duration (years) lived or worked on farm or market garden RF 10-19 years 10073510
416 Creutzfeldt-Jakob disease human Duration (years) lived or worked on farm or market garden RF >=20 years 10073510
423 Creutzfeldt-Jakob disease human Ear piercing RF females only 12196646
462 Creutzfeldt-Jakob disease human Ferret contact RF 3066847
467 Creutzfeldt-Jakob disease human Frequent exposure RF frequent exposure to leather products 9660576
467 Creutzfeldt-Jakob disease human Frequent exposure RF exposure to fertiliser consisting of hoofs and horns 9660576
487 Creutzfeldt-Jakob disease human hGH(human cadaver-sourced growth hormone) treatment RF 30045957
487 Creutzfeldt-Jakob disease human hGH(human cadaver-sourced growth hormone) treatment RF Proportion of doses risk category 1 (batches 1, 2, 3, 4, 7, 21, 26) 30045957
487 Creutzfeldt-Jakob disease human hGH(human cadaver-sourced growth hormone) treatment RF Proportion of doses risk category 2 (batches 10, 12, 13, 18, 24) 30045957
487 Creutzfeldt-Jakob disease human hGH(human cadaver-sourced growth hormone) treatment RF Proportion of doses risk category 3 (batches 5, 6, 8, 9, 11, 14, 15, 16, 17, 19, 20, 22, 23, 25, 27) 30045957
502 Creutzfeldt-Jakob disease human human growth hormone extract RF received human growth hormone extract for various period of time (mean +/- SD, 2.9 years) 8797466
533 Creutzfeldt-Jakob disease human Keeping cats RF 3066847
576 Creutzfeldt-Jakob disease human Number of surgical procedures RF 1 time 12196646
576 Creutzfeldt-Jakob disease human Number of surgical procedures RF 2 times 12196646
576 Creutzfeldt-Jakob disease human Number of surgical procedures RF >=3 times 12196646
579 Creutzfeldt-Jakob disease human Occupational Exposure RF occupational exposure to animal laboratory 19144172
601 Creutzfeldt-Jakob disease human Pets RF other than cats/dogs 3066847
627 Creutzfeldt-Jakob disease human Psychiatric visit RF 12196646
631 Creutzfeldt-Jakob disease human regular GP visits RF 19144172
632 Creutzfeldt-Jakob disease human regular medication RF 19144172
634 Creutzfeldt-Jakob disease human Residence or employment RF Live or employed in farms 10073510
665 Creutzfeldt-Jakob disease human Surgery RF undergo surgery 18257690
665 Creutzfeldt-Jakob disease human Surgery PF undergo surgery 18257690
665 Creutzfeldt-Jakob disease human Surgery PF undergo surgery;used proxy informants to acquire information about case subjects and control subjects (consistent ascertainment) 18257690
665 Creutzfeldt-Jakob disease human Surgery RF undergo surgery;proxy informants acted only on behalf of case subjects (inconsistent data ascertainment) 18257690
665 Creutzfeldt-Jakob disease human Surgery RF 10073510
665 Creutzfeldt-Jakob disease human Surgery PF Surgery at any time 3066847
665 Creutzfeldt-Jakob disease human Surgery RF Any surgery 12196646
665 Creutzfeldt-Jakob disease human Surgery PF Tonsillectomy 12196646
665 Creutzfeldt-Jakob disease human Surgery PF Appendectomy 12196646
665 Creutzfeldt-Jakob disease human Surgery RF Gynecologic 12196646
665 Creutzfeldt-Jakob disease human Surgery RF 18843192
665 Creutzfeldt-Jakob disease human Surgery RF predating clinical onset by 1 or more years 18843192
665 Creutzfeldt-Jakob disease human Surgery RF at a 1- to 9-year time lag 18843192
665 Creutzfeldt-Jakob disease human Surgery RF ophthalmological surgery (> 1980) 19144172
665 Creutzfeldt-Jakob disease human Surgery RF orthopaedic surgery 19144172
665 Creutzfeldt-Jakob disease human Surgery RF orthopaedic surgery (> 1980) 19144172
707 Creutzfeldt-Jakob disease human Zoster RF Zoster in adult life 3066847
907 Creutzfeldt-Jakob disease human Cerebroside sulfotransferase (GAL3ST1) RF 32870568
908 Creutzfeldt-Jakob disease human GAL3ST1 RF 32625160
231 Creutzfeldt-Jakob disease human PRNP RF 33138082
917 Creutzfeldt-Jakob disease human STX6(Syntaxin-6) RF 33138082
917 Creutzfeldt-Jakob disease human STX6(Syntaxin-6) RF 33138082
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