Creutzfeldt-Jakob Disease

Creutzfeldt–Jakob disease (CJD) also known as classic Creutzfeldt–Jakob disease, is a fatal degenerative brain disorder.[4][1]

Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances.[4] Later symptoms include dementia, involuntary movements, blindness, weakness, and coma.[4] About 70% of people die within a year of diagnosis.[4] CJD is caused by a protein known as a prion.[5] Infectious prions are misfolded proteins that can cause normally folded proteins to become misfolded.[4] Most cases occur spontaneously, while about 7.5% of cases are inherited from a person's parents in an autosomal dominant manner.[4] Exposure to brain or spinal tissue from an infected person may also result in spread.[4] There is no evidence that it can spread between people via normal contact or blood transfusions.[4] Diagnosis involves ruling out other potential causes.[4] An electroencephalogram, spinal tap, or magnetic resonance imaging may support the diagnosis.[4]


[4]"Creutzfeldt–Jakob Disease Fact Sheet | National Institute of Neurological Disorders and Stroke". NINDS. March 2003. Archived from the original on 4 July 2017. Retrieved 16 July 2017.
[1]"Creutzfeldt-Jakob Disease, Classic (CJD)". CDC. 2 October 2018. Retrieved 21 November 2018.
[5]"Creutzfeldt-Jakob Disease, Classic (CJD) | Prion Diseases | CDC". www.cdc.gov. 1 February 2019. Retrieved 17 June 2019. Classic CJD is a human prion disease
The search result for the NDD Category "Creutzfeldt-Jakob Disease"
A total of 157 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Phase Condition Year PMID
310 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
1117 Creutzfeldt-Jakob disease Human Surgical types PF Diagnosis 1998 9660576
315 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
4179 Creutzfeldt-Jakob disease Human Surgical types RF Diagnosis 2011 20547628
4184 Creutzfeldt-Jakob disease Human Surgical types RF Diagnosis 2011 20547628
312 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
1119 Creutzfeldt-Jakob disease Human Surgical types PF Diagnosis 2002 12196646
317 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
322 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 1998 9660576
4181 Creutzfeldt-Jakob disease Human Surgical types RF Diagnosis 2011 20547628
309 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
314 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
4178 Creutzfeldt-Jakob disease Human Surgical types RF Diagnosis 2011 20547628
324 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 1998 9660576
4183 Creutzfeldt-Jakob disease Human Surgical types RF Diagnosis 2011 20547628
311 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
1118 Creutzfeldt-Jakob disease Human Surgical types PF Diagnosis 2002 12196646
316 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
4180 Creutzfeldt-Jakob disease Human Surgical types RF Diagnosis 2011 20547628
313 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis 2009 19193271
4177 Creutzfeldt-Jakob disease Human Surgical types RF Diagnosis 2011 20547628
323 Creutzfeldt-Jakob disease Human Surgical types Not Related Diagnosis Except for brain and vertebral column 1998 9660576
4182 Creutzfeldt-Jakob disease Human Surgical types RF Diagnosis 2011 20547628
4169 Creutzfeldt-Jakob disease Human Occupational types RF Diagnosis 1999 10073510
297 Creutzfeldt-Jakob disease Human Occupational types Not Related Diagnosis 1998 9660576
4171 Creutzfeldt-Jakob disease Human Occupational types RF Diagnosis 1999 10073510
4168 Creutzfeldt-Jakob disease Human Occupational types RF Diagnosis 2009 19144172
4173 Creutzfeldt-Jakob disease Human Occupational types RF Diagnosis 1999 10073510
4170 Creutzfeldt-Jakob disease Human Occupational types RF Diagnosis 1999 10073510
4172 Creutzfeldt-Jakob disease Human Occupational types RF Diagnosis 1999 10073510
2939 Creutzfeldt-Jakob disease Human APOE RF ε4 allele 1994 7968026
2315 Creutzfeldt-Jakob disease Human APOE RF ε4 allele 1994 7968026
2606 Creutzfeldt-Jakob disease Human APOE RF ε4 allele 1994 7968026
729 Creutzfeldt-Jakob disease Human CALHM1 PF 2012 22874670
2544 Creutzfeldt-Jakob disease Human CALHM1 RF Genotype:GG 2012 22874670
3670 Creutzfeldt-Jakob disease Human Cerebroside sulfotransferase (GAL3ST1) RF 2020 32565065
2595 Creutzfeldt-Jakob disease Human CHN2 RF 2012 22210626
3122 Creutzfeldt-Jakob disease Human CTSD RF Genotype:CT 2008 18426579
2424 Creutzfeldt-Jakob disease Human CTSD RF Genotype:CC 2008 18426579
1923 Creutzfeldt-Jakob disease Human GAL3ST1 RF 2020 32949544
3004 Creutzfeldt-Jakob disease Human PRNP RF Diagnosis 2021 34831353
2166 Creutzfeldt-Jakob disease Human PRNP RF BACE1?C-allele carriers 2012 22952813
3316 Creutzfeldt-Jakob disease Human PRNP RF Codon 129: Val homozygosity 1996 8707291
3794 Creutzfeldt-Jakob disease Human PRNP RF Diagnosis 2021 33917419
2405 Creutzfeldt-Jakob disease Human PRNP RF BACE1?C-allele carriers 2012 22952813
2918 Creutzfeldt-Jakob disease Human PRNP RF 2009 19081515
3793 Creutzfeldt-Jakob disease Human PRNP RF Diagnosis 2021 33917419
2484 Creutzfeldt-Jakob disease Human PRNP RF 2012 22210626
2882 Creutzfeldt-Jakob disease Human PRNP RF 2009 19081515
2974 Creutzfeldt-Jakob disease Human PRNP RF APOE?ε4 carriers 2011 21799773
1964 Creutzfeldt-Jakob disease Human PRNP RF 2020 32949544
1917 Creutzfeldt-Jakob disease Human STX6(Syntaxin-6) RF 2020 32949544
2866 Creutzfeldt-Jakob disease Human Dementia in family RF 1988 3066847
2664 Creutzfeldt-Jakob disease Human Zoster RF Zoster in adult life 1988 3066847
2706 Creutzfeldt-Jakob disease Human Duration (years) lived or worked on farm or market garden RF 10-19 years 1999 10073510
2714 Creutzfeldt-Jakob disease Human Duration (years) lived or worked on farm or market garden RF >=20 years 1999 10073510
1423 Creutzfeldt-Jakob disease Human Frequent exposure RF frequent exposure to leather products 1998 9660576
1431 Creutzfeldt-Jakob disease Human Frequent exposure RF exposure to fertiliser consisting of hoofs and horns 1998 9660576
4174 Creutzfeldt-Jakob disease Human Occupational exposure RF Diagnosis 1998 9660576
4175 Creutzfeldt-Jakob disease Human Occupational exposure RF Diagnosis 1998 9660576
3117 Creutzfeldt-Jakob disease Human Occupational Exposure RF occupational exposure to animal laboratory 2009 19144172
3687 Creutzfeldt-Jakob disease Human Physicians RF 2020 32687038
2653 Creutzfeldt-Jakob disease Human Residence or employment RF Live or employed in farms 1999 10073510
1766 Creutzfeldt-Jakob disease Human hGH(human cadaver-sourced growth hormone) treatment RF Proportion of doses risk category 1 (batches 1, 2, 3, 4, 7, 21, 26) 2018 30045957
1637 Creutzfeldt-Jakob disease Human hGH(human cadaver-sourced growth hormone) treatment RF 2018 30045957
1758 Creutzfeldt-Jakob disease Human hGH(human cadaver-sourced growth hormone) treatment RF Proportion of doses risk category 3 (batches 5, 6, 8, 9, 11, 14, 15, 16, 17, 19, 20, 22, 23, 25, 27) 2018 30045957
1728 Creutzfeldt-Jakob disease Human hGH(human cadaver-sourced growth hormone) treatment RF Proportion of doses risk category 2 (batches 10, 12, 13, 18, 24) 2018 30045957
3462 Creutzfeldt-Jakob disease Human human growth hormone extract RF received human growth hormone extract for various period of time (mean +/- SD, 2.9 years) 1996 8797466
2185 Creutzfeldt-Jakob disease Human Number of surgical procedures RF >=3 times 2002 12196646
2464 Creutzfeldt-Jakob disease Human Number of surgical procedures RF 2 times 2002 12196646
2314 Creutzfeldt-Jakob disease Human Number of surgical procedures RF 1 time 2002 12196646
2576 Creutzfeldt-Jakob disease Human regular medication RF 2009 19144172
321 Creutzfeldt-Jakob disease Human Organ transplantation Not Related Diagnosis Tanspant recipient 1999 10073510
320 Creutzfeldt-Jakob disease Human Dental treament Not Related Diagnosis 1999 10073510
318 Creutzfeldt-Jakob disease Human Dental treament Not Related Diagnosis 2007 17299423
2669 Creutzfeldt-Jakob disease Human Surgery RF predating clinical onset by 1 or more years 2008 18843192
2329 Creutzfeldt-Jakob disease Human Surgery RF undergo surgery 2008 18257690
4193 Creutzfeldt-Jakob disease Human Surgery RF Diagnosis 2002 12196646
325 Creutzfeldt-Jakob disease Human Surgery Not Related Diagnosis 2002 12196646
701 Creutzfeldt-Jakob disease Human Surgery PF undergo surgery;used proxy informants to acquire information about case subjects and control subjects (consistent ascertainment) 2008 18257690
2313 Creutzfeldt-Jakob disease Human Surgery RF Any surgery 2002 12196646
4189 Creutzfeldt-Jakob disease Human Surgery RF Diagnosis 2008 18843192
4195 Creutzfeldt-Jakob disease Human Surgery RF Diagnosis 2002 12196646
2668 Creutzfeldt-Jakob disease Human Surgery RF at a 1- to 9-year time lag 2008 18843192
4192 Creutzfeldt-Jakob disease Human Surgery RF Diagnosis 1999 10073510
2992 Creutzfeldt-Jakob disease Human Surgery RF orthopaedic surgery 2009 19144172
2117 Creutzfeldt-Jakob disease Human Surgery RF Gynecologic 2002 12196646
676 Creutzfeldt-Jakob disease Human Surgery PF Surgery at any time 1988 3066847
2241 Creutzfeldt-Jakob disease Human Surgery RF undergo surgery;proxy informants acted only on behalf of case subjects (inconsistent data ascertainment) 2008 18257690
2692 Creutzfeldt-Jakob disease Human Surgery RF ophthalmological surgery (> 1980) 2009 19144172
4194 Creutzfeldt-Jakob disease Human Surgery RF Diagnosis 2002 12196646
2856 Creutzfeldt-Jakob disease Human Surgery RF orthopaedic surgery (> 1980) 2009 19144172
528 Creutzfeldt-Jakob disease Human Surgery PF Tonsillectomy 2002 12196646
2174 Creutzfeldt-Jakob disease Human Surgery RF 2008 18843192
717 Creutzfeldt-Jakob disease Human Surgery PF undergo surgery 2008 18257690
4191 Creutzfeldt-Jakob disease Human Surgery RF Diagnosis 1999 10073510
2515 Creutzfeldt-Jakob disease Human Surgery RF 1999 10073510
675 Creutzfeldt-Jakob disease Human Surgery PF Appendectomy 2002 12196646
4188 Creutzfeldt-Jakob disease Human Medication RF Diagnosis 2009 19144172
4187 Creutzfeldt-Jakob disease Human GP visits RF Diagnosis 2009 19144172
4186 Creutzfeldt-Jakob disease Human Orthopaedic surgery RF Diagnosis 2009 19144172
4185 Creutzfeldt-Jakob disease Human Ophthalmological surgery RF Diagnosis 2009 19144172
4176 Creutzfeldt-Jakob disease Human Blood transfusion RF Diagnosis 2011 21214582
319 Creutzfeldt-Jakob disease Human Blood transfusion Not Related Diagnosis 1999 10073510
308 Creutzfeldt-Jakob disease Human Orthodontics Not Related Diagnosis 2012 23222357
307 Creutzfeldt-Jakob disease Human Haemostasis Not Related Diagnosis 2012 23222357
306 Creutzfeldt-Jakob disease Human Intravenous sedation Not Related Diagnosis 2012 23222357
305 Creutzfeldt-Jakob disease Human Surgical extractions Not Related Diagnosis 2012 23222357
304 Creutzfeldt-Jakob disease Human Periodontal treatment Not Related Diagnosis 2012 23222357
303 Creutzfeldt-Jakob disease Human Other minor oral surgery Not Related Diagnosis 2012 23222357
302 Creutzfeldt-Jakob disease Human Root canal treatment Not Related Diagnosis 2012 23222357
301 Creutzfeldt-Jakob disease Human Non-surgical extractions Not Related Diagnosis 2012 23222357
300 Creutzfeldt-Jakob disease Human Extensive fillings Not Related Diagnosis 2012 23222357
299 Creutzfeldt-Jakob disease Human Minimal fillings Not Related Diagnosis 2012 23222357
298 Creutzfeldt-Jakob disease Human Basic periodontal examination Not Related Diagnosis 2012 23222357
2812 Creutzfeldt-Jakob disease Human Dietary Risk RF Kielbasa 2014 24977122
2603 Creutzfeldt-Jakob disease Human Dietary Risk RF Pepperoni 2014 24977122
3079 Creutzfeldt-Jakob disease Human Dietary Risk RF Hot Dogs 2014 24977122
2739 Creutzfeldt-Jakob disease Human Dietary Risk RF “Other” Canned Meat 2014 24977122
1405 Creutzfeldt-Jakob disease Human Dietary Risk RF consumption of brain 1998 9660576
2398 Creutzfeldt-Jakob disease Human Dietary Risk RF kidneys,ever 2009 19144172
2959 Creutzfeldt-Jakob disease Human Dietary Risk RF Sausage 2014 24977122
1397 Creutzfeldt-Jakob disease Human Dietary Risk RF consumption of raw meat 1998 9660576
606 Creutzfeldt-Jakob disease Human Drinking PF Current alcohol 1988 3066847
2187 Creutzfeldt-Jakob disease Human Ear piercing RF females only 2002 12196646
4196 Creutzfeldt-Jakob disease Human Ear piercing RF Diagnosis 2002 12196646
2502 Creutzfeldt-Jakob disease Human Ferret contact RF 1988 3066847
2469 Creutzfeldt-Jakob disease Human Keeping cats RF 1988 3066847
2960 Creutzfeldt-Jakob disease Human Pets RF other than cats/dogs 1988 3066847
3059 Creutzfeldt-Jakob disease Human regular GP visits RF 2009 19144172
2658 Creutzfeldt-Jakob disease Human Psychiatric visit RF 2002 12196646
4197 Creutzfeldt-Jakob disease Human Psychiatric visit RF Diagnosis 2002 12196646
4167 Creutzfeldt-Jakob disease Human All stressful events RF Diagnosis All stressful life events were assessed and subsequently grouped into one of the following three subgroups: psychosocial stress events, medical operations with hospitalisation, and other serious medical examinations. 1999 10543352
4166 Creutzfeldt-Jakob disease Human Frequent travels abroad RF Diagnosis 2009 19144172
4165 Creutzfeldt-Jakob disease Human Brain RF Diagnosis 1998 9660576
4164 Creutzfeldt-Jakob disease Human Raw meat RF Diagnosis 1998 9660576
293 Creutzfeldt-Jakob disease Human Lamb Not Related Diagnosis 1998 9660576
292 Creutzfeldt-Jakob disease Human Veal Not Related Diagnosis 1998 9660576
4161 Creutzfeldt-Jakob disease Human Meat pies RF Diagnosis 2006 16287153
4160 Creutzfeldt-Jakob disease Human Burgers RF Diagnosis 2006 16287153
4158 Creutzfeldt-Jakob disease Human Kidneys RF Diagnosis 2009 19144172
4157 Creutzfeldt-Jakob disease Human Beef Internal Organ Tissue RF Diagnosis 2014 24977122
4156 Creutzfeldt-Jakob disease Human Beef Stomach/Intestine RF Diagnosis 2014 24977122
4155 Creutzfeldt-Jakob disease Human Bologna RF Diagnosis 2014 24977122
4154 Creutzfeldt-Jakob disease Human Kielbasa RF Diagnosis 2014 24977122
4153 Creutzfeldt-Jakob disease Human Pepperoni RF Diagnosis 2014 24977122
4150 Creutzfeldt-Jakob disease Human Salami RF Diagnosis 2014 24977122
4149 Creutzfeldt-Jakob disease Human Hot dog RF Diagnosis 2014 24977122
4163 Creutzfeldt-Jakob disease Human Chicken RF Diagnosis 2006 16287153
4162 Creutzfeldt-Jakob disease Human Chicken RF Diagnosis 2006 16287153
295 Creutzfeldt-Jakob disease Human Cheese Not Related Diagnosis 1998 9660576
4151 Creutzfeldt-Jakob disease Human Sausage RF Diagnosis 2014 24977122
4152 Creutzfeldt-Jakob disease Human Sausage RF Diagnosis 2014 24977122
294 Creutzfeldt-Jakob disease Human Pork Not Related Diagnosis 1998 9660576
291 Creutzfeldt-Jakob disease Human Beef Not Related Diagnosis 1998 9660576
4159 Creutzfeldt-Jakob disease Human Beef RF Diagnosis 2006 16287153
296 Creutzfeldt-Jakob disease Human Milk Not Related Diagnosis 1998 9660576
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