Frontotemporal Dementia

The frontotemporal dementias (FTD) encompass six types of dementia involving the frontal or temporal lobes. They are: behavioral variant of FTD, semantic variant primary progressive aphasia, nonfluent agrammatic variant primary progressive aphasia, corticobasal syndrome, progressive supranuclear palsy, and FTD associated with motor neuron disease.[1]

One variant is the clinical presentation of frontotemporal lobar degeneration, which is characterized by progressive neuronal loss predominantly involving the frontal or temporal lobes, and typical loss of over 70% of spindle neurons, while other neuron types remain intact.[2]Common signs and symptoms include significant changes in social and personal behavior, apathy, blunting of emotions, and deficits in both expressive and receptive language. Currently, there is no cure for FTD, but there are treatments that help alleviate symptoms.


[1]Finger, EC (April 2016). "Frontotemporal Dementias". Continuum (Minneapolis, Minn.). 22 (2 Dementia): 464–89. doi:10.1212/CON.0000000000000300. PMC 5390934. PMID 27042904.
[2]"Brain Cells for Socializing". Smithsonian. Retrieved 30 October 2015.

The search result for the NDD Category "Frontotemporal Dementia"
A total of 58 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Phase Condition Year PMID
3907 Frontotemporal Dementia Human heart health RF Diagnosis 2022 35767471
2697 Frontotemporal Dementia Human APOE RF 2006 15904995
825 Frontotemporal Dementia Human APOE PF 2002 12107813
3193 Frontotemporal Dementia Human APOE RF 2017 28888721
2754 Frontotemporal Dementia Human APOE RF 2013 23887281
3186 Frontotemporal Dementia Human APOE RF 2013 23887281
521 Frontotemporal Dementia Human APOE PF 2006 15904995
826 Frontotemporal Dementia Human APOE PF 2017 28888721
3797 Frontotemporal Dementia Human APOE?4 RF Diagnosis in the C9orf72 noncarriers 2021 32972771
3202 Frontotemporal Dementia Human ATXN2 RF ATXN2 intermediary polyQ expansions 2014 25098532
2778 Amyotrophic lateral sclerosis with frontotemporal dementia Human ATXN2 RF Diagnosis 2022 35521889
2700 Frontotemporal Dementia Human ATXN2 RF Diagnosis 2022 35521889
1489 Frontotemporal Dementia Human GRN RF Diagnosis 2021 32972771
3285 Frontotemporal Dementia Human MAPT RF a rare microtubule-associated protein tau (MAPT) sequence variant, c.454G>A (p.A152T) 2013 23518664
2782 Frontotemporal Dementia Human MAPT RF 2012 22556362
2746 Frontotemporal Dementia Human MAPT H2 haplotype RF APOE e4 negatives 2006 16410051
2332 Frontotemporal Dementia Human MAPT H2 haplotype RF 2006 16410051
2437 Frontotemporal Dementia Human MAPT H2H3 genetype RF APOE e4 negatives 2006 16410051
837 Frontotemporal Dementia Human TMEM106B PF C9ORF72 expansion carriers;Cohort 1 – controls and C9ORF72 repeat expansion carriers (FTD, FTD/MND, and MND, or other diagnosis) 2014 24385136
836 Frontotemporal Dementia Human TMEM106B PF C9ORF72 expansion carriers;Cohort 1 – controls and C9ORF72 repeat expansion carriers (FTD, FTD/MND, and MND, or other diagnosis) 2014 24385136
1488 Frontotemporal Dementia Human TP53 RF Diagnosis 2021 32972771
3361 Frontotemporal Dementia Human TREM2 RF 2018 29557178
3011 Frontotemporal Dementia Human TREM2 RF 2013 23800361
1631 Frontotemporal Dementia Human first-degree relatives RF First-degree relatives(parents) 1998 9633692
3119 Frontotemporal Dementia Human tau haplotype in combination with apoE epsilon4 RF between genotypes with tau alleles A0 or A1 only (A3-) and apoE genotypes with at least one ε4 allele (ε4?) 2001 11303757
3652 Frontotemporal Dementia Human the H1 haplotype of the tau gene and the E2 allele of APOE RF 2002 12056929
3552 Frontotemporal Dementia Human apo(a) low molecular weight (MW RF 2003 14665416
3631 Frontotemporal Dementia Human SORT1(the neuronal receptor for granulin) RF 2018 29555433
3795 Frontotemporal Dementia Human female sex RF Prognosis 2021 34921446
3796 Frontotemporal Dementia Human age of onset RF Prognosis 2021 34921446
3906 Frontotemporal Dementia Human cardiovascular disease (CVD) RF Diagnosis 2022 35767471
2993 Frontotemporal Dementia Human Diabetes RF 2014 24995127
567 Frontotemporal Dementia Human heart disease PF 2012 22465176
2931 Frontotemporal Dementia Human exposure to Aluminum RF 2020 33138082
2708 Frontotemporal Dementia Human Overall solvents and dyes RF 2020 33138082
3102 Frontotemporal Dementia Human Excluding specific neuroprotective supplements RF after onset of disease 2020 33138082
2824 Frontotemporal Dementia Human Head injury RF 2003 14617722
2842 Frontotemporal Dementia Human head trauma RF 2020 33138082
2961 Frontotemporal Dementia Human traumatic brain injury (TBI) RF 2012 22465176
2806 Frontotemporal Dementia Human traumatic brain injury (TBI) RF 2017 28946566
1483 Frontotemporal Dementia Human traumatic brain injury (TBI) RF 2015 25982564
2809 Frontotemporal Dementia Human Pesticides RF Insecticides,Herbicides,Fungicides 2020 33138082
508 Frontotemporal Dementia Human Alcohol consumption PF in current alcohol consumers 2017 28946566
531 Frontotemporal Dementia Human Alcohol consumption PF 2017 28946566
3083 Frontotemporal Dementia Human Use of dietary supplements containing selenium RF 2020 33138082
3905 Frontotemporal Dementia Human Education level RF Diagnosis 2022 35767471
2954 Frontotemporal Dementia Human cycling RF 2020 33138082
2673 Frontotemporal Dementia Human football RF 2020 33138082
545 Frontotemporal Dementia Human Playing sports PF 2020 33138082
1615 Frontotemporal Dementia Human loneliness RF Diagnosis 2023 36482759
2676 Frontotemporal Dementia Human Obesity RF 2019 30792733
2015 Frontotemporal Dementia Human Smoking RF Ever smoking 2020 33138082
1956 Frontotemporal Dementia Human Smoking RF Passive smoking exposure 2020 33138082
327 Frontotemporal Dementia Human Smoking Not Related Diagnosis 2017 28946566
326 Frontotemporal Dementia Human Coffee Not Related Diagnosis 2017 28946566
1121 Frontotemporal Dementia Human Alcohol status PF Diagnosis 2017 28946566
1120 Frontotemporal Dementia Human Alcohol PF Diagnosis 2017 28946566
1122 Frontotemporal Dementia Human Alcohol PF Diagnosis 2017 28946566
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