Frontotemporal Dementia

The frontotemporal dementias (FTD) encompass six types of dementia involving the frontal or temporal lobes. They are: behavioral variant of FTD, semantic variant primary progressive aphasia, nonfluent agrammatic variant primary progressive aphasia, corticobasal syndrome, progressive supranuclear palsy, and FTD associated with motor neuron disease.[1]

One variant is the clinical presentation of frontotemporal lobar degeneration, which is characterized by progressive neuronal loss predominantly involving the frontal or temporal lobes, and typical loss of over 70% of spindle neurons, while other neuron types remain intact.[2]Common signs and symptoms include significant changes in social and personal behavior, apathy, blunting of emotions, and deficits in both expressive and receptive language. Currently, there is no cure for FTD, but there are treatments that help alleviate symptoms.


[1]Finger, EC (April 2016). "Frontotemporal Dementias". Continuum (Minneapolis, Minn.). 22 (2 Dementia): 464–89. doi:10.1212/CON.0000000000000300. PMC 5390934. PMID 27042904.
[2]"Brain Cells for Socializing". Smithsonian. Retrieved 30 October 2015.

The search result for the NDD Category "Frontotemporal Dementia"
A total of 44 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Condition PMID
15 Frontotemporal Dementia human APOE RF 23887281
15 Frontotemporal Dementia human APOE PF 12107813
15 Frontotemporal Dementia human APOE PF 15904995
15 Frontotemporal Dementia human APOE RF 15904995
15 Frontotemporal Dementia human APOE RF 28888721
15 Frontotemporal Dementia human APOE PF 28888721
15 Frontotemporal Dementia human APOE RF 23887281
33 Frontotemporal Dementia human ATXN2 RF ATXN2 intermediary polyQ expansions 25098532
173 Frontotemporal Dementia human MAPT RF a rare microtubule-associated protein tau (MAPT) sequence variant, c.454G>A (p.A152T) 23518664
173 Frontotemporal Dementia human MAPT RF 22556362
175 Frontotemporal Dementia human MAPT H2 haplotype RF APOE e4 negatives 16410051
175 Frontotemporal Dementia human MAPT H2 haplotype RF 16410051
176 Frontotemporal Dementia human MAPT H2H3 genetype RF APOE e4 negatives 16410051
287 Frontotemporal Dementia human TMEM106B PF C9ORF72 expansion carriers;Cohort 1 – controls and C9ORF72 repeat expansion carriers (FTD, FTD/MND, and MND, or other diagnosis) 24385136
287 Frontotemporal Dementia human TMEM106B PF C9ORF72 expansion carriers;Cohort 1 – controls and C9ORF72 repeat expansion carriers (FTD, FTD/MND, and MND, or other diagnosis) 24385136
293 Frontotemporal Dementia human TREM2 RF 29557178
293 Frontotemporal Dementia human TREM2 RF 23800361
333 Frontotemporal Dementia human alcohol consumption PF 28946566
333 Frontotemporal Dementia human alcohol consumption PF in current alcohol consumers 28946566
401 Frontotemporal Dementia human Diabetes RF 24995127
464 Frontotemporal Dementia human first-degree relatives RF First-degree relatives(parents) 9633692
478 Frontotemporal Dementia human head injury RF 14617722
480 Frontotemporal Dementia human heart disease PF 22465176
315 Frontotemporal Dementia human obesity RF 30792733
678 Frontotemporal Dementia human traumatic brain injury (TBI) RF 28946566
678 Frontotemporal Dementia human traumatic brain injury (TBI) RF 25982564
678 Frontotemporal Dementia human traumatic brain injury (TBI) RF 22465176
725 Frontotemporal Dementia human apo(a) low molecular weight (MW RF 14665416
838 Frontotemporal Dementia human SORT1(the neuronal receptor for granulin) RF 29555433
883 Frontotemporal Dementia Human the H1 haplotype of the tau gene and the E2 allele of APOE RF 12056929
884 Frontotemporal Dementia Human tau haplotype in combination with apoE epsilon4 RF between genotypes with tau alleles A0 or A1 only (A3-) and apoE genotypes with at least one ε4 allele (ε4?) 11303757
122 Frontotemporal dementia human GRN RF in CC homozygous patients 32946420
918 Frontotemporal dementia human TP53 RF 33138082
980 Frontotemporal dementia human exposure to Aluminum RF 33138082
981 Frontotemporal dementia human pesticides RF Insecticides,Herbicides,Fungicides 33138082
982 Frontotemporal dementia human Overall solvents and dyes RF 33138082
952 Frontotemporal dementia human Head trauma RF 33138082
983 Frontotemporal dementia human Playing sports PF 33138082
984 Frontotemporal dementia human football RF 33138082
985 Frontotemporal dementia human cycling RF 33138082
986 Frontotemporal dementia human Use of dietary supplements containing selenium RF 33138082
987 Frontotemporal dementia human Excluding specific neuroprotective supplements RF after onset of disease 33138082
652 Frontotemporal dementia human smoking RF Ever smoking 33138082
652 Frontotemporal dementia human smoking RF Passive smoking exposure 33138082