| RF_ID |
Disease Name |
2ndClass |
3rdClass |
4thClass |
Species |
RF_Name |
Association |
Condition |
PMID |
| 1890 |
Amyotrophic Lateral Sclerosis |
Medical methods |
Medicines |
lipid-lowering drugs |
Human |
HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase (HMGCR) inhibitors |
RF |
|
37688479 |
| 902 |
Alzheimer's Disease |
Medical methods |
Medicines |
Antidiabetic |
Human |
Glucagon-like peptide 1 (GLP-1) agonists |
PF |
|
35128745 |
| 442 |
Alzheimer's Disease |
Medical methods |
Medicines |
Antidiabetic |
Human |
metformin |
PF |
Type 2 diabetes mellitus (T2DM) |
36109050 |
| 2528 |
Parkinson disease |
Medical methods |
Medicines |
anticholinergic drugs |
Human |
anticholinergic drugs |
RF |
|
37357543 |
| 1468 |
Parkinson disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
antidepressants |
RF |
|
35748105 |
| 919 |
Parkinson disease |
Medical methods |
Medicines |
targeted medicine |
Human |
LRRK2 inhibition |
PF |
|
35675433 |
| 1458 |
Alzheimer's Disease |
Medical methods |
Medicines |
Antidiabetic |
Human |
insulin |
RF |
Type 2 diabetes mellitus (T2DM) |
37095270 |
| 1465 |
Alzheimer's Disease |
Medical methods |
Medicines |
Antidiabetic |
Human |
Pioglitazone |
RF |
Type 2 diabetes mellitus (T2DM) |
37095270 |
| 1459 |
Parkinson disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
anxiolytics |
RF |
|
35748105 |
| 484 |
Alzheimer's Disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
anxiolytics |
PF |
|
35196953 |
| 1831 |
Alzheimer's Disease |
Medical methods |
Medicines |
Antihypertensive |
Human |
hypertension medication |
RF |
|
35196953 |
| 1836 |
Alzheimer's Disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
antipsychotics |
RF |
|
35196953 |
| 1779 |
Alzheimer's Disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Muscle relaxant |
RF |
|
36641664 |
| 1778 |
Alzheimer's Disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Muscle relaxant |
RF |
|
36641664 |
| 1775 |
Alzheimer's Disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Muscle relaxant |
RF |
|
36641664 |
| 1446 |
Tuberous sclerosis complex |
Medical methods |
Medicines |
|
Human |
administration of multiple antiepileptic drugs |
RF |
|
20113608 |
| 761 |
Amyotrophic Lateral Sclerosis |
Medical methods |
Medicines |
Antidiabetic |
Human |
antidiabetics |
PF |
|
32097525 |
| 551 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
anti-histamines |
PF |
|
34494887 |
| 1776 |
Alzheimer's Disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
benzodiazepine and related drug (BZDR) |
RF |
|
29851063 |
| 2474 |
Progressive Supranuclear Palsy |
Medical methods |
Medicines |
|
Human |
beta-blocker use |
RF |
|
31420308 |
| 3399 |
Parkinson disease |
Medical methods |
Medicines |
|
rat |
cinnarizine(a calcium antagonist that produces human parkinsonism) |
RF |
(a calcium antagonist that produces human parkinsonism) |
15993444 |
| 870 |
Alzheimer's Disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
mice |
dexibuprofen (DXI) |
PF |
|
34294142 |
| 401 |
Parkinson disease |
Medical methods |
Medicines |
Antidiabetic |
Human |
Dipeptidyl peptidase-4 (DPP4) inhibitors |
PF |
|
33895825 |
| 397 |
Parkinson disease |
Medical methods |
Medicines |
Antidiabetic |
Human |
Dipeptidyl peptidase-4 (DPP4) inhibitors |
PF |
in diabetic patients |
38110464 |
| 1884 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
duration of exposure to levodopa |
RF |
|
23836370 |
| 1885 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
duration of exposure to levodopa |
RF |
|
23836370 |
| 819 |
Amyotrophic Lateral Sclerosis |
Medical methods |
Medicines |
|
Human |
Duration of OCP(oral contraceptive) use (per year) |
PF |
female |
28835399 |
| 519 |
Alzheimer's Disease |
Medical methods |
Medicines |
|
Human |
Estrogen-replacement therapy |
PF |
postmenopausal women |
9566385 |
| 3102 |
Frontotemporal Dementia |
Medical methods |
Medicines |
|
Human |
Excluding specific neuroprotective supplements |
RF |
after onset of disease |
33138082 |
| 2611 |
Multiple System Atrophy |
Medical methods |
Medicines |
|
Human |
Herbal medications |
RF |
|
20623770 |
| 1802 |
Multiple System Atrophy |
Medical methods |
Medicines |
|
Human |
Herbal medications |
RF |
|
20623770 |
| 514 |
Amyotrophic Lateral Sclerosis |
Medical methods |
Medicines |
|
Human |
Immunosuppressive drugs |
PF |
|
25059395 |
| 2733 |
Alzheimer's Disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
inappropriate use anti-dementia drugs |
RF |
|
32251456 |
| 2155 |
Alzheimer's Disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
irregular medication use anti-dementia drugs |
RF |
|
32251456 |
| 1882 |
Parkinson disease |
Medical methods |
Medicines |
Antihypertensive |
Human |
metoprolol |
RF |
|
34598055 |
| 3889 |
Tuberous sclerosis complex |
Medical methods |
Medicines |
|
Human |
multiple antiepileptic drugs |
RF |
|
33225634 |
| 566 |
Alzheimer's Disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
no chronic use of nonsteroidal anti-inflammatory drugs |
PF |
|
18446027 |
| 392 |
Alzheimer's Disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Non-aspirin NSAIDS |
PF |
|
33435977 |
| 373 |
Parkinson disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Non-aspirin NSAIDS |
PF |
|
33435977 |
| 400 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
non-hydroxychloroquine immunosuppressant therapy |
PF |
Sj?gren syndrome (SS) |
30946325 |
| 702 |
Amyotrophic Lateral Sclerosis |
Medical methods |
Medicines |
contraceptive pills |
Human |
OCP(oral contraceptive) |
PF |
female |
28835399 |
| 2930 |
Amyotrophic Lateral Sclerosis |
Medical methods |
Medicines |
contraceptive pills |
Human |
OCP(oral contraceptive) |
RF |
postmenopausal |
37493444 |
| 1777 |
Parkinson disease |
Medical methods |
Medicines |
Gastrointestinal drugs |
Human |
Proton pump inhibitors (PPIs) |
RF |
1-year lag period was applied between PPI exposure and PD development |
38096177 |
| 3499 |
Alzheimer's Disease |
Medical methods |
Medicines |
Gastrointestinal drugs |
Human |
Proton pump inhibitors (PPIs) |
RF |
Chronic consumption of PPIs |
20456731 |
| 469 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Statin therapy |
PF |
|
32753051 |
| 2478 |
Parkinson disease |
Medical methods |
Medicines |
Statin |
Human |
statin use |
RF |
|
34347020 |
| 897 |
Parkinson disease |
Medical methods |
Medicines |
Statin |
Human |
statin use |
PF |
|
34275907 |
| 817 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
statin use |
PF |
|
33804752 |
| 398 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
statin use |
PF |
|
20533968 |
| 735 |
Multiple System Atrophy |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) |
PF |
|
31661696 |
| 766 |
Multiple System Atrophy |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) |
PF |
Cumulative doses were used to divide observations into tertiles creating 3 groups of equal size (T1–3) based on the consumption in defined daily dose(DDD) with T1 representing the group with the lowest use and T3 the highest. |
31661696 |
| 645 |
Multiple System Atrophy |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) |
PF |
Cumulative doses were used to divide observations into tertiles creating 3 groups of equal size (T1–3) based on the consumption in DDDs with T1 representing the group with the lowest use and T3 the highest. |
31661696 |
| 583 |
Amyotrophic Lateral Sclerosis |
Medical methods |
Medicines |
Statin |
Human |
Use of statins |
PF |
|
25059395 |
| 1993 |
Amyotrophic Lateral Sclerosis |
Medical methods |
Medicines |
Statin |
Human |
Use of statins |
RF |
|
32097525 |
| 803 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
β-agonists |
PF |
|
34598055 |
| 1940 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
β-antagonists |
RF |
|
34598055 |
| 361 |
Progressive Supranuclear Palsy |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Non-steroidal anti-inflammatory drug (except
aspirin) |
Not Related |
|
19864660 |
| 539 |
Parkinson disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Aspirin |
PF |
|
34494887 |
| 360 |
Progressive Supranuclear Palsy |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Aspirin |
Not Related |
|
19864660 |
| 1125 |
Multiple System Atrophy |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Aspirin |
PF |
|
18307243 |
| 359 |
Progressive Supranuclear Palsy |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Anti-inflammatory agent |
Not Related |
|
19864660 |
| 1325 |
Parkinson disease |
Medical methods |
Medicines |
Asthma drugs |
Human |
β2-agonists |
PF |
|
30311974 |
| 1324 |
Parkinson disease |
Medical methods |
Medicines |
Asthma drugs |
Human |
β2-agonists |
PF |
|
30311974 |
| 1323 |
Parkinson disease |
Medical methods |
Medicines |
Asthma drugs |
Human |
β2-agonists |
PF |
|
30311974 |
| 4372 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
Propranolol |
RF |
|
30311974 |
| 2237 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
Propranolol |
RF |
|
34598055 |
| 4373 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
Propranolol |
RF |
|
30311974 |
| 1321 |
Parkinson disease |
Medical methods |
Medicines |
Antidiabetic |
Human |
Glitazone(GTZ) |
PF |
People with diabetes |
28861893 |
| 4370 |
Parkinson disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
Methamphetamine/amphetamine abuse |
RF |
(ICD-9-CM 304.4, 305.7, 969.7, E854.2) |
25479916 |
| 4369 |
Parkinson disease |
Medical methods |
Medicines |
hypnagogue |
Human |
Zolpidem |
RF |
Zolpidem use in patients with sleep disturbance |
25124550 |
| 4368 |
Parkinson disease |
Medical methods |
Medicines |
hypnagogue |
Human |
Zolpidem |
RF |
Zolpidem use in patients with sleep disturbance |
25124550 |
| 1320 |
Parkinson disease |
Medical methods |
Medicines |
Antihypertensive |
Human |
ARBs(angiotensin receptor blockers) |
PF |
Antihypertensive agents |
24910980 |
| 1319 |
Parkinson disease |
Medical methods |
Medicines |
Antihypertensive |
Human |
ACEIs(angiotensin converting enzyme inhibitors) |
PF |
Antihypertensive agents |
24910980 |
| 1318 |
Parkinson disease |
Medical methods |
Medicines |
Antihypertensive |
Human |
CCB(calcium channel blockers) |
PF |
Antihypertensive agents ;Centrally-acting dihydropyridine CCB use |
24910980 |
| 4367 |
Parkinson disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
Benzamides |
RF |
Neuroleptics |
23019267 |
| 4366 |
Parkinson disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
Phenothiazines |
RF |
Neuroleptics |
23019267 |
| 4365 |
Parkinson disease |
Medical methods |
Medicines |
Neuroleptics |
Human |
Neuroleptics |
RF |
All Neuroleptics |
23019267 |
| 4363 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
Polypharmacy |
RF |
|
21951955 |
| 4362 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
Polypharmacy |
RF |
|
21951955 |
| 2131 |
Alzheimer's Disease |
Medical methods |
Medicines |
|
Human |
Polypharmacy |
RF |
|
32251456 |
| 4364 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
Polypharmacy |
RF |
|
21951955 |
| 4361 |
Parkinson disease |
Medical methods |
Medicines |
|
Human |
Polypharmacy |
RF |
|
21951955 |
| 1315 |
Parkinson disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
Ibuprofen |
PF |
There was a dose-response relationship between tablets of ibuprofen taken per week and PD risk (p trend = 0.01). |
21368281 |
| 1313 |
Parkinson disease |
Medical methods |
Medicines |
Antihypertensive |
Human |
L-type calcium channel blockers |
PF |
|
20437557 |
| 1312 |
Parkinson disease |
Medical methods |
Medicines |
Antihypertensive |
Human |
Antihypertensives(Calcium channel blockers) |
PF |
|
18256367 |
| 4188 |
Creutzfeldt-Jakob disease |
Medical methods |
Medicines |
|
Human |
Medication |
RF |
|
19144172 |
| 1076 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Atorvastatin |
PF |
|
15974900 |
| 68 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Simvastatin |
Not Related |
|
21795660 |
| 343 |
Parkinson disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
NSAIDs |
Not Related |
|
17851257 |
| 66 |
Alzheimer's Disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
NSAIDs |
Not Related |
|
18519870 |
| 67 |
Alzheimer's Disease |
Medical methods |
Medicines |
Analgesic and anti-inflammatory drugs |
Human |
NSAIDs |
Not Related |
|
10192221 |
| 1788 |
Parkinson disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
RF |
hyperlipidemia |
35276584 |
| 1774 |
Parkinson disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
RF |
hyperlipidemia |
35276584 |
| 378 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
|
33435977 |
| 1079 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
|
20533968 |
| 1317 |
Parkinson disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
Statin treatment |
24304212 |
| 1314 |
Parkinson disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
Short-term (
| 20629142 |
|
| 1078 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
|
18931004 |
| 1075 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
|
25408208 |
| 1316 |
Parkinson disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
|
22410446 |
| 1080 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
|
19595865 |
| 384 |
Parkinson disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
|
33435977 |
| 1077 |
Alzheimer's Disease |
Medical methods |
Medicines |
Statin |
Human |
Statin |
PF |
|
14739574 |