Motor Neuron Disease

Motor Neuron Disease(MND), also known as Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease, is a specific disease that causes the death of neurons controlling voluntary muscles.[4][9]

ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.[2] It may begin with weakness in the arms or legs, or with difficulty speaking or swallowing.[10] About half of the people affected develop at least mild difficulties with thinking and behavior and most people experience pain.[11][12] Most eventually lose the ability to walk, use their hands, speak, swallow, and breathe.[5]


[4]"Amyotrophic Lateral Sclerosis (ALS) Fact Sheet". National Institute of Neurological Disorders and Stroke. 19 September 2014. Archived from the original on 5 January 2017. Retrieved 2 January 2015.
[9]"Motor neurone disease". NHS Choices. Archived from the original on 29 December 2014. Retrieved 2 January 2015.
[2]"Motor Neuron Diseases Fact Sheet". National Institute of Neurological Disorders and Stroke. Archived from the original on 13 April 2014. Retrieved 7 November 2010.
[10]Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH (October 2017). "Amyotrophic lateral sclerosis". Nature Reviews. Disease Primers. 3 (17071): 17071. doi:10.1038/nrdp.2017.71. PMID 28980624.
[11]van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, van den Berg LH (November 2017). "Amyotrophic lateral sclerosis". Lancet. 390 (10107): 2084–2098. doi:10.1016/S0140-6736(17)31287-4. PMID 28552366.
[12]Chiò A, Mora G, Lauria G (February 2017). "Pain in amyotrophic lateral sclerosis". The Lancet. Neurology. 16 (2): 144–57. arXiv:1607.02870. doi:10.1016/S1474-4422(16)30358-1. PMID 27964824.
[5]Hobson EV, McDermott CJ (September 2016). "Supportive and symptomatic management of amyotrophic lateral sclerosis". Nature Reviews. Neurology. 12 (9): 526–38. doi:10.1038/nrneurol.2016.111. PMID 27514291.

The search result for the NDD Category "Motor Neuron Disease"
A total of 33 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Phase Condition Year PMID
2854 Motor Neuron Disease Human cleaning products RF Diagnosis 2022 35318275
3121 Motor Neuron Disease Human disinfectants RF Diagnosis 2022 35318275
2629 Motor Neuron Disease Human textile fibres RF Diagnosis 2022 35318275
2547 Motor Neuron Disease Human petrol/diesel fuel RF Diagnosis 2022 35318275
3025 Motor Neuron Disease Human methyl bromide RF Diagnosis 2022 35318275
2911 Motor Neuron Disease Human Fumigants RF Diagnosis 2022 35318275
3296 Motor Neuron Disease Human NEFH RF Genotype: SS 2004 14722583
3819 Motor Neuron Disease Human cyanide metabolites, nutritional deficiencies, psycho-emotional and geo-environmental factors RF Diagnosis 2021 33964344
1428 Motor Neuron Disease Human number of children RF number of children:3 1991 1745327
2655 Motor Neuron Disease Human manual occupation RF 1993 8229031
2197 Motor Neuron Disease Human Occupation RF Work as farmers and breeders 1991 1745327
3041 Motor Neuron Disease Human Occupational Exposure RF occupational exposure to lead 1993 8229031
2825 Motor Neuron Disease Human Occupational Exposure RF occupational exposure to solvents/chemicals 1993 8229031
2382 Motor Neuron Disease Human Solvent exposure RF Diagnosis 2022 35318275
1432 Motor Neuron Disease Human Age at menarche RF Age at menarche: >=16 1991 1745327
1441 Motor Neuron Disease Human Age at natural menopause RF Age at natural menopause: <=44 1991 1745327
1434 Motor Neuron Disease Human Age at natural menopause RF Age at natural menopause: 45-49 1991 1745327
2192 Motor Neuron Disease Human Mechanical injuries RF Site: Lower limbs 1991 1745327
2827 Motor Neuron Disease Human Mechanical injuries RF Site: Trunk 1991 1745327
2879 Motor Neuron Disease Human Mechanical injuries RF Site: Column 1991 1745327
2196 Motor Neuron Disease Human Mechanical injuries RF All sites 1991 1745327
2662 Motor Neuron Disease Human Mechanical injuries RF Site: Upper limbs 1991 1745327
2989 Motor Neuron Disease Human Fungicides RF Diagnosis 2022 35318275
2820 Motor Neuron Disease Human Insecticides RF Diagnosis 2022 35318275
2802 Motor Neuron Disease Human Insecticides RF Diagnosis 2022 35318275
3060 Motor Neuron Disease Human Insecticides RF Diagnosis 2022 35318275
3610 Motor Neuron Disease Human Manganese RF excess intake of manganese from food 1994 8029710
3567 Motor Neuron Disease horse Copper RF 2006 16426221
2271 Motor Neuron Disease Human Pesticides RF Diagnosis 2022 35318275
386 Motor Neuron Disease Human Obesity PF BMI>=30 2012 22559076
1346 Motor Neuron Disease Human Smoking RF Ever smokers 2012 22559076
3608 Motor Neuron Disease Human magnesium RF low intake of magnesium from drinking water 1994 8029710
3638 Motor Neuron Disease horse Vitamin E RF 2006 16426221
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