Motor Neuron Disease

Motor Neuron Disease(MND), also known as Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease, is a specific disease that causes the death of neurons controlling voluntary muscles.[4][9]

ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size.[2] It may begin with weakness in the arms or legs, or with difficulty speaking or swallowing.[10] About half of the people affected develop at least mild difficulties with thinking and behavior and most people experience pain.[11][12] Most eventually lose the ability to walk, use their hands, speak, swallow, and breathe.[5]


[4]"Amyotrophic Lateral Sclerosis (ALS) Fact Sheet". National Institute of Neurological Disorders and Stroke. 19 September 2014. Archived from the original on 5 January 2017. Retrieved 2 January 2015.
[9]"Motor neurone disease". NHS Choices. Archived from the original on 29 December 2014. Retrieved 2 January 2015.
[2]"Motor Neuron Diseases Fact Sheet". National Institute of Neurological Disorders and Stroke. Archived from the original on 13 April 2014. Retrieved 7 November 2010.
[10]Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH (October 2017). "Amyotrophic lateral sclerosis". Nature Reviews. Disease Primers. 3 (17071): 17071. doi:10.1038/nrdp.2017.71. PMID 28980624.
[11]van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, van den Berg LH (November 2017). "Amyotrophic lateral sclerosis". Lancet. 390 (10107): 2084–2098. doi:10.1016/S0140-6736(17)31287-4. PMID 28552366.
[12]Chiò A, Mora G, Lauria G (February 2017). "Pain in amyotrophic lateral sclerosis". The Lancet. Neurology. 16 (2): 144–57. arXiv:1607.02870. doi:10.1016/S1474-4422(16)30358-1. PMID 27964824.
[5]Hobson EV, McDermott CJ (September 2016). "Supportive and symptomatic management of amyotrophic lateral sclerosis". Nature Reviews. Neurology. 12 (9): 526–38. doi:10.1038/nrneurol.2016.111. PMID 27514291.

The search result for the NDD Category "Motor Neuron Disease"
A total of 20 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Condition PMID
193 Motor Neuron Disease human NEFH RF Genotype: SS 14722583
322 Motor Neuron Disease human Age at menarche RF Age at menarche: >=16 1745327
323 Motor Neuron Disease human Age at natural menopause RF Age at natural menopause: 45-49 1745327
323 Motor Neuron Disease human Age at natural menopause RF Age at natural menopause: <=44 1745327
547 Motor Neuron Disease human manual occupation RF 8229031
558 Motor Neuron Disease human Mechanical injuries RF Site: Column 1745327
558 Motor Neuron Disease human Mechanical injuries RF Site: Upper limbs 1745327
558 Motor Neuron Disease human Mechanical injuries RF Site: Lower limbs 1745327
558 Motor Neuron Disease human Mechanical injuries RF Site: Trunk 1745327
558 Motor Neuron Disease human Mechanical injuries RF All sites 1745327
575 Motor Neuron Disease human number of children RF number of children:3 1745327
315 Motor Neuron Disease human Obesity PF BMI>=30 22559076
578 Motor Neuron Disease human Occupation RF Work as farmers and breeders 1745327
579 Motor Neuron Disease human Occupational Exposure RF occupational exposure to lead 8229031
579 Motor Neuron Disease human Occupational Exposure RF occupational exposure to solvents/chemicals 8229031
652 Motor Neuron Disease human Smoking RF Ever smokers 22559076
744 Motor Neuron Disease horse copper RF 16426221
803 Motor Neuron Disease human magnesium RF low intake of magnesium from drinking water 8029710
805 Motor Neuron Disease human manganese RF excess intake of manganese from food 8029710
848 Motor Neuron Disease horse vitamin E RF 16426221
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