Multiple System Atrophy

Multiple system atrophy (MSA) is a rare neurodegenerative disorder[1] characterized by autonomic dysfunction, tremors, slow movement, muscle rigidity, and postural instability (collectively known as parkinsonism) and ataxia. This is caused by progressive degeneration of neurons in several parts of the brain including the basal ganglia, inferior olivary nucleus, and cerebellum.

MSA is distinct from multisystem proteinopathy, a more common muscle wasting syndrome. It should also not be confused with multiple organ dysfunction syndrome, sometimes referred to as multiple organ failure, or with multiple organ system failure, an often-fatal complication of septic shock or other very severe illnesses or injuries.


[1]"multiple system atrophy" at Dorland's Medical Dictionary

The search result for the NDD Category "Multiple System Atrophy"
A total of 64 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Phase Condition Year PMID
4199 Multiple System Atrophy Human Occupational types RF Diagnosis 2008 18307243
470 Multiple System Atrophy Human SNCA + well water nondrinkers PF Diagnosis 2022 35748722
467 Multiple System Atrophy Human SNCA + alcohol nonusers PF Diagnosis 2022 35748722
468 Multiple System Atrophy Human COQ2 + current smokers PF Diagnosis 2022 35748722
466 Multiple System Atrophy Human COQ2 + pesticide nonexposure PF Diagnosis 2022 35748722
3154 Multiple System Atrophy Human ACT RF 2005 15907346
3820 Multiple System Atrophy Human C9orf72 RF Diagnosis 2021 35007998
3219 Multiple System Atrophy Human chromosome 22 RF 2017 29187220
3218 Multiple System Atrophy Human chromosome 22 RF 2017 29187220
3224 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3221 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3223 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3220 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3222 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3226 Multiple System Atrophy Human chromosome 5 RF 2017 29187220
3225 Multiple System Atrophy Human chromosome 5 RF 2017 29187220
465 Multiple System Atrophy Human COQ2 PF Diagnosis 2022 35748722
3228 Multiple System Atrophy Human COQ2 RF 2016 27123473
3277 Multiple System Atrophy Human IL-1β RF 2018 29251119
3280 Multiple System Atrophy Human LRRK2 RF 2018 29480226
2379 Multiple System Atrophy Human MAPT RF H1 haplotype 2011 21321341
3330 Multiple System Atrophy Human SCA1 RF 2018 29715545
3331 Multiple System Atrophy Human SCA3 RF 2007 17133518
2358 Multiple System Atrophy Human TNF-α RF allele 2018 29251119
1968 Multiple System Atrophy Human TNF-α RF genotype 2018 29251119
2893 Multiple System Atrophy Human TREM2 p.R47H RF patients with clinically diagnosed MSA 2018 30109269
1813 Multiple System Atrophy Human TREM2 p.R47H RF patients with clinically diagnosed MSA 2018 30109269
2958 Multiple System Atrophy Human TREM2 p.R47H RF patients with pathologically confirmed MSA 2018 30109269
1817 Multiple System Atrophy Human TREM2 p.R47H RF patients with pathologically confirmed MSA 2018 30109269
3821 Multiple System Atrophy Human vascular risk factors RF Diagnosis 2021 34764851
2966 Multiple System Atrophy Human farming RF MSA cases vs. population controls;>20 years 2005 15382209
1821 Multiple System Atrophy Human farming RF MSA cases vs. population controls 2005 15382209
1826 Multiple System Atrophy Human farming RF 1-20 years 2016 27670212
2579 Multiple System Atrophy Human farming RF MSA cases vs. hospital controls 2005 15382209
1796 Multiple System Atrophy Human farming RF >20 years 2016 27670212
2859 Multiple System Atrophy Human farming RF 1-20 years 2016 27670212
1804 Multiple System Atrophy Human farming RF MSA cases vs. hospital controls 2005 15382209
3030 Multiple System Atrophy Human farming RF >20 years 2016 27670212
1825 Multiple System Atrophy Human farming RF MSA cases vs. population controls;>20 years 2005 15382209
2852 Multiple System Atrophy Human farming RF MSA cases vs. population controls 2005 15382209
333 Multiple System Atrophy Human Occupational exposure Not Related Diagnosis 2008 18307243
332 Multiple System Atrophy Human Occupational exposure Not Related Diagnosis 2008 18307243
331 Multiple System Atrophy Human Occupational exposure Not Related Diagnosis 2008 18307243
1802 Multiple System Atrophy Human Herbal medications RF 2010 20623770
2611 Multiple System Atrophy Human Herbal medications RF 2010 20623770
735 Multiple System Atrophy Human use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) PF 2020 31661696
645 Multiple System Atrophy Human use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) PF Cumulative doses were used to divide observations into tertiles creating 3 groups of equal size (T1–3) based on the consumption in DDDs with T1 representing the group with the lowest use and T3 the highest. 2020 31661696
766 Multiple System Atrophy Human use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) PF Cumulative doses were used to divide observations into tertiles creating 3 groups of equal size (T1–3) based on the consumption in defined daily dose(DDD) with T1 representing the group with the lowest use and T3 the highest. 2020 31661696
1125 Multiple System Atrophy Human Aspirin PF Diagnosis 2008 18307243
3031 Multiple System Atrophy Human plant and machine operators and assemblers RF ≤ 11 years 2008 18307243
2777 Multiple System Atrophy Human plant and machine operators and assemblers RF ≥ 11years 2008 18307243
2414 Multiple System Atrophy Human plant and machine operators and assemblers RF 2008 18307243
3822 Multiple System Atrophy Human Excessive daytime sleepiness (EDS) RF Diagnosis with the non-motor dysfunction 2021 35087473
328 Multiple System Atrophy Human Smoking Not Related Diagnosis 2000 10636135
330 Multiple System Atrophy Human Smoking Not Related Diagnosis 2000 10636135
329 Multiple System Atrophy Human Smoking Not Related Diagnosis 2000 10636135
2899 Multiple System Atrophy Human Smoking RF ≥40 pack-years 2010 20623770
1816 Multiple System Atrophy Human Smoking RF ≥40 pack-years 2010 20623770
2779 Multiple System Atrophy Human Education RF ≤ 12 years;In another French region 2008 18307243
2848 Multiple System Atrophy Human Education RF ≤ 12 years;In Paris 2008 18307243
2814 Multiple System Atrophy Human Education RF ≤ 12 years 2008 18307243
1124 Multiple System Atrophy Human Fish and seafood PF Diagnosis 2008 18307243
4198 Multiple System Atrophy Human Meat and poultry RF Diagnosis 2008 18307243
1123 Multiple System Atrophy Human Wine PF Diagnosis 2008 18307243
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