Multiple System Atrophy

Multiple system atrophy (MSA) is a rare neurodegenerative disorder[1] characterized by autonomic dysfunction, tremors, slow movement, muscle rigidity, and postural instability (collectively known as parkinsonism) and ataxia. This is caused by progressive degeneration of neurons in several parts of the brain including the basal ganglia, inferior olivary nucleus, and cerebellum.

MSA is distinct from multisystem proteinopathy, a more common muscle wasting syndrome. It should also not be confused with multiple organ dysfunction syndrome, sometimes referred to as multiple organ failure, or with multiple organ system failure, an often-fatal complication of septic shock or other very severe illnesses or injuries.


[1]"multiple system atrophy" at Dorland's Medical Dictionary

The search result for the NDD Category "Multiple System Atrophy"
A total of 45 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Condition PMID
8 Multiple System Atrophy human ACT RF 15907346
63 Multiple System Atrophy human chromosome 22 RF 29187220
63 Multiple System Atrophy human chromosome 22 RF 29187220
64 Multiple System Atrophy human chromosome 4 RF 29187220
64 Multiple System Atrophy human chromosome 4 RF 29187220
64 Multiple System Atrophy human chromosome 4 RF 29187220
64 Multiple System Atrophy human chromosome 4 RF 29187220
64 Multiple System Atrophy human chromosome 4 RF 29187220
65 Multiple System Atrophy human chromosome 5 RF 29187220
65 Multiple System Atrophy human chromosome 5 RF 29187220
72 Multiple System Atrophy human COQ2 RF 27123473
146 Multiple System Atrophy human IL-1β RF 29251119
168 Multiple System Atrophy human LRRK2 RF 29480226
173 Multiple System Atrophy human MAPT RF H1 haplotype 21321341
244 Multiple System Atrophy human SCA1 RF 29715545
245 Multiple System Atrophy human SCA3 RF 17133518
290 Multiple System Atrophy human TNF-α RF genotype 29251119
290 Multiple System Atrophy human TNF-α RF allele 29251119
294 Multiple System Atrophy human TREM2 p.R47H RF patients with pathologically confirmed MSA 30109269
294 Multiple System Atrophy human TREM2 p.R47H RF patients with clinically diagnosed MSA 30109269
294 Multiple System Atrophy human TREM2 p.R47H RF patients with pathologically confirmed MSA 30109269
294 Multiple System Atrophy human TREM2 p.R47H RF patients with clinically diagnosed MSA 30109269
425 Multiple System Atrophy human education RF ≤ 12 years 18307243
425 Multiple System Atrophy human education RF ≤ 12 years;In Paris 18307243
425 Multiple System Atrophy human education RF ≤ 12 years;In another French region 18307243
460 Multiple System Atrophy human farming RF 1-20 years 27670212
460 Multiple System Atrophy human farming RF 1-20 years 27670212
460 Multiple System Atrophy human farming RF >20 years 27670212
460 Multiple System Atrophy human farming RF >20 years 27670212
460 Multiple System Atrophy human farming RF MSA cases vs. hospital controls 15382209
460 Multiple System Atrophy human farming RF MSA cases vs. hospital controls 15382209
460 Multiple System Atrophy human farming RF MSA cases vs. population controls 15382209
460 Multiple System Atrophy human farming RF MSA cases vs. population controls 15382209
460 Multiple System Atrophy human farming RF MSA cases vs. population controls;>20 years 15382209
460 Multiple System Atrophy human farming RF MSA cases vs. population controls;>20 years 15382209
485 Multiple System Atrophy human Herbal medications RF 20623770
485 Multiple System Atrophy human Herbal medications RF 20623770
607 Multiple System Atrophy human plant and machine operators and assemblers RF 18307243
607 Multiple System Atrophy human plant and machine operators and assemblers RF ≤ 11 years 18307243
607 Multiple System Atrophy human plant and machine operators and assemblers RF ≥ 11years 18307243
652 Multiple System Atrophy human Smoking RF ≥40 pack-years 20623770
652 Multiple System Atrophy human Smoking RF ≥40 pack-years 20623770
990 Multiple System Atrophy human use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) PF 31661696
990 Multiple System Atrophy human use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) PF Cumulative doses were used to divide observations into tertiles creating 3 groups of equal size (T1–3) based on the consumption in defined daily dose(DDD) with T1 representing the group with the lowest use and T3 the highest. 31661696
990 Multiple System Atrophy human use of non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) PF Cumulative doses were used to divide observations into tertiles creating 3 groups of equal size (T1–3) based on the consumption in DDDs with T1 representing the group with the lowest use and T3 the highest. 31661696
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