Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Thinking and behavioral problems may also occur. Dementia becomes common in the advanced stages of the disease. Depression and anxiety are also common, occurring in more than a third of people with PD.
The search result for the NDD Category "Parkinson's disease"
A total of 248 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Condition PMID
6 Parkinson's Disease human ABCB1 RF 24572589
7 Parkinson's Disease human ACE RF 12084438
7 Parkinson's Disease human ACE RF 12084438
9 Parkinson's Disease human ADH1B RF 30483881
44 Parkinson's Disease human C9ORF72 RF 23845100
46 Parkinson's Disease human CARD15 RF 17174426
47 Parkinson's Disease human CCDC62/HIP1R RF 25818163
48 Parkinson's Disease human CCL2 RF 30761072
48 Parkinson's Disease human CCL2 RF 30761072
49 Parkinson's Disease human CD14 RF 16337421
50 Parkinson's Disease rat CD157/BST1 RF 24795584
57 Parkinson's Disease human CHCHD2 RF 27626775
70 Parkinson's Disease human COMT PF not Caucasian populations 23466833
70 Parkinson's Disease human COMT PF not Caucasian populations 23466833
70 Parkinson's Disease human COMT RF not Caucasian populations 23466833
70 Parkinson's Disease human COMT RF 9503277
88 Parkinson's Disease human DGCR8 RF 24018986
88 Parkinson's Disease human DGCR8 RF 24018986
90 Parkinson's Disease human DMT1 RF 25817364
90 Parkinson's Disease human DMT1 RF 21777657
96 Parkinson's Disease human DYRK1A RF especially for males 27546826
98 Parkinson's Disease human EMTP variation RF 30675927
107 Parkinson's Disease human Famliy history of familial Parkinson's disease RF 21059511
107 Parkinson's Disease human Famliy history of familial Parkinson's disease RF 8771062
108 Parkinson's Disease human FGF20 RF 26070653
108 Parkinson's Disease human FGF20 RF 26070653
108 Parkinson's Disease human FGF20 RF 24942208
108 Parkinson's Disease human FGF20 RF 22342445
108 Parkinson's Disease human FGF20 RF 15122513
108 Parkinson's Disease human FGF20 RF 15122513
115 Parkinson's Disease human GBA RF Patients with early-onset were more likely to carry GBA mutations than those with late-onset 26868973
115 Parkinson's Disease human GBA RF strong risk factors in FPD, especially for autosomal dominant PD 24126159
115 Parkinson's Disease human GBA RF 24997549
115 Parkinson's Disease human GBA RF 22812582
115 Parkinson's Disease human GBA RF 22387070
115 Parkinson's Disease human GBA RF 20131388
115 Parkinson's Disease human GBA RF 17702778
115 Parkinson's Disease human GBA RF 26000814
115 Parkinson's Disease human GBA RF 30765263
115 Parkinson's Disease human GBA RF 30765263
115 Parkinson's Disease human GBA RF 30765263
116 Parkinson's Disease human GBA1 RF non-N370S mutations associated with Gaucher disease 22968580
117 Parkinson's Disease human GCH1 RF 27871051
118 Parkinson's Disease human GLIS1 RF 22759478
120 Parkinson's Disease human GRIN2A RF taking creatine who also have high levels of caffeine intake 28320167
121 Parkinson's Disease human GRIN2A T allele RF taking creatine who also have high levels of caffeine intake 28320167
128 Parkinson's Disease human HFE PF Australian PD patients 12098643
128 Parkinson's Disease human HFE PF Australian PD patients 12098643
128 Parkinson's Disease human HFE RF 16824219
128 Parkinson's Disease human HFE RF 16824219
132 Parkinson's Disease human HLA-DRA RF 25319953
140 Parkinson's Disease human IL-10 RF 21241672
140 Parkinson's Disease human IL-10 RF 22387064
143 Parkinson's Disease human IL-18 RF 21241672
168 Parkinson's Disease human LRRK2 RF especially in early-onset patients 26234753
168 Parkinson's Disease human LRRK2 RF 23624603
168 Parkinson's Disease human LRRK2 PF 23115130
168 Parkinson's Disease human LRRK2 RF 23115130
168 Parkinson's Disease human LRRK2 RF 20629711
168 Parkinson's Disease human LRRK2 RF 21167764
168 Parkinson's Disease human LRRK2 RF 20673920
168 Parkinson's Disease human LRRK2 RF 19672984
168 Parkinson's Disease human LRRK2 RF 18201193
168 Parkinson's Disease human LRRK2 RF 18716801
168 Parkinson's Disease human LRRK2 RF 17960808
168 Parkinson's Disease human LRRK2 RF 17314670
168 Parkinson's Disease human LRRK2 RF 17019612
168 Parkinson's Disease human LRRK2 RF reater frequency of the G2019S mutation in Jewish than in non-Jewish cases with Parkinson disease 17050822
168 Parkinson's Disease human LRRK2 RF 16633828
168 Parkinson's Disease human LRRK2 RF 19854095
168 Parkinson's Disease human LRRK2 RF 19699188
172 Parkinson's Disease human MAO RF 7913737
172 Parkinson's Disease human MAO RF 7913737
173 Parkinson's Disease human MAPT RF 19912324
173 Parkinson's Disease human MAPT RF 15627775
177 Parkinson's Disease human MC1R RF 19194882
177 Parkinson's Disease human MC1R RF 19194882
199 Parkinson's Disease human NOD2 RF associated with late-onset PD 23651603
206 Parkinson's Disease human Omi/HTRA2 RF 21338583
209 Parkinson's Disease human P2X7 RF 23648388
211 Parkinson's Disease human PARK16 PF 27174169
211 Parkinson's Disease human PARK16 RF 27174169
211 Parkinson's Disease human PARK16 RF 21419001
212 Parkinson's Disease human PARK2 RF 12056932
212 Parkinson's Disease human PARK2 RF 24729340
212 Parkinson's Disease human PARK2 RF 24729340
213 Parkinson's Disease human PARKIN RF 19636047
213 Parkinson's Disease human PARKIN RF 10511432
213 Parkinson's Disease human PARKIN RF 10511432
216 Parkinson's Disease human PD in first-degree relatives RF 11060508
221 Parkinson's Disease human PINK1 RF 16969854
221 Parkinson's Disease human PINK1 RF 27807026
223 Parkinson's Disease human PLA2G6 RF 22213678
229 Parkinson's Disease human positive family history of PD RF 9778597
243 Parkinson's Disease human Saitohin PF 25168738
243 Parkinson's Disease human Saitohin RF 25168738
246 Parkinson's Disease human SEMA5A PF 18950607
246 Parkinson's Disease human SEMA5A PF 18950607
246 Parkinson's Disease human SEMA5A RF 18950607
246 Parkinson's Disease human SEMA5A RF 18950607
246 Parkinson's Disease human SEMA5A PF 24706317
250 Parkinson's Disease human SLC6A3 RF 24211691
250 Parkinson's Disease human SLC6A3 RF 24211691
250 Parkinson's Disease human SLC6A3 RF 24211691
250 Parkinson's Disease human SLC6A3 RF 24211691
250 Parkinson's Disease human SLC6A3 PF 24211691
255 Parkinson's Disease human SMPD1 RF 26169695
255 Parkinson's Disease human SMPD1 RF 23535491
256 Parkinson's Disease human SNCA RF 27699750
256 Parkinson's Disease human SNCA RF 22349157
256 Parkinson's Disease human SNCA RF 18404644
256 Parkinson's Disease human SNCA RF 18404644
267 Parkinson's Disease human STK39 RF 26469904
279 Parkinson's Disease human TFAM RF 19925850
281 Parkinson's Disease human TH RF 20809526
293 Parkinson's Disease human TREM2 RF 23800361
299 Parkinson's Disease human UCHL1 RF 22839974
303 Parkinson's Disease human VEGF RF 27481110
305 Parkinson's Disease human VMAT2 RF 27137201
315 Parkinson's Disease human Obesity RF 31019987
317 Parkinson's Disease human Adult nutrient intake RF 10661654
319 Parkinson's Disease human Age PF GCH1 genotype T allele carries 27871051
319 Parkinson's Disease rhesus monkey Age RF 21587290
319 Parkinson's Disease human Age RF 17884509
343 Parkinson's Disease human Anxiety RF 12784267
370 Parkinson's Disease human caffeine intake RF GRIN2A rs4998386 T allele;taking creatine who also have high levels of caffeine intake 28320167
380 Parkinson's Disease human chronic exposure to metals RF 9065542
384 Parkinson's Disease human chronic renal dysfunction RF Older adults 31021467
386 Parkinson's Disease rat cinnarizine(a calcium antagonist that produces human parkinsonism) RF (a calcium antagonist that produces human parkinsonism) 15993444
387 Parkinson's Disease rat Circadian rhythm dysfunction (CRD) RF 27046648
391 Parkinson's Disease human Constipation RF the relative risk was higher for men than for women 27234704
391 Parkinson's Disease human Constipation RF 27444575
400 Parkinson's Disease human Depression RF 25995056
400 Parkinson's Disease human Depression RF 24089392
400 Parkinson's Disease human Depression RF Previous history of depression 21059511
401 Parkinson's Disease human Diabetes RF 19467671
401 Parkinson's Disease human Diabetes RF 19467671
401 Parkinson's Disease human Diabetes RF 24955210
407 Parkinson's Disease human Dietary Vitamin E PF 30863359
408 Parkinson's Disease human dipstick-positive proteinuria RF Older adults 31021467
415 Parkinson's Disease human Drug-induced parkinsonism RF 9703296
415 Parkinson's Disease human Drug-induced parkinsonism RF 9703296
418 Parkinson's Disease human duration of exposure to levodopa RF 23836370
418 Parkinson's Disease human duration of exposure to levodopa RF 23836370
434 Parkinson's Disease human exercise PF 12140099
434 Parkinson's Disease human exercise PF 12140099
437 Parkinson's Disease human exposure to hydrocarbon solvents RF 10980731
439 Parkinson's Disease human exposure to metals RF high reported industrial release of copper or manganese 20959505
439 Parkinson's Disease human exposure to metals RF high reported industrial release of copper or manganese 20959505
441 Parkinson's Disease human Exposure to neuroleptic drugs RF 10047927
443 Parkinson's Disease human exposure to Pb RF 17185278
444 Parkinson's Disease human Exposure to Pesticide RF 11437458
444 Parkinson's Disease human Exposure to Pesticide RF 21059511
444 Parkinson's Disease rat Exposure to Pesticide RF 22563483
449 Parkinson's Disease human exposure to trichloroethylene (TCE) RF 22083847
451 Parkinson's Disease human well water ingestion RF 1584237
460 Parkinson's Disease human farming RF 11437458
315 Parkinson's Disease human Obesity RF 24955210
469 Parkinson's Disease human gender RF 20111594
471 Parkinson's Disease human glyphosate exposure RF 30799335
478 Parkinson's Disease human head injury RF early in life 25603768
478 Parkinson's Disease human head injury RF 12140099
478 Parkinson's Disease human head injury RF 28748275
484 Parkinson's Disease human Hepatitis C virus(HCV) RF 26701382
484 Parkinson's Disease human Hepatitis C virus(HCV) RF 25608223
484 Parkinson's Disease human Hepatitis C virus(HCV) RF 30710864
506 Parkinson's Disease human Hypertension RF 9778597
511 Parkinson's Disease human Idiopathic rapid eye movement sleep behaviour disorde RF 19843648
521 Parkinson's Disease human infection RF 30632012
564 Parkinson's Disease human motor neuron disease (MND) RF 20669307
570 Parkinson's Disease human non‐apnea sleep disorders (NSD) RF 28470725
571 Parkinson's Disease human non-hydroxychloroquine immunosuppressant therapy PF Sj?gren syndrome (SS) 30946325
587 Parkinson's Disease human organophosphate (OP) or carbamate (CM) poisoning RF 27781262
591 Parkinson's Disease human paraquat exposure RF 23150532
598 Parkinson's Disease rat Peripheral inflammation RF 20584104
608 Parkinson's Disease human Plant Extract PF 24955210
610 Parkinson's Disease human Polychlorinated biphenyls (PCBs)exposure RF greater susceptibility of females. 22906799
610 Parkinson's Disease human Polychlorinated biphenyls (PCBs)exposure RF greater susceptibility of females. 22906799
619 Parkinson's Disease human pretreatment motor dysfunction RF especially among older patients 9447497
620 Parkinson's Disease human Prior stroke RF 31019987
626 Parkinson's Disease human psychiatric disorder RF particularly in people under age 50 18080857
636 Parkinson's Disease human Rosacea constitutes RF 26999031
637 Parkinson's Disease human Rural living RF 21059511
637 Parkinson's Disease human Rural living RF 11437458
637 Parkinson's Disease human Rural living RF 11437458
637 Parkinson's Disease human Rural living RF 9778597
649 Parkinson's Disease human Sj?gren syndrome (SS) RF 30946325
652 Parkinson's Disease human Smoking PF 21059511
652 Parkinson's Disease human Smoking PF 19540050
652 Parkinson's Disease human Smoking PF 11060508
652 Parkinson's Disease human Smoking PF 19188574
652 Parkinson's Disease human Smoking PF 30772279
653 Parkinson's Disease human SN hyperechogenicity (SN+) RF 23115051
663 Parkinson's Disease human stroke RF 26576320
663 Parkinson's Disease human stroke RF 9778597
666 Parkinson's Disease human tea drinking RF 11060508
672 Parkinson's Disease human Total daily physical activity PF Older adults 31046115
675 Parkinson's Disease human Toxins other than pesticide RF 21059511
678 Parkinson's Disease human Traumatic brain injury (TBI) RF 23150532
681 Parkinson's Disease human Trichloroethylene RF 18157908
682 Parkinson's Disease human type 1 Gaucher disease RF 20177787
683 Parkinson's Disease human Type 2 diabetes RF 17251276
683 Parkinson's Disease human Type 2 diabetes RF 17251276
689 Parkinson's Disease human Uric Acid PF 24955210
696 Parkinson's Disease human Vitamin D and Vitamin E PF 24955210
702 Parkinson's Disease human welding RF 11148228
451 Parkinson's Disease human well water ingestion RF 18464276
451 Parkinson's Disease human well water ingestion RF 12140099
451 Parkinson's Disease human well water ingestion RF 11437458
451 Parkinson's Disease human well water ingestion RF 9778597
721 Parkinson's Disease human alpha-synuclein (NACP-Rep1) PF 15670652
728 Parkinson's Disease human apolipoprotein E ( APOE) ε3 allele PF 30526202
728 Parkinson's Disease human apolipoprotein E ( APOE) ε3 allele RF 30526202
730 Parkinson's Disease human Apolipoprotein E4 RF 15924299
745 Parkinson's Disease human C-reactive protein (CRP) RF 31057478
745 Parkinson's Disease human C-reactive protein (CRP) RF 31057478
745 Parkinson's Disease human C-reactive protein (CRP) RF 31057478
753 Parkinson's Disease human disturbance of the plasmatic rate of Cu RF 23868039
754 Parkinson's Disease human DNA Methylation cg10917602 site RF 27466229
776 Parkinson's Disease human high serum lipid peroxidation rates RF 1641180
792 Parkinson's Disease human lncRNA AK021630 PF 27151187
793 Parkinson's Disease human lncRNA AL049437 RF 27151187
795 Parkinson's Disease human Loss of aromatase cytochrome P450 function RF 18063054
798 Parkinson's Disease human Low plasma uric acid level RF 17443703
824 Parkinson's Disease human Plasma Se or Fe elevation RF 24340079
826 Parkinson's Disease human plasma Zn elevation PF 24340079
829 Parkinson's Disease human Reduced serum progranulin(GRN) level RF 23398167
887 Parkinson's Disease human combine Traumatic brain injury and paraquat exposure RF 23150532
889 Parkinson's Disease human combined residential exposures（residential, non-occupational pesticide and heavy metal exposure） RF 19818671
904 Parkinson's Disease human Monoamine?oxidase-B?(MAO-B) RF levodopa-induced dyskinesia(LID) 32979926
27 Parkinson's Disease human ATP10B RF recessive loss of function mutations 33177243
909 Parkinson's Disease human GP1BA RF 32625160
910 Parkinson's Disease human GP6 RF 32625160
913 Parkinson's Disease human ITGB5 RF 33006184
915 Parkinson's Disease human P2RY12 RF 32687038
991 Parkinson's Disease human well water(containing heavy metals and nitrates) RF Consumption of well water containing heavy metals and nitrates in early life 32351250
992 Parkinson's Disease human Vascular Inflammation:blood-brain barrier(BBB) RF 32733633
993 Parkinson's Disease human Education? PF 32865628
506 Parkinson's Disease human Hypertension RF 32865628
388 Parkinson's Disease human coffee consumption PF 32943485
652 Parkinson's Disease human smoking PF 32943485
604 Parkinson's Disease human physical activity PF 32943485
994 Parkinson's Disease human family history of PD RF 32943485
995 Parkinson's Disease human dyspepsia RF 32943485
962 Parkinson's Disease human exposure to pesticides RF 32943485
996 Parkinson's Disease human oils RF 32943485
997 Parkinson's Disease human metals RF 32943485
998 Parkinson's Disease human general anesthesia RF 32943485
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