Biochemical Factors

Biochemical factors mainly include some biochemical indicators.
The search result for the Risk factor Category "Biochemical"
A total of 188 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Condition PMID
709 Alzheimer's Disease human anti-AT1R RF 26401573
710 Frontotemporal Lobar Degeneration human Delayed, prolonged Orthostatic hypotension (OH) RF compared to subjects without OH in subjects with MCI and patients with dementia 31381517
710 Frontotemporal Lobar Degeneration human Delayed, prolonged Orthostatic hypotension (OH) RF compared to subjects without OH in subjects with MCI and patients with dementia 31381517
710 Frontotemporal Lobar Degeneration human Delayed, prolonged Orthostatic hypotension (OH) RF compared to subjects without OH in subjects with MCI and patients with dementia 31381517
711 Alzheimer's Disease human free copper RF 23760784
712 Amyotrophic lateral sclerosis human high amounts of PC(phycocyanin concentration) exposure RF 28470570
714 Alzheimer's Disease human the lowest folate tertile RF 28698453
715 Alzheimer's Disease human a protective response to proteostatic stress, directed by the NRF1-sMAF complex RF people carrying the risk (A) allele of rs667897 29179108
716 Alzheimer's Disease human accumulation of p16(INK4a)-positive senescent astrocytes RF 22984612
717 Amyotrophic lateral sclerosis human Aerosolization of cyanobacteria RF 23246360
718 Amyotrophic lateral sclerosis mice age-related decreases in ADAR2(adenosine deaminase acting on RNA 2) activity RF 22916266
719 Alzheimer's disease mice age-related increase in chemokine CCL11 RF antagonizing CCR3 may bring therapeutic benefits to?AD 27878757
720 Alzheimer's Disease human Albuminuria RF Model 1:adjusted for age and sex 29353232
720 Alzheimer's Disease human Albuminuria RF Model 2:adjusted for Model 1 plus educational level, history of stroke, systolic blood pressure, the use of antihypertensive agents, diabetes mellitus, total cholesterol, body mass index, smoking habits, alcohol intake, and regular exercise 29353232
720 Alzheimer's Disease Albuminuria RF Model 3:adjusted for Model 2 plus eGFR 29353232
720 Alzheimer's Disease human Albuminuria RF Model 1:adjusted for age and sex 29353232
720 Alzheimer's Disease Albuminuria RF Model 2:adjusted for Model 1 plus educational level, history of stroke, systolic blood pressure, the use of antihypertensive agents, diabetes mellitus, total cholesterol, body mass index, smoking habits, alcohol intake, and regular exercise 29353232
720 Alzheimer's Disease human Albuminuria RF Model 3:adjusted for Model 2 plus eGFR 29353232
721 Parkinson's Disease human alpha-synuclein (NACP-Rep1) PF 15670652
722 Alzheimer’s Disease human Aluminum RF 7507666
722 Alzheimer’s Disease rat Aluminum RF 18-day fetal rats 8537015
723 Alzheimer's disease Amyloid-β (Aβ)(42) RF 21955816
724 Alzheimer's Disease human annexin A5 RF 23576984
725 Frontotemporal Dementia human apo(a) low molecular weight (MW RF 14665416
726 Amyotrophic Lateral Sclerosis human APOE(protein) RF 11940705
727 Alzheimer’s Disease human apoE protein activity RF 7672107
728 Parkinson's Disease human apolipoprotein E ( APOE) ε3 allele PF 30526202
728 Parkinson's Disease human apolipoprotein E ( APOE) ε3 allele RF 30526202
729 Alzheimer’s Disease human Apolipoprotein E (APOE)-epsilon4 RF 29605385
730 Parkinson's Disease human Apolipoprotein E4 RF 15924299
731 Amyotrophic Lateral Sclerosis human Ataxin-2 intermediate-length polyglutamine expansions RF 21292779
732 Alzheimer’s Disease human benzodiazepine and related drug (BZDR) RF 29851063
733 Alzheimer’s Disease human beta-amyloid (Abeta) accumulation RF 29592889
734 Alzheimer’s Disease human beta-amyloid precursor protein (APP) processing RF 9041854
735 Alzheimer’s Disease Caenorhabditis elegans betaine PF both the presence and absence of 1 mM homocysteine; independent of the remethylation pathway but requires the transsulfuration pathway mediated by cystathionine-β-synthase 30065790
736 Alzheimer's disease human Bleomycin hydrolase (BLH) RF 20308784
737 Alzheimer’s Disease human Blood levels of alpha-1-antichymotrypsin(ACT) RF 10629358
738 Alzheimer’s Disease human Branched-chain amino acids (BCAAs) RF 29802157
739 Alzheimer’s Disease mice CB1 receptor desensitization RF Seven-month-old male 3xTg-AD mice 29865071
740 Alzheimer's Disease human cerebral hypoperfusion RF 23295908
741 Alzheimer's disease human coexistence of the APOE-ε4 allele and 3 SNPs in the BCHE gene RF 30914707
742 Alzheimer's disease human combine Rate of brain aging and APOE ε4 RF interventions that slow aging may substantially reduce risk of neurological disease and decline even in the presence of APOE ε4. 31133613
743 Alzheimer’s Disease human Complement Receptor 1 (CR1) Density RF 30044434
744 Motor Neuron Disease horse copper RF 16426221
745 Parkinson's Disease human C-reactive protein (CRP) RF 31057478
745 Parkinson's Disease human C-reactive protein (CRP) RF 31057478
745 Parkinson's Disease human C-reactive protein (CRP) RF 31057478
746 Alzheimer’s Disease human CSF AβPET(amyloid beta brain PET imaging) RF Associated with AD progression 29982466
747 Alzheimer’s Disease human CSF Tau(cerebrospinal fluid tau) and P-tau(phosphorylated tau) RF Associated with AD progression 29982466
748 Alzheimer's disease human decreased 25-hydroxyvitamin D(25OHD) level RF 27856775
749 Alzheimer's disease human decreased expression of FERMT2 RF 27215977
750 Amyotrophic lateral sclerosis human decreased SOD1 stability and increased protein aggregation RF 28558143
751 Alzheimer’s Disease human decreasing Aβ1-42 rates RF 30250861
752 Alzheimer’s Disease human depression-related monoaminergic systems RF including serotonin and noradrenaline 29685068
753 Parkinson's Disease human disturbance of the plasmatic rate of Cu RF 23868039
754 Parkinson's Disease human DNA Methylation cg10917602 site RF 27466229
755 Alzheimer's disease human Dysfunction of the mTOR pathway RF is independent of the ApoE status of the patients 24252508
756 Amyotrophic lateral sclerosis human dysregulation modulation of proteasome activity RF 24450587
757 Alzheimer's disease human Elevated blood plasma levels of α7(1-208) nAChR-specific antibodies RF 21593571
758 Alzheimer's disease human Elevated Low-density Lipoprotein Cholesterol Levels(LDL-C) RF 31135820
759 Alzheimer's disease human elevated malondialdehyde levels RF The elevated malondialdehyde levels increases the risk of Alzheimer's disease by 9.342. 26835020
760 Alzheimer’s Disease human elevated midlife total cholesterol level RF 12160362
761 Amyotrophic lateral sclerosis human ER(endoplasmic reticulum) proteostasis imbalance RF 26869642
762 Alzheimer’s Disease human Estrogen-replacement therapy PF postmenopausal women 9566385
763 Amyotrophic Lateral Sclerosis human Expanded glutamine repeats of the ataxin-2 (ATXN2) protein RF CAG repeat length >26 21610160
764 Amyotrophic Lateral Sclerosis human Expanded glutamine repeats of the ataxin-2 (ATXN3) protein RF CAG repeat length >30 21610160
765 Alzheimer's Disease human fasting plasma glucose (FPG) RF Model I: adjusted for age and sex 28705834
765 Alzheimer's Disease human fasting plasma glucose (FPG) RF Model II: adjusted for age, sex, FPG,HbA1c, insured amount and insured unit (see Table 1), smoking, alcohol consumption, duration of diabetes, type of hypoglycemic drug, hypertension drug treatment, and obesity 28705834
765 Alzheimer's Disease human fasting plasma glucose (FPG) RF Model III: adjusted for CAD, CHF, stroke, cancer, hyperlipidemia, hypertension, atrial fibrillation, chronic hepatitis, COPD, and hypoglycemia along with all other confounders in model II 28705834
765 Alzheimer's Disease human fasting plasma glucose (FPG) RF Model IV: adjusted for PFG CV and HbA1c CV along with all other confounders in model III 28705834
766 Alzheimer's disease mice glucose regulation PF 31034991
767 Alzheimer's Disease human glycated hemoglobin (HbA1c) RF Model I: adjusted for age and sex 28705834
767 Alzheimer's Disease human glycated hemoglobin (HbA1c) RF Model II: adjusted for age, sex, FPG,HbA1c, insured amount and insured unit (see Table 1), smoking, alcohol consumption, duration of diabetes, type of hypoglycemic drug, hypertension drug treatment, and obesity 28705834
767 Alzheimer's Disease human glycated hemoglobin (HbA1c) RF Model III: adjusted for CAD, CHF, stroke, cancer, hyperlipidemia, hypertension, atrial fibrillation, chronic hepatitis, COPD, and hypoglycemia along with all other confounders in model II 28705834
767 Alzheimer's Disease human glycated hemoglobin (HbA1c) RF Model IV: adjusted for PFG CV and HbA1c CV along with all other confounders in model III 28705834
768 Alzheimer’s Disease human H4K16ac enrichment RF related to aging 29507413
769 Alzheimer's disease human high blood lipids and insulin resistance RF 21033433
770 Alzheimer’s Disease human High CSF(cerebrospinal fluid) MCP-1(monocyte chemoattractant protein 1) RF Associated with AD progression 29982466
771 Amyotrophic lateral sclerosis human high HbA1c(Hemoglobin A1c) levels RF 28934974
772 Alzheimer's disease high level of Dkk1 RF 26880631
773 progressive supranuclear palsy human high levels of uric acid PF 26686202
774 Alzheimer’s Disease human high midlife systolic blood pressure RF 12160362
775 Alzheimer's Disease human high plasma clusterin levels RF 26402636
776 Parkinson's Disease human high serum lipid peroxidation rates RF 1641180
777 Alzheimer’s Disease human High thiamine diphosphate level PF 29718773
778 Alzheimer’s Disease human IL-17A/IL-23 axis RF 30081688
779 Alzheimer’s Disease human increased cholesterol or blood pressure RF 30112972
780 Alzheimer's disease human increased expression of NUP160 PF 27215977
781 Alzheimer's disease human increased fibrillar amyloid-{beta} RF individuals with a family history of late-onset Alzheimer's;particularly in persons with an AD mother 20231448
782 Alzheimer's disease human increased gene dosage of MIR138-2 RF 30909216
783 Alzheimer's disease human Increased levels of specific sub-fractions of LDL cholesterol RF 17982892
784 Alzheimer's disease human increased plasma adiponectin levels RF 22213409
785 Alzheimer’s Disease human increased platelet membrane fluidity RF first-degree relatives of probands with Alzheimer's disease 8610834
786 Alzheimer's disease human increased skeletal muscle mass PF 30700801
787 Alzheimer's disease mice inhibition of angiotensin-converting enzyme (ACE) activity RF 31072831
788 Alzheimer's disease human intracellular iron accumulation RF 24199959
789 Alzheimer's disease ischemia/HIF-1α RF 24478626
790 Alzheimer's disease human levels of homocysteine RF 20885792
791 Alzheimer's disease human lifetime-acquired loss of chromosome Y (LOY) RF in blood cells 27231129
792 Parkinson's Disease human lncRNA AK021630 PF 27151187
793 Parkinson's Disease human lncRNA AL049437 RF 27151187
794 Alzheimer’s Disease human Longitudinal Changes in Serum Glucose Levels RF 29480176
795 Parkinson's Disease human Loss of aromatase cytochrome P450 function RF 18063054
796 Frontotemporal Lobar Degeneration human Low levels of serum uric acid (UA) PF 28620833
797 Alzheimer's Disease human low NAA/MI(N-Acetyl Aspartate/Myo-Inositol)ratios RF 28968236
798 Parkinson's Disease human Low plasma uric acid level RF 17443703
799 Alzheimer's disease human low serum paraoxonase activity RF 20980077
800 Alzheimer's Disease human lower plasma apoE levels RF in middle age 19720974
801 Alzheimer's Disease human lower serum leptin levels RF 26425011
802 Alzheimer's disease human lower serum level of folate PF 18446027
803 Motor Neuron Disease human magnesium RF low intake of magnesium from drinking water 8029710
804 Alzheimer’s Disease mice mammalian target of rapamycin (mTOR) RF Tg2576 mice 29729422
805 Motor Neuron Disease human manganese RF excess intake of manganese from food 8029710
806 Alzheimer's disease human Manganese (Mn) deficiency RF 28273828
807 Alzheimer’s Disease mice meningeal lymphatics RF wild-type mice (C57BL/6J background) 30046111
808 Alzheimer’s Disease human menopause transition (MT) RF decreased metabolic activity and increased brain amyloid-beta deposition 30298180
809 Alzheimer’s Disease human Methionine synthase RF 12876480
809 Alzheimer’s Disease human Methionine synthase RF 12876480
809 Alzheimer’s Disease human Methionine synthase RF 12876480
809 Alzheimer’s Disease human Methionine synthase RF 12876480
810 Alzheimer's Disease human microglia RF 29207277
811 Alzheimer's disease mice microglial functions(specifically microglial plaque coverage) RF APOE4 genotype 31113487
812 Alzheimer's Disease human Midlife serum total cholesterol RF Model 1 is unadjusted 19648749
812 Alzheimer's Disease human Midlife serum total cholesterol RF Model 2 is adjusted for age (as time scale), sex, education, race/ethnic group, midlife BMI, diabetes and hypertension; for AD, the model is additionally adjusted for late-life stroke. 19648749
813 Alzheimer's disease human mtDNA sub-haplogroup H5 RF in particular for females and independently from the APOE genotype 20700462
814 Amyotrophic Lateral Sclerosis human mutations in neurofilaments RF 16084104
815 Alzheimer’s Disease human Myeloperoxidase(MPO) polymorphism RF 9918702
816 Amyotrophic lateral sclerosis human neuronal apoptosis inhibitory protein RF 29311650
817 Alzheimer’s Disease human NO(Nitric Oxide) bioavailability and cortical, extracranial, and peripheral circulation RF 29593548
818 Frontotemporal Lobar Degeneration human Orthostatic hypotension (OH) RF in subjects with MCI, and patients with dementia compared to subjects with SCD 31381517
818 Frontotemporal Lobar Degeneration human Orthostatic hypotension (OH) RF in subjects with MCI, and patients with dementia compared to subjects with SCD 31381517
818 Frontotemporal Lobar Degeneration human Orthostatic hypotension (OH) RF in subjects with MCI, and patients with dementia compared to subjects with SCD 31381517
819 Alzheimer’s Disease mice Pantoea agglomerans-derived lipopolysaccharide (LPSp) PF fed a high-fat diet, oral administration of LPSp at 0.3 or 1 mg/kg body weight.day for 18 weeks 29856882
820 Alzheimer’s Disease human pathogenic mutations in CSF1R TK domain RF in concert with TREM2, TYROBP, and GRN 29544907
821 Amyotrophic lateral sclerosis human perturbations of the ER proteostasis network RF 25913742
822 Alzheimer's Disease human plasma ApoE levels RF 25547651
823 Alzheimer's disease human Plasma clusterin levels RF elderly persons 27453932
823 Alzheimer's disease human Plasma clusterin levels PF younger participants 27453932
824 Parkinson's Disease human Plasma Se or Fe elevation RF 24340079
825 Alzheimer's disease human plasma total homocysteine RF 27031476
826 Parkinson's Disease human plasma Zn elevation PF 24340079
827 Alzheimer’s Disease mice plasmin (PL) RF Tg6799 transgenic mice (referred to as AD mice) are double-transgenic for human APP/Presenilin 1 30254165
828 Alzheimer's disease human reduced 25-hydroxyvitamin D (25[OH]D) RF 23871764
829 Parkinson's Disease human Reduced serum progranulin(GRN) level RF 23398167
830 Alzheimer’s Disease rabbit royal jelly (RJ) PF male White Hair and Black Eyes (WHBE) rabbits (3–4 months old, 1.8–2.0 kg) 29556189
831 Alzheimer's disease human self-assembly of the Apolipoprotein E4 RF impacts on ε4/ε4 individuals more severely than those with ε3/ε4 31051176
832 Alzheimer's Disease human serum Ang-1 RF 23094194
833 Alzheimer's disease human Serum apoE RF 26876448
834 Amyotrophic Lateral Sclerosis human Serum Ferritin RF 19452011
835 Alzheimer’s Disease human serum folate RF 9823829
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Controlled for age and sex. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Controlled for age and sex. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Also adjusted for educational attainment, smoking, occupational work intensity, and family history of amyotrophic lateral sclerosis. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Also adjusted for educational attainment, smoking, occupational work intensity, and family history of amyotrophic lateral sclerosis. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Controlled for age and sex and also adjusted for body mass index and self-reported diabetes. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Controlled for age and sex and also adjusted for body mass index and self-reported diabetes. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Adjusted for educational attainment, smoking, occupational work intensity, and family history of amyotrophic lateral sclerosis and also adjusted for estimated glomerular filtration rate. 29482216
836 Amyotrophic lateral sclerosis human Serum Retinol-Binding Protein 4 Concentration PF Adjusted for educational attainment, smoking, occupational work intensity, and family history of amyotrophic lateral sclerosis and also adjusted for estimated glomerular filtration rate. 29482216
837 Alzheimer's Disease human serum sEPCR levels RF 25588409
838 Frontotemporal Dementia human SORT1(the neuronal receptor for granulin) RF 29555433
839 Alzheimer's disease human telomere length (TL) RF shorter telomeres in AD patients 27091133
840 Alzheimer’s Disease human tHcy level RF 9823829
841 Lewy body dementia human the Casp2-generated tau fragment Δtau314 RF 31362787
842 Alzheimer's Disease human The highest Hcy RF 28698453
843 Alzheimer's Disease human Triggering receptor expressed in myeloid cells-2 (TREM2) RF in Down Syndrome 29278889
844 Alzheimer’s Disease human Type 2 diabetes (T2D) RF 30112972
845 Alzheimer's Disease human Type 2 diabetic RF 23478310
846 Alzheimer’s Disease human vitamin B12 RF 9823829
847 Frontotemporal Lobar Degeneration human Vitamin B12 deficiency RF 25722508
848 Motor Neuron Disease horse vitamin E RF 16426221
849 Alzheimer's disease human White matter hyperintensities(WMH) load RF 30678723
850 Alzheimer's disease human α-synuclein rs356182 variants PF 30598082
920 Alzheimer's disease human Aβ misfolding(measured in blood plasma) RF 33138082
921 Alzheimer's disease human body mass index [BMI] PF 33138082
922 Alzheimer's disease human diastolic blood pressure [DBP] RF 33138082
923 Alzheimer's disease human Fasting glucose RF 32043803
924 Alzheimer's disease human high-density lipoprotein cholesterol [HDL-C] RF 32767997
924 Alzheimer's disease human high-density lipoprotein cholesterol [HDL-C] RF 32647856
924 Amyotrophic lateral sclerosis human high-density lipoprotein cholesterol [HDL-C] RF Higher levels of HDL-C 32172343
925 Alzheimer's disease human indices of HbA1c variability RF 33021140
926 Alzheimer's disease human low-density lipoprotein cholesterol [LDL-C] RF 33021140
926 Alzheimer's disease human low-density lipoprotein cholesterol [LDL-C] RF 33168078
927 Alzheimer's disease human pulse pressure [PP] PF 33070529
928 Alzheimer's disease human systolic blood pressure [SBP] PF 32949544
929 Alzheimer's disease human total cholesterol [TC] RF 32949544
929 Alzheimer's disease human total cholesterol [TC] RF 32949544
930 Alzheimer's disease human triglycerides [TG] RF 20154673
848 Amyotrophic lateral sclerosis human Vitamin E RF higher serum Vitamin E 32625160
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