RF_ID |
Disease Name |
Species |
RF_Name |
Association |
Condition |
PMID |
851 |
Alzheimer's Disease |
Human |
BuChE-K variant and ApoE allele |
RF |
|
29254094 |
852 |
Alzheimer's Disease |
Human |
Depressed 2 years + sleep disturbance |
RF |
Model 1: Main effect unadjusted |
29077487 |
852 |
Alzheimer's Disease |
Human |
Depressed 2 years + sleep disturbance |
RF |
Model 2: Main effects adjusted for sex, education, age, and race |
29077487 |
852 |
Alzheimer's Disease |
Human |
Depressed 2 years + sleep disturbance |
RF |
Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status |
29077487 |
852 |
Alzheimer's Disease |
Human |
Depressed 2 years + sleep disturbance |
RF |
Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. |
29077487 |
853 |
Alzheimer's Disease |
Human |
Depression lifetime + sleep disturbance |
RF |
Model 1: Main effect unadjusted |
29077487 |
853 |
Alzheimer's Disease |
Human |
Depression lifetime + sleep disturbance |
RF |
Model 2: Main effects adjusted for sex, education, age, and race |
29077487 |
853 |
Alzheimer's Disease |
Human |
Depression lifetime + sleep disturbance |
RF |
Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status |
29077487 |
853 |
Alzheimer's Disease |
Human |
Depression lifetime + sleep disturbance |
RF |
Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. |
29077487 |
854 |
Alzheimer's Disease |
Human |
Clinician-verified depression + sleep disturbance |
RF |
Model 1: Main effect unadjusted |
29077487 |
854 |
Alzheimer's Disease |
Human |
Clinician-verified depression + sleep disturbance |
RF |
Model 2: Main effects adjusted for sex, education, age, and race |
29077487 |
854 |
Alzheimer's Disease |
Human |
Clinician-verified depression + sleep disturbance |
RF |
Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status |
29077487 |
854 |
Alzheimer's Disease |
Human |
Clinician-verified depression + sleep disturbance |
RF |
Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. |
29077487 |
855 |
Alzheimer's Disease |
Human |
Sleep Disturbance + anxiety |
RF |
Model 1: Main effect unadjusted |
29077487 |
855 |
Alzheimer's Disease |
Human |
Sleep Disturbance + anxiety |
RF |
Model 2: Main effects adjusted for sex, education, age, and race |
29077487 |
855 |
Alzheimer's Disease |
Human |
Sleep Disturbance + anxiety |
RF |
Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status |
29077487 |
855 |
Alzheimer's Disease |
Human |
Sleep Disturbance + anxiety |
RF |
Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. |
29077487 |
856 |
Alzheimer's Disease |
Human |
Depressed 2 years + anxiety |
RF |
Model 1: Main effect unadjusted |
29077487 |
856 |
Alzheimer's Disease |
Human |
Depressed 2 years + anxiety |
RF |
Model 2: Main effects adjusted for sex, education, age, and race |
29077487 |
856 |
Alzheimer's Disease |
Human |
Depressed 2 years + anxiety |
RF |
Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status |
29077487 |
856 |
Alzheimer's Disease |
Human |
Depressed 2 years + anxiety |
RF |
Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. |
29077487 |
857 |
Alzheimer's Disease |
Human |
Depression lifetime + anxiety |
RF |
Model 1: Main effect unadjusted |
29077487 |
857 |
Alzheimer's Disease |
Human |
Depression lifetime + anxiety |
RF |
Model 2: Main effects adjusted for sex, education, age, and race |
29077487 |
857 |
Alzheimer's Disease |
Human |
Depression lifetime + anxiety |
RF |
Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status |
29077487 |
857 |
Alzheimer's Disease |
Human |
Depression lifetime + anxiety |
RF |
Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. |
29077487 |
858 |
Alzheimer's Disease |
Human |
Clinician-verified depression + anxiety |
RF |
Model 1: Main effect unadjusted |
29077487 |
858 |
Alzheimer's Disease |
Human |
Clinician-verified depression + anxiety |
RF |
Model 2: Main effects adjusted for sex, education, age, and race |
29077487 |
858 |
Alzheimer's Disease |
Human |
Clinician-verified depression + anxiety |
RF |
Model 3: Main effects adjusted for adjusted for sex, education, age, race, and e4 carrier status |
29077487 |
858 |
Alzheimer's Disease |
Human |
Clinician-verified depression + anxiety |
RF |
Model 4: Main effects adjusted for adjusted for sex, education, age, race, e4 carrier status, the presence of hypertension and hypercholesterolemia. |
29077487 |
859 |
Alzheimer's Disease |
Human |
APOE e4 and GSTM1 null deletion |
RF |
|
29072550 |
860 |
Alzheimer's Disease |
Human |
APOE4 and woman |
RF |
|
24623176 |
861 |
Alzheimer's Disease |
Human |
the genotypes GG and APOEε4 |
RF |
|
24575113 |
862 |
Alzheimer's Disease |
Human |
COMT (Val158 Met) polymorphism with APOE epsilon4 allele |
RF |
GG allele |
19793392 |
863 |
Alzheimer's Disease |
Human |
COMT (Val158 Met) polymorphism with APOE epsilon5 allele |
RF |
AG allele |
19793392 |
864 |
Alzheimer's Disease |
Human |
The combined effects of TNFa, IL-6 and IL-10 variant alleles |
RF |
|
19744138 |
865 |
Alzheimer's Disease |
Human |
female and the APOE ε3/ε4 genotype |
RF |
between the ages of 65 and 75 years |
28846757 |
866 |
Alzheimer's Disease |
Human |
male and the APOE ε3/ε4 genotype |
RF |
between the ages of 65 and 75 years |
28846757 |
867 |
Alzheimer's disease |
human |
interaction between a GRS comprised of AD SNPs and midlife triglyceride levels |
RF |
rs11218343 and APOE?4 |
30412497 |
868 |
Alzheimer's disease |
human |
combine TGG haplotype and APOEε4 |
RF |
|
27188425 |
869 |
Alzheimer's disease |
human |
combine SUMO1 rs12472035 CT genotype,SUMO2 rs35271045 GA genotype and SUMO2 rs9913676 TC genotype |
RF |
|
27084229 |
870 |
Alzheimer's disease |
human |
combine levels of leptin, adiponectin and insulin |
RF |
|
26906354 |
871 |
Alzheimer's disease |
human |
combine SOD2 gene rs4880-T genotype and APOEε4 genotype |
RF |
|
26696693 |
872 |
Alzheimer's disease |
human |
combine APOC1 insertion mutation and APOE ε4 |
RF |
|
24498013 |
873 |
Alzheimer's disease |
human |
carriers of the CTSD T and APOE ε4 alleles |
RF |
|
24281128 |
874 |
Alzheimer's disease |
human |
Higher estrone (E1) levels and carrying the APOE ε4 allele |
RF |
|
21211518 |
875 |
Alzheimer's disease |
human |
MTHFR 677 T allele and APOE epsilon4 allele |
RF |
|
18258338 |
876 |
Amyotrophic Lateral Sclerosis |
Human |
SNP(combination SNP1 and SNP2) |
RF |
The estimations using the proposed method (unadjusted estimates) |
19740415 |
876 |
Amyotrophic Lateral Sclerosis |
Human |
SNP(combination SNP1 and SNP2) |
RF |
The estimations using the proposed method (adjusted estimates) |
19740415 |
877 |
Amyotrophic Lateral Sclerosis |
Human |
SNP(combination SNP1 and SNP3) |
RF |
The estimations using the proposed method (unadjusted estimates) |
19740415 |
877 |
Amyotrophic Lateral Sclerosis |
Human |
SNP(combination SNP1 and SNP3) |
RF |
The estimations using the proposed method (adjusted estimates) |
19740415 |
878 |
Amyotrophic Lateral Sclerosis |
Human |
SMN1(one or three copies of SMN1 gene were pooled) |
RF |
|
16931506 |
879 |
Amyotrophic Lateral Sclerosis |
Human |
combination of multiple genetic and environmental factors |
RF |
|
18421219 |
880 |
Amyotrophic Lateral Sclerosis |
Human |
high intakes of carbohydrate and low intakes of fat and some kinds of fatty acids(when combined) |
RF |
|
17852010 |
881 |
Amyotrophic Lateral Sclerosis |
Human |
Multivariate analysis (with covariates age, smoking, education, and occupation) |
RF |
|
17923612 |
882 |
Amyotrophic Lateral Sclerosis |
Human |
Lifestyle factors(combination Type A behavior and Intake of green-yellow vegetables) |
RF |
|
19342254 |
883 |
Frontotemporal Dementia |
Human |
the H1 haplotype of the tau gene and the E2 allele of APOE |
RF |
|
12056929 |
884 |
Frontotemporal Dementia |
Human |
tau haplotype in combination with apoE epsilon4 |
RF |
between genotypes with tau alleles A0 or A1 only (A3-) and apoE genotypes with at least one ε4 allele (ε4?) |
11303757 |
885 |
Alzheimer’s Disease |
rat |
combination of risk factor hHcy(Hyperhomocysteinemia) with IRI(ischemia-reperfusion injury) |
RF |
Adult male Wistar rats 5–6 months old and weighing 300–400 g |
30003389 |
886 |
Alzheimer's disease |
human |
combination therapy with insulin |
RF |
|
24489845 |
887 |
Parkinson's Disease |
human |
combine Traumatic brain injury and paraquat exposure |
RF |
|
23150532 |
888 |
Alzheimer's disease |
human |
combine Type 2 diabetes and diabetic ketoacidosis (DKA) |
RF |
|
30481578 |
889 |
Parkinson's Disease |
human |
combined residential exposures(residential, non-occupational pesticide and heavy metal exposure) |
RF |
|
19818671 |
890 |
Alzheimer’s Disease |
human |
diabetes and hyperlipidemia |
RF |
|
29971140 |
880 |
Amyotrophic Lateral Sclerosis |
human |
high intakes of carbohydrate and low intakes of fat and some kinds of fatty acids(when combined) |
RF |
|
17852010 |
891 |
Amyotrophic lateral sclerosis |
human |
joint contribution of genetics and environmental exposures |
RF |
|
28355414 |
892 |
Alzheimer's Disease |
human |
MDFK(mineral turpentine, diesel oil, fuel oil and kerosene) |
RF |
adjusted for age, education and sex, using logistic regression;Model 1 |
25028582 |
892 |
Alzheimer's Disease |
human |
MDFK(mineral turpentine, diesel oil, fuel oil and kerosene) |
RF |
adjusted for age, education and sex, using logistic regression;Model 2 |
25028582 |
892 |
Alzheimer's Disease |
human |
MDFK(mineral turpentine, diesel oil, fuel oil and kerosene) |
RF |
adjusted for age, education and sex, using logistic regression;Model 3 |
25028582 |
893 |
Alzheimer's disease |
|
Mercury (Hg) and lead (Pb) |
RF |
|
30603762 |
881 |
Amyotrophic Lateral Sclerosis |
human |
Multivariate analysis (with covariates age, smoking, education, and occupation) |
RF |
|
17923612 |
894 |
Alzheimer's Disease |
human |
APOE and gender |
RF |
|
29278785 |
894 |
Alzheimer's Disease |
human |
APOE and gender |
RF |
|
29278785 |
895 |
Alzheimer’s Disease |
human |
ApoE + deposition of β-amyloid (Aβ) |
RF |
|
29527500 |
896 |
Alzheimer’s Disease |
human |
Depression + depression-related monoaminergic systems |
RF |
including serotonin and noradrenaline |
29685068 |
897 |
Alzheimer’s Disease |
human |
APOE ε4 allele + family history |
RF |
family history of late-onset AD (FH) |
30134963 |
898 |
Alzheimer’s Disease |
human |
CHD5 rs11121295 + drinking |
RF |
|
29861839 |
898 |
Alzheimer’s Disease |
human |
CHD5 rs11121295 + drinking |
RF |
|
29861839 |
899 |
Alzheimer’s Disease |
human |
ApoE + ApoE protein |
RF |
effect the formation of protein polymers and fibrilization through interaction with tau and Abeta |
7695621 |
900 |
Alzheimer’s Disease |
human |
Traumatic brain injury (TBI) + S100A9 protein |
RF |
S100A9-driven amyloid-neurodegenerative cascade |
30150640 |
901 |
Alzheimer’s Disease |
human |
APOE ε4 allele + alpha 1-antichymotrypsin polymorphism |
RF |
|
7670501 |
902 |
Alzheimer’s Disease |
human |
APOE ε4 allele + Herpes simplex virus type 1(HSV1) |
RF |
Frontal lobe |
9014911 |
902 |
Alzheimer’s Disease |
human |
APOE ε4 allele + Herpes simplex virus type 1(HSV1) |
RF |
Temporal lobe |
9014911 |
902 |
Alzheimer’s Disease |
human |
APOE ε4 allele + Herpes simplex virus type 1(HSV1) |
RF |
Overall |
9014911 |