RF_ID |
Disease Name |
Species |
RF_Name |
Association |
Phase |
Condition |
Year |
PMID |
3372 |
Amyotrophic Lateral Sclerosis |
Human |
Rare CNVs |
RF |
|
|
2008 |
18313986 |
3825 |
Parkinson disease |
Human |
TMEM |
RF |
Diagnosis |
|
2021 |
33279243 |
3826 |
Parkinson disease |
Human |
TMEM |
RF |
Diagnosis |
|
2021 |
33279243 |
2204 |
Alzheimer's Disease |
Human |
TMEM |
RF |
|
APOE-?2 |
2021 |
33576571 |
4007 |
Fatal familial insomnia (FFI) |
Human |
SRSF11 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4009 |
Fatal familial insomnia (FFI) |
Human |
SRSF11 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4008 |
Fatal familial insomnia (FFI) |
Human |
SRSF11 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4000 |
Fatal familial insomnia (FFI) |
Human |
NR1H9P |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
3999 |
Fatal familial insomnia (FFI) |
Human |
NR1H8P |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
3998 |
Fatal familial insomnia (FFI) |
Human |
NR1H7P |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
3997 |
Fatal familial insomnia (FFI) |
Human |
NR1H6P |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
3996 |
Fatal familial insomnia (FFI) |
Human |
NR1H5P |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4001 |
Fatal familial insomnia (FFI) |
Human |
NR1H10P |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4010 |
Fatal familial insomnia (FFI) |
Human |
MSANTD3 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4012 |
Fatal familial insomnia (FFI) |
Human |
MSANTD3 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4014 |
Fatal familial insomnia (FFI) |
Human |
MSANTD3 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4011 |
Fatal familial insomnia (FFI) |
Human |
MSANTD3 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4013 |
Fatal familial insomnia (FFI) |
Human |
MSANTD3 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4016 |
Amyotrophic Lateral Sclerosis |
Human |
HTT |
RF |
Diagnosis |
|
2023 |
36599142 |
4002 |
Fatal familial insomnia (FFI) |
Human |
GNA13P1 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4003 |
Fatal familial insomnia (FFI) |
Human |
GNA13P1 |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4005 |
Fatal familial insomnia (FFI) |
Human |
EXOC1L |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4004 |
Fatal familial insomnia (FFI) |
Human |
EXOC1L |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
4006 |
Fatal familial insomnia (FFI) |
Human |
EXOC1L |
RF |
Diagnosis |
These genetic variants are absent in FFI patients with early disease onset (19-40 years) |
2023 |
37626863 |
1839 |
Alzheimer's Disease |
Human |
MT-ND2 |
RF |
Diagnosis |
|
2023 |
34854014 |
1840 |
Alzheimer's Disease |
Human |
MT-ND5 |
RF |
Diagnosis |
|
2023 |
34854014 |
3991 |
Amyotrophic Lateral Sclerosis |
Human |
hsa-miR-152-3p |
RF |
Diagnosis |
|
2023 |
37261630 |
929 |
Amyotrophic Lateral Sclerosis |
Human |
hsa-miR-139-5p |
PF |
Diagnosis |
|
2023 |
37261630 |
928 |
Amyotrophic Lateral Sclerosis |
Human |
hsa-miR-27b-3p |
PF |
Diagnosis |
|
2023 |
37261630 |
3990 |
Tourette Syndrome |
Human |
ASH1L |
RF |
Diagnosis |
|
2022 |
35307981 |
3989 |
Tourette Syndrome |
Human |
ASH1L |
RF |
Diagnosis |
|
2022 |
35307981 |
685 |
Lewy Body Disease |
Human |
Mitochondrial genomic variation |
PF |
Diagnosis |
|
2022 |
35836284 |
3986 |
Amyotrophic Lateral Sclerosis |
human and mice |
SARM1 |
RF |
Diagnosis |
|
2022 |
34991663 |
1912 |
Amyotrophic Lateral Sclerosis |
Human |
APOB |
RF |
Diagnosis |
|
2023 |
37688479 |
1947 |
Amyotrophic Lateral Sclerosis |
Human |
HMGCR |
RF |
Diagnosis |
|
2023 |
37688479 |
1666 |
Amyotrophic Lateral Sclerosis |
Human |
LRP1 |
RF |
Diagnosis |
|
2023 |
37142397 |
1571 |
Amyotrophic Lateral Sclerosis |
Human |
THSD7A |
RF |
Diagnosis |
|
2023 |
37142397 |
1677 |
Amyotrophic Lateral Sclerosis |
Human |
FGF1 |
RF |
Diagnosis |
|
2023 |
37142397 |
1829 |
Parkinson disease |
Human |
MIDN |
RF |
Diagnosis |
|
2023 |
36858566 |
3953 |
Parkinson disease |
Human |
CD4 |
RF |
Diagnosis |
|
2022 |
36224715 |
3952 |
Parkinson disease |
Human |
CD4 |
RF |
Diagnosis |
|
2022 |
36224715 |
1710 |
Parkinson disease |
Human |
LRP1B |
RF |
Prognosis |
|
2023 |
36348503 |
2021 |
Parkinson disease |
Human |
DRD4 |
RF |
Diagnosis |
|
2022 |
35532648 |
2090 |
Parkinson disease |
Human |
DRD4 |
RF |
Diagnosis |
|
2022 |
35532648 |
3938 |
Alzheimer's Disease |
Human |
MYO15A |
RF |
Diagnosis |
|
2023 |
36788216 |
3937 |
Alzheimer's Disease |
Human |
COX7C |
RF |
Diagnosis |
|
2023 |
36788216 |
2264 |
Alzheimer's Disease |
Human |
ABCA1 |
RF |
Diagnosis |
|
2022 |
36411364 |
3936 |
Alzheimer's Disease |
Human |
ABCA1 |
RF |
Diagnosis |
|
2023 |
36788216 |
2118 |
Alzheimer's Disease |
Human |
ATP8B4 |
RF |
Diagnosis |
|
2022 |
36411364 |
3930 |
Alzheimer's Disease |
Human |
IDE |
RF |
Diagnosis |
|
2022 |
35236268 |
3926 |
Alzheimer's Disease |
Human |
Hsa-miR-320a |
RF |
Diagnosis |
related to AD and depression |
2022 |
36040555 |
3925 |
Alzheimer's Disease |
Human |
Hsa-miR-451a |
RF |
Diagnosis |
related to AD and depression |
2022 |
36040555 |
3924 |
Alzheimer's Disease |
Human |
Hsa-miR-27a-3p |
RF |
Diagnosis |
related to AD and depression |
2022 |
36040555 |
3923 |
Alzheimer's Disease |
Human |
Hsa-miR-664a-3p |
RF |
Diagnosis |
related to AD and depression |
2022 |
36040555 |
3922 |
Alzheimer's Disease |
Human |
Hsa-miR-181c-5p |
RF |
Diagnosis |
related to AD and depression |
2022 |
36040555 |
3920 |
Alzheimer's Disease |
Human |
Hsa-miR-497-5p |
RF |
Diagnosis |
related to AD and education |
2022 |
36040555 |
3919 |
Alzheimer's Disease |
Human |
Hsa-miR-20a-5p |
RF |
Diagnosis |
related to AD and education |
2022 |
36040555 |
3921 |
Alzheimer's Disease |
Human |
Hsa-miR-185-5p |
RF |
Diagnosis |
related to AD and depression |
2022 |
36040555 |
3918 |
Alzheimer's Disease |
Human |
Hsa-miR-185-5p |
RF |
Diagnosis |
related to AD and education |
2022 |
36040555 |
3904 |
Alzheimer's Disease |
Human |
NOTCH2 |
RF |
Diagnosis |
|
2023 |
37355909 |
2220 |
Alzheimer's Disease |
Human |
5, 10-methylenetetrahydrofolate dehydrogenase gene (MTHFD1) |
RF |
|
|
2010 |
20217437 |
2267 |
Alzheimer's Disease |
Human |
5-HTT |
RF |
|
homozygous low activity genotype: ε4 alleles of the ApoE gene |
1997 |
9106747 |
2305 |
Alzheimer's Disease |
Human |
5-LO |
RF |
|
A allele |
2010 |
20110601 |
3147 |
Amyotrophic Lateral Sclerosis |
Human |
A90V TDP-43 variant |
RF |
|
|
2008 |
18505686 |
767 |
Parkinson disease |
Human |
ABCA7 |
PF |
Diagnosis |
|
2022 |
35709878 |
721 |
Alzheimer's Disease |
Human |
ABCA7 |
PF |
|
National Alzheimer’s Coordinating Center (NACC) cohort |
2018 |
30128317 |
3955 |
Parkinson disease |
Human |
ABCA7 |
RF |
Diagnosis |
|
2022 |
35709878 |
2972 |
Alzheimer's Disease |
Human |
ABCA7 |
RF |
|
|
2018 |
29589097 |
3149 |
Alzheimer's Disease |
Human |
ABCA7 |
RF |
|
|
2018 |
29589097 |
3148 |
Alzheimer's Disease |
Human |
ABCA7 |
RF |
|
|
2018 |
29589097 |
1974 |
Alzheimer's Disease |
Human |
ABCA7 |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
1942 |
Alzheimer's Disease |
Human |
ABCA7 |
RF |
|
|
2016 |
26795201 |
3150 |
Alzheimer's Disease |
Human |
ABCA7 |
RF |
|
with both ApoEε4-carrier and aging being factors enhancing its risk |
2014 |
24113560 |
2986 |
Alzheimer's Disease |
Human |
ABCA8 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2900 |
Alzheimer's Disease |
Human |
ABCA8 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3110 |
Parkinson disease |
Human |
ABCB1 |
RF |
|
|
2014 |
24572589 |
546 |
Alzheimer's Disease |
Human |
ACAT1 |
PF |
|
|
2021 |
33057949 |
2349 |
Alzheimer's Disease |
Human |
ACAT1 |
RF |
|
|
2021 |
33057949 |
3152 |
Alzheimer's Disease |
Human |
ACE |
RF |
|
in subjects aged 73 years and above. |
2009 |
19539712 |
2495 |
Alzheimer's Disease |
Human |
ACE |
RF |
|
|
2000 |
11078932 |
2023 |
Parkinson disease |
Human |
ACE |
RF |
|
|
2002 |
12084438 |
3151 |
Alzheimer's Disease |
Human |
ACE |
RF |
|
|
2010 |
21537449 |
3153 |
Alzheimer's Disease |
Human |
ACE |
RF |
|
in subjects aged 73 years and above. |
2009 |
19539712 |
3835 |
Parkinson disease |
Human |
ACE |
RF |
Prognosis |
|
2021 |
34945793 |
2022 |
Parkinson disease |
Human |
ACE |
RF |
|
|
2002 |
12084438 |
1896 |
Alzheimer's Disease |
Human |
ACT |
RF |
|
especially in Caucasians |
2012 |
22294107 |
1976 |
Alzheimer's Disease |
Human |
ACT |
RF |
|
especially in Caucasians |
2012 |
22294107 |
3154 |
Multiple System Atrophy |
Human |
ACT |
RF |
|
|
2005 |
15907346 |
1894 |
Alzheimer's Disease |
Human |
ACT |
RF |
|
A allele carriers are associated with increased susceptibility to AD in variant populations |
2013 |
22272609 |
1897 |
Alzheimer's Disease |
Human |
ACT |
RF |
|
A allele carriers are associated with increased susceptibility to AD in variant populations |
2013 |
22272609 |
2889 |
Parkinson disease |
Human |
ADAM10 |
RF |
|
|
2021 |
33527480 |
2513 |
Parkinson disease |
Human |
ADH1B |
RF |
|
|
2019 |
30483881 |
512 |
Alzheimer's Disease |
Human |
ADH1C |
PF |
|
|
2021 |
33551739 |
3811 |
Lewy Body Disease |
Human |
AD-PRS |
RF |
Diagnosis |
|
2021 |
34308904 |
1951 |
Alzheimer's Disease |
Human |
AKNAD1 |
RF |
|
APOE-?3 |
2021 |
33576571 |
756 |
Alzheimer's Disease |
Human |
AKNAD1 |
PF |
|
APOE-?3 |
2021 |
33576571 |
2337 |
Alzheimer's Disease |
Human |
AKNAD1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2803 |
Alzheimer's Disease |
Human |
ALDH2 |
RF |
|
dependent on APOE epsilon4 status in Chinese |
2008 |
18201725 |
691 |
Alzheimer's Disease |
Human |
ALDH5A1 |
PF |
|
APOE-?3 |
2021 |
33576571 |
3155 |
Alzheimer's Disease |
Human |
ALOX5 |
RF |
|
|
2016 |
26944113 |
2325 |
Alzheimer's Disease |
Human |
ANK1 |
RF |
|
|
2016 |
26611832 |
3856 |
Parkinson disease |
Human |
ANKK1 |
RF |
|
|
2021 |
34151861 |
1656 |
Alzheimer's Disease |
Human |
APOC1 |
RF |
|
using Cox regression、Dataset:FHS(Framingham Heart Study) |
2018 |
29107063 |
3157 |
Alzheimer's Disease |
Human |
APOC1 |
RF |
|
not in African Americans |
2014 |
24498013 |
3156 |
Alzheimer's Disease |
Human |
APOC1 |
RF |
|
|
2018 |
30443289 |
1670 |
Alzheimer's Disease |
Human |
APOC1 |
RF |
|
using Cox regression、Dataset:CHS(Cardiovascular Health Study) |
2018 |
29107063 |
2536 |
Alzheimer's Disease |
Human |
APOC1 |
RF |
|
using logistic regression、Dataset:FHS(Framingham Heart Study) |
2018 |
29107063 |
3158 |
Alzheimer's Disease |
Human |
APOD |
RF |
|
in APOEε4 (-) subgroup |
2013 |
23690001 |
2260 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
using logistic regression、Dataset:LOADFS(Late Onset Alzheimer's Disease Family Study ) |
2018 |
29107063 |
826 |
Frontotemporal Dementia |
Human |
APOE |
PF |
|
|
2017 |
28888721 |
3160 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele |
2018 |
29592889 |
2463 |
Alzheimer's Disease |
Human |
APOE |
RF |
Diagnosis |
|
2022 |
35135450 |
2829 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2019 |
30894904 |
3185 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2008 |
18560129 |
2601 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
A/A genotype |
2009 |
19172988 |
2339 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2010 |
19819468 |
3139 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
lowers age at onset of LOAD significantly |
2008 |
18416843 |
1848 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2012 |
22068907 |
2272 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε3ε4+ε4ε4 vs. ε3ε3 |
2017 |
28487499 |
3166 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele |
1994 |
7977635 |
602 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
ε2 allele |
2018 |
29990559 |
2754 |
Frontotemporal Dementia |
Human |
APOE |
RF |
|
|
2013 |
23887281 |
1761 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2021 |
33397450 |
3190 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
APOE haplotypes |
2014 |
24596166 |
2610 |
Dementia with Lewy bodies |
Human |
APOE |
RF |
|
|
2018 |
29263008 |
3171 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2019 |
30890475 |
2929 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2014 |
23871727 |
527 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
National Alzheimer’s Coordinating Center (NACC) cohort; ε4 |
2018 |
30128317 |
2113 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
using logistic regression、Dataset:CHS( Cardiovascular Health Study) |
2018 |
29107063 |
3023 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ε4/4; adjusted for age and education, and stratified by gender |
2018 |
30205398 |
2807 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ε4/-; adjusted for age and education, and stratified by gender |
2018 |
30205398 |
697 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
APOEε2ε3 |
2015 |
25673977 |
2289 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε2ε2 vs. ε3ε3 |
2017 |
28487499 |
3082 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2002 |
12095653 |
3177 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2015 |
26738348 |
2936 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2010 |
20217437 |
822 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
|
2012 |
22068907 |
3182 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
The rate of APOE4 carrier status and the frequency of the ε4 allele were 47% and 27% for LOAD, 50% and 31% for EOAD, |
2011 |
21552550 |
2505 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele |
2002 |
12160362 |
3162 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele |
1994 |
7841371 |
2348 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2008 |
18446027 |
2750 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2014 |
24281128 |
1717 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2014 |
24045327 |
3187 |
Dementia with Lewy bodies |
Human |
APOE |
RF |
|
|
2014 |
24973356 |
3666 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2020 |
32043803 |
562 |
Dementia with Lewy bodies |
Human |
APOE |
PF |
|
|
2019 |
30798004 |
3014 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ?3/?4; AD without depression |
2018 |
29703883 |
3168 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
1996 |
8993485 |
2697 |
Frontotemporal Dementia |
Human |
APOE |
RF |
|
|
2006 |
15904995 |
1572 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
using Cox regression、Dataset:CHS(Cardiovascular Health Study) |
2018 |
29107063 |
2356 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Gender: female; Calculated by Forced entry model |
1999 |
10213175 |
2759 |
Dementia with Lewy bodies |
Human |
APOE |
RF |
|
|
2019 |
30798004 |
1771 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2018 |
30450407 |
3192 |
Progressive Supranuclear Palsy |
Human |
APOE |
RF |
|
|
2003 |
12552038 |
2522 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ε3/4; adjusted for age and education, and stratified by gender |
2018 |
30205398 |
3174 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2016 |
27033052 |
2855 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Carrying at least one ε4 allele; Calculated by Step-wise model |
1999 |
10213175 |
2898 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Individuals with 2 epsilon 4 alleles had a higher risk for AD than subjects with only 1 such allele |
2008 |
18317248 |
3086 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele |
2001 |
11376902 |
2449 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
APOE ε4ε4 |
2015 |
25673977 |
3179 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2013 |
23887281 |
2939 |
Creutzfeldt-Jakob disease |
Human |
APOE |
RF |
|
ε4 allele |
1994 |
7968026 |
2734 |
Alzheimer's Disease |
Human |
APOE |
RF |
Diagnosis |
with APOE*4?allele |
2023 |
36528961 |
2864 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele; associated with heterozygosity |
1994 |
8128961 |
825 |
Frontotemporal Dementia |
Human |
APOE |
PF |
|
|
2002 |
12107813 |
3044 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
PENN cohort; ε2 |
2018 |
30128317 |
2823 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
at least one epsilon 4 allele |
1995 |
8786847 |
3159 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2012 |
22712640 |
1679 |
Parkinson disease |
Human |
APOE |
RF |
Prognosis |
|
2023 |
36348503 |
3184 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2010 |
20385913 |
2509 |
Dementia with Lewy bodies |
Human |
APOE |
RF |
|
4 allele |
2006 |
16956959 |
3164 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε2 allele |
2018 |
29562509 |
2350 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ε3/4; adjusted for age and education, and stratified by gender |
2018 |
30205398 |
2753 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε4 allele |
2013 |
23887281 |
1722 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2011 |
21649613 |
2231 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε4 vs. ε3 allele model |
2017 |
28487499 |
3189 |
Dementia with Lewy bodies |
Human |
APOE |
RF |
|
The rate of APOE4 carrier status and the frequency of the ε4 allele were 42% and 31% for DLB |
2011 |
21552550 |
571 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
ε3 allele |
2014 |
24632849 |
2146 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε4 vs. ε2+ε3+ε4 allele model |
2017 |
28487499 |
3170 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2019 |
30991302 |
3194 |
Dementia with Lewy bodies |
Human |
APOE |
RF |
|
|
2016 |
27312774 |
2976 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele; AD without depression |
2018 |
29703883 |
521 |
Frontotemporal Dementia |
Human |
APOE |
PF |
|
|
2006 |
15904995 |
2847 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Th1/E47cs polymorphism allele |
2002 |
12095653 |
2894 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele; AD all |
2018 |
29703883 |
2675 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ε3/4; adjusted for age and education, and stratified by gender |
2018 |
30205398 |
3176 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
The ε4 allele increases the risk of Alzheimer's disease by 5.114 times |
2016 |
26835020 |
2717 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: AA |
1999 |
10213175 |
1643 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2020 |
32767997 |
2366 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Gender: female; Calculated by Step-wise model |
1999 |
10213175 |
2298 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype/Allele: A/A |
2018 |
29990559 |
3181 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2011 |
21556001 |
2375 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
APOE ε3ε4 |
2015 |
25673977 |
2774 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ?4/?4; AD without depression |
2018 |
29703883 |
2912 |
Alzheimer's Disease |
Human |
APOE |
RF |
Diagnosis |
|
2022 |
35135450 |
719 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
Genotype/Allele: T |
2018 |
29990559 |
3161 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele |
2018 |
30112972 |
3186 |
Frontotemporal Dementia |
Human |
APOE |
RF |
|
|
2013 |
23887281 |
2606 |
Creutzfeldt-Jakob disease |
Human |
APOE |
RF |
|
ε4 allele |
1994 |
7968026 |
2957 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2018 |
29307083 |
2340 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε2ε2 vs. ε3ε3+ε3ε2 |
2017 |
28487499 |
2140 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2008 |
18317248 |
3167 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
1997 |
9008509 |
2315 |
Creutzfeldt-Jakob disease |
Human |
APOE |
RF |
|
ε4 allele |
1994 |
7968026 |
2696 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε4 allele |
2006 |
15904995 |
3065 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2011 |
22737475 |
3799 |
Lewy Body Disease |
Human |
APOE |
RF |
|
|
2021 |
34308904 |
2433 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2002 |
12095653 |
2755 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
National Alzheimer’s Coordinating Center (NACC) cohort; ε2 |
2018 |
30128317 |
1762 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2020 |
32485802 |
2480 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
APOE ε4 |
2000 |
10912224 |
2844 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Carrying at least one ε4 allele; Calculated by Forced entry model |
1999 |
10213175 |
3191 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
?4 allele |
2015 |
23038715 |
625 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
Genotype/Allele: A/T |
2018 |
29990559 |
2208 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε3ε4 vs. ε3ε3 |
2017 |
28487499 |
3172 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2017 |
28461186 |
1620 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
using Cox regression、Dataset:HRS(Health and Retirement Study) |
2018 |
29107063 |
2982 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele; associated with homozygosity |
1994 |
8128961 |
3695 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2021 |
34336000 |
532 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
ε3 allele |
2018 |
29990559 |
2851 |
Dementia with Lewy bodies |
Human |
APOE |
RF |
|
|
2002 |
12411758 |
2897 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ?3/?4; AD all |
2018 |
29703883 |
3178 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2014 |
24326531 |
2592 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ε4/-; adjusted for age and education, and stratified by gender |
2018 |
30205398 |
2938 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2014 |
23871727 |
2728 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε4ε4 vs. ε3ε3+ε3ε4 |
2017 |
28487499 |
2368 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
using logistic regression、Dataset:HRS(Health and Retirement Study) |
2018 |
29107063 |
542 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
|
2008 |
18317248 |
2126 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε4 vs. ε2+ε3+ε4 carrier model |
2017 |
28487499 |
3042 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ε4/4; adjusted for age and education, and stratified by gender |
2018 |
30205398 |
1331 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2010 |
20376800 |
2818 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε4ε4 vs. ε3ε3 |
2017 |
28487499 |
2906 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele |
2014 |
24632849 |
3183 |
Alzheimer's Disease |
human and mice |
APOE |
RF |
|
nutritional imbalance |
2010 |
20413864 |
2646 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2011 |
22311091 |
3163 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε2 allele |
1994 |
7824157 |
3667 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2020 |
32116259 |
500 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
PENN cohort; ε4 |
2018 |
30128317 |
3188 |
Dementia with Lewy bodies |
Human |
APOE |
RF |
|
epsilon 4 allele |
1994 |
7970234 |
2143 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
RF |
|
ε4 vs. ε2 allele model |
2017 |
28487499 |
2654 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype: ε4/-; adjusted for age and education, and stratified by gender |
2018 |
30205398 |
3015 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Carrying at least one ε4 allele |
1999 |
10213175 |
3169 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
1998 |
9811931 |
3193 |
Frontotemporal Dementia |
Human |
APOE |
RF |
|
|
2017 |
28888721 |
520 |
Frontotemporal Lobar Degeneration |
Human |
APOE |
PF |
|
ε2 allele |
2006 |
15904995 |
3175 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2015 |
26885125 |
3080 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2017 |
29348964 |
3115 |
Alzheimer's Disease |
Human |
APOE |
RF |
Diagnosis |
|
2022 |
35135450 |
2857 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2011 |
20682755 |
705 |
Alzheimer's Disease |
Human |
APOE |
PF |
|
|
2008 |
18317248 |
3089 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
ε4 allele |
2018 |
29990559 |
1669 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2021 |
33397450 |
3180 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
|
2011 |
21637534 |
2087 |
Alzheimer's Disease |
Human |
APOE |
RF |
|
Genotype/Allele: A |
2018 |
29990559 |
732 |
Alzheimer's Disease |
Human |
APOE ε2/ε3 |
PF |
|
|
2017 |
28846757 |
620 |
Alzheimer's Disease |
Human |
APOE ε2/ε3 |
PF |
|
|
2017 |
28846757 |
2828 |
Alzheimer's Disease |
Human |
APOE ε3/ε4 |
RF |
|
from ages 55 to 85 years |
2017 |
28846757 |
2794 |
Alzheimer's Disease |
Human |
APOE ε3/ε4 |
RF |
|
from ages 55 to 85 years |
2017 |
28846757 |
2793 |
Alzheimer's Disease |
Human |
ApoE ε4/ε3 |
RF |
|
ε4/ε3 genotype |
2014 |
24632849 |
2435 |
Alzheimer's Disease |
Human |
ApoE ε4/ε4 |
RF |
|
ε4/ε4 genotype |
2014 |
24632849 |
2946 |
Alzheimer's Disease |
Human |
APOE,ACT |
RF |
|
ACT Genotype: AA; One Copy of ε4 |
1996 |
8993481 |
3114 |
Alzheimer's Disease |
Human |
APOE,ACT |
RF |
|
ACT Genotype: AT; Two Copies of ε4 |
1996 |
8993481 |
2811 |
Alzheimer's Disease |
Human |
APOE,ACT |
RF |
|
ACT Genotype: TT; Two Copies of ε4 |
1996 |
8993481 |
2657 |
Alzheimer's Disease |
Human |
APOE,ACT |
RF |
|
ACT Genotype: TT; One Copy of ε4 |
1996 |
8993481 |
2915 |
Alzheimer's Disease |
Human |
APOE,ACT |
RF |
|
ACT Genotype: AA; Two Copies of ε4 |
1996 |
8993481 |
2813 |
Alzheimer's Disease |
Human |
APOE,ACT |
RF |
|
ACT Genotype: AT; One Copy of ε4 |
1996 |
8993481 |
2510 |
Frontotemporal Lobar Degeneration |
Human |
APOE,TOMM40 |
RF |
|
APOE-TOMM40 haplotype: ε4 GAC |
2013 |
23546992 |
869 |
Alzheimer's Disease |
Human |
APOE?2 |
PF |
|
substantially attenuated among Black people |
2021 |
34334408 |
2956 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
|
|
2021 |
33732104 |
3805 |
Lewy Body Disease |
Human |
APOE?4 |
RF |
Diagnosis |
|
2021 |
33646158 |
2439 |
Parkinson disease |
Human |
APOE?4 |
RF |
|
|
2021 |
33057949 |
3694 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
|
substantially attenuated among Black people |
2021 |
34334408 |
2591 |
Chronic Traumatic Encephalopathy |
Human |
APOE?4 |
RF |
Diagnosis |
|
2022 |
35759276 |
2642 |
Lewy Body Disease |
Human |
APOE?4 |
RF |
Diagnosis |
|
2021 |
34308904 |
3749 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
|
|
2021 |
33009037 |
2666 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
Diagnosis |
|
2023 |
37182880 |
3797 |
Frontotemporal Dementia |
Human |
APOE?4 |
RF |
Diagnosis |
in the C9orf72 noncarriers |
2021 |
32972771 |
3705 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
|
|
2021 |
34214049 |
3917 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
Diagnosis |
|
2022 |
36226340 |
3009 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
|
|
2021 |
33541779 |
3731 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
|
|
2021 |
33686543 |
3756 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
|
|
2021 |
33196771 |
3697 |
Alzheimer's Disease |
Human |
APOE?4 |
RF |
|
|
2021 |
34266503 |
1952 |
Parkinson disease |
Human |
apolipoprotein E ( APOE) ε3 allele |
RF |
|
|
2019 |
30526202 |
809 |
Parkinson disease |
Human |
apolipoprotein E ( APOE) ε3 allele |
PF |
|
|
2019 |
30526202 |
3555 |
Alzheimer's Disease |
Human |
Apolipoprotein E (APOE)-epsilon4 |
RF |
|
|
2018 |
29605385 |
871 |
Alzheimer's Disease |
Human |
apolipoprotein E ?3 |
PF |
|
|
2021 |
34258926 |
3556 |
Parkinson disease |
Human |
Apolipoprotein E4 |
RF |
|
|
2005 |
15924299 |
3195 |
Dementia with Lewy bodies |
Human |
APP |
RF |
|
|
2016 |
27312774 |
3914 |
Alzheimer's Disease |
Human |
APP |
RF |
Diagnosis |
|
2023 |
37145212 |
1800 |
Alzheimer's Disease |
Human |
Arg972 IRS1 |
RF |
|
A Allele |
2014 |
24589556 |
1819 |
Alzheimer's Disease |
Human |
Arg972 IRS1 |
RF |
|
AA genotype |
2014 |
24589556 |
1808 |
Alzheimer's Disease |
Human |
Arg972 IRS1 |
RF |
|
GA genotype |
2014 |
24589556 |
513 |
Alzheimer's Disease |
Human |
ARHGAP33 |
PF |
|
APOE-?3 |
2021 |
33576571 |
3196 |
Alzheimer's Disease |
Human |
ASTN2 |
RF |
|
|
2015 |
25410587 |
3197 |
Amyotrophic Lateral Sclerosis |
Human |
ATAXIN2 |
RF |
|
≥ 31 CAG-repeat length |
2012 |
22425256 |
2580 |
Alzheimer's Disease |
Human |
ATP10B |
RF |
|
|
2013 |
22950421 |
3668 |
Parkinson disease |
Human |
ATP10B |
RF |
|
recessive loss of function mutations |
2020 |
32172343 |
2640 |
Alzheimer's Disease |
Human |
ATP6V0E2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2142 |
Alzheimer's Disease |
Human |
ATP7B |
RF |
|
|
2013 |
22950421 |
2177 |
Alzheimer's Disease |
Human |
ATP8B |
RF |
|
|
2013 |
22950421 |
2284 |
Alzheimer's Disease |
Human |
ATP9B |
RF |
|
|
2013 |
22950421 |
2417 |
Amyotrophic Lateral Sclerosis |
Human |
ATRN |
RF |
|
|
2013 |
27455347 |
3980 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN1 |
RF |
Diagnosis |
|
2022 |
35525134 |
3198 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN1 |
RF |
|
|
2014 |
25023141 |
3203 |
Frontotemporal Lobar Degeneration |
Human |
ATXN2 |
RF |
|
ATXN2 intermediary repeat length>=29 |
2014 |
25098532 |
2841 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
|
|
2019 |
30847648 |
3200 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
|
|
2012 |
23197749 |
2991 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
|
ATXN2 high-length alleles (≥29 CAG repeats) |
2011 |
21670397 |
3038 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
|
CAG repeat length >30 |
2011 |
21610160 |
3202 |
Frontotemporal Dementia |
Human |
ATXN2 |
RF |
|
ATXN2 intermediary polyQ expansions |
2014 |
25098532 |
3073 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
Diagnosis |
|
2022 |
35521889 |
3199 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
|
|
2015 |
26208502 |
3981 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
Diagnosis |
|
2022 |
35525134 |
3113 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
|
ATXN2 high-length alleles (≥29 CAG repeats) |
2011 |
21670397 |
3201 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
|
ATXN2 polyQ repeat expansions greater than 27 |
2011 |
21741123 |
2778 |
Amyotrophic lateral sclerosis with frontotemporal dementia |
Human |
ATXN2 |
RF |
Diagnosis |
|
2022 |
35521889 |
2700 |
Frontotemporal Dementia |
Human |
ATXN2 |
RF |
Diagnosis |
|
2022 |
35521889 |
2176 |
Amyotrophic Lateral Sclerosis |
Human |
ATXN2 |
RF |
|
CAG repeat length >26 |
2011 |
21610160 |
2323 |
Alzheimer's Disease |
Human |
AZU1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
659 |
Alzheimer's Disease |
Human |
B3GAT2 |
PF |
|
APOE-?3 |
2021 |
33576571 |
2107 |
Alzheimer's Disease |
Human |
BACE1 |
RF |
|
with APOEε4 carrier status |
2015 |
26550136 |
2413 |
Alzheimer's Disease |
Human |
BACE1 |
RF |
|
in carrying the ApoE epsilon4 allele |
2008 |
18182766 |
1935 |
Alzheimer's Disease |
Human |
BACE2 |
RF |
|
Rheumatoid arthritis (RA) RA-SNPs Association with AD |
2011 |
21595938 |
592 |
Alzheimer's Disease |
Human |
BCL2L13 |
PF |
|
APOE-?2 |
2021 |
33576571 |
3833 |
Parkinson disease |
Human |
BDNF |
RF |
Prognosis |
|
2021 |
34945793 |
2353 |
Alzheimer's Disease |
Human |
BDNF C270T |
RF |
|
|
2015 |
26136901 |
1906 |
Alzheimer's Disease |
Human |
BIN1 |
RF |
|
Calculated by random effect model |
2018 |
29504051 |
3205 |
Alzheimer's Disease |
Human |
BIN1 |
RF |
|
|
2017 |
26768592 |
3067 |
Alzheimer's Disease |
Human |
BIN1 |
RF |
|
|
2021 |
33732104 |
1920 |
Alzheimer's Disease |
Human |
BIN1 |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
714 |
Alzheimer's Disease |
Human |
BIN1 |
PF |
|
National Alzheimer’s Coordinating Center (NACC) cohort |
2018 |
30128317 |
682 |
Alzheimer's Disease |
Human |
BIN1 |
PF |
|
National Alzheimer’s Coordinating Center (NACC) cohort |
2018 |
30128317 |
1916 |
Alzheimer's Disease |
Human |
BIN1 |
RF |
|
Calculated by random effect model |
2018 |
29504051 |
3204 |
Alzheimer's Disease |
Human |
BIN1 |
RF |
|
|
2017 |
26768592 |
1910 |
Alzheimer's Disease |
Human |
BIN1 |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
1891 |
Alzheimer's Disease |
Human |
BIN1 |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
2948 |
Amyotrophic Lateral Sclerosis |
Human |
BIRC6 |
RF |
|
|
2013 |
27455347 |
744 |
Alzheimer's Disease |
Human |
BMS1 |
PF |
|
APOE-?3 |
2021 |
33576571 |
2441 |
Alzheimer's Disease |
Human |
C1orf185 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2865 |
Amyotrophic Lateral Sclerosis |
Human |
C1QTNF7 |
RF |
|
|
2013 |
27455347 |
828 |
Alzheimer's Disease |
Human |
C282Y HFE |
PF |
|
|
2009 |
19429178 |
2860 |
Frontotemporal Lobar Degeneration |
Human |
C4orf27 |
RF |
|
Discovery stage |
2019 |
30739198 |
3206 |
Amyotrophic Lateral Sclerosis |
Human |
C7orf57 |
RF |
|
|
2014 |
25023141 |
2875 |
Parkinson disease |
Human |
C9orf72 |
RF |
|
|
2021 |
34440384 |
3208 |
Amyotrophic Lateral Sclerosis |
Human |
C9orf72 |
RF |
|
|
2018 |
29528390 |
2447 |
Amyotrophic Lateral Sclerosis |
Human |
C9orf72 |
RF |
|
|
2020 |
33168078 |
2274 |
Parkinson disease |
Human |
C9orf72 |
RF |
|
|
2021 |
34440384 |
3207 |
Amyotrophic Lateral Sclerosis |
Human |
C9orf72 |
RF |
|
|
2014 |
25023141 |
3979 |
Amyotrophic Lateral Sclerosis |
Human |
C9orf72 |
RF |
Diagnosis |
|
2022 |
35525134 |
2409 |
Amyotrophic Lateral Sclerosis |
Human |
C9orf72 |
RF |
|
|
2010 |
20801718 |
3209 |
Frontotemporal Lobar Degeneration |
Human |
C9orf72 |
RF |
|
C9orf72 repeat expansions; All FTD patients with mutations had a positive family history for dementia or ALS |
2014 |
25108559 |
3027 |
Amyotrophic Lateral Sclerosis |
Human |
C9orf72 |
RF |
|
|
2020 |
33168078 |
2869 |
Amyotrophic Lateral Sclerosis |
Human |
C9orf72 |
RF |
Diagnosis |
|
2021 |
33563800 |
3051 |
Parkinson disease |
Human |
C9orf72 |
RF |
|
|
2013 |
23845100 |
2751 |
Alzheimer's Disease |
Human |
C9orf72 |
RF |
|
|
2021 |
33935096 |
3978 |
Amyotrophic Lateral Sclerosis |
Human |
C9orf72 |
RF |
Diagnosis |
|
2022 |
36511680 |
3820 |
Multiple System Atrophy |
Human |
C9orf72 |
RF |
Diagnosis |
|
2021 |
35007998 |
3669 |
Amyotrophic Lateral Sclerosis |
Human |
CACNA1H |
RF |
|
|
2020 |
32143681 |
1954 |
Alzheimer's Disease |
Human |
CALHM1 |
RF |
|
|
2010 |
20061624 |
729 |
Creutzfeldt-Jakob disease |
Human |
CALHM1 |
PF |
|
|
2012 |
22874670 |
2544 |
Creutzfeldt-Jakob disease |
Human |
CALHM1 |
RF |
|
Genotype:GG |
2012 |
22874670 |
3100 |
Alzheimer's Disease |
Human |
CALHM2 |
RF |
|
APOE-?3 |
2021 |
33576571 |
2281 |
Parkinson disease |
Human |
CARD15 |
RF |
|
|
2007 |
17174426 |
2926 |
Alzheimer's Disease |
Human |
CCDC60 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3210 |
Parkinson disease |
Human |
CCDC62/HIP1R |
RF |
|
|
2015 |
25818163 |
1854 |
Parkinson disease |
Human |
CCL2 |
RF |
|
|
2019 |
30761072 |
1863 |
Parkinson disease |
Human |
CCL2 |
RF |
|
|
2019 |
30761072 |
1985 |
Parkinson disease |
Human |
CD14 |
RF |
|
|
2006 |
16337421 |
3211 |
Parkinson disease |
rat |
CD157/BST1 |
RF |
|
|
2014 |
24795584 |
3212 |
Alzheimer's Disease |
Human |
CD163L1 |
RF |
|
|
2017 |
29177109 |
3664 |
Alzheimer's Disease |
Human |
CD33 |
RF |
|
|
2020 |
32647856 |
3213 |
Alzheimer's Disease |
Human |
CD33 |
RF |
|
|
2012 |
22382309 |
901 |
Parkinson disease |
Human |
CD33 |
PF |
Diagnosis |
|
2021 |
33582190 |
593 |
Alzheimer's Disease |
Human |
CD33 |
PF |
|
in APOE e4 carriers |
2012 |
22167654 |
2162 |
Alzheimer's Disease |
Human |
CD33 |
RF |
Diagnosis |
|
2022 |
35408990 |
815 |
Alzheimer's Disease |
Human |
CD33 |
PF |
|
this association was not significant in Asians |
2016 |
26795201 |
3954 |
Parkinson disease |
Human |
CD33 |
RF |
Diagnosis |
|
2023 |
37479176 |
926 |
Parkinson disease |
Human |
CD33 |
PF |
Diagnosis |
|
2023 |
37479176 |
563 |
Alzheimer's Disease |
Human |
CD33 |
PF |
|
in APOE e4 carriers |
2012 |
22167654 |
630 |
Alzheimer's Disease |
Human |
CD36 |
PF |
|
Genotype: GT; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. |
2018 |
30235742 |
2221 |
Alzheimer's Disease |
Human |
CD36 |
RF |
|
Genotype: Recessive |
2018 |
30235742 |
2389 |
Alzheimer's Disease |
Human |
CD36 |
RF |
|
Genotype: Dominant |
2018 |
30235742 |
664 |
Alzheimer's Disease |
Human |
CD36 |
PF |
|
Genotype: Dominant; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. |
2018 |
30235742 |
641 |
Alzheimer's Disease |
Human |
CD36 |
PF |
|
Genotype: GT |
2018 |
30235742 |
2477 |
Alzheimer's Disease |
Human |
CD36 |
RF |
|
Genotype: GG; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. |
2018 |
30235742 |
2247 |
Alzheimer's Disease |
Human |
CD36 |
RF |
|
Genotype: Dominant; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. |
2018 |
30235742 |
2598 |
Alzheimer's Disease |
Human |
CD36 |
RF |
|
Genotype: GG |
2018 |
30235742 |
681 |
Alzheimer's Disease |
Human |
CD36 |
PF |
|
Genotype: Dominant |
2018 |
30235742 |
3670 |
Creutzfeldt-Jakob disease |
Human |
Cerebroside sulfotransferase (GAL3ST1) |
RF |
|
|
2020 |
32565065 |
2203 |
Alzheimer's Disease |
Human |
CHAT |
RF |
|
|
2016 |
27272392 |
3214 |
Alzheimer's Disease |
Human |
CHAT |
RF |
|
|
2008 |
18562794 |
2236 |
Alzheimer's Disease |
Human |
CHAT |
RF |
|
|
2016 |
27272392 |
3215 |
Dementia with Lewy bodies |
Human |
CHCHD2 |
RF |
|
|
2015 |
26561290 |
3216 |
Parkinson disease |
Human |
CHCHD2 |
RF |
|
|
2016 |
27626775 |
2878 |
Amyotrophic Lateral Sclerosis |
Human |
CHGB |
RF |
|
|
2009 |
20007371 |
2608 |
Amyotrophic Lateral Sclerosis |
Human |
CHGB |
RF |
|
|
2009 |
20007371 |
2551 |
Alzheimer's Disease |
Human |
CHI3L1 |
RF |
|
TT |
2019 |
30223258 |
2200 |
Alzheimer's Disease |
Human |
CHI3L1 |
RF |
|
CT+TT |
2019 |
30223258 |
680 |
Alzheimer's Disease |
Human |
CHI3L1 |
PF |
|
CG+GG |
2019 |
30223258 |
2127 |
Alzheimer's Disease |
Human |
CHI3L1 |
RF |
|
T allele |
2019 |
30223258 |
687 |
Alzheimer's Disease |
Human |
CHI3L1 |
PF |
|
G allele |
2019 |
30223258 |
2595 |
Creutzfeldt-Jakob disease |
Human |
CHN2 |
RF |
|
|
2012 |
22210626 |
3217 |
Alzheimer's Disease |
Human |
chromosome 12q24.22 |
RF |
|
|
2014 |
24361131 |
3218 |
Multiple System Atrophy |
Human |
chromosome 22 |
RF |
|
|
2017 |
29187220 |
3219 |
Multiple System Atrophy |
Human |
chromosome 22 |
RF |
|
|
2017 |
29187220 |
3223 |
Multiple System Atrophy |
Human |
chromosome 4 |
RF |
|
|
2017 |
29187220 |
3220 |
Multiple System Atrophy |
Human |
chromosome 4 |
RF |
|
|
2017 |
29187220 |
3222 |
Multiple System Atrophy |
Human |
chromosome 4 |
RF |
|
|
2017 |
29187220 |
3224 |
Multiple System Atrophy |
Human |
chromosome 4 |
RF |
|
|
2017 |
29187220 |
3221 |
Multiple System Atrophy |
Human |
chromosome 4 |
RF |
|
|
2017 |
29187220 |
3226 |
Multiple System Atrophy |
Human |
chromosome 5 |
RF |
|
|
2017 |
29187220 |
3225 |
Multiple System Atrophy |
Human |
chromosome 5 |
RF |
|
|
2017 |
29187220 |
2336 |
Alzheimer's Disease |
Human |
chromosome 9p21.3 |
RF |
|
|
2010 |
20427016 |
1991 |
Alzheimer's Disease |
Human |
chromosome 9p21.3 |
RF |
|
C allele |
2011 |
19664850 |
2096 |
Alzheimer's Disease |
Human |
chromosome 9p21.3 |
RF |
|
in non-APOE epsilon4 |
2010 |
20427016 |
3227 |
Alzheimer's Disease |
Human |
CLECL1 |
RF |
|
|
2017 |
29177109 |
2969 |
Alzheimer's Disease |
Human |
CLU |
RF |
|
|
2016 |
26757186 |
1860 |
Alzheimer's Disease |
Human |
CLU |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
502 |
Alzheimer's Disease |
Human |
CLU |
PF |
|
|
2016 |
26757186 |
1859 |
Alzheimer's Disease |
Human |
CLU |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
2922 |
Alzheimer's Disease |
Human |
CLU |
RF |
Diagnosis |
|
2022 |
35135450 |
1856 |
Alzheimer's Disease |
Human |
CLU |
RF |
|
Calculated by random effect model |
2018 |
29504051 |
1858 |
Alzheimer's Disease |
Human |
CLU |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
2072 |
Parkinson disease |
Human |
Clusterin (CLU) |
RF |
Diagnosis |
|
2021 |
33295114 |
2683 |
Alzheimer's Disease |
Human |
CNGB1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2410 |
Alzheimer's Disease |
Human |
CNGB1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2326 |
Alzheimer's Disease |
Human |
CNGB1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2684 |
Alzheimer's Disease |
Human |
CNGB1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2377 |
Tourette Syndrome |
Human |
CNR 1 |
RF |
|
|
2020 |
32194619 |
3767 |
Alzheimer's Disease |
Human |
CNR1 |
RF |
|
|
2021 |
33523009 |
2134 |
Dementia with Lewy bodies |
Human |
CNTN1 |
RF |
|
|
2018 |
29263008 |
2097 |
Amyotrophic Lateral Sclerosis |
Human |
CNTN4 |
RF |
Diagnosis |
|
2021 |
34421992 |
3564 |
Alzheimer's Disease |
Human |
coexistence of the APOE-ε4 allele and 3 SNPs in the BCHE gene |
RF |
|
|
2019 |
30914707 |
2324 |
Alzheimer's Disease |
Human |
COMT |
RF |
|
without APOE ε4 allele carriers |
2014 |
24575113 |
2868 |
Alzheimer's Disease |
Human |
COMT |
RF |
|
|
2021 |
33900525 |
3005 |
Alzheimer's Disease |
Human |
COMT |
RF |
|
|
2021 |
33900525 |
2228 |
Parkinson disease |
Human |
COMT |
RF |
|
|
1997 |
9503277 |
3002 |
Alzheimer's Disease |
Human |
COMT |
RF |
|
without APOE ε4 allele carriers;in men |
2014 |
24575113 |
465 |
Multiple System Atrophy |
Human |
COQ2 |
PF |
Diagnosis |
|
2022 |
35748722 |
3228 |
Multiple System Atrophy |
Human |
COQ2 |
RF |
|
|
2016 |
27123473 |
673 |
Alzheimer's Disease |
Human |
COX11 |
PF |
|
APOE-?2 |
2021 |
33576571 |
2125 |
Alzheimer's Disease |
Human |
COX-2 |
RF |
|
G allele |
2010 |
20110601 |
2100 |
Alzheimer's Disease |
Human |
COX-2 |
RF |
|
GG allele |
2010 |
20110601 |
2403 |
Alzheimer's Disease |
Human |
CPT1B |
RF |
|
APOE-?2 |
2021 |
33576571 |
1899 |
Alzheimer's Disease |
Human |
CR1 |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
633 |
Alzheimer's Disease |
Human |
CR1 |
PF |
|
PENN cohort |
2018 |
30128317 |
1905 |
Alzheimer's Disease |
Human |
CR1 |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
747 |
Alzheimer's Disease |
Human |
CR1 |
PF |
|
National Alzheimer’s Coordinating Center (NACC) cohort |
2018 |
30128317 |
1979 |
Alzheimer's Disease |
Human |
CR1 |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
3077 |
Amyotrophic Lateral Sclerosis |
Human |
CREB3L2 |
RF |
|
|
2013 |
27455347 |
688 |
Alzheimer's Disease |
Human |
CRTC3 |
PF |
|
APOE-?2 |
2021 |
33576571 |
2206 |
Frontotemporal Lobar Degeneration |
Human |
CST3 |
RF |
|
negative for the presence of PGRN mutations;haplotype B |
2010 |
19674067 |
2532 |
Alzheimer's Disease |
Human |
CST3 |
RF |
|
Caucasians |
2000 |
10993992 |
2572 |
Alzheimer's Disease |
Human |
CST3 |
RF |
|
CST3-A allele; APOE ε4 carrier |
2001 |
11711204 |
3081 |
Alzheimer's Disease |
Human |
CST3 |
RF |
|
CST3-A allele; Non-APOE ε4 carrier |
2001 |
11711204 |
2257 |
Frontotemporal Lobar Degeneration |
Human |
CST3 |
RF |
|
negative for the presence of PGRN mutations;AB/BB genotypes |
2010 |
19674067 |
3229 |
Alzheimer's Disease |
Human |
CTNNA1 |
RF |
|
|
2017 |
29177109 |
2485 |
Alzheimer's Disease |
Human |
CTSB |
RF |
|
APOE-?2 |
2021 |
33576571 |
2632 |
Alzheimer's Disease |
Human |
CTSD |
RF |
|
|
2014 |
24281128 |
2424 |
Creutzfeldt-Jakob disease |
Human |
CTSD |
RF |
|
Genotype:CC |
2008 |
18426579 |
3122 |
Creutzfeldt-Jakob disease |
Human |
CTSD |
RF |
|
Genotype:CT |
2008 |
18426579 |
2362 |
Amyotrophic Lateral Sclerosis |
Human |
CX3CR1 |
RF |
|
|
2014 |
24806473 |
3230 |
Amyotrophic Lateral Sclerosis |
Human |
CX3CR1 |
RF |
|
|
2014 |
24806473 |
2651 |
Amyotrophic Lateral Sclerosis |
Human |
CX3CR1 |
RF |
|
|
2014 |
24806473 |
3732 |
Alzheimer's Disease |
Human |
CXCL12 |
RF |
|
|
2021 |
33687622 |
3232 |
Alzheimer's Disease |
Human |
CYP19A1 |
RF |
|
|
2016 |
27583919 |
2211 |
Alzheimer's Disease |
Human |
CYP2B6 |
RF |
|
APOE-?2 |
2021 |
33576571 |
1919 |
Alzheimer's Disease |
Human |
CYP2B6 |
RF |
|
APOE-?3 |
2021 |
33576571 |
3233 |
Alzheimer's Disease |
Human |
CYP2D6 |
RF |
|
CYP2D6B allele; in the Lewy body variant of AD |
1995 |
7818242 |
2710 |
Alzheimer's Disease |
Human |
CYP2J2 |
RF |
|
total;Genotype GT + TT |
2015 |
25796175 |
2687 |
Alzheimer's Disease |
Human |
CYP2J2 |
RF |
|
total;Allele T |
2015 |
25796175 |
2137 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
Overall; Genotype:TT; dominant mode |
2018 |
29516283 |
3120 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
APOE ε4 carrier; Genotype:CC |
2018 |
29516283 |
2688 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
APOE ε4 carrier; Genotype:TT; dominant mode |
2018 |
29516283 |
3234 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
CYP46A1 gene variations |
2009 |
19286353 |
2594 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
APOE ε3/ε4; Genotype:CC; additive model |
2018 |
29516283 |
2259 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
|
2012 |
22528464 |
2136 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
Overall; Genotype:TC; logistic regression model |
2018 |
29516283 |
2665 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
APOE ε3/ε4; Genotype:TT; dominant mode |
2018 |
29516283 |
2636 |
Alzheimer's Disease |
Human |
CYP46A1 |
RF |
|
APOE ε4 carrier; Genotype:CC; additive model |
2018 |
29516283 |
3790 |
Amyotrophic lateral sclerosis,Parkinson disease |
Human |
DAB1 |
RF |
Diagnosis |
|
2021 |
34707478 |
753 |
Alzheimer's Disease |
Human |
DAPK1 |
PF |
|
especially the homozygotes |
2011 |
21167819 |
2034 |
Alzheimer's Disease |
Human |
DAPK1 |
RF |
|
|
2011 |
21167819 |
3832 |
Parkinson disease |
Human |
DBH |
RF |
Prognosis |
|
2021 |
34945793 |
2459 |
Amyotrophic Lateral Sclerosis |
Human |
DCC |
RF |
|
|
2013 |
27455347 |
2920 |
Frontotemporal Lobar Degeneration |
Human |
DCUN1D1 |
RF |
|
Genotype:GG |
2009 |
19473369 |
629 |
Alzheimer's Disease |
Human |
DDIT4L |
PF |
|
APOE-?2 |
2021 |
33576571 |
1842 |
Parkinson disease |
Human |
DGCR8 |
RF |
|
|
2013 |
24018986 |
1841 |
Parkinson disease |
Human |
DGCR8 |
RF |
|
|
2013 |
24018986 |
1783 |
Alzheimer's Disease |
Human |
DHCR7 |
RF |
|
Chinese population |
2021 |
33692822 |
3789 |
Amyotrophic Lateral Sclerosis |
Human |
DHTKD1 |
RF |
Diagnosis |
|
2021 |
35052424 |
3235 |
Amyotrophic Lateral Sclerosis |
Human |
DISC1 |
RF |
|
|
2014 |
25023141 |
3724 |
Alzheimer's Disease |
Human |
DLD gene |
RF |
|
|
2021 |
33917565 |
2128 |
Parkinson disease |
Human |
DMRT2/SMARCA2 |
RF |
Diagnosis |
|
2021 |
33510632 |
2279 |
Parkinson disease |
Human |
DMT1 |
RF |
|
|
2011 |
21777657 |
3236 |
Parkinson disease |
Human |
DMT1 |
RF |
|
|
2015 |
25817364 |
2074 |
Parkinson disease |
Human |
DNA methylation (DNAm) CD56 |
RF |
Diagnosis |
|
2021 |
34768133 |
786 |
Parkinson disease |
Human |
DNA methylation (DNAm) EFEMP-1 |
PF |
Diagnosis |
|
2021 |
34768133 |
3109 |
Parkinson disease |
Human |
DNA Methylation cg10917602 site |
RF |
|
|
2016 |
27466229 |
892 |
Parkinson disease |
Human |
DOPA decarboxylase gene (DDC) |
PF |
Treatment |
|
2021 |
33051953 |
3237 |
Amyotrophic Lateral Sclerosis |
Human |
DPP6 |
RF |
|
|
2014 |
25023141 |
2621 |
Frontotemporal Lobar Degeneration |
Human |
DPP6 |
RF |
|
Discovery stage |
2019 |
30739198 |
693 |
Amyotrophic Lateral Sclerosis |
Human |
DPP6 |
PF |
Diagnosis |
|
2021 |
34421992 |
2627 |
Frontotemporal Lobar Degeneration |
Human |
DPP6 |
RF |
|
Discovery stage |
2019 |
30739198 |
2765 |
Amyotrophic Lateral Sclerosis |
Human |
DPYSL3(CRMP4) |
RF |
|
|
2013 |
23568759 |
504 |
Alzheimer's Disease |
Human |
DR4 |
PF |
|
GGC haplotype |
2013 |
25207117 |
581 |
Alzheimer's Disease |
Human |
DR4 |
PF |
|
ACA haplotype |
2013 |
25207117 |
830 |
Alzheimer's Disease |
Human |
DR4 |
PF |
|
the GA genotype |
2013 |
25207117 |
648 |
Alzheimer's Disease |
Human |
DR4 |
PF |
|
GGA haplotype |
2013 |
25207117 |
2076 |
Alzheimer's Disease |
Human |
DR4 |
RF |
|
GCA haplotype |
2013 |
25207117 |
2384 |
Alzheimer's Disease |
Human |
DR4 |
RF |
|
GCC haplotype |
2013 |
25207117 |
3834 |
Parkinson disease |
Human |
DRD2 |
RF |
Prognosis |
|
2021 |
34945793 |
3238 |
Tourette Syndrome |
Human |
DRD2 |
RF |
|
|
2010 |
20431429 |
779 |
Progressive Supranuclear Palsy |
Human |
DUSP10 |
PF |
|
Meta-analysis |
2018 |
29986742 |
2278 |
Parkinson disease |
Human |
DYRK1A |
RF |
|
especially for males |
2016 |
27546826 |
2038 |
Progressive Supranuclear Palsy |
Human |
EIF2AK3 |
RF |
Diagnosis |
|
2021 |
33897612 |
765 |
Progressive Supranuclear Palsy |
Human |
EIF2AK3 |
PF |
|
Meta-analysis |
2018 |
29986742 |
3239 |
Parkinson disease |
Human |
EMTP variation |
RF |
|
|
2019 |
30675927 |
2222 |
Alzheimer's Disease |
Human |
ENST00000414107 |
RF |
|
|
2018 |
29027019 |
549 |
Alzheimer's Disease |
Human |
EPHA7 |
PF |
|
APOE-?2 |
2021 |
33576571 |
2062 |
Alzheimer's Disease |
Human |
EPHA7 |
RF |
|
APOE-?3 |
2021 |
33576571 |
3240 |
Amyotrophic Lateral Sclerosis |
Human |
ERp57/PDIA3 |
RF |
|
|
2015 |
25913742 |
2239 |
Alzheimer's Disease |
Human |
ESR1 |
RF |
|
|
2012 |
20674091 |
653 |
Alzheimer's Disease |
Human |
ESR1 |
PF |
|
|
2012 |
20674091 |
1999 |
Alzheimer's Disease |
Human |
ESR1 |
RF |
|
|
2012 |
20674091 |
3017 |
Alzheimer's Disease |
Human |
ESR1 and ESR2 |
RF |
|
the genetic profile created with the combination of the less represented alleles of these SNPs (expressed as XPAA) |
2013 |
24052609 |
2372 |
Alzheimer's Disease |
Human |
ESR2 |
RF |
|
predominantly Caucasian AIMS-defined ancestry |
2014 |
24326520 |
2371 |
Alzheimer's Disease |
Human |
ESR2 |
RF |
|
predominantly Caucasian AIMS-defined ancestry |
2014 |
24326520 |
2195 |
Alzheimer's Disease |
Human |
ESR2 |
RF |
|
predominantly Caucasian AIMS-defined ancestry |
2014 |
24326520 |
2194 |
Alzheimer's Disease |
Human |
ESR2 |
RF |
|
predominantly Caucasian AIMS-defined ancestry |
2014 |
24326520 |
678 |
Alzheimer's Disease |
Human |
ESR3 |
PF |
|
|
2014 |
24326520 |
1925 |
Alzheimer's Disease |
Human |
EXOC3L2 |
RF |
|
|
2017 |
28423615 |
814 |
Alzheimer's Disease |
Human |
EXOC3L2 |
PF |
|
|
2017 |
28423615 |
3021 |
Alzheimer's Disease |
Human |
FAM107B |
RF |
|
APOE-?2 |
2021 |
33576571 |
703 |
Alzheimer's Disease |
Human |
FAM47E |
PF |
|
|
2021 |
33654092 |
2584 |
Alzheimer's Disease |
Human |
FAM71E2 |
RF |
|
APOE-?3 |
2021 |
33576571 |
2769 |
Parkinson disease |
Human |
Famliy history of familial Parkinson's disease |
RF |
|
|
2010 |
21059511 |
2444 |
Parkinson disease |
Human |
Famliy history of familial Parkinson's disease |
RF |
|
|
1996 |
8771062 |
3242 |
Parkinson disease |
Human |
FGF20 |
RF |
|
|
2012 |
22342445 |
1911 |
Parkinson disease |
Human |
FGF20 |
RF |
|
|
2014 |
24942208 |
3244 |
Parkinson disease |
Human |
FGF20 |
RF |
|
|
2004 |
15122513 |
3241 |
Parkinson disease |
Human |
FGF20 |
RF |
|
|
2015 |
26070653 |
3140 |
Parkinson disease |
Human |
FGF20 |
RF |
|
|
2015 |
26070653 |
3243 |
Parkinson disease |
Human |
FGF20 |
RF |
|
|
2004 |
15122513 |
2294 |
Alzheimer's Disease |
Human |
FOXN1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2246 |
Alzheimer's Disease |
Human |
FRMD4A |
RF |
|
|
2013 |
22430674 |
3245 |
Amyotrophic Lateral Sclerosis |
Human |
FUS |
RF |
|
|
2017 |
28054830 |
3759 |
Alzheimer's Disease |
Human |
FZD3 |
RF |
|
|
2021 |
32966694 |
2685 |
Alzheimer's Disease |
Human |
G-308A( TNF-alpha gene) |
RF |
|
A-allele |
2008 |
18992723 |
3097 |
Alzheimer's Disease |
Human |
GAB2 |
RF |
|
|
2011 |
21285854 |
792 |
Alzheimer's Disease |
Human |
GAB2 |
PF |
|
|
2015 |
26770425 |
3247 |
Alzheimer's Disease |
Human |
GAB2 |
RF |
|
|
2011 |
21285854 |
3246 |
Alzheimer's Disease |
Human |
GAB2 |
RF |
|
ApoE epsilon4 non-carriers |
2009 |
19276544 |
3127 |
Alzheimer's Disease |
Human |
GAB2 |
RF |
|
a minor genetic determinant of AD |
2008 |
18272374 |
2471 |
Alzheimer's Disease |
Human |
GAB2 |
RF |
|
|
2011 |
21285854 |
2032 |
Alzheimer's Disease |
Human |
GAB2 |
RF |
|
|
2011 |
21108942 |
3248 |
Alzheimer's Disease |
Human |
GAB2 |
RF |
|
|
2011 |
21285854 |
785 |
Alzheimer's Disease |
Human |
GAB2 |
PF |
|
|
2015 |
26770425 |
1923 |
Creutzfeldt-Jakob disease |
Human |
GAL3ST1 |
RF |
|
|
2020 |
32949544 |
3249 |
Alzheimer's Disease |
Human |
GALR3 |
RF |
|
|
2017 |
29177109 |
2518 |
Alzheimer's Disease |
Human |
GAMT |
RF |
|
APOE-?2 |
2021 |
33576571 |
2043 |
Alzheimer's Disease |
Human |
GAMT |
RF |
|
APOE-?3 |
2021 |
33576571 |
3250 |
Amyotrophic Lateral Sclerosis |
Human |
GARS |
RF |
|
|
2019 |
30661401 |
3063 |
Parkinson disease |
Human |
GBA |
RF |
|
|
2019 |
30765263 |
3255 |
Parkinson disease |
Human |
GBA |
RF |
|
strong risk factors in FPD, especially for autosomal dominant PD |
2014 |
24126159 |
3252 |
Dementia with Lewy bodies |
Human |
GBA |
RF |
|
|
2016 |
27312774 |
3800 |
Lewy Body Disease |
Human |
GBA |
RF |
|
|
2021 |
34308904 |
3257 |
Parkinson disease |
Human |
GBA |
RF |
|
|
2019 |
30765263 |
3096 |
Parkinson disease |
Human |
GBA |
RF |
|
|
2007 |
17702778 |
2647 |
Dementia with Lewy bodies |
Human |
GBA |
RF |
|
|
2018 |
29263008 |
3254 |
Parkinson disease |
Human |
GBA |
RF |
|
Patients with early-onset were more likely to carry GBA mutations than those with late-onset |
2016 |
26868973 |
3836 |
Parkinson disease |
Human |
GBA |
RF |
Diagnosis |
|
2021 |
34951095 |
3804 |
Lewy Body Disease |
Human |
GBA |
RF |
Diagnosis |
|
2021 |
33646158 |
3259 |
Dementia with Lewy bodies |
Human |
GBA |
RF |
|
|
2008 |
18332251 |
2990 |
Lewy Body Disease |
Human |
GBA |
RF |
Diagnosis |
|
2021 |
34308904 |
2944 |
Parkinson disease |
Human |
GBA |
RF |
|
|
2013 |
22812582 |
3251 |
Dementia with Lewy bodies |
Human |
GBA |
RF |
|
|
2016 |
27723861 |
3099 |
Parkinson disease |
Human |
GBA |
RF |
|
|
2010 |
20131388 |
3256 |
Parkinson disease |
Human |
GBA |
RF |
|
|
2016 |
26000814 |
1658 |
Parkinson disease |
Human |
GBA |
RF |
Prognosis |
|
2023 |
36348503 |
3253 |
Dementia with Lewy bodies |
Human |
GBA |
RF |
|
|
2016 |
27027900 |
3258 |
Parkinson disease |
Human |
GBA |
RF |
|
|
2019 |
30765263 |
2767 |
Parkinson disease |
Human |
GBA |
RF |
|
|
2012 |
22387070 |
1838 |
Parkinson disease |
Human |
GBA1 |
RF |
Diagnosis |
|
2022 |
37633302 |
2773 |
Parkinson disease |
Human |
GBA1 |
RF |
|
non-N370S mutations associated with Gaucher disease |
2013 |
22968580 |
2179 |
Parkinson disease |
Human |
GBA1 |
RF |
Diagnosis |
|
2022 |
37633302 |
3095 |
Dementia with Lewy bodies |
Human |
GBA1 |
RF |
|
|
2013 |
23588557 |
898 |
Parkinson disease |
Human |
GCase gene therapy |
PF |
|
|
2021 |
34062940 |
3260 |
Parkinson disease |
Human |
GCH1 |
RF |
|
|
2017 |
27871051 |
2293 |
Alzheimer's Disease |
Human |
GCH1 |
RF |
|
|
2018 |
29432188 |
1989 |
Parkinson disease |
Human |
GLIS1 |
RF |
|
|
2012 |
22759478 |
3761 |
Alzheimer's Disease |
Human |
GOLGA8B |
RF |
|
|
2021 |
32966694 |
2065 |
Alzheimer's Disease |
Human |
GOLPH2 |
RF |
|
|
2012 |
22167654 |
2066 |
Alzheimer's Disease |
Human |
GOLPH2 |
RF |
|
|
2012 |
22167654 |
3107 |
Alzheimer's Disease |
Human |
GORASP2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2737 |
Parkinson disease |
Human |
GP1BA |
RF |
|
|
2020 |
33021140 |
2213 |
Parkinson disease |
Human |
GP6 |
RF |
|
|
2020 |
33021140 |
601 |
Alzheimer's Disease |
Human |
GPIHBP1 |
PF |
|
APOE-?2 |
2021 |
33576571 |
3047 |
Alzheimer's Disease |
Human |
GPR37 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3261 |
Parkinson disease |
Human |
GRIN2A |
RF |
|
taking creatine who also have high levels of caffeine intake |
2017 |
28320167 |
3262 |
Parkinson disease |
Human |
GRIN2A T allele |
RF |
|
taking creatine who also have high levels of caffeine intake |
2017 |
28320167 |
1489 |
Frontotemporal Dementia |
Human |
GRN |
RF |
Diagnosis |
|
2021 |
32972771 |
3671 |
Frontotemporal Lobar Degeneration |
Human |
GRN |
RF |
|
FTLD with TAR DNA-binding protein (TDP-43) inclusions |
2010 |
20154673 |
1934 |
Alzheimer's Disease |
Human |
GRN |
RF |
|
|
2017 |
26820675 |
2808 |
Frontotemporal Lobar Degeneration |
Human |
GRN |
RF |
|
Genotype:TT |
2008 |
18723524 |
3815 |
Lewy Body Disease |
Human |
GRN |
RF |
Diagnosis |
|
2021 |
34854996 |
3263 |
Frontotemporal Lobar Degeneration |
Human |
GRN |
RF |
|
|
2014 |
24503614 |
2219 |
Frontotemporal Lobar Degeneration |
Human |
GRN |
RF |
|
more common (T) allele |
2010 |
20154673 |
3018 |
Alzheimer's Disease |
Human |
GSN |
RF |
|
APOE-?2 |
2021 |
33576571 |
2498 |
Alzheimer's Disease |
Human |
GSTM1 |
RF |
|
|
2012 |
22381228 |
2905 |
Parkinson disease |
Human |
GSTM1 |
RF |
Diagnosis |
|
2021 |
32359946 |
2867 |
Alzheimer's Disease |
Human |
GSTM1 |
RF |
|
|
2018 |
29072550 |
2772 |
Parkinson disease |
Human |
GSTM1/T1 null genotypes |
RF |
Diagnosis |
|
2021 |
32359946 |
3264 |
Alzheimer's Disease |
Human |
GSTP1 |
RF |
|
mainly in the presence of the apoE 4 allele |
2008 |
18298341 |
2225 |
Alzheimer's Disease |
Human |
GSTT1 |
RF |
|
|
2018 |
29072550 |
3032 |
Parkinson disease |
Human |
GSTT1 |
RF |
Diagnosis |
|
2021 |
32359946 |
1412 |
Amyotrophic Lateral Sclerosis |
Human |
H63D |
RF |
|
|
2020 |
33070529 |
591 |
Alzheimer's Disease |
Human |
HAP1 |
PF |
|
APOE-?3 |
2021 |
33576571 |
587 |
Alzheimer's Disease |
Human |
HAP1 |
PF |
|
APOE-?3 |
2021 |
33576571 |
3265 |
Alzheimer's Disease |
Human |
hemochromatosis (HFE) |
RF |
|
|
2014 |
27081498 |
683 |
Parkinson disease |
Human |
HFE |
PF |
|
Australian PD patients |
2002 |
12098643 |
2798 |
Amyotrophic Lateral Sclerosis |
Human |
HFE |
RF |
|
Genotype:GC |
2011 |
20642794 |
2845 |
Amyotrophic Lateral Sclerosis |
Human |
HFE |
RF |
|
Genotype:GC/GG |
2011 |
20642794 |
3267 |
Parkinson disease |
Human |
HFE |
RF |
|
|
2006 |
16824219 |
2874 |
Amyotrophic Lateral Sclerosis |
Human |
HFE |
RF |
|
Genotype:G allele frequency |
2011 |
20642794 |
684 |
Parkinson disease |
Human |
HFE |
PF |
|
Australian PD patients |
2002 |
12098643 |
3266 |
Parkinson disease |
Human |
HFE |
RF |
|
|
2006 |
16824219 |
3268 |
Alzheimer's Disease |
Human |
HIF3A |
RF |
|
eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD |
2018 |
30319691 |
1437 |
Alzheimer's Disease |
Human |
HLA-A24 |
RF |
|
|
2008 |
18936542 |
2486 |
Frontotemporal Lobar Degeneration |
Human |
HLA-DQA2 |
RF |
|
Discovery stage |
2019 |
30739198 |
2338 |
Frontotemporal Lobar Degeneration |
Human |
HLA-DQA2 |
RF |
|
Replication stage |
2019 |
30739198 |
3269 |
Parkinson disease |
Human |
HLA-DRA |
RF |
|
|
2014 |
25319953 |
2738 |
Amyotrophic Lateral Sclerosis |
Human |
HLA-DRA/HLA-DRB5 |
RF |
|
the AA genotype at rs9268856 |
2017 |
28131168 |
1931 |
Alzheimer's Disease |
Human |
HLA-DRB1 |
RF |
|
non-APOE ε4 carriers with rs9271192 genotype CC;additive model |
2017 |
29190991 |
2488 |
Alzheimer's Disease |
Human |
HLA-DRB1 |
RF |
|
under a recessive model in the total sample |
2017 |
29190991 |
2667 |
Alzheimer's Disease |
Human |
HLA-DRB1 |
RF |
|
non-APOE ε4 carriers with rs9271192 genotype CC;recessive model |
2017 |
29190991 |
533 |
Frontotemporal Lobar Degeneration |
Human |
HMCN1 |
PF |
|
Discovery stage |
2019 |
30739198 |
2597 |
Frontotemporal Lobar Degeneration |
Human |
hnRNP-A1 |
RF |
|
C/C genotype |
2011 |
21548758 |
2217 |
Frontotemporal Lobar Degeneration |
Human |
hnRNP-A1 |
RF |
|
C/C genotype |
2011 |
21548758 |
554 |
Alzheimer's Disease |
Human |
HSP70/HSPA1A |
PF |
|
Genotype: A/C; AD without depression |
2018 |
29703883 |
2934 |
Alzheimer's Disease |
Human |
Ig γ marker (GM) allotypes |
RF |
|
encoded by highly polymorphic IGHG genes on chromosome 14q32 |
2020 |
32709662 |
2628 |
Alzheimer's Disease |
Human |
IGFALS |
RF |
|
APOE-?3 |
2021 |
33576571 |
2063 |
Alzheimer's Disease |
Human |
IL-1 beta promoter polymorphism |
RF |
|
APOE4 presence:No stratified |
2008 |
18717723 |
2691 |
Alzheimer's Disease |
Human |
IL-1 beta promoter polymorphism |
RF |
|
APOE4 presence:APOE4 yes |
2008 |
18717723 |
2205 |
Alzheimer's Disease |
Human |
IL-1 beta promoter polymorphism |
RF |
|
APOE4 presence:APOE4 no |
2008 |
18717723 |
3270 |
Alzheimer's Disease |
Human |
IL-1 genes cluster |
RF |
|
|
2012 |
22498095 |
831 |
Alzheimer's Disease |
Human |
IL-1 genes cluster |
PF |
|
|
2012 |
22498095 |
3272 |
Parkinson disease |
Human |
IL-10 |
RF |
|
|
2012 |
22387064 |
3271 |
Parkinson disease |
Human |
IL-10 |
RF |
|
|
2012 |
21241672 |
3273 |
Parkinson disease |
Human |
IL-18 |
RF |
|
|
2012 |
21241672 |
3275 |
Alzheimer's Disease |
Human |
IL-1B |
RF |
|
|
2017 |
26768592 |
3274 |
Alzheimer's Disease |
Human |
IL-1B |
RF |
|
|
2017 |
26768592 |
3276 |
Alzheimer's Disease |
Human |
IL-1α |
RF |
|
|
2016 |
27014584 |
3277 |
Multiple System Atrophy |
Human |
IL-1β |
RF |
|
|
2018 |
29251119 |
2201 |
Frontotemporal Lobar Degeneration |
Human |
IMMP2L |
RF |
|
Discovery stage |
2019 |
30739198 |
628 |
Alzheimer's Disease |
Human |
INO80D |
PF |
|
APOE-?2 |
2021 |
33576571 |
2764 |
Amyotrophic Lateral Sclerosis |
Human |
INPP5B |
RF |
Diagnosis |
|
2021 |
34421992 |
3738 |
Alzheimer's Disease |
mice |
INPP5D |
RF |
|
|
2021 |
33631273 |
2280 |
Alzheimer's Disease |
Human |
insulin degrading enzyme gene (IDE) |
RF |
|
|
2012 |
20880607 |
2997 |
Alzheimer's Disease |
Human |
insulin degrading enzyme gene (IDE) |
RF |
|
CC genotype was significantly associated with earlier age at onset |
2012 |
20880607 |
2832 |
Amyotrophic Lateral Sclerosis |
Human |
Intergenic |
RF |
|
The estimations using the proposed method (unadjusted estimates) |
2009 |
19740415 |
2787 |
Amyotrophic Lateral Sclerosis |
Human |
Intergenic |
RF |
|
The estimations using the proposed method (adjusted estimates) |
2009 |
19740415 |
2880 |
Amyotrophic Lateral Sclerosis |
Human |
Intergenic and SHROOM3 |
RF |
|
The estimations using the proposed method (unadjusted estimates) |
2009 |
19740415 |
2838 |
Amyotrophic Lateral Sclerosis |
Human |
Intergenic and SHROOM4 |
RF |
|
The estimations using the proposed method (adjusted estimates) |
2009 |
19740415 |
3028 |
Amyotrophic Lateral Sclerosis |
Human |
intermediate-length alleles when present in both alleles |
RF |
|
Carriership of two intermediate-length alleles was associated with ALS, when the longer allele was ≥ 17 repeats |
2020 |
33168078 |
2448 |
Amyotrophic Lateral Sclerosis |
Human |
intermediate-length alleles when present in both alleles |
RF |
|
Carriership of two intermediate-length alleles was associated with ALS, when the longer allele was ≥ 21 repeats |
2020 |
33168078 |
696 |
Frontotemporal Lobar Degeneration |
Human |
IRF2 |
PF |
|
Discovery stage |
2019 |
30739198 |
1932 |
Alzheimer's Disease |
Human |
ITGA2B |
RF |
|
APOE-?3 |
2021 |
33576571 |
2256 |
Alzheimer's Disease |
Human |
ITGA4 |
RF |
|
Dominant; Genotype/Allele: AG+GG; Multivariate analysis |
2018 |
29769839 |
2360 |
Alzheimer's Disease |
Human |
ITGA4 |
RF |
|
Codominant; Genotype/Allele: AG; Univariate analysis |
2018 |
29769839 |
2242 |
Alzheimer's Disease |
Human |
ITGA4 |
RF |
|
Overdominant; Genotype/Allele: AG; Multivariate analysis |
2018 |
29769839 |
2302 |
Alzheimer's Disease |
Human |
ITGA4 |
RF |
|
Dominant; Genotype/Allele: AG+GG; Univariate analysis |
2018 |
29769839 |
2334 |
Alzheimer's Disease |
Human |
ITGA4 |
RF |
|
Overdominant; Genotype/Allele: AG; Univariate analysis |
2018 |
29769839 |
1970 |
Parkinson disease |
Human |
ITGB5 |
RF |
|
|
2020 |
33021140 |
3278 |
Amyotrophic Lateral Sclerosis |
Human |
ITPR2 |
RF |
|
|
2014 |
25023141 |
2181 |
Alzheimer's Disease |
Human |
KCNJ15 |
RF |
|
|
2018 |
29432188 |
574 |
Alzheimer's Disease |
Human |
KIBRA |
PF |
|
|
2013 |
24190487 |
3810 |
Lewy Body Disease |
Human |
KIF17 |
RF |
Diagnosis |
|
2021 |
34124335 |
3078 |
Amyotrophic Lateral Sclerosis |
Human |
KIF5A |
RF |
|
|
2013 |
27455347 |
3124 |
Alzheimer's Disease |
Human |
LAMA2 |
RF |
|
APOE-?3 |
2021 |
33576571 |
2215 |
Alzheimer's Disease |
Human |
LAMA2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
535 |
Alzheimer's Disease |
Human |
LAMA2 |
PF |
|
APOE-?2 |
2021 |
33576571 |
3279 |
Alzheimer's Disease |
Human |
LCORL |
RF |
|
|
2018 |
29860282 |
2108 |
Alzheimer's Disease |
Human |
LDLR |
RF |
|
|
2008 |
18065781 |
489 |
Alzheimer's Disease |
Human |
LHCGR |
PF |
|
carrying an APOE epsilon4 allele |
2008 |
18439297 |
2091 |
Alzheimer's Disease |
Human |
LOC100505811 |
RF |
|
|
2018 |
29027019 |
2183 |
Alzheimer's Disease |
Human |
LOC100505811 |
RF |
|
|
2018 |
29027019 |
2149 |
Alzheimer's Disease |
Human |
LOC100505811 |
RF |
|
|
2018 |
29027019 |
2180 |
Alzheimer's Disease |
Human |
LOC100505811 |
RF |
|
|
2018 |
29027019 |
2105 |
Frontotemporal Lobar Degeneration |
Human |
LOC101927354 |
RF |
|
Discovery stage |
2019 |
30739198 |
2061 |
Amyotrophic Lateral Sclerosis |
Human |
LOC107987057 |
RF |
|
|
2010 |
20801717 |
1960 |
Amyotrophic Lateral Sclerosis |
Human |
LOC107987057 |
RF |
|
In the joint analysis |
2010 |
20801717 |
2526 |
Amyotrophic Lateral Sclerosis |
Human |
LOC107987057 |
RF |
|
|
2010 |
20801718 |
2057 |
Amyotrophic Lateral Sclerosis |
Human |
LOC107987057,LOC112268043 |
RF |
|
|
2010 |
20801717 |
1961 |
Amyotrophic Lateral Sclerosis |
Human |
LOC107987057,LOC112268043 |
RF |
|
In the joint analysis |
2010 |
20801717 |
2520 |
Amyotrophic Lateral Sclerosis |
Human |
LOC112268043,LOC107987057 |
RF |
|
|
2010 |
20801718 |
2418 |
Alzheimer's Disease |
Human |
LPA |
RF |
|
APOE-?2 |
2021 |
33576571 |
3775 |
Amyotrophic Lateral Sclerosis |
Human |
LRP10 |
RF |
|
|
2021 |
32690342 |
2052 |
Alzheimer's Disease |
Human |
LRP2 |
RF |
|
|
2011 |
20971101 |
783 |
Alzheimer's Disease |
Human |
LRRC17 |
PF |
|
APOE-?3 |
2021 |
33576571 |
656 |
Alzheimer's Disease |
Human |
LRRC17 |
PF |
|
APOE-?2 |
2021 |
33576571 |
2005 |
Alzheimer's Disease |
Human |
LRRC17 |
RF |
|
APOE-?3 |
2021 |
33576571 |
2098 |
Alzheimer's Disease |
Human |
LRRC2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2981 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2013 |
23624603 |
805 |
Parkinson disease |
Human |
LRRK2 |
PF |
|
|
2012 |
23115130 |
3112 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
reater frequency of the G2019S mutation in Jewish than in non-Jewish cases with Parkinson disease |
2006 |
17050822 |
3855 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2021 |
34060004 |
1941 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2012 |
23115130 |
3872 |
Parkinson disease |
Human |
LRRK2 |
RF |
Diagnosis |
|
2021 |
33742109 |
3141 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2009 |
19699188 |
3280 |
Multiple System Atrophy |
Human |
LRRK2 |
RF |
|
|
2018 |
29480226 |
3711 |
Alzheimer's Disease |
Human |
LRRK2 |
RF |
|
|
2021 |
34135785 |
2514 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2008 |
18716801 |
3282 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2007 |
17960808 |
2682 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2007 |
17314670 |
2904 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2008 |
18201193 |
2335 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2010 |
19854095 |
2504 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2007 |
17019612 |
2511 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
especially in early-onset patients |
2015 |
26234753 |
2888 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2009 |
19672984 |
2487 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2010 |
20673920 |
2548 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2006 |
16633828 |
3874 |
Parkinson disease |
Human |
LRRK2 |
RF |
Diagnosis |
|
2021 |
33574311 |
1719 |
Parkinson disease |
Human |
LRRK2 |
RF |
Diagnosis |
|
2023 |
35733392 |
3281 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2011 |
21167764 |
2327 |
Parkinson disease |
Human |
LRRK2 |
RF |
|
|
2011 |
20629711 |
2801 |
Alzheimer's Disease |
Human |
LTBP1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2800 |
Alzheimer's Disease |
Human |
LTBP1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
631 |
Alzheimer's Disease |
Human |
LTBP1 |
PF |
|
APOE-?3 |
2021 |
33576571 |
2491 |
Amyotrophic Lateral Sclerosis |
Human |
M1(C/C) |
RF |
|
|
2007 |
17503480 |
555 |
Amyotrophic Lateral Sclerosis |
Human |
M5(A/A) |
PF |
|
|
2007 |
17503480 |
2908 |
Amyotrophic Lateral Sclerosis |
Human |
M6(T/T) |
RF |
|
|
2007 |
17503480 |
3283 |
Parkinson disease |
Human |
MAO |
RF |
|
|
1994 |
7913737 |
3284 |
Parkinson disease |
Human |
MAO |
RF |
|
|
1994 |
7913737 |
2783 |
Frontotemporal Lobar Degeneration |
Human |
MAPT |
RF |
|
|
2012 |
22556362 |
2379 |
Multiple System Atrophy |
Human |
MAPT |
RF |
|
H1 haplotype |
2011 |
21321341 |
2079 |
Parkinson disease |
Human |
MAPT |
RF |
|
|
2005 |
15627775 |
3049 |
Frontotemporal Lobar Degeneration |
Human |
MAPT |
RF |
|
H2H2 vs. H1H2 + H1H1 |
2006 |
16410051 |
498 |
Progressive Supranuclear Palsy |
Human |
MAPT |
PF |
Diagnosis |
|
2021 |
33897612 |
618 |
Progressive Supranuclear Palsy |
Human |
MAPT |
PF |
|
Meta-analysis |
2018 |
29986742 |
3985 |
Amyotrophic Lateral Sclerosis |
Human |
MAPT |
RF |
Diagnosis |
|
2023 |
38002967 |
3285 |
Frontotemporal Dementia |
Human |
MAPT |
RF |
|
a rare microtubule-associated protein tau (MAPT) sequence variant, c.454G>A (p.A152T) |
2013 |
23518664 |
2782 |
Frontotemporal Dementia |
Human |
MAPT |
RF |
|
|
2012 |
22556362 |
3037 |
Progressive Supranuclear Palsy |
Human |
MAPT |
RF |
|
Meta-analysis |
2018 |
29986742 |
2582 |
Progressive Supranuclear Palsy |
Human |
MAPT |
RF |
Diagnosis |
|
2021 |
33897612 |
3135 |
Parkinson disease |
Human |
MAPT |
RF |
|
|
2010 |
19912324 |
2568 |
Alzheimer's Disease |
Human |
MAPT |
RF |
|
|
2012 |
22556362 |
2332 |
Frontotemporal Dementia |
Human |
MAPT H2 haplotype |
RF |
|
|
2006 |
16410051 |
2746 |
Frontotemporal Dementia |
Human |
MAPT H2 haplotype |
RF |
|
APOE e4 negatives |
2006 |
16410051 |
2437 |
Frontotemporal Dementia |
Human |
MAPT H2H3 genetype |
RF |
|
APOE e4 negatives |
2006 |
16410051 |
3287 |
Parkinson disease |
Human |
MC1R |
RF |
|
|
2009 |
19194882 |
2411 |
Alzheimer's Disease |
Human |
MC1R |
RF |
|
|
2017 |
28059796 |
3286 |
Parkinson disease |
Human |
MC1R |
RF |
|
|
2009 |
19194882 |
3712 |
Alzheimer's Disease |
Human |
MEF2C |
RF |
|
|
2021 |
34163341 |
3288 |
Frontotemporal Lobar Degeneration |
Human |
MFSD8 |
RF |
|
|
2019 |
30382371 |
3776 |
Amyotrophic Lateral Sclerosis |
Human |
MFSD8 |
RF |
Diagnosis |
|
2021 |
33226711 |
3665 |
Amyotrophic Lateral Sclerosis |
Human |
MFSD8 |
RF |
|
|
2021 |
33226711 |
3048 |
Alzheimer's Disease |
Human |
MGME1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
573 |
Alzheimer's Disease |
Human |
MIA2 |
PF |
|
APOE-?3 |
2021 |
33576571 |
768 |
Alzheimer's Disease |
Human |
MIA2 |
PF |
|
APOE-?3 |
2021 |
33576571 |
796 |
Alzheimer's Disease |
Human |
microtubule-associated protein tau (MAPT) gene |
PF |
|
individuals with a GG genotype of rs242557G/A |
2018 |
29098924 |
3289 |
Alzheimer's Disease |
Human |
MIEF1 |
RF |
|
|
2017 |
29177109 |
2129 |
Frontotemporal Lobar Degeneration |
Human |
MIR548AP |
RF |
|
Discovery stage |
2019 |
30739198 |
3290 |
Alzheimer's Disease |
Human |
MLKL |
RF |
|
MLKL loss-of-function mutation |
2018 |
29656768 |
3291 |
Amyotrophic Lateral Sclerosis |
Human |
MOB3B |
RF |
|
|
2014 |
25023141 |
2554 |
Amyotrophic Lateral Sclerosis |
Human |
MOB3B |
RF |
|
|
2010 |
20801718 |
715 |
Progressive Supranuclear Palsy |
Human |
MOBP |
PF |
|
Meta-analysis |
2018 |
29986742 |
3786 |
Amyotrophic Lateral Sclerosis |
Human |
MOBP |
RF |
Diagnosis |
Greece |
2021 |
34694630 |
2840 |
Parkinson disease |
Human |
Monoamine oxidase-B (MAO-B) |
RF |
|
levodopa-induced dyskinesia(LID) |
2020 |
32346620 |
3292 |
Alzheimer's Disease |
Human |
mosaic aneuploidy in the brain |
RF |
|
|
2014 |
24602248 |
1888 |
Alzheimer's Disease |
Human |
MS4A4E |
RF |
|
|
2015 |
26770425 |
3293 |
Alzheimer's Disease |
Human |
MS4A6A |
RF |
|
|
2012 |
22382309 |
1857 |
Alzheimer's Disease |
Human |
MS4A6A |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
1862 |
Alzheimer's Disease |
Human |
MS4A6A |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
802 |
Alzheimer's Disease |
Human |
MS4A6A |
PF |
|
|
2015 |
26770425 |
1861 |
Alzheimer's Disease |
Human |
MS4A6A |
RF |
|
Calculated by fixed effect model |
2018 |
29504051 |
2331 |
Alzheimer's Disease |
Human |
MTHFD1L |
RF |
|
the results were influenced by APOE status |
2011 |
21741665 |
1992 |
Alzheimer's Disease |
Human |
MTHFR |
RF |
|
without APOE epsilon4 alleles |
2010 |
20600372 |
1937 |
Alzheimer's Disease |
Human |
MTHFR |
RF |
|
in APOE?4 or in non-APOE?4 carriers |
2017 |
28211809 |
2771 |
Alzheimer's Disease |
Human |
MTHFR |
RF |
|
AA genotype |
2013 |
23659764 |
3294 |
Alzheimer's Disease |
Human |
MTHFR |
RF |
|
increased the odds of developing AD by 2.5 |
2012 |
22015309 |
2648 |
Amyotrophic Lateral Sclerosis |
Human |
MTHFR(T677T) |
RF |
|
|
2012 |
22385294 |
2748 |
Amyotrophic Lateral Sclerosis |
Human |
MTHFR(T677T/A1298A) |
RF |
|
|
2012 |
22385294 |
2749 |
Amyotrophic Lateral Sclerosis |
Human |
MTHFR(T677T/A1298A) |
RF |
|
|
2012 |
22385294 |
3295 |
Alzheimer's Disease |
Human |
MTNR1A |
RF |
|
|
2018 |
29982836 |
3844 |
Parkinson disease |
Human |
MTPAP |
RF |
|
|
2021 |
34394198 |
2639 |
Parkinson disease |
Human |
MUL1 |
RF |
Diagnosis |
|
2021 |
34946922 |
3480 |
Tuberous sclerosis complex |
Human |
mutations in TSC2 |
RF |
|
|
2015 |
26631248 |
3773 |
Alzheimer's Disease |
mice |
MUTYH |
RF |
Treatment |
|
2021 |
34970419 |
2402 |
Alzheimer's Disease |
Human |
MYEOV |
RF |
|
APOE-?2 |
2021 |
33576571 |
3758 |
Alzheimer's Disease |
Human |
MYH11 |
RF |
|
|
2021 |
32966694 |
3296 |
Motor Neuron Disease |
Human |
NEFH |
RF |
|
Genotype: SS |
2004 |
14722583 |
3094 |
Amyotrophic Lateral Sclerosis |
Human |
NEK1 |
RF |
|
|
2013 |
27455347 |
2614 |
Amyotrophic Lateral Sclerosis |
Human |
NEK1 |
RF |
|
|
2013 |
27455347 |
2613 |
Amyotrophic Lateral Sclerosis |
Human |
NEK1 |
RF |
|
|
2013 |
27455347 |
2689 |
Amyotrophic Lateral Sclerosis |
Human |
NEK1 |
RF |
|
|
2013 |
27455347 |
2071 |
Alzheimer's Disease |
Human |
NEP gene (MME) |
RF |
|
|
2012 |
22493749 |
1330 |
Alzheimer's Disease |
Human |
neprilysin (NEP) |
RF |
|
|
2010 |
20376800 |
541 |
Alzheimer's Disease |
Human |
NINJ2 |
PF |
|
|
2011 |
21674003 |
537 |
Alzheimer's Disease |
Human |
NINJ2 |
PF |
|
|
2011 |
21674003 |
575 |
Alzheimer's Disease |
Human |
NINJ2 |
PF |
|
|
2011 |
21674003 |
3297 |
Amyotrophic Lateral Sclerosis |
Human |
NIPA1 |
RF |
|
|
2012 |
22378146 |
3298 |
Parkinson disease |
Human |
NOD2 |
RF |
|
associated with late-onset PD |
2013 |
23651603 |
762 |
Alzheimer's Disease |
Human |
NOP56 |
PF |
|
APOE-?3 |
2021 |
33576571 |
672 |
Alzheimer's Disease |
Human |
NOP56 |
PF |
|
APOE-?2 |
2021 |
33576571 |
1333 |
Alzheimer's Disease |
Human |
NOS3 |
RF |
|
in the APOE epsilon 4 noncarriers |
2008 |
18183499 |
2226 |
Frontotemporal Lobar Degeneration |
Human |
NOS3 |
RF |
|
|
2009 |
19087148 |
1332 |
Alzheimer's Disease |
Human |
NOS3 |
RF |
|
in the APOE epsilon 4 noncarriers |
2008 |
18183499 |
3299 |
Alzheimer's Disease |
Human |
NOS3 |
RF |
|
|
2010 |
20505439 |
1966 |
Alzheimer's Disease |
Human |
NQO1 |
RF |
|
|
2008 |
18253865 |
711 |
Alzheimer's Disease |
Human |
NQO1 |
PF |
|
significant difference in the APOE epsilon4 non-carriers |
2008 |
18253865 |
2304 |
Alzheimer's Disease |
Human |
NT-3 |
RF |
|
homozygotes or heterozygotes for the mutated type (Glu[-63]) |
1998 |
9502217 |
599 |
Alzheimer's Disease |
Human |
NTF-3 |
PF |
|
in patients lacking the ApoE-?4 allele |
2015 |
26814132 |
2652 |
Alzheimer's Disease |
Human |
NUMA1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2626 |
Alzheimer's Disease |
Human |
NUMA1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2287 |
Frontotemporal Lobar Degeneration |
Human |
OLFM1 |
RF |
|
Discovery stage |
2019 |
30739198 |
3085 |
Parkinson disease |
Human |
Omi/HTRA2 |
RF |
|
|
2011 |
21338583 |
2475 |
Alzheimer's Disease |
Human |
OPRD1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2286 |
Alzheimer's Disease |
Human |
OPRD1 |
RF |
|
APOE-?3 |
2021 |
33576571 |
2216 |
Alzheimer's Disease |
Human |
OR1S2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2273 |
Alzheimer's Disease |
Human |
OR1S2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2036 |
Alzheimer's Disease |
Human |
OR2B2 |
RF |
|
|
2021 |
33654092 |
652 |
Alzheimer's Disease |
Human |
OR52E6 |
PF |
|
APOE-?2 |
2021 |
33576571 |
671 |
Alzheimer's Disease |
Human |
OR52E6 |
PF |
|
APOE-?2 |
2021 |
33576571 |
640 |
Alzheimer's Disease |
Human |
OR52E6 |
PF |
|
APOE-?2 |
2021 |
33576571 |
649 |
Alzheimer's Disease |
Human |
OR52E6 |
PF |
|
APOE-?2 |
2021 |
33576571 |
657 |
Alzheimer's Disease |
Human |
OR52E6 |
PF |
|
APOE-?2 |
2021 |
33576571 |
3301 |
Alzheimer's Disease |
Human |
OX2R |
RF |
|
A allele may be a susceptible factor for AD |
2019 |
30955315 |
3300 |
Alzheimer's Disease |
Human |
OX2R |
RF |
|
A allele may be a susceptible factor for AD |
2019 |
30955315 |
3126 |
Alzheimer's Disease |
Human |
oxidized LDL receptor 1(OLR1) |
RF |
|
|
2011 |
21709374 |
3137 |
Alzheimer's Disease |
Human |
oxidized LDL receptor 1(OLR1) |
RF |
|
|
2011 |
21709374 |
2953 |
Parkinson disease |
Human |
P2RY12 |
RF |
|
|
2020 |
33021140 |
3302 |
Parkinson disease |
Human |
P2X7 |
RF |
|
|
2013 |
23648388 |
3303 |
Amyotrophic Lateral Sclerosis |
Human |
P4HB/PDIA1 |
RF |
|
|
2015 |
25913742 |
3718 |
Alzheimer's Disease |
Human |
paraoxonase 1 (PON1) |
RF |
|
can be ameliorated by B-vitamins in individuals with MCI |
2021 |
33935094 |
2396 |
Parkinson disease |
Human |
PARK16 |
RF |
|
|
2011 |
21419001 |
3851 |
Parkinson disease |
Human |
PARK16 |
RF |
|
|
2021 |
34373950 |
728 |
Parkinson disease |
Human |
PARK16 |
PF |
|
|
2016 |
27174169 |
3304 |
Parkinson disease |
Human |
PARK16 |
RF |
|
|
2016 |
27174169 |
3306 |
Parkinson disease |
Human |
PARK2 |
RF |
|
|
2014 |
24729340 |
3305 |
Parkinson disease |
Human |
PARK2 |
RF |
|
|
2002 |
12056932 |
3307 |
Parkinson disease |
Human |
PARK2 |
RF |
|
|
2014 |
24729340 |
2386 |
Parkinson disease |
Human |
PARKIN |
RF |
|
|
1999 |
10511432 |
3308 |
Parkinson disease |
Human |
PARKIN |
RF |
|
|
2009 |
19636047 |
2387 |
Parkinson disease |
Human |
PARKIN |
RF |
|
|
1999 |
10511432 |
1855 |
Tourette Syndrome |
Human |
PCNT |
RF |
|
|
2020 |
32099372 |
1852 |
Tourette Syndrome |
Human |
PCNT |
RF |
|
|
2020 |
32099372 |
1853 |
Tourette Syndrome |
Human |
PCNT |
RF |
|
|
2020 |
32099372 |
3309 |
Parkinson disease |
Human |
PD in first-degree relatives |
RF |
|
|
2000 |
11060508 |
3812 |
Lewy Body Disease |
Human |
PD-PRS |
RF |
Diagnosis |
|
2021 |
34308904 |
2434 |
Amyotrophic Lateral Sclerosis |
Human |
PEAK1 |
RF |
|
|
2013 |
27455347 |
572 |
Alzheimer's Disease |
Human |
PELO |
PF |
|
APOE-?2 |
2021 |
33576571 |
638 |
Alzheimer's Disease |
Human |
PELO |
PF |
|
APOE-?3 |
2021 |
33576571 |
2103 |
Alzheimer's Disease |
Human |
PEMT |
RF |
|
|
2012 |
21881829 |
2545 |
Amyotrophic Lateral Sclerosis |
Human |
PFN1 |
RF |
|
|
2014 |
24309268 |
2760 |
Alzheimer's Disease |
Human |
PGP |
RF |
|
APOE-?2 |
2021 |
33576571 |
2352 |
Alzheimer's Disease |
Human |
PICALM |
RF |
|
PENN cohort |
2018 |
30128317 |
2508 |
Alzheimer's Disease |
Human |
PICALM |
RF |
|
PENN cohort |
2018 |
30128317 |
3818 |
major depressive disorder (MDD),AD,NDD |
Human |
PICALM mRNA expression |
RF |
|
|
2021 |
33386803 |
3824 |
Parkinson disease |
Human |
PICALM mRNA expression |
RF |
Diagnosis |
|
2021 |
33386803 |
1869 |
Parkinson disease |
Human |
PINK1 |
RF |
|
|
2017 |
27807026 |
3310 |
Parkinson disease |
Human |
PINK1 |
RF |
|
|
2006 |
16969854 |
3311 |
Alzheimer's Disease |
Human |
PLA2G3 |
RF |
|
|
2010 |
20930276 |
3312 |
Parkinson disease |
Human |
PLA2G6 |
RF |
|
|
2012 |
22213678 |
3313 |
Alzheimer's Disease |
Human |
PLEKHG5 |
RF |
|
|
2017 |
29177109 |
752 |
Parkinson disease |
Human |
PLEKHN1 |
PF |
Diagnosis |
|
2021 |
33510632 |
832 |
Alzheimer's Disease |
Human |
PM20D1 |
PF |
|
in a particular genetic background |
2018 |
29736028 |
3314 |
Hereditary Motor and Sensory Neuropathy |
Human |
PMP22 |
RF |
|
17p11.2 duplication |
1997 |
9183252 |
3315 |
Hereditary Motor and Sensory Neuropathy |
Human |
PMP22 |
RF |
|
17p11.2 duplication |
1994 |
8179301 |
3995 |
Charcot-Marie-Tooth (CMT) disease |
Human |
PMP22 |
RF |
Diagnosis |
|
2023 |
36581210 |
695 |
Alzheimer's Disease |
Human |
POMT1 |
PF |
|
APOE-?2 |
2021 |
33576571 |
2086 |
Amyotrophic Lateral Sclerosis |
Human |
PON1 Q192R(major allele is Q) |
RF |
|
Additive |
2006 |
16822965 |
2106 |
Amyotrophic Lateral Sclerosis |
Human |
PON1 Q192R(major allele is Q) |
RF |
|
Dominant (RR and QR vs QQ) |
2006 |
16822965 |
2390 |
Amyotrophic Lateral Sclerosis |
Human |
PON1 Q192R(major allele is Q) |
RF |
|
Recessive (RR vs other) |
2006 |
16822965 |
2132 |
Amyotrophic Lateral Sclerosis |
Human |
PON2 C311S (major allele is S) |
RF |
|
Dominant (CC and CS vs SS) |
2006 |
16822965 |
2046 |
Amyotrophic Lateral Sclerosis |
Human |
PON2 C311S (major allele is S) |
RF |
|
Additive |
2006 |
16822965 |
2836 |
Parkinson disease |
Human |
positive family history of PD |
RF |
|
|
1998 |
9778597 |
2631 |
Alzheimer's Disease |
Human |
PRAME |
RF |
|
APOE-?2 |
2021 |
33576571 |
1699 |
Alzheimer's Disease |
Human |
presence of one or more APOE ε4 alleles |
RF |
|
in females |
2015 |
26343475 |
746 |
Alzheimer's Disease |
Human |
PRKAG3 |
PF |
|
APOE-?3 |
2021 |
33576571 |
2588 |
Alzheimer's Disease |
Human |
PRKAG3 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3846 |
Parkinson disease |
Human |
PRKN |
RF |
|
|
2021 |
34434164 |
1784 |
Parkinson disease |
Human |
PRKN |
RF |
Diagnosis |
|
2021 |
33448283 |
3871 |
Parkinson disease |
Human |
PRKN |
RF |
Diagnosis |
|
2021 |
33742109 |
1964 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
|
|
2020 |
32949544 |
2166 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
|
BACE1?C-allele carriers |
2012 |
22952813 |
3793 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
Diagnosis |
|
2021 |
33917419 |
3316 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
|
Codon 129: Val homozygosity |
1996 |
8707291 |
3878 |
Prion disease |
moose |
PRNP |
RF |
Diagnosis |
|
2021 |
34346562 |
2918 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
|
|
2009 |
19081515 |
2884 |
Fatal familial insomnia (FFI) |
Human |
PRNP |
RF |
Diagnosis |
|
2021 |
34667102 |
3004 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
Diagnosis |
|
2021 |
34831353 |
3794 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
Diagnosis |
|
2021 |
33917419 |
2882 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
|
|
2009 |
19081515 |
2974 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
|
APOE?ε4 carriers |
2011 |
21799773 |
2484 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
|
|
2012 |
22210626 |
2405 |
Creutzfeldt-Jakob disease |
Human |
PRNP |
RF |
|
BACE1?C-allele carriers |
2012 |
22952813 |
3022 |
Alzheimer's Disease |
Human |
PRPH |
RF |
|
APOE-?2 |
2021 |
33576571 |
2161 |
Alzheimer's Disease |
Human |
PRSS48 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2415 |
Alzheimer's Disease |
Human |
PS-1 |
RF |
|
APOE ε4 |
1999 |
10581373 |
3318 |
Alzheimer's Disease |
Human |
PS-1 |
RF |
|
|
1997 |
9298817 |
3317 |
Alzheimer's Disease |
Human |
PS-1 |
RF |
|
|
1996 |
8930979 |
3105 |
Alzheimer's Disease |
Human |
PS-2 |
RF |
|
APOE ε4 |
1999 |
10581373 |
3319 |
Alzheimer's Disease |
Human |
PSEN1 |
RF |
|
|
2014 |
25104557 |
3320 |
Dementia with Lewy bodies |
Human |
PSEN1 |
RF |
|
|
2016 |
27312774 |
3321 |
Alzheimer's Disease |
Human |
PSEN2 |
RF |
|
|
2014 |
25104557 |
3928 |
Alzheimer's Disease |
Human |
PSEN2 |
RF |
Diagnosis |
|
2022 |
36362122 |
3322 |
Alzheimer's Disease |
Human |
PSEN2 |
RF |
|
|
2014 |
24927704 |
2233 |
Alzheimer's Disease |
Human |
PSMB7 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3101 |
Alzheimer's Disease |
Human |
PTBP1 |
RF |
|
APOE-?3 |
2021 |
33576571 |
642 |
Alzheimer's Disease |
Human |
PTCH1 |
PF |
|
APOE-?2 |
2021 |
33576571 |
763 |
Alzheimer's Disease |
Human |
PTK2B |
PF |
|
National Alzheimer’s Coordinating Center (NACC) cohort |
2018 |
30128317 |
3791 |
Amyotrophic lateral sclerosis,Parkinson disease |
Human |
PTPRT |
RF |
Diagnosis |
|
2021 |
34707478 |
3324 |
Alzheimer's Disease |
Human |
PVRL2 |
RF |
|
eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD |
2018 |
30319691 |
3323 |
Alzheimer's Disease |
Human |
PVRL2 |
RF |
|
eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD |
2018 |
30319691 |
2261 |
Alzheimer's Disease |
Human |
PVRL2 |
RF |
|
using logistic regression、Dataset:LOADFS(Late Onset Alzheimer's Disease Family Study ) |
2018 |
29107063 |
2064 |
Alzheimer's Disease |
Human |
PVRL2 |
RF |
|
using logistic regression、Dataset:CHS( Cardiovascular Health Study) |
2018 |
29107063 |
2114 |
Alzheimer's Disease |
Human |
PVRL2 |
RF |
|
using logistic regression、Dataset:HRS(Health and Retirement Study) |
2018 |
29107063 |
3325 |
Alzheimer's Disease |
Human |
PVRL2 |
RF |
|
eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD |
2018 |
30319691 |
1573 |
Alzheimer's Disease |
Human |
PVRL2 |
RF |
|
using Cox regression、Dataset:CHS(Cardiovascular Health Study) |
2018 |
29107063 |
3091 |
Alzheimer's Disease |
Human |
QPCTL |
RF |
|
APOE-?2 |
2021 |
33576571 |
4015 |
Huntington's disease (HD) |
Human |
RCAN1 |
RF |
Treatment |
RCAN1 knockdown rescued patient-derived medium spiny neurons (MSNs) |
2023 |
38066314 |
3326 |
Alzheimer's Disease |
Human |
RCAN1 |
RF |
|
|
2015 |
26497675 |
3327 |
Alzheimer's Disease |
Human |
RCAN1 |
RF |
|
|
2015 |
26497675 |
2019 |
Alzheimer's Disease |
Human |
reduced folate carrier gene (RFC1) |
RF |
|
especially for female individuals |
2009 |
18258338 |
2058 |
Alzheimer's Disease |
Human |
reduced folate carrier gene (RFC1) |
RF |
|
especially for female individuals |
2009 |
18258338 |
700 |
Frontotemporal Lobar Degeneration |
Human |
RERG |
PF |
|
Discovery stage |
2019 |
30739198 |
2378 |
Alzheimer's Disease |
Human |
RIPK2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3845 |
Parkinson disease |
Human |
RP11-305E6 |
RF |
|
|
2021 |
34394198 |
833 |
Parkinson disease |
Human |
Saitohin |
PF |
|
|
2015 |
25168738 |
3329 |
Parkinson disease |
Human |
Saitohin |
RF |
|
|
2015 |
25168738 |
3330 |
Multiple System Atrophy |
Human |
SCA1 |
RF |
|
|
2018 |
29715545 |
3331 |
Multiple System Atrophy |
Human |
SCA3 |
RF |
|
|
2007 |
17133518 |
3003 |
Alzheimer's Disease |
Human |
SCAF11 |
RF |
|
APOE-?3 |
2021 |
33576571 |
558 |
Alzheimer's Disease |
Human |
SCAF11 |
PF |
|
APOE-?2 |
2021 |
33576571 |
1833 |
Lewy Body Disease |
Human |
SCARB2 |
RF |
Diagnosis |
|
2021 |
34308904 |
553 |
Parkinson disease |
Human |
SEMA5A |
PF |
|
|
2008 |
18950607 |
2308 |
Parkinson disease |
Human |
SEMA5A |
RF |
|
|
2008 |
18950607 |
552 |
Parkinson disease |
Human |
SEMA5A |
PF |
|
|
2008 |
18950607 |
2307 |
Parkinson disease |
Human |
SEMA5A |
RF |
|
|
2008 |
18950607 |
798 |
Parkinson disease |
Human |
SEMA5A |
PF |
|
|
2014 |
24706317 |
3019 |
Alzheimer's Disease |
Human |
SEMA6A |
RF |
|
APOE-?2 |
2021 |
33576571 |
3106 |
Alzheimer's Disease |
Human |
SERPINE1 |
RF |
|
women were at an increased risk over their male genotype counterparts |
2017 |
28466654 |
2965 |
Alzheimer's Disease |
Human |
SERPINE1 |
RF |
|
women were at an increased risk over their male genotype counterparts |
2017 |
28466654 |
2925 |
Alzheimer's Disease |
Human |
SERPINE2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2309 |
Alzheimer's Disease |
Human |
SFTPB |
RF |
|
APOE-?2 |
2021 |
33576571 |
2763 |
Alzheimer's Disease |
Human |
SH3D19 |
RF |
|
APOE-?3 |
2021 |
33576571 |
3052 |
Alzheimer's Disease |
Human |
SHARPIN |
RF |
|
|
2019 |
31216982 |
3707 |
Alzheimer's Disease |
Human |
SIGLEC14 |
RF |
|
|
2021 |
34208838 |
3332 |
Alzheimer's Disease |
Human |
SIRT2 |
RF |
|
|
2014 |
24139700 |
2227 |
Alzheimer's Disease |
Human |
SIRT2 |
RF |
|
APOEε4 noncarriers |
2014 |
24139700 |
595 |
Alzheimer's Disease |
Human |
SLC35G6 |
PF |
|
APOE-?2 |
2021 |
33576571 |
617 |
Alzheimer's Disease |
Human |
SLC35G6 |
PF |
|
APOE-?2 |
2021 |
33576571 |
1982 |
Parkinson disease |
Human |
SLC6A3 |
RF |
|
|
2014 |
24211691 |
2051 |
Parkinson disease |
Human |
SLC6A3 |
RF |
|
|
2014 |
24211691 |
770 |
Parkinson disease |
Human |
SLC6A3 |
PF |
|
|
2014 |
24211691 |
1981 |
Parkinson disease |
Human |
SLC6A3 |
RF |
|
|
2014 |
24211691 |
2050 |
Parkinson disease |
Human |
SLC6A3 |
RF |
|
|
2014 |
24211691 |
578 |
Alzheimer's Disease |
Human |
SLC6A4/5-HTT |
PF |
|
S allele; AD with depression |
2018 |
29703883 |
709 |
Progressive Supranuclear Palsy |
Human |
SLCO1A2 |
PF |
|
Meta-analysis |
2018 |
29986742 |
2661 |
Amyotrophic Lateral Sclerosis |
Human |
SMN1 |
RF |
|
three copies |
2006 |
16931506 |
2723 |
Amyotrophic Lateral Sclerosis |
Human |
SMN1 |
RF |
|
one or three copies of SMN1 gene were pooled |
2006 |
16931506 |
3994 |
Spinal muscular atrophy (SMA) |
Human |
SMN1 |
RF |
Diagnosis |
|
2023 |
37964750 |
2796 |
Amyotrophic Lateral Sclerosis |
Human |
SMN1 |
RF |
|
one copy |
2006 |
16931506 |
2596 |
Amyotrophic Lateral Sclerosis |
Human |
SMN1 |
RF |
|
abnormal SMN1 copy numbers |
2009 |
19922137 |
3333 |
Amyotrophic Lateral Sclerosis |
Human |
SMN2 |
RF |
|
|
2011 |
22187232 |
3334 |
Parkinson disease |
Human |
SMPD1 |
RF |
|
|
2015 |
26169695 |
2330 |
Alzheimer's Disease |
Human |
SMPD4 |
RF |
|
APOE-?3 |
2021 |
33576571 |
621 |
Alzheimer's Disease |
Human |
SMTNL1 |
PF |
|
APOE-?2 |
2021 |
33576571 |
733 |
Alzheimer's Disease |
Human |
SMTNL1 |
PF |
|
APOE-?3 |
2021 |
33576571 |
3838 |
Parkinson disease |
Human |
SNCA |
RF |
Diagnosis |
|
2021 |
33994928 |
742 |
Dementia with Lewy bodies |
Human |
SNCA |
PF |
|
|
2018 |
29263008 |
1972 |
Parkinson disease |
Human |
SNCA |
RF |
|
|
2008 |
18404644 |
3129 |
Parkinson disease |
Human |
SNCA |
RF |
Diagnosis |
|
2021 |
33705925 |
3843 |
Parkinson disease |
Human |
SNCA |
RF |
|
|
2021 |
34394198 |
2047 |
Lewy Body Disease |
Human |
SNCA |
RF |
Diagnosis |
|
2021 |
34308904 |
1971 |
Parkinson disease |
Human |
SNCA |
RF |
|
|
2008 |
18404644 |
708 |
Parkinson disease |
Human |
SNCA |
PF |
Diagnosis |
|
2021 |
34946922 |
3808 |
Lewy Body Disease |
Human |
SNCA |
RF |
Diagnosis |
|
2021 |
33994928 |
3142 |
Parkinson disease |
Human |
SNCA |
RF |
|
|
2016 |
27699750 |
3801 |
Lewy Body Disease |
Human |
SNCA |
RF |
|
|
2021 |
34308904 |
2357 |
Parkinson disease |
Human |
SNCA |
RF |
|
|
2012 |
22349157 |
2419 |
Alzheimer's Disease |
Human |
SNX27 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3335 |
Amyotrophic Lateral Sclerosis |
Human |
SOD1 |
RF |
|
Expression of N19S-SOD1, an SOD1 Mutant |
2005 |
16035108 |
3336 |
Amyotrophic Lateral Sclerosis |
Human |
SOD1 |
RF |
|
|
2014 |
24591609 |
627 |
Alzheimer's Disease |
Human |
SOD1 gene |
PF |
|
After Bonferroni correction;additive model |
2014 |
25440013 |
590 |
Alzheimer's Disease |
Human |
SOD1 gene |
PF |
|
Logistic regression analysis controlled for age, genderand APOE carrier status;recessive model |
2014 |
25440013 |
589 |
Alzheimer's Disease |
Human |
SOD1 gene |
PF |
|
Logistic regression analysis controlled for age, genderand APOE carrier status;additive model |
2014 |
25440013 |
637 |
Alzheimer's Disease |
Human |
SOD1 gene |
PF |
|
After Bonferroni correction;recessive model |
2014 |
25440013 |
3760 |
Alzheimer's Disease |
Human |
SORCS3 |
RF |
|
|
2021 |
32966694 |
3338 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
|
|
2009 |
19368828 |
3916 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
Diagnosis |
|
2022 |
35457051 |
3706 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
|
|
2021 |
34214049 |
2059 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
|
adjusted for age and gender |
2015 |
25881907 |
3908 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
Diagnosis |
|
2022 |
35456392 |
3108 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
|
when restricting the analysis to the 205 cases with a positive family history |
2016 |
26303663 |
2404 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
|
|
2014 |
24486888 |
2053 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
|
adjusted foe age, gender, APOE 4 |
2015 |
25881907 |
3337 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
|
with the A allele |
2015 |
25450149 |
3010 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
|
|
2016 |
26303663 |
3915 |
Alzheimer's Disease |
Human |
SORL1 |
RF |
Diagnosis |
|
2022 |
35457051 |
834 |
Alzheimer's Disease |
Human |
SORL1 |
PF |
|
|
2008 |
18407551 |
823 |
Alzheimer's Disease |
Human |
SORL1 |
PF |
|
|
2018 |
30009200 |
674 |
Alzheimer's Disease |
Human |
SORT1 |
PF |
|
|
2016 |
27392867 |
3339 |
Amyotrophic Lateral Sclerosis |
Human |
SPG4 |
RF |
|
|
2005 |
16009903 |
3672 |
Amyotrophic Lateral Sclerosis |
Human |
SPG7 mutations |
RF |
|
|
2020 |
32447552 |
3340 |
Amyotrophic Lateral Sclerosis |
Human |
SQSTM1 |
RF |
|
|
2012 |
22972638 |
3341 |
Alzheimer's Disease |
Human |
SREBF2 |
RF |
|
significant dual associations with LOAD pathological biomarkers and gene expression levels |
2018 |
29503034 |
2529 |
Alzheimer's Disease |
Human |
STARD6 |
RF |
|
in combination with the APOE ε4 allele |
2019 |
30666118 |
559 |
Alzheimer's Disease |
Human |
STEAP1B |
PF |
|
APOE-?2 |
2021 |
33576571 |
1987 |
Alzheimer's Disease |
Human |
STH |
RF |
|
especially in caucasian population, late‐onset AD subjects and studies with high quality |
2017 |
28211174 |
2218 |
Parkinson disease |
Human |
STK39 |
RF |
|
|
2015 |
26469904 |
2914 |
Amyotrophic Lateral Sclerosis |
Human |
STX12 |
RF |
|
|
2013 |
27455347 |
775 |
Progressive Supranuclear Palsy |
Human |
STX6 |
PF |
|
Meta-analysis |
2018 |
29986742 |
1917 |
Creutzfeldt-Jakob disease |
Human |
STX6(Syntaxin-6) |
RF |
|
|
2020 |
32949544 |
3343 |
Amyotrophic Lateral Sclerosis |
Human |
SUN3, HUS1 |
RF |
|
|
2014 |
25023141 |
3869 |
Parkinson disease |
Human |
SV2C |
RF |
Diagnosis |
|
2021 |
33760272 |
3344 |
Alzheimer's Disease |
Human |
SYMPK |
RF |
|
eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD |
2018 |
30319691 |
2147 |
Alzheimer's Disease |
Human |
SYTL2 |
RF |
|
APOE-?3 |
2021 |
33576571 |
639 |
Alzheimer's Disease |
Human |
SYTL2 |
PF |
|
APOE-?2 |
2021 |
33576571 |
2376 |
Alzheimer's Disease |
Human |
SYTL2 |
RF |
|
APOE-?3 |
2021 |
33576571 |
596 |
Alzheimer's Disease |
Human |
SYTL2 |
PF |
|
APOE-?2 |
2021 |
33576571 |
650 |
Alzheimer's Disease |
Human |
SYTL2 |
PF |
|
APOE-?2 |
2021 |
33576571 |
2858 |
Alzheimer's Disease |
Human |
SYTL2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
667 |
Alzheimer's Disease |
Human |
SYTL2 |
PF |
|
APOE-?2 |
2021 |
33576571 |
3346 |
Frontotemporal Lobar Degeneration |
Human |
TARDBP |
RF |
|
|
2008 |
18505686 |
3345 |
Amyotrophic Lateral Sclerosis |
Human |
TARDBP |
RF |
|
|
2014 |
25023141 |
3778 |
Amyotrophic Lateral Sclerosis |
Human |
TATA-box binding protein gene (TBP) |
RF |
Diagnosis |
|
2021 |
33377399 |
2686 |
Frontotemporal Lobar Degeneration |
Human |
tau |
RF |
|
tau Genotype:H1H1;absence of APOE E2 allele |
2002 |
12056929 |
3927 |
Alzheimer's Disease |
Human |
tau |
RF |
Diagnosis |
|
2022 |
35348036 |
2846 |
Frontotemporal Lobar Degeneration |
Human |
tau |
RF |
|
tau Genotype:H1H2+H2H2;presence of APOE E2 allele |
2002 |
12056929 |
3349 |
Progressive Supranuclear Palsy |
Human |
tau A0/A0 genotype |
RF |
|
|
1998 |
9708963 |
3348 |
Progressive Supranuclear Palsy |
Human |
tau A0/A0 genotype |
RF |
|
|
1998 |
9708963 |
3118 |
Frontotemporal Lobar Degeneration |
Human |
tau,APOE |
RF |
|
tau A3,APOE ε4 |
2001 |
11303757 |
2971 |
Alzheimer's Disease |
Human |
TBC1D4 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2367 |
Alzheimer's Disease |
Human |
TCF7 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3828 |
Parkinson disease |
Human |
TENM4 |
RF |
Diagnosis |
|
2021 |
33185019 |
2535 |
Alzheimer's Disease |
Human |
TESK2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2310 |
Parkinson disease |
Human |
TFAM |
RF |
|
|
2010 |
19925850 |
2381 |
Alzheimer's Disease |
Human |
TFAM |
RF |
|
|
2008 |
18430995 |
2311 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
without the ApoE ε4 allele;G |
2016 |
26327336 |
2472 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
Genotype AC |
2016 |
26327336 |
2160 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
without the ApoE ε4allele;C |
2016 |
26327336 |
2270 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
without the ApoE ε4 allele;AC |
2016 |
26327336 |
2238 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
allele C |
2016 |
26327336 |
2081 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
allele G |
2016 |
26327336 |
2229 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
Genotype TG |
2016 |
26327336 |
2713 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
AC+ CC vs AA |
2016 |
26327336 |
2363 |
Alzheimer's Disease |
Human |
TGF-β1 |
RF |
|
without the ApoE ε4 allele;TG |
2016 |
26327336 |
3143 |
Parkinson disease |
Human |
TH |
RF |
|
|
2010 |
20809526 |
3350 |
Alzheimer's Disease |
Human |
THBS2 |
RF |
|
|
2017 |
29177109 |
3351 |
Dementia with Lewy bodies |
Human |
The apolipoprotein E (APOE) ε4 allele |
RF |
|
|
2011 |
21552550 |
2490 |
Alzheimer's Disease |
Human |
THG1L |
RF |
|
APOE-?2 |
2021 |
33576571 |
2481 |
Amyotrophic Lateral Sclerosis |
Human |
TIAM1 |
RF |
|
|
2010 |
20801718 |
3352 |
Amyotrophic Lateral Sclerosis |
Human |
TIAM1 |
RF |
|
|
2014 |
25023141 |
643 |
Alzheimer's Disease |
Human |
TLR2 |
PF |
|
|
2015 |
26738351 |
835 |
Alzheimer's Disease |
Human |
TLR4 |
PF |
|
when incorporated into a haplotype with rs10759930, the strongest association was detected |
2012 |
22272615 |
3798 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
Diagnosis |
|
2021 |
33314436 |
2479 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association; Denotes the associated SNP’s from the GWAS. |
2011 |
21257233 |
662 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
PF |
|
GRN carriers |
2014 |
25085782 |
3814 |
Lewy Body Disease |
Human |
TMEM106B |
RF |
Diagnosis |
|
2021 |
34854996 |
2553 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association; Denotes the associated SNP’s from the GWAS;Denotes the associated SNP’s from the ALS GWAS |
2011 |
21257233 |
2607 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association; Denotes the associated SNP’s from the GWAS. |
2011 |
21257233 |
2512 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association |
2011 |
21257233 |
2317 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association |
2011 |
21257233 |
2235 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 1 SNP association |
2011 |
21257233 |
2244 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association |
2011 |
21257233 |
2549 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association |
2011 |
21257233 |
837 |
Frontotemporal Dementia |
Human |
TMEM106B |
PF |
|
C9ORF72 expansion carriers;Cohort 1 – controls and C9ORF72 repeat expansion carriers (FTD, FTD/MND, and MND, or other diagnosis) |
2014 |
24385136 |
3673 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
FTLD with TAR DNA-binding protein (TDP-43) inclusions |
2010 |
20154673 |
668 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
PF |
|
for SNPs on chromosomes 1, 8, 10 and 11 genotyped |
2011 |
21257233 |
1849 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 1 SNP association |
2011 |
21257233 |
836 |
Frontotemporal Dementia |
Human |
TMEM106B |
PF |
|
C9ORF72 expansion carriers;Cohort 1 – controls and C9ORF72 repeat expansion carriers (FTD, FTD/MND, and MND, or other diagnosis) |
2014 |
24385136 |
2318 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association; Denotes the associated SNP’s from the GWAS. |
2011 |
21257233 |
2489 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association |
2011 |
21257233 |
3777 |
Amyotrophic Lateral Sclerosis |
Human |
TMEM106B |
RF |
Diagnosis |
|
2021 |
33314436 |
3353 |
Alzheimer's Disease |
Human |
TMEM106B |
RF |
|
APOE interact |
2014 |
24166182 |
2942 |
Frontotemporal Lobar Degeneration |
Human |
TMEM106B |
RF |
|
for chromosome 9 SNP association |
2011 |
21257233 |
1830 |
Lewy Body Disease |
Human |
TMEM175 |
RF |
Diagnosis |
|
2021 |
34308904 |
3354 |
Alzheimer's Disease |
Human |
TMP21 |
RF |
|
|
2018 |
28233271 |
3733 |
Alzheimer's Disease |
Human |
TNFRSF13C |
RF |
|
|
2021 |
33687622 |
3355 |
Alzheimer's Disease |
Human |
TNFRSF1A, CDH1, CASP7, LRP1B and TG |
RF |
|
|
2015 |
26621834 |
1968 |
Multiple System Atrophy |
Human |
TNF-α |
RF |
|
genotype |
2018 |
29251119 |
2358 |
Multiple System Atrophy |
Human |
TNF-α |
RF |
|
allele |
2018 |
29251119 |
1329 |
Alzheimer's Disease |
Human |
TNF-α |
RF |
|
in the APOE epsilon4 non-carriers |
2008 |
18396294 |
1334 |
Alzheimer's Disease |
Human |
TNF-α |
RF |
|
in the APOE epsilon4 non-carriers |
2008 |
18396294 |
2770 |
Alzheimer's Disease |
Human |
TNF-α -308 |
RF |
|
AA vs. GG |
2015 |
25647294 |
2452 |
Alzheimer's Disease |
Human |
TNF-α -308 |
RF |
|
AA vs. AG |
2015 |
25647294 |
2766 |
Alzheimer's Disease |
Human |
TNF-α -308 |
RF |
|
AA vs. AG + GG (recessive) |
2015 |
25647294 |
2104 |
Alzheimer's Disease |
Human |
TNF-α -308 |
RF |
|
AA + AG vs. GG (dominant) |
2015 |
25647294 |
2295 |
Alzheimer's Disease |
Human |
TNF-α -308 |
RF |
|
A vs. G allele |
2015 |
25647294 |
3358 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
|
2018 |
30443289 |
2885 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
APOE ε4+ |
2021 |
32725468 |
690 |
Alzheimer's Disease |
Human |
TOMM40 |
PF |
|
the association between the Asian and Caucasian groups was significantly different |
2016 |
26795201 |
1589 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using Cox regression、Dataset:HRS(Health and Retirement Study) |
2018 |
29107063 |
2896 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
APOE ε4+ |
2021 |
32725468 |
1673 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using Cox regression、Dataset:CHS(Cardiovascular Health Study) |
2018 |
29107063 |
2184 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using logistic regression、Dataset:HRS(Health and Retirement Study) |
2018 |
29107063 |
2565 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using logistic regression、Dataset:FHS(Framingham Heart Study) |
2018 |
29107063 |
1621 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using Cox regression、Dataset:FHS(Framingham Heart Study) |
2018 |
29107063 |
3696 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
|
2021 |
34336000 |
2115 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using logistic regression、Dataset:HRS(Health and Retirement Study) |
2018 |
29107063 |
3357 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
|
2018 |
29797398 |
1588 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using Cox regression、Dataset:HRS(Health and Retirement Study) |
2018 |
29107063 |
2445 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
APOE ε4+ |
2021 |
32725468 |
2935 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
APOE ε4+ |
2021 |
32725468 |
2564 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using logistic regression、Dataset:CHS( Cardiovascular Health Study) |
2018 |
29107063 |
3839 |
Parkinson disease |
Human |
TOMM40 |
RF |
|
carriage of shorter '523' alleles |
2021 |
34234128 |
2440 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
APOE ε4+ |
2021 |
32725468 |
2862 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using logistic regression、Dataset:LOADFS(Late Onset Alzheimer's Disease Family Study ) |
2018 |
29107063 |
3356 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
|
2018 |
29797398 |
2964 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
APOE ε4+ |
2021 |
32725468 |
894 |
Parkinson disease |
Human |
TOMM40 |
PF |
|
carriage of longer '523' alleles |
2021 |
34234128 |
2116 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
using logistic regression、Dataset:HRS(Health and Retirement Study) |
2018 |
29107063 |
2735 |
Alzheimer's Disease |
Human |
TOMM40 |
RF |
|
the association between the Asian and Caucasian groups was significantly different |
2016 |
26795201 |
2585 |
Alzheimer's Disease |
Human |
TOX |
RF |
|
APOE-?2 |
2021 |
33576571 |
1488 |
Frontotemporal Dementia |
Human |
TP53 |
RF |
Diagnosis |
|
2021 |
32972771 |
594 |
Alzheimer's Disease |
Human |
TRAF3IP2 |
PF |
|
APOE-?2 |
2021 |
33576571 |
739 |
Alzheimer's Disease |
Human |
TRAF3IP2 |
PF |
|
APOE-?3 |
2021 |
33576571 |
3011 |
Frontotemporal Dementia |
Human |
TREM2 |
RF |
|
|
2013 |
23800361 |
2559 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
CT vs. CC |
2018 |
29322490 |
3363 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
Compound heterozygosity |
2018 |
29557178 |
2693 |
Parkinson disease |
Human |
TREM2 |
RF |
|
|
2013 |
23800361 |
2427 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
the T allele of the rs75932628 variant of TREM2 |
2015 |
25260849 |
2704 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2015 |
25936935 |
3076 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2849 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2013 |
23855982 |
2678 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
T vs. G |
2018 |
29322490 |
3360 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2018 |
29794134 |
2383 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2014 |
24439484 |
3365 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
Compound heterozygosity |
2018 |
29557178 |
2933 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2014 |
24041969 |
2680 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
GT vs. GG |
2018 |
29322490 |
2907 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
APOE-?3 |
2021 |
33576571 |
2558 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
CT+TT vs. CC |
2018 |
29322490 |
3362 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
A large consanguineous Colombian family segregating autosomal recessive FTLD |
2013 |
23582655 |
2609 |
Amyotrophic Lateral Sclerosis |
Human |
TREM2 |
RF |
|
|
2014 |
24535663 |
2928 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2013 |
23380991 |
3367 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
Homozygosity |
2018 |
29557178 |
2703 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2015 |
26037549 |
2617 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
T vs. C |
2018 |
29322490 |
2816 |
Dementia with Lewy bodies |
Human |
TREM2 |
RF |
|
|
2017 |
28003435 |
3359 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2018 |
30222607 |
2552 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
carrier T vs. C |
2018 |
29322490 |
3012 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
|
2013 |
23800361 |
3364 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
|
2018 |
29557178 |
2932 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2014 |
24041969 |
2679 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
carrier T vs. G |
2018 |
29322490 |
2534 |
Alzheimer's Disease |
Human |
TREM2 |
RF |
|
|
2014 |
25160042 |
3361 |
Frontotemporal Dementia |
Human |
TREM2 |
RF |
|
|
2018 |
29557178 |
3366 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
|
2018 |
29557178 |
2681 |
Frontotemporal Lobar Degeneration |
Human |
TREM2 |
RF |
|
GT+TT vs. GG |
2018 |
29322490 |
2958 |
Multiple System Atrophy |
Human |
TREM2 p.R47H |
RF |
|
patients with pathologically confirmed MSA |
2018 |
30109269 |
1813 |
Multiple System Atrophy |
Human |
TREM2 p.R47H |
RF |
|
patients with clinically diagnosed MSA |
2018 |
30109269 |
2893 |
Multiple System Atrophy |
Human |
TREM2 p.R47H |
RF |
|
patients with clinically diagnosed MSA |
2018 |
30109269 |
1817 |
Multiple System Atrophy |
Human |
TREM2 p.R47H |
RF |
|
patients with pathologically confirmed MSA |
2018 |
30109269 |
811 |
Alzheimer's Disease |
Human |
TREML2 |
PF |
|
|
2014 |
24439484 |
3884 |
Tuberous sclerosis complex |
Human |
TSC2 |
RF |
Diagnosis |
|
2021 |
33225634 |
2804 |
Alzheimer's Disease |
Human |
TTC38 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2359 |
Alzheimer's Disease |
Human |
TTLL13 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2328 |
Alzheimer's Disease |
Human |
TTLL13 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2987 |
Alzheimer's Disease |
Human |
TXNRD3NB |
RF |
|
APOE-?2 |
2021 |
33576571 |
3368 |
Alzheimer's Disease |
Human |
TYROBP |
RF |
|
|
2016 |
27658901 |
2031 |
Frontotemporal Lobar Degeneration |
Human |
UBAP1 |
RF |
|
Haplotype:TGC |
2009 |
19217189 |
2069 |
Frontotemporal Lobar Degeneration |
Human |
UBAP1 |
RF |
|
Haplotype:TGC |
2009 |
19217189 |
2068 |
Frontotemporal Lobar Degeneration |
Human |
UBAP1 |
RF |
|
Haplotype:GCT |
2009 |
19217189 |
2232 |
Alzheimer's Disease |
Human |
UBASH3B |
RF |
|
APOE-?2 |
2021 |
33576571 |
2173 |
Parkinson disease |
Human |
UCHL1 |
RF |
|
|
2012 |
22839974 |
738 |
Alzheimer's Disease |
Human |
UGT3A1 |
PF |
|
APOE-?3 |
2021 |
33576571 |
663 |
Alzheimer's Disease |
Human |
UGT3A1 |
PF |
|
APOE-?2 |
2021 |
33576571 |
2099 |
Frontotemporal Lobar Degeneration |
Human |
UNC13A |
RF |
|
Discovery stage |
2019 |
30739198 |
2171 |
Frontotemporal Lobar Degeneration |
Human |
UNC13A |
RF |
|
Replication stage |
2019 |
30739198 |
1904 |
Amyotrophic Lateral Sclerosis |
Human |
UNC13A |
RF |
|
especially in Caucasian and European subjects |
2019 |
31201598 |
3370 |
Amyotrophic Lateral Sclerosis |
zebrafish |
VAPB |
RF |
|
|
2013 |
23446633 |
3369 |
Amyotrophic Lateral Sclerosis |
Mice |
VAPB |
RF |
|
|
2013 |
23446633 |
3762 |
Alzheimer's Disease |
Human |
vascular apoE |
RF |
|
|
2021 |
33321072 |
2112 |
Parkinson disease |
Human |
VEGF |
RF |
|
|
2016 |
27481110 |
2020 |
Frontotemporal Lobar Degeneration |
Human |
VEGF |
RF |
|
A allele |
2008 |
18729809 |
2049 |
Frontotemporal Lobar Degeneration |
Human |
VEGF |
RF |
|
A allele |
2008 |
18729809 |
3069 |
Progressive Supranuclear Palsy |
Human |
VEGF haplotypes(AGG) |
RF |
|
|
2010 |
20413880 |
3852 |
Parkinson disease |
Human |
vitamin D Receptor(VDR) |
RF |
|
|
2021 |
34365149 |
3854 |
Parkinson disease |
Human |
vitamin D Receptor(VDR) |
RF |
|
|
2021 |
34365149 |
3853 |
Parkinson disease |
Human |
vitamin D Receptor(VDR) |
RF |
|
|
2021 |
34365149 |
3371 |
Parkinson disease |
Human |
VMAT2 |
RF |
|
|
2016 |
27137201 |
3020 |
Alzheimer's Disease |
Human |
VSTM5 |
RF |
|
APOE-?2 |
2021 |
33576571 |
3870 |
Parkinson disease |
Human |
WBSCR17 |
RF |
Diagnosis |
|
2021 |
33760272 |
2450 |
Amyotrophic Lateral Sclerosis |
Human |
WDR49 |
RF |
|
|
2013 |
27455347 |
797 |
Alzheimer's Disease |
Human |
WDR60 |
PF |
|
APOE-?3 |
2021 |
33576571 |
622 |
Alzheimer's Disease |
Human |
YDJC |
PF |
|
APOE-?2 |
2021 |
33576571 |
2182 |
Alzheimer's Disease |
Human |
ZAR1 |
RF |
|
APOE-?3 |
2021 |
33576571 |
2638 |
Alzheimer's Disease |
Human |
ZAR1 |
RF |
|
APOE-?2 |
2021 |
33576571 |
584 |
Alzheimer's Disease |
Human |
ZCCHC9 |
PF |
|
APOE-?2 |
2021 |
33576571 |
740 |
Parkinson disease |
Human |
ZFP64/TSHZ2 |
PF |
Diagnosis |
|
2021 |
33510632 |
3779 |
Amyotrophic Lateral Sclerosis |
Human |
ZNF512B |
RF |
Prognosis |
|
2021 |
33387304 |
2616 |
Alzheimer's Disease |
Human |
ZNF596 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2599 |
Alzheimer's Disease |
Human |
ZNF778 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2385 |
Alzheimer's Disease |
Human |
ZNF804B |
RF |
|
APOE-?3 |
2021 |
33576571 |
2493 |
Alzheimer's Disease |
Human |
ZNF90 |
RF |
|
APOE-?2 |
2021 |
33576571 |
2451 |
Amyotrophic Lateral Sclerosis |
Human |
ZSCAN5B |
RF |
|
|
2013 |
27455347 |
2775 |
Tourette Syndrome |
Human |
ADHD family history positive |
RF |
|
|
2010 |
20654033 |
3442 |
Tourette Syndrome |
Human |
family history |
RF |
|
|
2012 |
22738448 |
2300 |
Amyotrophic Lateral Sclerosis |
Human |
family history of ALS |
RF |
Diagnosis |
|
2021 |
33563800 |
3443 |
Alzheimer's Disease |
Human |
family history of cardiovascular diseases |
RF |
|
|
2014 |
24596166 |
3444 |
Dementia with Lewy bodies |
Human |
Family history of dementia |
RF |
|
|
2006 |
16801670 |
2705 |
Alzheimer's Disease |
Human |
Family history of dementia (FH) |
RF |
|
|
2016 |
26531229 |
3445 |
Alzheimer's Disease |
Human |
family history of dementia (within third-degree relatives) |
RF |
|
people with mild memory impairment/no dementia (MMI/ND) |
2011 |
21205364 |
2817 |
Parkinson disease |
Human |
family history of PD |
RF |
|
|
2020 |
32943485 |
2461 |
Tourette Syndrome |
Human |
first-degree relatives |
RF |
|
|
2015 |
26083307 |
1631 |
Frontotemporal Dementia |
Human |
first-degree relatives |
RF |
|
First-degree relatives(parents) |
1998 |
9633692 |
2743 |
Alzheimer's Disease |
Human |
Having a first-degree relative or a parent with dementia |
RF |
|
|
2016 |
26531229 |