Genetic Factors

Genetic factors mainly include genes, mutations, family history, etc.
The search result for the Risk factor Category "Genetic"
A total of 1211 results found based on your keywords
RF_ID Disease Name Species RF_Name Association Phase Condition Year PMID
3372 Amyotrophic Lateral Sclerosis Human Rare CNVs RF 2008 18313986
3825 Parkinson disease Human TMEM RF Diagnosis 2021 33279243
3826 Parkinson disease Human TMEM RF Diagnosis 2021 33279243
2204 Alzheimer's Disease Human TMEM RF APOE-?2 2021 33576571
4007 Fatal familial insomnia (FFI) Human SRSF11 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4009 Fatal familial insomnia (FFI) Human SRSF11 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4008 Fatal familial insomnia (FFI) Human SRSF11 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4000 Fatal familial insomnia (FFI) Human NR1H9P RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
3999 Fatal familial insomnia (FFI) Human NR1H8P RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
3998 Fatal familial insomnia (FFI) Human NR1H7P RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
3997 Fatal familial insomnia (FFI) Human NR1H6P RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
3996 Fatal familial insomnia (FFI) Human NR1H5P RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4001 Fatal familial insomnia (FFI) Human NR1H10P RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4010 Fatal familial insomnia (FFI) Human MSANTD3 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4012 Fatal familial insomnia (FFI) Human MSANTD3 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4014 Fatal familial insomnia (FFI) Human MSANTD3 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4011 Fatal familial insomnia (FFI) Human MSANTD3 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4013 Fatal familial insomnia (FFI) Human MSANTD3 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4016 Amyotrophic Lateral Sclerosis Human HTT RF Diagnosis 2023 36599142
4002 Fatal familial insomnia (FFI) Human GNA13P1 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4003 Fatal familial insomnia (FFI) Human GNA13P1 RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4005 Fatal familial insomnia (FFI) Human EXOC1L RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4004 Fatal familial insomnia (FFI) Human EXOC1L RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
4006 Fatal familial insomnia (FFI) Human EXOC1L RF Diagnosis These genetic variants are absent in FFI patients with early disease onset (19-40 years) 2023 37626863
1839 Alzheimer's Disease Human MT-ND2 RF Diagnosis 2023 34854014
1840 Alzheimer's Disease Human MT-ND5 RF Diagnosis 2023 34854014
3991 Amyotrophic Lateral Sclerosis Human hsa-miR-152-3p RF Diagnosis 2023 37261630
929 Amyotrophic Lateral Sclerosis Human hsa-miR-139-5p PF Diagnosis 2023 37261630
928 Amyotrophic Lateral Sclerosis Human hsa-miR-27b-3p PF Diagnosis 2023 37261630
3990 Tourette Syndrome Human ASH1L RF Diagnosis 2022 35307981
3989 Tourette Syndrome Human ASH1L RF Diagnosis 2022 35307981
685 Lewy Body Disease Human Mitochondrial genomic variation PF Diagnosis 2022 35836284
3986 Amyotrophic Lateral Sclerosis human and mice SARM1 RF Diagnosis 2022 34991663
1912 Amyotrophic Lateral Sclerosis Human APOB RF Diagnosis 2023 37688479
1947 Amyotrophic Lateral Sclerosis Human HMGCR RF Diagnosis 2023 37688479
1666 Amyotrophic Lateral Sclerosis Human LRP1 RF Diagnosis 2023 37142397
1571 Amyotrophic Lateral Sclerosis Human THSD7A RF Diagnosis 2023 37142397
1677 Amyotrophic Lateral Sclerosis Human FGF1 RF Diagnosis 2023 37142397
1829 Parkinson disease Human MIDN RF Diagnosis 2023 36858566
3953 Parkinson disease Human CD4 RF Diagnosis 2022 36224715
3952 Parkinson disease Human CD4 RF Diagnosis 2022 36224715
1710 Parkinson disease Human LRP1B RF Prognosis 2023 36348503
2021 Parkinson disease Human DRD4 RF Diagnosis 2022 35532648
2090 Parkinson disease Human DRD4 RF Diagnosis 2022 35532648
3938 Alzheimer's Disease Human MYO15A RF Diagnosis 2023 36788216
3937 Alzheimer's Disease Human COX7C RF Diagnosis 2023 36788216
2264 Alzheimer's Disease Human ABCA1 RF Diagnosis 2022 36411364
3936 Alzheimer's Disease Human ABCA1 RF Diagnosis 2023 36788216
2118 Alzheimer's Disease Human ATP8B4 RF Diagnosis 2022 36411364
3930 Alzheimer's Disease Human IDE RF Diagnosis 2022 35236268
3926 Alzheimer's Disease Human Hsa-miR-320a RF Diagnosis related to AD and depression 2022 36040555
3925 Alzheimer's Disease Human Hsa-miR-451a RF Diagnosis related to AD and depression 2022 36040555
3924 Alzheimer's Disease Human Hsa-miR-27a-3p RF Diagnosis related to AD and depression 2022 36040555
3923 Alzheimer's Disease Human Hsa-miR-664a-3p RF Diagnosis related to AD and depression 2022 36040555
3922 Alzheimer's Disease Human Hsa-miR-181c-5p RF Diagnosis related to AD and depression 2022 36040555
3920 Alzheimer's Disease Human Hsa-miR-497-5p RF Diagnosis related to AD and education 2022 36040555
3919 Alzheimer's Disease Human Hsa-miR-20a-5p RF Diagnosis related to AD and education 2022 36040555
3921 Alzheimer's Disease Human Hsa-miR-185-5p RF Diagnosis related to AD and depression 2022 36040555
3918 Alzheimer's Disease Human Hsa-miR-185-5p RF Diagnosis related to AD and education 2022 36040555
3904 Alzheimer's Disease Human NOTCH2 RF Diagnosis 2023 37355909
2220 Alzheimer's Disease Human 5, 10-methylenetetrahydrofolate dehydrogenase gene (MTHFD1) RF 2010 20217437
2267 Alzheimer's Disease Human 5-HTT RF homozygous low activity genotype: ε4 alleles of the ApoE gene 1997 9106747
2305 Alzheimer's Disease Human 5-LO RF A allele 2010 20110601
3147 Amyotrophic Lateral Sclerosis Human A90V TDP-43 variant RF 2008 18505686
767 Parkinson disease Human ABCA7 PF Diagnosis 2022 35709878
721 Alzheimer's Disease Human ABCA7 PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
3955 Parkinson disease Human ABCA7 RF Diagnosis 2022 35709878
2972 Alzheimer's Disease Human ABCA7 RF 2018 29589097
3149 Alzheimer's Disease Human ABCA7 RF 2018 29589097
3148 Alzheimer's Disease Human ABCA7 RF 2018 29589097
1974 Alzheimer's Disease Human ABCA7 RF Calculated by fixed effect model 2018 29504051
1942 Alzheimer's Disease Human ABCA7 RF 2016 26795201
3150 Alzheimer's Disease Human ABCA7 RF with both ApoEε4-carrier and aging being factors enhancing its risk 2014 24113560
2986 Alzheimer's Disease Human ABCA8 RF APOE-?2 2021 33576571
2900 Alzheimer's Disease Human ABCA8 RF APOE-?2 2021 33576571
3110 Parkinson disease Human ABCB1 RF 2014 24572589
546 Alzheimer's Disease Human ACAT1 PF 2021 33057949
2349 Alzheimer's Disease Human ACAT1 RF 2021 33057949
3152 Alzheimer's Disease Human ACE RF in subjects aged 73 years and above. 2009 19539712
2495 Alzheimer's Disease Human ACE RF 2000 11078932
2023 Parkinson disease Human ACE RF 2002 12084438
3151 Alzheimer's Disease Human ACE RF 2010 21537449
3153 Alzheimer's Disease Human ACE RF in subjects aged 73 years and above. 2009 19539712
3835 Parkinson disease Human ACE RF Prognosis 2021 34945793
2022 Parkinson disease Human ACE RF 2002 12084438
1896 Alzheimer's Disease Human ACT RF especially in Caucasians 2012 22294107
1976 Alzheimer's Disease Human ACT RF especially in Caucasians 2012 22294107
3154 Multiple System Atrophy Human ACT RF 2005 15907346
1894 Alzheimer's Disease Human ACT RF A allele carriers are associated with increased susceptibility to AD in variant populations 2013 22272609
1897 Alzheimer's Disease Human ACT RF A allele carriers are associated with increased susceptibility to AD in variant populations 2013 22272609
2889 Parkinson disease Human ADAM10 RF 2021 33527480
2513 Parkinson disease Human ADH1B RF 2019 30483881
512 Alzheimer's Disease Human ADH1C PF 2021 33551739
3811 Lewy Body Disease Human AD-PRS RF Diagnosis 2021 34308904
1951 Alzheimer's Disease Human AKNAD1 RF APOE-?3 2021 33576571
756 Alzheimer's Disease Human AKNAD1 PF APOE-?3 2021 33576571
2337 Alzheimer's Disease Human AKNAD1 RF APOE-?2 2021 33576571
2803 Alzheimer's Disease Human ALDH2 RF dependent on APOE epsilon4 status in Chinese 2008 18201725
691 Alzheimer's Disease Human ALDH5A1 PF APOE-?3 2021 33576571
3155 Alzheimer's Disease Human ALOX5 RF 2016 26944113
2325 Alzheimer's Disease Human ANK1 RF 2016 26611832
3856 Parkinson disease Human ANKK1 RF 2021 34151861
1656 Alzheimer's Disease Human APOC1 RF using Cox regression、Dataset：FHS（Framingham Heart Study） 2018 29107063
3157 Alzheimer's Disease Human APOC1 RF not in African Americans 2014 24498013
3156 Alzheimer's Disease Human APOC1 RF 2018 30443289
1670 Alzheimer's Disease Human APOC1 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 2018 29107063
2536 Alzheimer's Disease Human APOC1 RF using logistic regression、Dataset：FHS(Framingham Heart Study) 2018 29107063
3158 Alzheimer's Disease Human APOD RF in APOEε4 (-) subgroup 2013 23690001
2260 Alzheimer's Disease Human APOE RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 2018 29107063
826 Frontotemporal Dementia Human APOE PF 2017 28888721
3160 Alzheimer's Disease Human APOE RF ε4 allele 2018 29592889
2829 Alzheimer's Disease Human APOE RF 2019 30894904
2339 Alzheimer's Disease Human APOE RF 2010 19819468
3185 Alzheimer's Disease Human APOE RF 2008 18560129
2463 Alzheimer's Disease Human APOE RF Diagnosis 2022 35135450
2601 Alzheimer's Disease Human APOE RF A/A genotype 2009 19172988
1848 Alzheimer's Disease Human APOE RF 2012 22068907
2272 Frontotemporal Lobar Degeneration Human APOE RF ε3ε4+ε4ε4 vs. ε3ε3 2017 28487499
3139 Alzheimer's Disease Human APOE RF lowers age at onset of LOAD significantly 2008 18416843
602 Alzheimer's Disease Human APOE PF ε2 allele 2018 29990559
3166 Alzheimer's Disease Human APOE RF ε4 allele 1994 7977635
2610 Dementia with Lewy bodies Human APOE RF 2018 29263008
3190 Alzheimer's Disease Human APOE RF APOE haplotypes 2014 24596166
2754 Frontotemporal Dementia Human APOE RF 2013 23887281
1761 Alzheimer's Disease Human APOE RF 2021 33397450
3171 Alzheimer's Disease Human APOE RF 2019 30890475
2929 Alzheimer's Disease Human APOE RF 2014 23871727
527 Alzheimer's Disease Human APOE PF National Alzheimer’s Coordinating Center (NACC) cohort; ε4 2018 30128317
2113 Alzheimer's Disease Human APOE RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 2018 29107063
697 Alzheimer's Disease Human APOE PF APOEε2ε3 2015 25673977
2289 Frontotemporal Lobar Degeneration Human APOE RF ε2ε2 vs. ε3ε3 2017 28487499
2807 Alzheimer's Disease Human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 2018 30205398
3023 Alzheimer's Disease Human APOE RF Genotype: ε4/4; adjusted for age and education, and stratified by gender 2018 30205398
2936 Alzheimer's Disease Human APOE RF 2010 20217437
3082 Alzheimer's Disease Human APOE RF 2002 12095653
3177 Alzheimer's Disease Human APOE RF 2015 26738348
822 Alzheimer's Disease Human APOE PF 2012 22068907
3182 Alzheimer's Disease Human APOE RF The rate of APOE4 carrier status and the frequency of the ε4 allele were 47% and 27% for LOAD, 50% and 31% for EOAD, 2011 21552550
2505 Alzheimer's Disease Human APOE RF ε4 allele 2002 12160362
3162 Alzheimer's Disease Human APOE RF ε4 allele 1994 7841371
2348 Alzheimer's Disease Human APOE RF 2008 18446027
3187 Dementia with Lewy bodies Human APOE RF 2014 24973356
2750 Alzheimer's Disease Human APOE RF 2014 24281128
3666 Alzheimer's Disease Human APOE RF 2020 32043803
1717 Alzheimer's Disease Human APOE RF 2014 24045327
562 Dementia with Lewy bodies Human APOE PF 2019 30798004
3014 Alzheimer's Disease Human APOE RF Genotype: ?3/?4; AD without depression 2018 29703883
3168 Alzheimer's Disease Human APOE RF 1996 8993485
2697 Frontotemporal Dementia Human APOE RF 2006 15904995
1572 Alzheimer's Disease Human APOE RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 2018 29107063
2356 Alzheimer's Disease Human APOE RF Gender: female; Calculated by Forced entry model 1999 10213175
3192 Progressive Supranuclear Palsy Human APOE RF 2003 12552038
2759 Dementia with Lewy bodies Human APOE RF 2019 30798004
1771 Alzheimer's Disease Human APOE RF 2018 30450407
2522 Alzheimer's Disease Human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 2018 30205398
3174 Alzheimer's Disease Human APOE RF 2016 27033052
2855 Alzheimer's Disease Human APOE RF Carrying at least one ε4 allele; Calculated by Step-wise model 1999 10213175
2898 Alzheimer's Disease Human APOE RF Individuals with 2 epsilon 4 alleles had a higher risk for AD than subjects with only 1 such allele 2008 18317248
2734 Alzheimer's Disease Human APOE RF Diagnosis with APOE*4?allele 2023 36528961
2939 Creutzfeldt-Jakob disease Human APOE RF ε4 allele 1994 7968026
2449 Alzheimer's Disease Human APOE RF APOE ε4ε4 2015 25673977
3086 Alzheimer's Disease Human APOE RF ε4 allele 2001 11376902
3179 Alzheimer's Disease Human APOE RF 2013 23887281
2864 Alzheimer's Disease Human APOE RF ε4 allele; associated with heterozygosity 1994 8128961
825 Frontotemporal Dementia Human APOE PF 2002 12107813
3159 Alzheimer's Disease Human APOE RF 2012 22712640
2823 Alzheimer's Disease Human APOE RF at least one epsilon 4 allele 1995 8786847
3044 Alzheimer's Disease Human APOE RF PENN cohort; ε2 2018 30128317
3184 Alzheimer's Disease Human APOE RF 2010 20385913
1679 Parkinson disease Human APOE RF Prognosis 2023 36348503
2509 Dementia with Lewy bodies Human APOE RF 4 allele 2006 16956959
3164 Alzheimer's Disease Human APOE RF ε2 allele 2018 29562509
2350 Alzheimer's Disease Human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 2018 30205398
3189 Dementia with Lewy bodies Human APOE RF The rate of APOE4 carrier status and the frequency of the ε4 allele were 42% and 31% for DLB 2011 21552550
2753 Frontotemporal Lobar Degeneration Human APOE RF ε4 allele 2013 23887281
1722 Alzheimer's Disease Human APOE RF 2011 21649613
2231 Frontotemporal Lobar Degeneration Human APOE RF ε4 vs. ε3 allele model 2017 28487499
571 Alzheimer's Disease Human APOE PF ε3 allele 2014 24632849
2146 Frontotemporal Lobar Degeneration Human APOE RF ε4 vs. ε2+ε3+ε4 allele model 2017 28487499
3170 Alzheimer's Disease Human APOE RF 2019 30991302
2847 Alzheimer's Disease Human APOE RF Th1/E47cs polymorphism allele 2002 12095653
3194 Dementia with Lewy bodies Human APOE RF 2016 27312774
521 Frontotemporal Dementia Human APOE PF 2006 15904995
2976 Alzheimer's Disease Human APOE RF ε4 allele; AD without depression 2018 29703883
2675 Alzheimer's Disease Human APOE RF Genotype: ε3/4; adjusted for age and education, and stratified by gender 2018 30205398
2894 Alzheimer's Disease Human APOE RF ε4 allele; AD all 2018 29703883
2717 Alzheimer's Disease Human APOE RF Genotype: AA 1999 10213175
1643 Alzheimer's Disease Human APOE RF 2020 32767997
3176 Alzheimer's Disease Human APOE RF The ε4 allele increases the risk of Alzheimer's disease by 5.114 times 2016 26835020
2366 Alzheimer's Disease Human APOE RF Gender: female; Calculated by Step-wise model 1999 10213175
2298 Alzheimer's Disease Human APOE RF Genotype/Allele: A/A 2018 29990559
3181 Alzheimer's Disease Human APOE RF 2011 21556001
2774 Alzheimer's Disease Human APOE RF Genotype: ?4/?4; AD without depression 2018 29703883
2375 Alzheimer's Disease Human APOE RF APOE ε3ε4 2015 25673977
719 Alzheimer's Disease Human APOE PF Genotype/Allele: T 2018 29990559
3161 Alzheimer's Disease Human APOE RF ε4 allele 2018 30112972
2912 Alzheimer's Disease Human APOE RF Diagnosis 2022 35135450
2606 Creutzfeldt-Jakob disease Human APOE RF ε4 allele 1994 7968026
2340 Frontotemporal Lobar Degeneration Human APOE RF ε2ε2 vs. ε3ε3+ε3ε2 2017 28487499
3186 Frontotemporal Dementia Human APOE RF 2013 23887281
2957 Alzheimer's Disease Human APOE RF 2018 29307083
2140 Alzheimer's Disease Human APOE RF 2008 18317248
3065 Alzheimer's Disease Human APOE RF 2011 22737475
3799 Lewy Body Disease Human APOE RF 2021 34308904
2315 Creutzfeldt-Jakob disease Human APOE RF ε4 allele 1994 7968026
3167 Alzheimer's Disease Human APOE RF 1997 9008509
2696 Frontotemporal Lobar Degeneration Human APOE RF ε4 allele 2006 15904995
2433 Alzheimer's Disease Human APOE RF 2002 12095653
2844 Alzheimer's Disease Human APOE RF Carrying at least one ε4 allele; Calculated by Forced entry model 1999 10213175
3191 Alzheimer's Disease Human APOE RF ?4 allele 2015 23038715
2755 Alzheimer's Disease Human APOE RF National Alzheimer’s Coordinating Center (NACC) cohort; ε2 2018 30128317
1762 Alzheimer's Disease Human APOE RF 2020 32485802
2480 Alzheimer's Disease Human APOE RF APOE ε4 2000 10912224
1620 Alzheimer's Disease Human APOE RF using Cox regression、Dataset：HRS（Health and Retirement Study） 2018 29107063
625 Alzheimer's Disease Human APOE PF Genotype/Allele: A/T 2018 29990559
2208 Frontotemporal Lobar Degeneration Human APOE RF ε3ε4 vs. ε3ε3 2017 28487499
3172 Alzheimer's Disease Human APOE RF 2017 28461186
2851 Dementia with Lewy bodies Human APOE RF 2002 12411758
532 Alzheimer's Disease Human APOE PF ε3 allele 2018 29990559
2982 Alzheimer's Disease Human APOE RF ε4 allele; associated with homozygosity 1994 8128961
3695 Alzheimer's Disease Human APOE RF 2021 34336000
2897 Alzheimer's Disease Human APOE RF Genotype: ?3/?4; AD all 2018 29703883
2728 Frontotemporal Lobar Degeneration Human APOE RF ε4ε4 vs. ε3ε3+ε3ε4 2017 28487499
2938 Alzheimer's Disease Human APOE RF 2014 23871727
2592 Alzheimer's Disease Human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 2018 30205398
3178 Alzheimer's Disease Human APOE RF 2014 24326531
2368 Alzheimer's Disease Human APOE RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
542 Alzheimer's Disease Human APOE PF 2008 18317248
2126 Frontotemporal Lobar Degeneration Human APOE RF ε4 vs. ε2+ε3+ε4 carrier model 2017 28487499
2906 Alzheimer's Disease Human APOE RF ε4 allele 2014 24632849
1331 Alzheimer's Disease Human APOE RF 2010 20376800
2818 Frontotemporal Lobar Degeneration Human APOE RF ε4ε4 vs. ε3ε3 2017 28487499
3042 Alzheimer's Disease Human APOE RF Genotype: ε4/4; adjusted for age and education, and stratified by gender 2018 30205398
3183 Alzheimer's Disease human and mice APOE RF nutritional imbalance 2010 20413864
2646 Alzheimer's Disease Human APOE RF 2011 22311091
3163 Alzheimer's Disease Human APOE RF ε2 allele 1994 7824157
3188 Dementia with Lewy bodies Human APOE RF epsilon 4 allele 1994 7970234
500 Alzheimer's Disease Human APOE PF PENN cohort; ε4 2018 30128317
3667 Alzheimer's Disease Human APOE RF 2020 32116259
2143 Frontotemporal Lobar Degeneration Human APOE RF ε4 vs. ε2 allele model 2017 28487499
3015 Alzheimer's Disease Human APOE RF Carrying at least one ε4 allele 1999 10213175
2654 Alzheimer's Disease Human APOE RF Genotype: ε4/-; adjusted for age and education, and stratified by gender 2018 30205398
3169 Alzheimer's Disease Human APOE RF 1998 9811931
3193 Frontotemporal Dementia Human APOE RF 2017 28888721
520 Frontotemporal Lobar Degeneration Human APOE PF ε2 allele 2006 15904995
3080 Alzheimer's Disease Human APOE RF 2017 29348964
3175 Alzheimer's Disease Human APOE RF 2015 26885125
3115 Alzheimer's Disease Human APOE RF Diagnosis 2022 35135450
2857 Alzheimer's Disease Human APOE RF 2011 20682755
705 Alzheimer's Disease Human APOE PF 2008 18317248
3180 Alzheimer's Disease Human APOE RF 2011 21637534
2087 Alzheimer's Disease Human APOE RF Genotype/Allele: A 2018 29990559
1669 Alzheimer's Disease Human APOE RF 2021 33397450
3089 Alzheimer's Disease Human APOE RF ε4 allele 2018 29990559
732 Alzheimer's Disease Human APOE ε2/ε3 PF 2017 28846757
620 Alzheimer's Disease Human APOE ε2/ε3 PF 2017 28846757
2828 Alzheimer's Disease Human APOE ε3/ε4 RF from ages 55 to 85 years 2017 28846757
2794 Alzheimer's Disease Human APOE ε3/ε4 RF from ages 55 to 85 years 2017 28846757
2793 Alzheimer's Disease Human ApoE ε4/ε3 RF ε4/ε3 genotype 2014 24632849
2435 Alzheimer's Disease Human ApoE ε4/ε4 RF ε4/ε4 genotype 2014 24632849
2946 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: AA; One Copy of ε4 1996 8993481
3114 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: AT; Two Copies of ε4 1996 8993481
2811 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: TT; Two Copies of ε4 1996 8993481
2657 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: TT; One Copy of ε4 1996 8993481
2915 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: AA; Two Copies of ε4 1996 8993481
2813 Alzheimer's Disease Human APOE,ACT RF ACT Genotype: AT; One Copy of ε4 1996 8993481
2510 Frontotemporal Lobar Degeneration Human APOE,TOMM40 RF APOE-TOMM40 haplotype: ε4 GAC 2013 23546992
869 Alzheimer's Disease Human APOE?2 PF substantially attenuated among Black people 2021 34334408
2956 Alzheimer's Disease Human APOE?4 RF 2021 33732104
2439 Parkinson disease Human APOE?4 RF 2021 33057949
3805 Lewy Body Disease Human APOE?4 RF Diagnosis 2021 33646158
3694 Alzheimer's Disease Human APOE?4 RF substantially attenuated among Black people 2021 34334408
2591 Chronic Traumatic Encephalopathy Human APOE?4 RF Diagnosis 2022 35759276
2642 Lewy Body Disease Human APOE?4 RF Diagnosis 2021 34308904
3749 Alzheimer's Disease Human APOE?4 RF 2021 33009037
2666 Alzheimer's Disease Human APOE?4 RF Diagnosis 2023 37182880
3797 Frontotemporal Dementia Human APOE?4 RF Diagnosis in the C9orf72 noncarriers 2021 32972771
3705 Alzheimer's Disease Human APOE?4 RF 2021 34214049
3917 Alzheimer's Disease Human APOE?4 RF Diagnosis 2022 36226340
3009 Alzheimer's Disease Human APOE?4 RF 2021 33541779
3731 Alzheimer's Disease Human APOE?4 RF 2021 33686543
3756 Alzheimer's Disease Human APOE?4 RF 2021 33196771
3697 Alzheimer's Disease Human APOE?4 RF 2021 34266503
1952 Parkinson disease Human apolipoprotein E ( APOE) ε3 allele RF 2019 30526202
809 Parkinson disease Human apolipoprotein E ( APOE) ε3 allele PF 2019 30526202
3555 Alzheimer's Disease Human Apolipoprotein E (APOE)-epsilon4 RF 2018 29605385
871 Alzheimer's Disease Human apolipoprotein E ?3 PF 2021 34258926
3556 Parkinson disease Human Apolipoprotein E4 RF 2005 15924299
3195 Dementia with Lewy bodies Human APP RF 2016 27312774
3914 Alzheimer's Disease Human APP RF Diagnosis 2023 37145212
1800 Alzheimer's Disease Human Arg972 IRS1 RF A Allele 2014 24589556
1819 Alzheimer's Disease Human Arg972 IRS1 RF AA genotype 2014 24589556
1808 Alzheimer's Disease Human Arg972 IRS1 RF GA genotype 2014 24589556
513 Alzheimer's Disease Human ARHGAP33 PF APOE-?3 2021 33576571
3196 Alzheimer's Disease Human ASTN2 RF 2015 25410587
3197 Amyotrophic Lateral Sclerosis Human ATAXIN2 RF ≥ 31 CAG-repeat length 2012 22425256
2580 Alzheimer's Disease Human ATP10B RF 2013 22950421
3668 Parkinson disease Human ATP10B RF recessive loss of function mutations 2020 32172343
2640 Alzheimer's Disease Human ATP6V0E2 RF APOE-?2 2021 33576571
2142 Alzheimer's Disease Human ATP7B RF 2013 22950421
2177 Alzheimer's Disease Human ATP8B RF 2013 22950421
2284 Alzheimer's Disease Human ATP9B RF 2013 22950421
2417 Amyotrophic Lateral Sclerosis Human ATRN RF 2013 27455347
3980 Amyotrophic Lateral Sclerosis Human ATXN1 RF Diagnosis 2022 35525134
3198 Amyotrophic Lateral Sclerosis Human ATXN1 RF 2014 25023141
3203 Frontotemporal Lobar Degeneration Human ATXN2 RF ATXN2 intermediary repeat length>=29 2014 25098532
2841 Amyotrophic Lateral Sclerosis Human ATXN2 RF 2019 30847648
3200 Amyotrophic Lateral Sclerosis Human ATXN2 RF 2012 23197749
2991 Amyotrophic Lateral Sclerosis Human ATXN2 RF ATXN2 high-length alleles (≥29 CAG repeats) 2011 21670397
3038 Amyotrophic Lateral Sclerosis Human ATXN2 RF CAG repeat length >30 2011 21610160
3202 Frontotemporal Dementia Human ATXN2 RF ATXN2 intermediary polyQ expansions 2014 25098532
3073 Amyotrophic Lateral Sclerosis Human ATXN2 RF Diagnosis 2022 35521889
3199 Amyotrophic Lateral Sclerosis Human ATXN2 RF 2015 26208502
3981 Amyotrophic Lateral Sclerosis Human ATXN2 RF Diagnosis 2022 35525134
3113 Amyotrophic Lateral Sclerosis Human ATXN2 RF ATXN2 high-length alleles (≥29 CAG repeats) 2011 21670397
3201 Amyotrophic Lateral Sclerosis Human ATXN2 RF ATXN2 polyQ repeat expansions greater than 27 2011 21741123
2778 Amyotrophic lateral sclerosis with frontotemporal dementia Human ATXN2 RF Diagnosis 2022 35521889
2700 Frontotemporal Dementia Human ATXN2 RF Diagnosis 2022 35521889
2176 Amyotrophic Lateral Sclerosis Human ATXN2 RF CAG repeat length >26 2011 21610160
2323 Alzheimer's Disease Human AZU1 RF APOE-?2 2021 33576571
659 Alzheimer's Disease Human B3GAT2 PF APOE-?3 2021 33576571
2107 Alzheimer's Disease Human BACE1 RF with APOEε4 carrier status 2015 26550136
2413 Alzheimer's Disease Human BACE1 RF in carrying the ApoE epsilon4 allele 2008 18182766
1935 Alzheimer's Disease Human BACE2 RF Rheumatoid arthritis (RA) RA-SNPs Association with AD 2011 21595938
592 Alzheimer's Disease Human BCL2L13 PF APOE-?2 2021 33576571
3833 Parkinson disease Human BDNF RF Prognosis 2021 34945793
2353 Alzheimer's Disease Human BDNF C270T RF 2015 26136901
1906 Alzheimer's Disease Human BIN1 RF Calculated by random effect model 2018 29504051
3205 Alzheimer's Disease Human BIN1 RF 2017 26768592
3067 Alzheimer's Disease Human BIN1 RF 2021 33732104
1920 Alzheimer's Disease Human BIN1 RF Calculated by fixed effect model 2018 29504051
714 Alzheimer's Disease Human BIN1 PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
682 Alzheimer's Disease Human BIN1 PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
1916 Alzheimer's Disease Human BIN1 RF Calculated by random effect model 2018 29504051
3204 Alzheimer's Disease Human BIN1 RF 2017 26768592
1910 Alzheimer's Disease Human BIN1 RF Calculated by fixed effect model 2018 29504051
1891 Alzheimer's Disease Human BIN1 RF Calculated by fixed effect model 2018 29504051
2948 Amyotrophic Lateral Sclerosis Human BIRC6 RF 2013 27455347
744 Alzheimer's Disease Human BMS1 PF APOE-?3 2021 33576571
2441 Alzheimer's Disease Human C1orf185 RF APOE-?2 2021 33576571
2865 Amyotrophic Lateral Sclerosis Human C1QTNF7 RF 2013 27455347
828 Alzheimer's Disease Human C282Y HFE PF 2009 19429178
2860 Frontotemporal Lobar Degeneration Human C4orf27 RF Discovery stage 2019 30739198
3206 Amyotrophic Lateral Sclerosis Human C7orf57 RF 2014 25023141
3208 Amyotrophic Lateral Sclerosis Human C9orf72 RF 2018 29528390
2875 Parkinson disease Human C9orf72 RF 2021 34440384
2447 Amyotrophic Lateral Sclerosis Human C9orf72 RF 2020 33168078
2274 Parkinson disease Human C9orf72 RF 2021 34440384
3207 Amyotrophic Lateral Sclerosis Human C9orf72 RF 2014 25023141
3979 Amyotrophic Lateral Sclerosis Human C9orf72 RF Diagnosis 2022 35525134
2409 Amyotrophic Lateral Sclerosis Human C9orf72 RF 2010 20801718
3209 Frontotemporal Lobar Degeneration Human C9orf72 RF C9orf72 repeat expansions; All FTD patients with mutations had a positive family history for dementia or ALS 2014 25108559
3027 Amyotrophic Lateral Sclerosis Human C9orf72 RF 2020 33168078
2869 Amyotrophic Lateral Sclerosis Human C9orf72 RF Diagnosis 2021 33563800
3051 Parkinson disease Human C9orf72 RF 2013 23845100
2751 Alzheimer's Disease Human C9orf72 RF 2021 33935096
3978 Amyotrophic Lateral Sclerosis Human C9orf72 RF Diagnosis 2022 36511680
3820 Multiple System Atrophy Human C9orf72 RF Diagnosis 2021 35007998
3669 Amyotrophic Lateral Sclerosis Human CACNA1H RF 2020 32143681
1954 Alzheimer's Disease Human CALHM1 RF 2010 20061624
729 Creutzfeldt-Jakob disease Human CALHM1 PF 2012 22874670
2544 Creutzfeldt-Jakob disease Human CALHM1 RF Genotype:GG 2012 22874670
3100 Alzheimer's Disease Human CALHM2 RF APOE-?3 2021 33576571
2281 Parkinson disease Human CARD15 RF 2007 17174426
2926 Alzheimer's Disease Human CCDC60 RF APOE-?2 2021 33576571
3210 Parkinson disease Human CCDC62/HIP1R RF 2015 25818163
1854 Parkinson disease Human CCL2 RF 2019 30761072
1863 Parkinson disease Human CCL2 RF 2019 30761072
1985 Parkinson disease Human CD14 RF 2006 16337421
3211 Parkinson disease rat CD157/BST1 RF 2014 24795584
3212 Alzheimer's Disease Human CD163L1 RF 2017 29177109
3664 Alzheimer's Disease Human CD33 RF 2020 32647856
3213 Alzheimer's Disease Human CD33 RF 2012 22382309
901 Parkinson disease Human CD33 PF Diagnosis 2021 33582190
593 Alzheimer's Disease Human CD33 PF in APOE e4 carriers 2012 22167654
2162 Alzheimer's Disease Human CD33 RF Diagnosis 2022 35408990
815 Alzheimer's Disease Human CD33 PF this association was not significant in Asians 2016 26795201
3954 Parkinson disease Human CD33 RF Diagnosis 2023 37479176
926 Parkinson disease Human CD33 PF Diagnosis 2023 37479176
563 Alzheimer's Disease Human CD33 PF in APOE e4 carriers 2012 22167654
630 Alzheimer's Disease Human CD36 PF Genotype: GT; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 2018 30235742
2221 Alzheimer's Disease Human CD36 RF Genotype: Recessive 2018 30235742
2389 Alzheimer's Disease Human CD36 RF Genotype: Dominant 2018 30235742
664 Alzheimer's Disease Human CD36 PF Genotype: Dominant; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 2018 30235742
641 Alzheimer's Disease Human CD36 PF Genotype: GT 2018 30235742
2477 Alzheimer's Disease Human CD36 RF Genotype: GG; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 2018 30235742
2247 Alzheimer's Disease Human CD36 RF Genotype: Dominant; Adjusting the physiological and biochemical factors, including age, FBG, BMI, SBP, DBP, HDLC [According to univariate analysis, there was a significant deviation (P<0.05)]. 2018 30235742
2598 Alzheimer's Disease Human CD36 RF Genotype: GG 2018 30235742
681 Alzheimer's Disease Human CD36 PF Genotype: Dominant 2018 30235742
3670 Creutzfeldt-Jakob disease Human Cerebroside sulfotransferase (GAL3ST1) RF 2020 32565065
2203 Alzheimer's Disease Human CHAT RF 2016 27272392
3214 Alzheimer's Disease Human CHAT RF 2008 18562794
2236 Alzheimer's Disease Human CHAT RF 2016 27272392
3215 Dementia with Lewy bodies Human CHCHD2 RF 2015 26561290
3216 Parkinson disease Human CHCHD2 RF 2016 27626775
2878 Amyotrophic Lateral Sclerosis Human CHGB RF 2009 20007371
2608 Amyotrophic Lateral Sclerosis Human CHGB RF 2009 20007371
2551 Alzheimer's Disease Human CHI3L1 RF TT 2019 30223258
2200 Alzheimer's Disease Human CHI3L1 RF CT+TT 2019 30223258
680 Alzheimer's Disease Human CHI3L1 PF CG+GG 2019 30223258
2127 Alzheimer's Disease Human CHI3L1 RF T allele 2019 30223258
687 Alzheimer's Disease Human CHI3L1 PF G allele 2019 30223258
2595 Creutzfeldt-Jakob disease Human CHN2 RF 2012 22210626
3217 Alzheimer's Disease Human chromosome 12q24.22 RF 2014 24361131
3218 Multiple System Atrophy Human chromosome 22 RF 2017 29187220
3219 Multiple System Atrophy Human chromosome 22 RF 2017 29187220
3223 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3220 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3222 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3224 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3221 Multiple System Atrophy Human chromosome 4 RF 2017 29187220
3226 Multiple System Atrophy Human chromosome 5 RF 2017 29187220
3225 Multiple System Atrophy Human chromosome 5 RF 2017 29187220
2336 Alzheimer's Disease Human chromosome 9p21.3 RF 2010 20427016
1991 Alzheimer's Disease Human chromosome 9p21.3 RF C allele 2011 19664850
2096 Alzheimer's Disease Human chromosome 9p21.3 RF in non-APOE epsilon4 2010 20427016
3227 Alzheimer's Disease Human CLECL1 RF 2017 29177109
2969 Alzheimer's Disease Human CLU RF 2016 26757186
1860 Alzheimer's Disease Human CLU RF Calculated by fixed effect model 2018 29504051
502 Alzheimer's Disease Human CLU PF 2016 26757186
1859 Alzheimer's Disease Human CLU RF Calculated by fixed effect model 2018 29504051
2922 Alzheimer's Disease Human CLU RF Diagnosis 2022 35135450
1856 Alzheimer's Disease Human CLU RF Calculated by random effect model 2018 29504051
1858 Alzheimer's Disease Human CLU RF Calculated by fixed effect model 2018 29504051
2072 Parkinson disease Human Clusterin (CLU) RF Diagnosis 2021 33295114
2683 Alzheimer's Disease Human CNGB1 RF APOE-?2 2021 33576571
2410 Alzheimer's Disease Human CNGB1 RF APOE-?2 2021 33576571
2326 Alzheimer's Disease Human CNGB1 RF APOE-?2 2021 33576571
2684 Alzheimer's Disease Human CNGB1 RF APOE-?2 2021 33576571
2377 Tourette Syndrome Human CNR 1 RF 2020 32194619
3767 Alzheimer's Disease Human CNR1 RF 2021 33523009
2134 Dementia with Lewy bodies Human CNTN1 RF 2018 29263008
2097 Amyotrophic Lateral Sclerosis Human CNTN4 RF Diagnosis 2021 34421992
3564 Alzheimer's Disease Human coexistence of the APOE-ε4 allele and 3 SNPs in the BCHE gene RF 2019 30914707
2324 Alzheimer's Disease Human COMT RF without APOE ε4 allele carriers 2014 24575113
3005 Alzheimer's Disease Human COMT RF 2021 33900525
2868 Alzheimer's Disease Human COMT RF 2021 33900525
2228 Parkinson disease Human COMT RF 1997 9503277
3002 Alzheimer's Disease Human COMT RF without APOE ε4 allele carriers;in men 2014 24575113
465 Multiple System Atrophy Human COQ2 PF Diagnosis 2022 35748722
3228 Multiple System Atrophy Human COQ2 RF 2016 27123473
673 Alzheimer's Disease Human COX11 PF APOE-?2 2021 33576571
2125 Alzheimer's Disease Human COX-2 RF G allele 2010 20110601
2100 Alzheimer's Disease Human COX-2 RF GG allele 2010 20110601
2403 Alzheimer's Disease Human CPT1B RF APOE-?2 2021 33576571
1899 Alzheimer's Disease Human CR1 RF Calculated by fixed effect model 2018 29504051
633 Alzheimer's Disease Human CR1 PF PENN cohort 2018 30128317
1905 Alzheimer's Disease Human CR1 RF Calculated by fixed effect model 2018 29504051
747 Alzheimer's Disease Human CR1 PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
1979 Alzheimer's Disease Human CR1 RF Calculated by fixed effect model 2018 29504051
3077 Amyotrophic Lateral Sclerosis Human CREB3L2 RF 2013 27455347
688 Alzheimer's Disease Human CRTC3 PF APOE-?2 2021 33576571
2206 Frontotemporal Lobar Degeneration Human CST3 RF negative for the presence of PGRN mutations;haplotype B 2010 19674067
2532 Alzheimer's Disease Human CST3 RF Caucasians 2000 10993992
2572 Alzheimer's Disease Human CST3 RF CST3-A allele; APOE ε4 carrier 2001 11711204
3081 Alzheimer's Disease Human CST3 RF CST3-A allele; Non-APOE ε4 carrier 2001 11711204
2257 Frontotemporal Lobar Degeneration Human CST3 RF negative for the presence of PGRN mutations;AB/BB genotypes 2010 19674067
3229 Alzheimer's Disease Human CTNNA1 RF 2017 29177109
2485 Alzheimer's Disease Human CTSB RF APOE-?2 2021 33576571
2632 Alzheimer's Disease Human CTSD RF 2014 24281128
2424 Creutzfeldt-Jakob disease Human CTSD RF Genotype:CC 2008 18426579
3122 Creutzfeldt-Jakob disease Human CTSD RF Genotype:CT 2008 18426579
2362 Amyotrophic Lateral Sclerosis Human CX3CR1 RF 2014 24806473
3230 Amyotrophic Lateral Sclerosis Human CX3CR1 RF 2014 24806473
2651 Amyotrophic Lateral Sclerosis Human CX3CR1 RF 2014 24806473
3732 Alzheimer's Disease Human CXCL12 RF 2021 33687622
3232 Alzheimer's Disease Human CYP19A1 RF 2016 27583919
2211 Alzheimer's Disease Human CYP2B6 RF APOE-?2 2021 33576571
1919 Alzheimer's Disease Human CYP2B6 RF APOE-?3 2021 33576571
3233 Alzheimer's Disease Human CYP2D6 RF CYP2D6B allele; in the Lewy body variant of AD 1995 7818242
2710 Alzheimer's Disease Human CYP2J2 RF total;Genotype GT + TT 2015 25796175
2687 Alzheimer's Disease Human CYP2J2 RF total;Allele T 2015 25796175
2137 Alzheimer's Disease Human CYP46A1 RF Overall; Genotype:TT; dominant mode 2018 29516283
3120 Alzheimer's Disease Human CYP46A1 RF APOE ε4 carrier; Genotype:CC 2018 29516283
2688 Alzheimer's Disease Human CYP46A1 RF APOE ε4 carrier; Genotype:TT; dominant mode 2018 29516283
3234 Alzheimer's Disease Human CYP46A1 RF CYP46A1 gene variations 2009 19286353
2594 Alzheimer's Disease Human CYP46A1 RF APOE ε3/ε4; Genotype:CC; additive model 2018 29516283
2259 Alzheimer's Disease Human CYP46A1 RF 2012 22528464
2136 Alzheimer's Disease Human CYP46A1 RF Overall; Genotype:TC; logistic regression model 2018 29516283
2665 Alzheimer's Disease Human CYP46A1 RF APOE ε3/ε4; Genotype:TT; dominant mode 2018 29516283
2636 Alzheimer's Disease Human CYP46A1 RF APOE ε4 carrier; Genotype:CC; additive model 2018 29516283
3790 Amyotrophic lateral sclerosis,Parkinson disease Human DAB1 RF Diagnosis 2021 34707478
753 Alzheimer's Disease Human DAPK1 PF especially the homozygotes 2011 21167819
2034 Alzheimer's Disease Human DAPK1 RF 2011 21167819
3832 Parkinson disease Human DBH RF Prognosis 2021 34945793
2459 Amyotrophic Lateral Sclerosis Human DCC RF 2013 27455347
2920 Frontotemporal Lobar Degeneration Human DCUN1D1 RF Genotype:GG 2009 19473369
629 Alzheimer's Disease Human DDIT4L PF APOE-?2 2021 33576571
1842 Parkinson disease Human DGCR8 RF 2013 24018986
1841 Parkinson disease Human DGCR8 RF 2013 24018986
1783 Alzheimer's Disease Human DHCR7 RF Chinese population 2021 33692822
3789 Amyotrophic Lateral Sclerosis Human DHTKD1 RF Diagnosis 2021 35052424
3235 Amyotrophic Lateral Sclerosis Human DISC1 RF 2014 25023141
3724 Alzheimer's Disease Human DLD gene RF 2021 33917565
2128 Parkinson disease Human DMRT2/SMARCA2 RF Diagnosis 2021 33510632
2279 Parkinson disease Human DMT1 RF 2011 21777657
3236 Parkinson disease Human DMT1 RF 2015 25817364
2074 Parkinson disease Human DNA methylation (DNAm) CD56 RF Diagnosis 2021 34768133
786 Parkinson disease Human DNA methylation (DNAm) EFEMP-1 PF Diagnosis 2021 34768133
3109 Parkinson disease Human DNA Methylation cg10917602 site RF 2016 27466229
892 Parkinson disease Human DOPA decarboxylase gene (DDC) PF Treatment 2021 33051953
3237 Amyotrophic Lateral Sclerosis Human DPP6 RF 2014 25023141
2621 Frontotemporal Lobar Degeneration Human DPP6 RF Discovery stage 2019 30739198
693 Amyotrophic Lateral Sclerosis Human DPP6 PF Diagnosis 2021 34421992
2627 Frontotemporal Lobar Degeneration Human DPP6 RF Discovery stage 2019 30739198
2765 Amyotrophic Lateral Sclerosis Human DPYSL3(CRMP4) RF 2013 23568759
504 Alzheimer's Disease Human DR4 PF GGC haplotype 2013 25207117
581 Alzheimer's Disease Human DR4 PF ACA haplotype 2013 25207117
830 Alzheimer's Disease Human DR4 PF the GA genotype 2013 25207117
648 Alzheimer's Disease Human DR4 PF GGA haplotype 2013 25207117
2076 Alzheimer's Disease Human DR4 RF GCA haplotype 2013 25207117
2384 Alzheimer's Disease Human DR4 RF GCC haplotype 2013 25207117
3834 Parkinson disease Human DRD2 RF Prognosis 2021 34945793
3238 Tourette Syndrome Human DRD2 RF 2010 20431429
779 Progressive Supranuclear Palsy Human DUSP10 PF Meta-analysis 2018 29986742
2278 Parkinson disease Human DYRK1A RF especially for males 2016 27546826
2038 Progressive Supranuclear Palsy Human EIF2AK3 RF Diagnosis 2021 33897612
765 Progressive Supranuclear Palsy Human EIF2AK3 PF Meta-analysis 2018 29986742
3239 Parkinson disease Human EMTP variation RF 2019 30675927
2222 Alzheimer's Disease Human ENST00000414107 RF 2018 29027019
549 Alzheimer's Disease Human EPHA7 PF APOE-?2 2021 33576571
2062 Alzheimer's Disease Human EPHA7 RF APOE-?3 2021 33576571
3240 Amyotrophic Lateral Sclerosis Human ERp57/PDIA3 RF 2015 25913742
2239 Alzheimer's Disease Human ESR1 RF 2012 20674091
653 Alzheimer's Disease Human ESR1 PF 2012 20674091
1999 Alzheimer's Disease Human ESR1 RF 2012 20674091
3017 Alzheimer's Disease Human ESR1 and ESR2 RF the genetic profile created with the combination of the less represented alleles of these SNPs (expressed as XPAA) 2013 24052609
2372 Alzheimer's Disease Human ESR2 RF predominantly Caucasian AIMS-defined ancestry 2014 24326520
2371 Alzheimer's Disease Human ESR2 RF predominantly Caucasian AIMS-defined ancestry 2014 24326520
2195 Alzheimer's Disease Human ESR2 RF predominantly Caucasian AIMS-defined ancestry 2014 24326520
2194 Alzheimer's Disease Human ESR2 RF predominantly Caucasian AIMS-defined ancestry 2014 24326520
678 Alzheimer's Disease Human ESR3 PF 2014 24326520
1925 Alzheimer's Disease Human EXOC3L2 RF 2017 28423615
814 Alzheimer's Disease Human EXOC3L2 PF 2017 28423615
3021 Alzheimer's Disease Human FAM107B RF APOE-?2 2021 33576571
703 Alzheimer's Disease Human FAM47E PF 2021 33654092
2584 Alzheimer's Disease Human FAM71E2 RF APOE-?3 2021 33576571
2769 Parkinson disease Human Famliy history of familial Parkinson's disease RF 2010 21059511
2444 Parkinson disease Human Famliy history of familial Parkinson's disease RF 1996 8771062
3242 Parkinson disease Human FGF20 RF 2012 22342445
1911 Parkinson disease Human FGF20 RF 2014 24942208
3244 Parkinson disease Human FGF20 RF 2004 15122513
3241 Parkinson disease Human FGF20 RF 2015 26070653
3140 Parkinson disease Human FGF20 RF 2015 26070653
3243 Parkinson disease Human FGF20 RF 2004 15122513
2294 Alzheimer's Disease Human FOXN1 RF APOE-?2 2021 33576571
2246 Alzheimer's Disease Human FRMD4A RF 2013 22430674
3245 Amyotrophic Lateral Sclerosis Human FUS RF 2017 28054830
3759 Alzheimer's Disease Human FZD3 RF 2021 32966694
2685 Alzheimer's Disease Human G-308A( TNF-alpha gene) RF A-allele 2008 18992723
3097 Alzheimer's Disease Human GAB2 RF 2011 21285854
792 Alzheimer's Disease Human GAB2 PF 2015 26770425
3247 Alzheimer's Disease Human GAB2 RF 2011 21285854
3246 Alzheimer's Disease Human GAB2 RF ApoE epsilon4 non-carriers 2009 19276544
3127 Alzheimer's Disease Human GAB2 RF a minor genetic determinant of AD 2008 18272374
2471 Alzheimer's Disease Human GAB2 RF 2011 21285854
2032 Alzheimer's Disease Human GAB2 RF 2011 21108942
3248 Alzheimer's Disease Human GAB2 RF 2011 21285854
785 Alzheimer's Disease Human GAB2 PF 2015 26770425
1923 Creutzfeldt-Jakob disease Human GAL3ST1 RF 2020 32949544
3249 Alzheimer's Disease Human GALR3 RF 2017 29177109
2518 Alzheimer's Disease Human GAMT RF APOE-?2 2021 33576571
2043 Alzheimer's Disease Human GAMT RF APOE-?3 2021 33576571
3250 Amyotrophic Lateral Sclerosis Human GARS RF 2019 30661401
3063 Parkinson disease Human GBA RF 2019 30765263
3255 Parkinson disease Human GBA RF strong risk factors in FPD, especially for autosomal dominant PD 2014 24126159
3252 Dementia with Lewy bodies Human GBA RF 2016 27312774
3800 Lewy Body Disease Human GBA RF 2021 34308904
3257 Parkinson disease Human GBA RF 2019 30765263
3096 Parkinson disease Human GBA RF 2007 17702778
2647 Dementia with Lewy bodies Human GBA RF 2018 29263008
3254 Parkinson disease Human GBA RF Patients with early-onset were more likely to carry GBA mutations than those with late-onset 2016 26868973
3836 Parkinson disease Human GBA RF Diagnosis 2021 34951095
3804 Lewy Body Disease Human GBA RF Diagnosis 2021 33646158
3259 Dementia with Lewy bodies Human GBA RF 2008 18332251
2990 Lewy Body Disease Human GBA RF Diagnosis 2021 34308904
2944 Parkinson disease Human GBA RF 2013 22812582
3251 Dementia with Lewy bodies Human GBA RF 2016 27723861
3099 Parkinson disease Human GBA RF 2010 20131388
3256 Parkinson disease Human GBA RF 2016 26000814
1658 Parkinson disease Human GBA RF Prognosis 2023 36348503
3253 Dementia with Lewy bodies Human GBA RF 2016 27027900
3258 Parkinson disease Human GBA RF 2019 30765263
2767 Parkinson disease Human GBA RF 2012 22387070
2773 Parkinson disease Human GBA1 RF non-N370S mutations associated with Gaucher disease 2013 22968580
1838 Parkinson disease Human GBA1 RF Diagnosis 2022 37633302
2179 Parkinson disease Human GBA1 RF Diagnosis 2022 37633302
3095 Dementia with Lewy bodies Human GBA1 RF 2013 23588557
898 Parkinson disease Human GCase gene therapy PF 2021 34062940
3260 Parkinson disease Human GCH1 RF 2017 27871051
2293 Alzheimer's Disease Human GCH1 RF 2018 29432188
1989 Parkinson disease Human GLIS1 RF 2012 22759478
3761 Alzheimer's Disease Human GOLGA8B RF 2021 32966694
2065 Alzheimer's Disease Human GOLPH2 RF 2012 22167654
2066 Alzheimer's Disease Human GOLPH2 RF 2012 22167654
3107 Alzheimer's Disease Human GORASP2 RF APOE-?2 2021 33576571
2737 Parkinson disease Human GP1BA RF 2020 33021140
2213 Parkinson disease Human GP6 RF 2020 33021140
601 Alzheimer's Disease Human GPIHBP1 PF APOE-?2 2021 33576571
3047 Alzheimer's Disease Human GPR37 RF APOE-?2 2021 33576571
3261 Parkinson disease Human GRIN2A RF taking creatine who also have high levels of caffeine intake 2017 28320167
3262 Parkinson disease Human GRIN2A T allele RF taking creatine who also have high levels of caffeine intake 2017 28320167
1489 Frontotemporal Dementia Human GRN RF Diagnosis 2021 32972771
3671 Frontotemporal Lobar Degeneration Human GRN RF FTLD with TAR DNA-binding protein (TDP-43) inclusions 2010 20154673
1934 Alzheimer's Disease Human GRN RF 2017 26820675
2808 Frontotemporal Lobar Degeneration Human GRN RF Genotype:TT 2008 18723524
3815 Lewy Body Disease Human GRN RF Diagnosis 2021 34854996
3263 Frontotemporal Lobar Degeneration Human GRN RF 2014 24503614
2219 Frontotemporal Lobar Degeneration Human GRN RF more common (T) allele 2010 20154673
3018 Alzheimer's Disease Human GSN RF APOE-?2 2021 33576571
2498 Alzheimer's Disease Human GSTM1 RF 2012 22381228
2905 Parkinson disease Human GSTM1 RF Diagnosis 2021 32359946
2867 Alzheimer's Disease Human GSTM1 RF 2018 29072550
2772 Parkinson disease Human GSTM1/T1 null genotypes RF Diagnosis 2021 32359946
3264 Alzheimer's Disease Human GSTP1 RF mainly in the presence of the apoE 4 allele 2008 18298341
2225 Alzheimer's Disease Human GSTT1 RF 2018 29072550
3032 Parkinson disease Human GSTT1 RF Diagnosis 2021 32359946
1412 Amyotrophic Lateral Sclerosis Human H63D RF 2020 33070529
591 Alzheimer's Disease Human HAP1 PF APOE-?3 2021 33576571
587 Alzheimer's Disease Human HAP1 PF APOE-?3 2021 33576571
3265 Alzheimer's Disease Human hemochromatosis (HFE) RF 2014 27081498
683 Parkinson disease Human HFE PF Australian PD patients 2002 12098643
2798 Amyotrophic Lateral Sclerosis Human HFE RF Genotype:GC 2011 20642794
2845 Amyotrophic Lateral Sclerosis Human HFE RF Genotype:GC/GG 2011 20642794
3267 Parkinson disease Human HFE RF 2006 16824219
2874 Amyotrophic Lateral Sclerosis Human HFE RF Genotype:G allele frequency 2011 20642794
684 Parkinson disease Human HFE PF Australian PD patients 2002 12098643
3266 Parkinson disease Human HFE RF 2006 16824219
3268 Alzheimer's Disease Human HIF3A RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
1437 Alzheimer's Disease Human HLA-A24 RF 2008 18936542
2486 Frontotemporal Lobar Degeneration Human HLA-DQA2 RF Discovery stage 2019 30739198
2338 Frontotemporal Lobar Degeneration Human HLA-DQA2 RF Replication stage 2019 30739198
3269 Parkinson disease Human HLA-DRA RF 2014 25319953
2738 Amyotrophic Lateral Sclerosis Human HLA-DRA/HLA-DRB5 RF the AA genotype at rs9268856 2017 28131168
1931 Alzheimer's Disease Human HLA-DRB1 RF non-APOE ε4 carriers with rs9271192 genotype CC;additive model 2017 29190991
2488 Alzheimer's Disease Human HLA-DRB1 RF under a recessive model in the total sample 2017 29190991
2667 Alzheimer's Disease Human HLA-DRB1 RF non-APOE ε4 carriers with rs9271192 genotype CC;recessive model 2017 29190991
533 Frontotemporal Lobar Degeneration Human HMCN1 PF Discovery stage 2019 30739198
2597 Frontotemporal Lobar Degeneration Human hnRNP-A1 RF C/C genotype 2011 21548758
2217 Frontotemporal Lobar Degeneration Human hnRNP-A1 RF C/C genotype 2011 21548758
554 Alzheimer's Disease Human HSP70/HSPA1A PF Genotype: A/C; AD without depression 2018 29703883
2934 Alzheimer's Disease Human Ig γ marker (GM) allotypes RF encoded by highly polymorphic IGHG genes on chromosome 14q32 2020 32709662
2628 Alzheimer's Disease Human IGFALS RF APOE-?3 2021 33576571
2063 Alzheimer's Disease Human IL-1 beta promoter polymorphism RF APOE4 presence:No stratified 2008 18717723
2691 Alzheimer's Disease Human IL-1 beta promoter polymorphism RF APOE4 presence:APOE4 yes 2008 18717723
2205 Alzheimer's Disease Human IL-1 beta promoter polymorphism RF APOE4 presence:APOE4 no 2008 18717723
3270 Alzheimer's Disease Human IL-1 genes cluster RF 2012 22498095
831 Alzheimer's Disease Human IL-1 genes cluster PF 2012 22498095
3272 Parkinson disease Human IL-10 RF 2012 22387064
3271 Parkinson disease Human IL-10 RF 2012 21241672
3273 Parkinson disease Human IL-18 RF 2012 21241672
3275 Alzheimer's Disease Human IL-1B RF 2017 26768592
3274 Alzheimer's Disease Human IL-1B RF 2017 26768592
3276 Alzheimer's Disease Human IL-1α RF 2016 27014584
3277 Multiple System Atrophy Human IL-1β RF 2018 29251119
2201 Frontotemporal Lobar Degeneration Human IMMP2L RF Discovery stage 2019 30739198
628 Alzheimer's Disease Human INO80D PF APOE-?2 2021 33576571
2764 Amyotrophic Lateral Sclerosis Human INPP5B RF Diagnosis 2021 34421992
3738 Alzheimer's Disease mice INPP5D RF 2021 33631273
2280 Alzheimer's Disease Human insulin degrading enzyme gene (IDE) RF 2012 20880607
2997 Alzheimer's Disease Human insulin degrading enzyme gene (IDE) RF CC genotype was significantly associated with earlier age at onset 2012 20880607
2832 Amyotrophic Lateral Sclerosis Human Intergenic RF The estimations using the proposed method (unadjusted estimates) 2009 19740415
2787 Amyotrophic Lateral Sclerosis Human Intergenic RF The estimations using the proposed method (adjusted estimates) 2009 19740415
2880 Amyotrophic Lateral Sclerosis Human Intergenic and SHROOM3 RF The estimations using the proposed method (unadjusted estimates) 2009 19740415
2838 Amyotrophic Lateral Sclerosis Human Intergenic and SHROOM4 RF The estimations using the proposed method (adjusted estimates) 2009 19740415
3028 Amyotrophic Lateral Sclerosis Human intermediate-length alleles when present in both alleles RF Carriership of two intermediate-length alleles was associated with ALS, when the longer allele was ≥ 17 repeats 2020 33168078
2448 Amyotrophic Lateral Sclerosis Human intermediate-length alleles when present in both alleles RF Carriership of two intermediate-length alleles was associated with ALS, when the longer allele was ≥ 21 repeats 2020 33168078
696 Frontotemporal Lobar Degeneration Human IRF2 PF Discovery stage 2019 30739198
1932 Alzheimer's Disease Human ITGA2B RF APOE-?3 2021 33576571
2256 Alzheimer's Disease Human ITGA4 RF Dominant; Genotype/Allele: AG+GG; Multivariate analysis 2018 29769839
2242 Alzheimer's Disease Human ITGA4 RF Overdominant; Genotype/Allele: AG; Multivariate analysis 2018 29769839
2360 Alzheimer's Disease Human ITGA4 RF Codominant; Genotype/Allele: AG; Univariate analysis 2018 29769839
2302 Alzheimer's Disease Human ITGA4 RF Dominant; Genotype/Allele: AG+GG; Univariate analysis 2018 29769839
2334 Alzheimer's Disease Human ITGA4 RF Overdominant; Genotype/Allele: AG; Univariate analysis 2018 29769839
1970 Parkinson disease Human ITGB5 RF 2020 33021140
3278 Amyotrophic Lateral Sclerosis Human ITPR2 RF 2014 25023141
2181 Alzheimer's Disease Human KCNJ15 RF 2018 29432188
574 Alzheimer's Disease Human KIBRA PF 2013 24190487
3810 Lewy Body Disease Human KIF17 RF Diagnosis 2021 34124335
3078 Amyotrophic Lateral Sclerosis Human KIF5A RF 2013 27455347
3124 Alzheimer's Disease Human LAMA2 RF APOE-?3 2021 33576571
2215 Alzheimer's Disease Human LAMA2 RF APOE-?2 2021 33576571
535 Alzheimer's Disease Human LAMA2 PF APOE-?2 2021 33576571
3279 Alzheimer's Disease Human LCORL RF 2018 29860282
2108 Alzheimer's Disease Human LDLR RF 2008 18065781
489 Alzheimer's Disease Human LHCGR PF carrying an APOE epsilon4 allele 2008 18439297
2091 Alzheimer's Disease Human LOC100505811 RF 2018 29027019
2183 Alzheimer's Disease Human LOC100505811 RF 2018 29027019
2149 Alzheimer's Disease Human LOC100505811 RF 2018 29027019
2180 Alzheimer's Disease Human LOC100505811 RF 2018 29027019
2105 Frontotemporal Lobar Degeneration Human LOC101927354 RF Discovery stage 2019 30739198
2061 Amyotrophic Lateral Sclerosis Human LOC107987057 RF 2010 20801717
1960 Amyotrophic Lateral Sclerosis Human LOC107987057 RF In the joint analysis 2010 20801717
2526 Amyotrophic Lateral Sclerosis Human LOC107987057 RF 2010 20801718
2057 Amyotrophic Lateral Sclerosis Human LOC107987057,LOC112268043 RF 2010 20801717
1961 Amyotrophic Lateral Sclerosis Human LOC107987057,LOC112268043 RF In the joint analysis 2010 20801717
2520 Amyotrophic Lateral Sclerosis Human LOC112268043,LOC107987057 RF 2010 20801718
2418 Alzheimer's Disease Human LPA RF APOE-?2 2021 33576571
3775 Amyotrophic Lateral Sclerosis Human LRP10 RF 2021 32690342
2052 Alzheimer's Disease Human LRP2 RF 2011 20971101
783 Alzheimer's Disease Human LRRC17 PF APOE-?3 2021 33576571
656 Alzheimer's Disease Human LRRC17 PF APOE-?2 2021 33576571
2005 Alzheimer's Disease Human LRRC17 RF APOE-?3 2021 33576571
2098 Alzheimer's Disease Human LRRC2 RF APOE-?2 2021 33576571
3112 Parkinson disease Human LRRK2 RF reater frequency of the G2019S mutation in Jewish than in non-Jewish cases with Parkinson disease 2006 17050822
805 Parkinson disease Human LRRK2 PF 2012 23115130
2981 Parkinson disease Human LRRK2 RF 2013 23624603
3855 Parkinson disease Human LRRK2 RF 2021 34060004
1941 Parkinson disease Human LRRK2 RF 2012 23115130
3872 Parkinson disease Human LRRK2 RF Diagnosis 2021 33742109
3141 Parkinson disease Human LRRK2 RF 2009 19699188
3280 Multiple System Atrophy Human LRRK2 RF 2018 29480226
3711 Alzheimer's Disease Human LRRK2 RF 2021 34135785
2514 Parkinson disease Human LRRK2 RF 2008 18716801
3282 Parkinson disease Human LRRK2 RF 2007 17960808
2682 Parkinson disease Human LRRK2 RF 2007 17314670
2904 Parkinson disease Human LRRK2 RF 2008 18201193
2335 Parkinson disease Human LRRK2 RF 2010 19854095
2504 Parkinson disease Human LRRK2 RF 2007 17019612
2511 Parkinson disease Human LRRK2 RF especially in early-onset patients 2015 26234753
2888 Parkinson disease Human LRRK2 RF 2009 19672984
2487 Parkinson disease Human LRRK2 RF 2010 20673920
2548 Parkinson disease Human LRRK2 RF 2006 16633828
3874 Parkinson disease Human LRRK2 RF Diagnosis 2021 33574311
1719 Parkinson disease Human LRRK2 RF Diagnosis 2023 35733392
3281 Parkinson disease Human LRRK2 RF 2011 21167764
2327 Parkinson disease Human LRRK2 RF 2011 20629711
2801 Alzheimer's Disease Human LTBP1 RF APOE-?2 2021 33576571
2800 Alzheimer's Disease Human LTBP1 RF APOE-?2 2021 33576571
631 Alzheimer's Disease Human LTBP1 PF APOE-?3 2021 33576571
2491 Amyotrophic Lateral Sclerosis Human M1(C/C) RF 2007 17503480
555 Amyotrophic Lateral Sclerosis Human M5(A/A) PF 2007 17503480
2908 Amyotrophic Lateral Sclerosis Human M6(T/T) RF 2007 17503480
3283 Parkinson disease Human MAO RF 1994 7913737
3284 Parkinson disease Human MAO RF 1994 7913737
2379 Multiple System Atrophy Human MAPT RF H1 haplotype 2011 21321341
2783 Frontotemporal Lobar Degeneration Human MAPT RF 2012 22556362
2079 Parkinson disease Human MAPT RF 2005 15627775
3049 Frontotemporal Lobar Degeneration Human MAPT RF H2H2 vs. H1H2 + H1H1 2006 16410051
498 Progressive Supranuclear Palsy Human MAPT PF Diagnosis 2021 33897612
618 Progressive Supranuclear Palsy Human MAPT PF Meta-analysis 2018 29986742
3985 Amyotrophic Lateral Sclerosis Human MAPT RF Diagnosis 2023 38002967
3285 Frontotemporal Dementia Human MAPT RF a rare microtubule-associated protein tau (MAPT) sequence variant, c.454G>A (p.A152T) 2013 23518664
2782 Frontotemporal Dementia Human MAPT RF 2012 22556362
3037 Progressive Supranuclear Palsy Human MAPT RF Meta-analysis 2018 29986742
2582 Progressive Supranuclear Palsy Human MAPT RF Diagnosis 2021 33897612
3135 Parkinson disease Human MAPT RF 2010 19912324
2568 Alzheimer's Disease Human MAPT RF 2012 22556362
2332 Frontotemporal Dementia Human MAPT H2 haplotype RF 2006 16410051
2746 Frontotemporal Dementia Human MAPT H2 haplotype RF APOE e4 negatives 2006 16410051
2437 Frontotemporal Dementia Human MAPT H2H3 genetype RF APOE e4 negatives 2006 16410051
3287 Parkinson disease Human MC1R RF 2009 19194882
2411 Alzheimer's Disease Human MC1R RF 2017 28059796
3286 Parkinson disease Human MC1R RF 2009 19194882
3712 Alzheimer's Disease Human MEF2C RF 2021 34163341
3288 Frontotemporal Lobar Degeneration Human MFSD8 RF 2019 30382371
3776 Amyotrophic Lateral Sclerosis Human MFSD8 RF Diagnosis 2021 33226711
3665 Amyotrophic Lateral Sclerosis Human MFSD8 RF 2021 33226711
3048 Alzheimer's Disease Human MGME1 RF APOE-?2 2021 33576571
573 Alzheimer's Disease Human MIA2 PF APOE-?3 2021 33576571
768 Alzheimer's Disease Human MIA2 PF APOE-?3 2021 33576571
796 Alzheimer's Disease Human microtubule-associated protein tau (MAPT) gene PF individuals with a GG genotype of rs242557G/A 2018 29098924
3289 Alzheimer's Disease Human MIEF1 RF 2017 29177109
2129 Frontotemporal Lobar Degeneration Human MIR548AP RF Discovery stage 2019 30739198
3290 Alzheimer's Disease Human MLKL RF MLKL loss-of-function mutation 2018 29656768
3291 Amyotrophic Lateral Sclerosis Human MOB3B RF 2014 25023141
2554 Amyotrophic Lateral Sclerosis Human MOB3B RF 2010 20801718
715 Progressive Supranuclear Palsy Human MOBP PF Meta-analysis 2018 29986742
3786 Amyotrophic Lateral Sclerosis Human MOBP RF Diagnosis Greece 2021 34694630
2840 Parkinson disease Human Monoamine oxidase-B (MAO-B) RF levodopa-induced dyskinesia(LID) 2020 32346620
3292 Alzheimer's Disease Human mosaic aneuploidy in the brain RF 2014 24602248
1888 Alzheimer's Disease Human MS4A4E RF 2015 26770425
3293 Alzheimer's Disease Human MS4A6A RF 2012 22382309
1857 Alzheimer's Disease Human MS4A6A RF Calculated by fixed effect model 2018 29504051
1862 Alzheimer's Disease Human MS4A6A RF Calculated by fixed effect model 2018 29504051
802 Alzheimer's Disease Human MS4A6A PF 2015 26770425
1861 Alzheimer's Disease Human MS4A6A RF Calculated by fixed effect model 2018 29504051
2331 Alzheimer's Disease Human MTHFD1L RF the results were influenced by APOE status 2011 21741665
1992 Alzheimer's Disease Human MTHFR RF without APOE epsilon4 alleles 2010 20600372
1937 Alzheimer's Disease Human MTHFR RF in APOE?4 or in non-APOE?4 carriers 2017 28211809
2771 Alzheimer's Disease Human MTHFR RF AA genotype 2013 23659764
3294 Alzheimer's Disease Human MTHFR RF increased the odds of developing AD by 2.5 2012 22015309
2648 Amyotrophic Lateral Sclerosis Human MTHFR(T677T) RF 2012 22385294
2748 Amyotrophic Lateral Sclerosis Human MTHFR(T677T/A1298A) RF 2012 22385294
2749 Amyotrophic Lateral Sclerosis Human MTHFR(T677T/A1298A) RF 2012 22385294
3295 Alzheimer's Disease Human MTNR1A RF 2018 29982836
3844 Parkinson disease Human MTPAP RF 2021 34394198
2639 Parkinson disease Human MUL1 RF Diagnosis 2021 34946922
3480 Tuberous sclerosis complex Human mutations in TSC2 RF 2015 26631248
3773 Alzheimer's Disease mice MUTYH RF Treatment 2021 34970419
2402 Alzheimer's Disease Human MYEOV RF APOE-?2 2021 33576571
3758 Alzheimer's Disease Human MYH11 RF 2021 32966694
3296 Motor Neuron Disease Human NEFH RF Genotype: SS 2004 14722583
3094 Amyotrophic Lateral Sclerosis Human NEK1 RF 2013 27455347
2614 Amyotrophic Lateral Sclerosis Human NEK1 RF 2013 27455347
2613 Amyotrophic Lateral Sclerosis Human NEK1 RF 2013 27455347
2689 Amyotrophic Lateral Sclerosis Human NEK1 RF 2013 27455347
2071 Alzheimer's Disease Human NEP gene (MME) RF 2012 22493749
1330 Alzheimer's Disease Human neprilysin (NEP) RF 2010 20376800
541 Alzheimer's Disease Human NINJ2 PF 2011 21674003
537 Alzheimer's Disease Human NINJ2 PF 2011 21674003
575 Alzheimer's Disease Human NINJ2 PF 2011 21674003
3297 Amyotrophic Lateral Sclerosis Human NIPA1 RF 2012 22378146
3298 Parkinson disease Human NOD2 RF associated with late-onset PD 2013 23651603
762 Alzheimer's Disease Human NOP56 PF APOE-?3 2021 33576571
672 Alzheimer's Disease Human NOP56 PF APOE-?2 2021 33576571
1333 Alzheimer's Disease Human NOS3 RF in the APOE epsilon 4 noncarriers 2008 18183499
2226 Frontotemporal Lobar Degeneration Human NOS3 RF 2009 19087148
1332 Alzheimer's Disease Human NOS3 RF in the APOE epsilon 4 noncarriers 2008 18183499
3299 Alzheimer's Disease Human NOS3 RF 2010 20505439
1966 Alzheimer's Disease Human NQO1 RF 2008 18253865
711 Alzheimer's Disease Human NQO1 PF significant difference in the APOE epsilon4 non-carriers 2008 18253865
2304 Alzheimer's Disease Human NT-3 RF homozygotes or heterozygotes for the mutated type (Glu[-63]) 1998 9502217
599 Alzheimer's Disease Human NTF-3 PF in patients lacking the ApoE-?4 allele 2015 26814132
2652 Alzheimer's Disease Human NUMA1 RF APOE-?2 2021 33576571
2626 Alzheimer's Disease Human NUMA1 RF APOE-?2 2021 33576571
2287 Frontotemporal Lobar Degeneration Human OLFM1 RF Discovery stage 2019 30739198
3085 Parkinson disease Human Omi/HTRA2 RF 2011 21338583
2475 Alzheimer's Disease Human OPRD1 RF APOE-?2 2021 33576571
2286 Alzheimer's Disease Human OPRD1 RF APOE-?3 2021 33576571
2216 Alzheimer's Disease Human OR1S2 RF APOE-?2 2021 33576571
2273 Alzheimer's Disease Human OR1S2 RF APOE-?2 2021 33576571
2036 Alzheimer's Disease Human OR2B2 RF 2021 33654092
652 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
671 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
640 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
649 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
657 Alzheimer's Disease Human OR52E6 PF APOE-?2 2021 33576571
3301 Alzheimer's Disease Human OX2R RF A allele may be a susceptible factor for AD 2019 30955315
3300 Alzheimer's Disease Human OX2R RF A allele may be a susceptible factor for AD 2019 30955315
3126 Alzheimer's Disease Human oxidized LDL receptor 1(OLR1) RF 2011 21709374
3137 Alzheimer's Disease Human oxidized LDL receptor 1(OLR1) RF 2011 21709374
2953 Parkinson disease Human P2RY12 RF 2020 33021140
3302 Parkinson disease Human P2X7 RF 2013 23648388
3303 Amyotrophic Lateral Sclerosis Human P4HB/PDIA1 RF 2015 25913742
3718 Alzheimer's Disease Human paraoxonase 1 (PON1) RF can be ameliorated by B-vitamins in individuals with MCI 2021 33935094
2396 Parkinson disease Human PARK16 RF 2011 21419001
3851 Parkinson disease Human PARK16 RF 2021 34373950
728 Parkinson disease Human PARK16 PF 2016 27174169
3304 Parkinson disease Human PARK16 RF 2016 27174169
3306 Parkinson disease Human PARK2 RF 2014 24729340
3305 Parkinson disease Human PARK2 RF 2002 12056932
3307 Parkinson disease Human PARK2 RF 2014 24729340
2386 Parkinson disease Human PARKIN RF 1999 10511432
3308 Parkinson disease Human PARKIN RF 2009 19636047
2387 Parkinson disease Human PARKIN RF 1999 10511432
1855 Tourette Syndrome Human PCNT RF 2020 32099372
1852 Tourette Syndrome Human PCNT RF 2020 32099372
1853 Tourette Syndrome Human PCNT RF 2020 32099372
3309 Parkinson disease Human PD in first-degree relatives RF 2000 11060508
3812 Lewy Body Disease Human PD-PRS RF Diagnosis 2021 34308904
2434 Amyotrophic Lateral Sclerosis Human PEAK1 RF 2013 27455347
572 Alzheimer's Disease Human PELO PF APOE-?2 2021 33576571
638 Alzheimer's Disease Human PELO PF APOE-?3 2021 33576571
2103 Alzheimer's Disease Human PEMT RF 2012 21881829
2545 Amyotrophic Lateral Sclerosis Human PFN1 RF 2014 24309268
2760 Alzheimer's Disease Human PGP RF APOE-?2 2021 33576571
2352 Alzheimer's Disease Human PICALM RF PENN cohort 2018 30128317
2508 Alzheimer's Disease Human PICALM RF PENN cohort 2018 30128317
3818 major depressive disorder (MDD),AD,NDD Human PICALM mRNA expression RF 2021 33386803
3824 Parkinson disease Human PICALM mRNA expression RF Diagnosis 2021 33386803
1869 Parkinson disease Human PINK1 RF 2017 27807026
3310 Parkinson disease Human PINK1 RF 2006 16969854
3311 Alzheimer's Disease Human PLA2G3 RF 2010 20930276
3312 Parkinson disease Human PLA2G6 RF 2012 22213678
3313 Alzheimer's Disease Human PLEKHG5 RF 2017 29177109
752 Parkinson disease Human PLEKHN1 PF Diagnosis 2021 33510632
832 Alzheimer's Disease Human PM20D1 PF in a particular genetic background 2018 29736028
3314 Hereditary Motor and Sensory Neuropathy Human PMP22 RF 17p11.2 duplication 1997 9183252
3315 Hereditary Motor and Sensory Neuropathy Human PMP22 RF 17p11.2 duplication 1994 8179301
3995 Charcot-Marie-Tooth (CMT) disease Human PMP22 RF Diagnosis 2023 36581210
695 Alzheimer's Disease Human POMT1 PF APOE-?2 2021 33576571
2086 Amyotrophic Lateral Sclerosis Human PON1 Q192R(major allele is Q) RF Additive 2006 16822965
2106 Amyotrophic Lateral Sclerosis Human PON1 Q192R(major allele is Q) RF Dominant (RR and QR vs QQ) 2006 16822965
2390 Amyotrophic Lateral Sclerosis Human PON1 Q192R(major allele is Q) RF Recessive (RR vs other) 2006 16822965
2132 Amyotrophic Lateral Sclerosis Human PON2 C311S (major allele is S) RF Dominant (CC and CS vs SS) 2006 16822965
2046 Amyotrophic Lateral Sclerosis Human PON2 C311S (major allele is S) RF Additive 2006 16822965
2836 Parkinson disease Human positive family history of PD RF 1998 9778597
2631 Alzheimer's Disease Human PRAME RF APOE-?2 2021 33576571
1699 Alzheimer's Disease Human presence of one or more APOE ε4 alleles RF in females 2015 26343475
746 Alzheimer's Disease Human PRKAG3 PF APOE-?3 2021 33576571
2588 Alzheimer's Disease Human PRKAG3 RF APOE-?2 2021 33576571
3846 Parkinson disease Human PRKN RF 2021 34434164
1784 Parkinson disease Human PRKN RF Diagnosis 2021 33448283
3871 Parkinson disease Human PRKN RF Diagnosis 2021 33742109
1964 Creutzfeldt-Jakob disease Human PRNP RF 2020 32949544
2166 Creutzfeldt-Jakob disease Human PRNP RF BACE1?C-allele carriers 2012 22952813
3793 Creutzfeldt-Jakob disease Human PRNP RF Diagnosis 2021 33917419
3316 Creutzfeldt-Jakob disease Human PRNP RF Codon 129: Val homozygosity 1996 8707291
3878 Prion disease moose PRNP RF Diagnosis 2021 34346562
2918 Creutzfeldt-Jakob disease Human PRNP RF 2009 19081515
2884 Fatal familial insomnia (FFI) Human PRNP RF Diagnosis 2021 34667102
3004 Creutzfeldt-Jakob disease Human PRNP RF Diagnosis 2021 34831353
3794 Creutzfeldt-Jakob disease Human PRNP RF Diagnosis 2021 33917419
2882 Creutzfeldt-Jakob disease Human PRNP RF 2009 19081515
2974 Creutzfeldt-Jakob disease Human PRNP RF APOE?ε4 carriers 2011 21799773
2484 Creutzfeldt-Jakob disease Human PRNP RF 2012 22210626
2405 Creutzfeldt-Jakob disease Human PRNP RF BACE1?C-allele carriers 2012 22952813
3022 Alzheimer's Disease Human PRPH RF APOE-?2 2021 33576571
2161 Alzheimer's Disease Human PRSS48 RF APOE-?2 2021 33576571
2415 Alzheimer's Disease Human PS-1 RF APOE ε4 1999 10581373
3318 Alzheimer's Disease Human PS-1 RF 1997 9298817
3317 Alzheimer's Disease Human PS-1 RF 1996 8930979
3105 Alzheimer's Disease Human PS-2 RF APOE ε4 1999 10581373
3319 Alzheimer's Disease Human PSEN1 RF 2014 25104557
3320 Dementia with Lewy bodies Human PSEN1 RF 2016 27312774
3321 Alzheimer's Disease Human PSEN2 RF 2014 25104557
3928 Alzheimer's Disease Human PSEN2 RF Diagnosis 2022 36362122
3322 Alzheimer's Disease Human PSEN2 RF 2014 24927704
2233 Alzheimer's Disease Human PSMB7 RF APOE-?2 2021 33576571
3101 Alzheimer's Disease Human PTBP1 RF APOE-?3 2021 33576571
642 Alzheimer's Disease Human PTCH1 PF APOE-?2 2021 33576571
763 Alzheimer's Disease Human PTK2B PF National Alzheimer’s Coordinating Center (NACC) cohort 2018 30128317
3791 Amyotrophic lateral sclerosis,Parkinson disease Human PTPRT RF Diagnosis 2021 34707478
3324 Alzheimer's Disease Human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
3323 Alzheimer's Disease Human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
2261 Alzheimer's Disease Human PVRL2 RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 2018 29107063
2064 Alzheimer's Disease Human PVRL2 RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 2018 29107063
3325 Alzheimer's Disease Human PVRL2 RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
2114 Alzheimer's Disease Human PVRL2 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
1573 Alzheimer's Disease Human PVRL2 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 2018 29107063
3091 Alzheimer's Disease Human QPCTL RF APOE-?2 2021 33576571
4015 Huntington's disease (HD) Human RCAN1 RF Treatment RCAN1 knockdown rescued patient-derived medium spiny neurons (MSNs) 2023 38066314
3326 Alzheimer's Disease Human RCAN1 RF 2015 26497675
3327 Alzheimer's Disease Human RCAN1 RF 2015 26497675
2019 Alzheimer's Disease Human reduced folate carrier gene (RFC1) RF especially for female individuals 2009 18258338
2058 Alzheimer's Disease Human reduced folate carrier gene (RFC1) RF especially for female individuals 2009 18258338
700 Frontotemporal Lobar Degeneration Human RERG PF Discovery stage 2019 30739198
2378 Alzheimer's Disease Human RIPK2 RF APOE-?2 2021 33576571
3845 Parkinson disease Human RP11-305E6 RF 2021 34394198
833 Parkinson disease Human Saitohin PF 2015 25168738
3329 Parkinson disease Human Saitohin RF 2015 25168738
3330 Multiple System Atrophy Human SCA1 RF 2018 29715545
3331 Multiple System Atrophy Human SCA3 RF 2007 17133518
3003 Alzheimer's Disease Human SCAF11 RF APOE-?3 2021 33576571
558 Alzheimer's Disease Human SCAF11 PF APOE-?2 2021 33576571
1833 Lewy Body Disease Human SCARB2 RF Diagnosis 2021 34308904
553 Parkinson disease Human SEMA5A PF 2008 18950607
2308 Parkinson disease Human SEMA5A RF 2008 18950607
552 Parkinson disease Human SEMA5A PF 2008 18950607
2307 Parkinson disease Human SEMA5A RF 2008 18950607
798 Parkinson disease Human SEMA5A PF 2014 24706317
3019 Alzheimer's Disease Human SEMA6A RF APOE-?2 2021 33576571
3106 Alzheimer's Disease Human SERPINE1 RF women were at an increased risk over their male genotype counterparts 2017 28466654
2965 Alzheimer's Disease Human SERPINE1 RF women were at an increased risk over their male genotype counterparts 2017 28466654
2925 Alzheimer's Disease Human SERPINE2 RF APOE-?2 2021 33576571
2309 Alzheimer's Disease Human SFTPB RF APOE-?2 2021 33576571
2763 Alzheimer's Disease Human SH3D19 RF APOE-?3 2021 33576571
3052 Alzheimer's Disease Human SHARPIN RF 2019 31216982
3707 Alzheimer's Disease Human SIGLEC14 RF 2021 34208838
3332 Alzheimer's Disease Human SIRT2 RF 2014 24139700
2227 Alzheimer's Disease Human SIRT2 RF APOEε4 noncarriers 2014 24139700
595 Alzheimer's Disease Human SLC35G6 PF APOE-?2 2021 33576571
617 Alzheimer's Disease Human SLC35G6 PF APOE-?2 2021 33576571
1982 Parkinson disease Human SLC6A3 RF 2014 24211691
2051 Parkinson disease Human SLC6A3 RF 2014 24211691
770 Parkinson disease Human SLC6A3 PF 2014 24211691
1981 Parkinson disease Human SLC6A3 RF 2014 24211691
2050 Parkinson disease Human SLC6A3 RF 2014 24211691
578 Alzheimer's Disease Human SLC6A4/5-HTT PF S allele; AD with depression 2018 29703883
709 Progressive Supranuclear Palsy Human SLCO1A2 PF Meta-analysis 2018 29986742
2661 Amyotrophic Lateral Sclerosis Human SMN1 RF three copies 2006 16931506
2723 Amyotrophic Lateral Sclerosis Human SMN1 RF one or three copies of SMN1 gene were pooled 2006 16931506
3994 Spinal muscular atrophy (SMA) Human SMN1 RF Diagnosis 2023 37964750
2796 Amyotrophic Lateral Sclerosis Human SMN1 RF one copy 2006 16931506
2596 Amyotrophic Lateral Sclerosis Human SMN1 RF abnormal SMN1 copy numbers 2009 19922137
3333 Amyotrophic Lateral Sclerosis Human SMN2 RF 2011 22187232
3334 Parkinson disease Human SMPD1 RF 2015 26169695
2330 Alzheimer's Disease Human SMPD4 RF APOE-?3 2021 33576571
621 Alzheimer's Disease Human SMTNL1 PF APOE-?2 2021 33576571
733 Alzheimer's Disease Human SMTNL1 PF APOE-?3 2021 33576571
3838 Parkinson disease Human SNCA RF Diagnosis 2021 33994928
742 Dementia with Lewy bodies Human SNCA PF 2018 29263008
1972 Parkinson disease Human SNCA RF 2008 18404644
3129 Parkinson disease Human SNCA RF Diagnosis 2021 33705925
3843 Parkinson disease Human SNCA RF 2021 34394198
2047 Lewy Body Disease Human SNCA RF Diagnosis 2021 34308904
1971 Parkinson disease Human SNCA RF 2008 18404644
708 Parkinson disease Human SNCA PF Diagnosis 2021 34946922
3808 Lewy Body Disease Human SNCA RF Diagnosis 2021 33994928
3142 Parkinson disease Human SNCA RF 2016 27699750
3801 Lewy Body Disease Human SNCA RF 2021 34308904
2357 Parkinson disease Human SNCA RF 2012 22349157
2419 Alzheimer's Disease Human SNX27 RF APOE-?2 2021 33576571
3335 Amyotrophic Lateral Sclerosis Human SOD1 RF Expression of N19S-SOD1, an SOD1 Mutant 2005 16035108
3336 Amyotrophic Lateral Sclerosis Human SOD1 RF 2014 24591609
627 Alzheimer's Disease Human SOD1 gene PF After Bonferroni correction；additive model 2014 25440013
590 Alzheimer's Disease Human SOD1 gene PF Logistic regression analysis controlled for age, genderand APOE carrier status；recessive model 2014 25440013
589 Alzheimer's Disease Human SOD1 gene PF Logistic regression analysis controlled for age, genderand APOE carrier status；additive model 2014 25440013
637 Alzheimer's Disease Human SOD1 gene PF After Bonferroni correction；recessive model 2014 25440013
3760 Alzheimer's Disease Human SORCS3 RF 2021 32966694
3338 Alzheimer's Disease Human SORL1 RF 2009 19368828
3916 Alzheimer's Disease Human SORL1 RF Diagnosis 2022 35457051
3706 Alzheimer's Disease Human SORL1 RF 2021 34214049
2059 Alzheimer's Disease Human SORL1 RF adjusted for age and gender 2015 25881907
3908 Alzheimer's Disease Human SORL1 RF Diagnosis 2022 35456392
3108 Alzheimer's Disease Human SORL1 RF when restricting the analysis to the 205 cases with a positive family history 2016 26303663
2404 Alzheimer's Disease Human SORL1 RF 2014 24486888
2053 Alzheimer's Disease Human SORL1 RF adjusted foe age, gender, APOE 4 2015 25881907
3010 Alzheimer's Disease Human SORL1 RF 2016 26303663
3337 Alzheimer's Disease Human SORL1 RF with the A allele 2015 25450149
3915 Alzheimer's Disease Human SORL1 RF Diagnosis 2022 35457051
834 Alzheimer's Disease Human SORL1 PF 2008 18407551
823 Alzheimer's Disease Human SORL1 PF 2018 30009200
674 Alzheimer's Disease Human SORT1 PF 2016 27392867
3339 Amyotrophic Lateral Sclerosis Human SPG4 RF 2005 16009903
3672 Amyotrophic Lateral Sclerosis Human SPG7 mutations RF 2020 32447552
3340 Amyotrophic Lateral Sclerosis Human SQSTM1 RF 2012 22972638
3341 Alzheimer's Disease Human SREBF2 RF significant dual associations with LOAD pathological biomarkers and gene expression levels 2018 29503034
2529 Alzheimer's Disease Human STARD6 RF in combination with the APOE ε4 allele 2019 30666118
559 Alzheimer's Disease Human STEAP1B PF APOE-?2 2021 33576571
1987 Alzheimer's Disease Human STH RF especially in caucasian population, late‐onset AD subjects and studies with high quality 2017 28211174
2218 Parkinson disease Human STK39 RF 2015 26469904
2914 Amyotrophic Lateral Sclerosis Human STX12 RF 2013 27455347
775 Progressive Supranuclear Palsy Human STX6 PF Meta-analysis 2018 29986742
1917 Creutzfeldt-Jakob disease Human STX6(Syntaxin-6) RF 2020 32949544
3343 Amyotrophic Lateral Sclerosis Human SUN3, HUS1 RF 2014 25023141
3869 Parkinson disease Human SV2C RF Diagnosis 2021 33760272
3344 Alzheimer's Disease Human SYMPK RF eQTL(expression quantitative trait loci) analysis for the five SNPs closely related to AD 2018 30319691
2147 Alzheimer's Disease Human SYTL2 RF APOE-?3 2021 33576571
639 Alzheimer's Disease Human SYTL2 PF APOE-?2 2021 33576571
2376 Alzheimer's Disease Human SYTL2 RF APOE-?3 2021 33576571
596 Alzheimer's Disease Human SYTL2 PF APOE-?2 2021 33576571
650 Alzheimer's Disease Human SYTL2 PF APOE-?2 2021 33576571
2858 Alzheimer's Disease Human SYTL2 RF APOE-?2 2021 33576571
667 Alzheimer's Disease Human SYTL2 PF APOE-?2 2021 33576571
3346 Frontotemporal Lobar Degeneration Human TARDBP RF 2008 18505686
3345 Amyotrophic Lateral Sclerosis Human TARDBP RF 2014 25023141
3778 Amyotrophic Lateral Sclerosis Human TATA-box binding protein gene (TBP) RF Diagnosis 2021 33377399
2686 Frontotemporal Lobar Degeneration Human tau RF tau Genotype:H1H1;absence of APOE E2 allele 2002 12056929
3927 Alzheimer's Disease Human tau RF Diagnosis 2022 35348036
2846 Frontotemporal Lobar Degeneration Human tau RF tau Genotype:H1H2+H2H2;presence of APOE E2 allele 2002 12056929
3349 Progressive Supranuclear Palsy Human tau A0/A0 genotype RF 1998 9708963
3348 Progressive Supranuclear Palsy Human tau A0/A0 genotype RF 1998 9708963
3118 Frontotemporal Lobar Degeneration Human tau,APOE RF tau A3,APOE ε4 2001 11303757
2971 Alzheimer's Disease Human TBC1D4 RF APOE-?2 2021 33576571
2367 Alzheimer's Disease Human TCF7 RF APOE-?2 2021 33576571
3828 Parkinson disease Human TENM4 RF Diagnosis 2021 33185019
2535 Alzheimer's Disease Human TESK2 RF APOE-?2 2021 33576571
2310 Parkinson disease Human TFAM RF 2010 19925850
2381 Alzheimer's Disease Human TFAM RF 2008 18430995
2311 Alzheimer's Disease Human TGF-β1 RF without the ApoE ε4 allele;G 2016 26327336
2472 Alzheimer's Disease Human TGF-β1 RF Genotype AC 2016 26327336
2160 Alzheimer's Disease Human TGF-β1 RF without the ApoE ε4allele;C 2016 26327336
2270 Alzheimer's Disease Human TGF-β1 RF without the ApoE ε4 allele;AC 2016 26327336
2238 Alzheimer's Disease Human TGF-β1 RF allele C 2016 26327336
2081 Alzheimer's Disease Human TGF-β1 RF allele G 2016 26327336
2229 Alzheimer's Disease Human TGF-β1 RF Genotype TG 2016 26327336
2713 Alzheimer's Disease Human TGF-β1 RF AC+ CC vs AA 2016 26327336
2363 Alzheimer's Disease Human TGF-β1 RF without the ApoE ε4 allele;TG 2016 26327336
3143 Parkinson disease Human TH RF 2010 20809526
3350 Alzheimer's Disease Human THBS2 RF 2017 29177109
3351 Dementia with Lewy bodies Human The apolipoprotein E (APOE) ε4 allele RF 2011 21552550
2490 Alzheimer's Disease Human THG1L RF APOE-?2 2021 33576571
2481 Amyotrophic Lateral Sclerosis Human TIAM1 RF 2010 20801718
3352 Amyotrophic Lateral Sclerosis Human TIAM1 RF 2014 25023141
643 Alzheimer's Disease Human TLR2 PF 2015 26738351
835 Alzheimer's Disease Human TLR4 PF when incorporated into a haplotype with rs10759930, the strongest association was detected 2012 22272615
3798 Frontotemporal Lobar Degeneration Human TMEM106B RF Diagnosis 2021 33314436
2479 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association; Denotes the associated SNP’s from the GWAS. 2011 21257233
662 Frontotemporal Lobar Degeneration Human TMEM106B PF GRN carriers 2014 25085782
3814 Lewy Body Disease Human TMEM106B RF Diagnosis 2021 34854996
2553 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association; Denotes the associated SNP’s from the GWAS;Denotes the associated SNP’s from the ALS GWAS 2011 21257233
2607 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association; Denotes the associated SNP’s from the GWAS. 2011 21257233
2512 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association 2011 21257233
2317 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association 2011 21257233
2235 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 1 SNP association 2011 21257233
2244 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association 2011 21257233
2549 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association 2011 21257233
837 Frontotemporal Dementia Human TMEM106B PF C9ORF72 expansion carriers;Cohort 1 – controls and C9ORF72 repeat expansion carriers (FTD, FTD/MND, and MND, or other diagnosis) 2014 24385136
3673 Frontotemporal Lobar Degeneration Human TMEM106B RF FTLD with TAR DNA-binding protein (TDP-43) inclusions 2010 20154673
668 Frontotemporal Lobar Degeneration Human TMEM106B PF for SNPs on chromosomes 1, 8, 10 and 11 genotyped 2011 21257233
1849 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 1 SNP association 2011 21257233
836 Frontotemporal Dementia Human TMEM106B PF C9ORF72 expansion carriers;Cohort 1 – controls and C9ORF72 repeat expansion carriers (FTD, FTD/MND, and MND, or other diagnosis) 2014 24385136
2318 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association; Denotes the associated SNP’s from the GWAS. 2011 21257233
2489 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association 2011 21257233
3353 Alzheimer's Disease Human TMEM106B RF APOE interact 2014 24166182
3777 Amyotrophic Lateral Sclerosis Human TMEM106B RF Diagnosis 2021 33314436
2942 Frontotemporal Lobar Degeneration Human TMEM106B RF for chromosome 9 SNP association 2011 21257233
1830 Lewy Body Disease Human TMEM175 RF Diagnosis 2021 34308904
3354 Alzheimer's Disease Human TMP21 RF 2018 28233271
3733 Alzheimer's Disease Human TNFRSF13C RF 2021 33687622
3355 Alzheimer's Disease Human TNFRSF1A, CDH1, CASP7, LRP1B and TG RF 2015 26621834
1968 Multiple System Atrophy Human TNF-α RF genotype 2018 29251119
2358 Multiple System Atrophy Human TNF-α RF allele 2018 29251119
1329 Alzheimer's Disease Human TNF-α RF in the APOE epsilon4 non-carriers 2008 18396294
1334 Alzheimer's Disease Human TNF-α RF in the APOE epsilon4 non-carriers 2008 18396294
2770 Alzheimer's Disease Human TNF-α -308 RF AA vs. GG 2015 25647294
2452 Alzheimer's Disease Human TNF-α -308 RF AA vs. AG 2015 25647294
2766 Alzheimer's Disease Human TNF-α -308 RF AA vs. AG + GG (recessive) 2015 25647294
2104 Alzheimer's Disease Human TNF-α -308 RF AA + AG vs. GG (dominant) 2015 25647294
2295 Alzheimer's Disease Human TNF-α -308 RF A vs. G allele 2015 25647294
3358 Alzheimer's Disease Human TOMM40 RF 2018 30443289
2885 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
690 Alzheimer's Disease Human TOMM40 PF the association between the Asian and Caucasian groups was significantly different 2016 26795201
1589 Alzheimer's Disease Human TOMM40 RF using Cox regression、Dataset：HRS（Health and Retirement Study） 2018 29107063
2896 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
1673 Alzheimer's Disease Human TOMM40 RF using Cox regression、Dataset：CHS（Cardiovascular Health Study） 2018 29107063
2184 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
2565 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：FHS(Framingham Heart Study) 2018 29107063
1621 Alzheimer's Disease Human TOMM40 RF using Cox regression、Dataset：FHS（Framingham Heart Study） 2018 29107063
2115 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
3696 Alzheimer's Disease Human TOMM40 RF 2021 34336000
3357 Alzheimer's Disease Human TOMM40 RF 2018 29797398
1588 Alzheimer's Disease Human TOMM40 RF using Cox regression、Dataset：HRS（Health and Retirement Study） 2018 29107063
2935 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
2445 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
2564 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：CHS( Cardiovascular Health Study) 2018 29107063
3839 Parkinson disease Human TOMM40 RF carriage of shorter '523' alleles 2021 34234128
2440 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
2862 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：LOADFS(Late Onset Alzheimer's Disease Family Study ) 2018 29107063
3356 Alzheimer's Disease Human TOMM40 RF 2018 29797398
2964 Alzheimer's Disease Human TOMM40 RF APOE ε4+ 2021 32725468
894 Parkinson disease Human TOMM40 PF carriage of longer '523' alleles 2021 34234128
2116 Alzheimer's Disease Human TOMM40 RF using logistic regression、Dataset：HRS(Health and Retirement Study) 2018 29107063
2735 Alzheimer's Disease Human TOMM40 RF the association between the Asian and Caucasian groups was significantly different 2016 26795201
2585 Alzheimer's Disease Human TOX RF APOE-?2 2021 33576571
1488 Frontotemporal Dementia Human TP53 RF Diagnosis 2021 32972771
594 Alzheimer's Disease Human TRAF3IP2 PF APOE-?2 2021 33576571
739 Alzheimer's Disease Human TRAF3IP2 PF APOE-?3 2021 33576571
3011 Frontotemporal Dementia Human TREM2 RF 2013 23800361
2559 Frontotemporal Lobar Degeneration Human TREM2 RF CT vs. CC 2018 29322490
2693 Parkinson disease Human TREM2 RF 2013 23800361
3363 Frontotemporal Lobar Degeneration Human TREM2 RF Compound heterozygosity 2018 29557178
2427 Alzheimer's Disease Human TREM2 RF the T allele of the rs75932628 variant of TREM2 2015 25260849
3076 Alzheimer's Disease Human TREM2 RF APOE-?2 2021 33576571
2704 Alzheimer's Disease Human TREM2 RF 2015 25936935
2849 Alzheimer's Disease Human TREM2 RF 2013 23855982
2678 Frontotemporal Lobar Degeneration Human TREM2 RF T vs. G 2018 29322490
3360 Alzheimer's Disease Human TREM2 RF 2018 29794134
2383 Alzheimer's Disease Human TREM2 RF 2014 24439484
3365 Frontotemporal Lobar Degeneration Human TREM2 RF Compound heterozygosity 2018 29557178
2933 Alzheimer's Disease Human TREM2 RF 2014 24041969
2680 Frontotemporal Lobar Degeneration Human TREM2 RF GT vs. GG 2018 29322490
2907 Alzheimer's Disease Human TREM2 RF APOE-?3 2021 33576571
2558 Frontotemporal Lobar Degeneration Human TREM2 RF CT+TT vs. CC 2018 29322490
3362 Frontotemporal Lobar Degeneration Human TREM2 RF A large consanguineous Colombian family segregating autosomal recessive FTLD 2013 23582655
2609 Amyotrophic Lateral Sclerosis Human TREM2 RF 2014 24535663
2703 Alzheimer's Disease Human TREM2 RF 2015 26037549
2928 Alzheimer's Disease Human TREM2 RF 2013 23380991
3367 Frontotemporal Lobar Degeneration Human TREM2 RF Homozygosity 2018 29557178
2617 Frontotemporal Lobar Degeneration Human TREM2 RF T vs. C 2018 29322490
2816 Dementia with Lewy bodies Human TREM2 RF 2017 28003435
2552 Frontotemporal Lobar Degeneration Human TREM2 RF carrier T vs. C 2018 29322490
3359 Alzheimer's Disease Human TREM2 RF 2018 30222607
3012 Frontotemporal Lobar Degeneration Human TREM2 RF 2013 23800361
3364 Frontotemporal Lobar Degeneration Human TREM2 RF 2018 29557178
2932 Alzheimer's Disease Human TREM2 RF 2014 24041969
2679 Frontotemporal Lobar Degeneration Human TREM2 RF carrier T vs. G 2018 29322490
2534 Alzheimer's Disease Human TREM2 RF 2014 25160042
3361 Frontotemporal Dementia Human TREM2 RF 2018 29557178
3366 Frontotemporal Lobar Degeneration Human TREM2 RF 2018 29557178
2681 Frontotemporal Lobar Degeneration Human TREM2 RF GT+TT vs. GG 2018 29322490
2958 Multiple System Atrophy Human TREM2 p.R47H RF patients with pathologically confirmed MSA 2018 30109269
1813 Multiple System Atrophy Human TREM2 p.R47H RF patients with clinically diagnosed MSA 2018 30109269
2893 Multiple System Atrophy Human TREM2 p.R47H RF patients with clinically diagnosed MSA 2018 30109269
1817 Multiple System Atrophy Human TREM2 p.R47H RF patients with pathologically confirmed MSA 2018 30109269
811 Alzheimer's Disease Human TREML2 PF 2014 24439484
3884 Tuberous sclerosis complex Human TSC2 RF Diagnosis 2021 33225634
2804 Alzheimer's Disease Human TTC38 RF APOE-?2 2021 33576571
2359 Alzheimer's Disease Human TTLL13 RF APOE-?2 2021 33576571
2328 Alzheimer's Disease Human TTLL13 RF APOE-?2 2021 33576571
2987 Alzheimer's Disease Human TXNRD3NB RF APOE-?2 2021 33576571
3368 Alzheimer's Disease Human TYROBP RF 2016 27658901
2031 Frontotemporal Lobar Degeneration Human UBAP1 RF Haplotype:TGC 2009 19217189
2069 Frontotemporal Lobar Degeneration Human UBAP1 RF Haplotype:TGC 2009 19217189
2068 Frontotemporal Lobar Degeneration Human UBAP1 RF Haplotype:GCT 2009 19217189
2232 Alzheimer's Disease Human UBASH3B RF APOE-?2 2021 33576571
2173 Parkinson disease Human UCHL1 RF 2012 22839974
738 Alzheimer's Disease Human UGT3A1 PF APOE-?3 2021 33576571
663 Alzheimer's Disease Human UGT3A1 PF APOE-?2 2021 33576571
2099 Frontotemporal Lobar Degeneration Human UNC13A RF Discovery stage 2019 30739198
2171 Frontotemporal Lobar Degeneration Human UNC13A RF Replication stage 2019 30739198
1904 Amyotrophic Lateral Sclerosis Human UNC13A RF especially in Caucasian and European subjects 2019 31201598
3370 Amyotrophic Lateral Sclerosis zebrafish VAPB RF 2013 23446633
3369 Amyotrophic Lateral Sclerosis Mice VAPB RF 2013 23446633
3762 Alzheimer's Disease Human vascular apoE RF 2021 33321072
2112 Parkinson disease Human VEGF RF 2016 27481110
2020 Frontotemporal Lobar Degeneration Human VEGF RF A allele 2008 18729809
2049 Frontotemporal Lobar Degeneration Human VEGF RF A allele 2008 18729809
3069 Progressive Supranuclear Palsy Human VEGF haplotypes(AGG) RF 2010 20413880
3852 Parkinson disease Human vitamin D Receptor(VDR) RF 2021 34365149
3854 Parkinson disease Human vitamin D Receptor(VDR) RF 2021 34365149
3853 Parkinson disease Human vitamin D Receptor(VDR) RF 2021 34365149
3371 Parkinson disease Human VMAT2 RF 2016 27137201
3020 Alzheimer's Disease Human VSTM5 RF APOE-?2 2021 33576571
3870 Parkinson disease Human WBSCR17 RF Diagnosis 2021 33760272
2450 Amyotrophic Lateral Sclerosis Human WDR49 RF 2013 27455347
797 Alzheimer's Disease Human WDR60 PF APOE-?3 2021 33576571
622 Alzheimer's Disease Human YDJC PF APOE-?2 2021 33576571
2182 Alzheimer's Disease Human ZAR1 RF APOE-?3 2021 33576571
2638 Alzheimer's Disease Human ZAR1 RF APOE-?2 2021 33576571
584 Alzheimer's Disease Human ZCCHC9 PF APOE-?2 2021 33576571
740 Parkinson disease Human ZFP64/TSHZ2 PF Diagnosis 2021 33510632
3779 Amyotrophic Lateral Sclerosis Human ZNF512B RF Prognosis 2021 33387304
2616 Alzheimer's Disease Human ZNF596 RF APOE-?2 2021 33576571
2599 Alzheimer's Disease Human ZNF778 RF APOE-?2 2021 33576571
2385 Alzheimer's Disease Human ZNF804B RF APOE-?3 2021 33576571
2493 Alzheimer's Disease Human ZNF90 RF APOE-?2 2021 33576571
2451 Amyotrophic Lateral Sclerosis Human ZSCAN5B RF 2013 27455347
2775 Tourette Syndrome Human ADHD family history positive RF 2010 20654033
3442 Tourette Syndrome Human family history RF 2012 22738448
2300 Amyotrophic Lateral Sclerosis Human family history of ALS RF Diagnosis 2021 33563800
3443 Alzheimer's Disease Human family history of cardiovascular diseases RF 2014 24596166
3444 Dementia with Lewy bodies Human Family history of dementia RF 2006 16801670
2705 Alzheimer's Disease Human Family history of dementia (FH) RF 2016 26531229
3445 Alzheimer's Disease Human family history of dementia (within third-degree relatives) RF people with mild memory impairment/no dementia (MMI/ND) 2011 21205364
2817 Parkinson disease Human family history of PD RF 2020 32943485
2461 Tourette Syndrome Human first-degree relatives RF 2015 26083307
1631 Frontotemporal Dementia Human first-degree relatives RF First-degree relatives(parents) 1998 9633692
2743 Alzheimer's Disease Human Having a first-degree relative or a parent with dementia RF 2016 26531229
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