| RF_ID |
Disease Name |
2ndClass |
3rdClass |
4thClass |
Species |
RF_Name |
Association |
Condition |
PMID |
| 876 |
Alzheimer's Disease |
Sign or Symptom |
|
|
mice |
restoring vascular functions(microvascular injury) |
PF |
|
33892818 |
| 3757 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
progressive brain energy decline |
RF |
|
33186671 |
| 3899 |
Alzheimer's Disease |
Sign or Symptom |
|
|
mice |
Endogenous melatonin reduction (EMR) |
RF |
|
35619714 |
| 1664 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
presence of cirrhosis |
RF |
infection with hepatitis C virus (HCV) |
36872452 |
| 2970 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
tremor |
RF |
even 5 to 10 years before diagnosis |
36342675 |
| 2002 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
gastrointestinal disorders |
RF |
|
36342675 |
| 1994 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
gastrointestinal disorders |
RF |
|
36342675 |
| 2012 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
skin disorders |
RF |
|
36342675 |
| 1902 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
skin disorders |
RF |
|
36342675 |
| 2018 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
changes of skin sensation |
RF |
|
36342675 |
| 1950 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
migraine |
RF |
|
36342675 |
| 2150 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
sleep apnea |
RF |
|
37185062 |
| 2089 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
sleep apnea |
RF |
|
36342675 |
| 1792 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
sleep apnea |
RF |
|
37269705 |
| 2525 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
anosmia |
RF |
|
36342675 |
| 1578 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
gait speed |
RF |
|
36912851 |
| 1642 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Exhaustion |
RF |
|
36912851 |
| 918 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
absence of impairment with prior daily functioning |
PF |
|
37454558 |
| 3940 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
impaired patient ability in the use of telephone |
RF |
|
37454558 |
| 3939 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
hearing impairment |
RF |
|
37454558 |
| 1420 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
limitation in physical function |
RF |
Main exposure variables were difficulty with activities of daily living, mobility, large muscle strength, gross motor and upper limb activities. |
35441254 |
| 3909 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Gait and/or balance disturbances |
RF |
|
37386779 |
| 1662 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Suicide |
RF |
|
33326004 |
| 1681 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
anemia |
RF |
|
24419041 |
| 1433 |
Amyotrophic Lateral Sclerosis |
Sign or Symptom |
|
|
Human |
AVM(arteriovenous malformation) |
RF |
all |
26260352 |
| 1436 |
Amyotrophic Lateral Sclerosis |
Sign or Symptom |
|
|
Human |
AVM(arteriovenous malformation) |
RF |
cerebral vessels |
26260352 |
| 2426 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Blood-Stasis |
RF |
|
33907404 |
| 2152 |
Amyotrophic Lateral Sclerosis |
Sign or Symptom |
|
|
Human |
bulbar onset |
RF |
|
33563800 |
| 3563 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
cerebral hypoperfusion |
RF |
|
23295908 |
| 3771 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
chronic corticosterone consumption |
RF |
|
34923495 |
| 3403 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
constipation |
RF |
colorectal cancer and AD have similar epidemiologic feature |
30323761 |
| 3876 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
constipation |
RF |
PD patients with constipation have a higher incidence of depression |
33564494 |
| 3404 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
constipation |
RF |
the relative risk was higher for men than for women |
27234704 |
| 1495 |
Dementia with Lewy bodies |
Sign or Symptom |
|
|
Human |
Cortical thinning |
RF |
patients with idiopathic REM sleep behavior disorder (iRBD) |
31069252 |
| 1519 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
dipstick-positive proteinuria |
RF |
Older adults |
31021467 |
| 2550 |
Amyotrophic Lateral Sclerosis |
Sign or Symptom |
|
|
Human |
dysarthria |
RF |
|
33563800 |
| 2322 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
dyspepsia |
RF |
|
32943485 |
| 3842 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Early morning off (EMO) |
RF |
people diagnosed with Parkinson's disease (PwPD) |
34421569 |
| 3441 |
Tourette Syndrome |
Sign or Symptom |
|
|
Human |
family control and fetal anoxia |
RF |
|
22738448 |
| 1646 |
Tourette Syndrome |
Sign or Symptom |
|
|
Human |
Febrile convulsions(FC) |
RF |
|
24907027 |
| 3946 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Frailty |
RF |
|
36912851 |
| 1542 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Frailty |
RF |
|
36912851 |
| 3754 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Frailty |
RF |
These risk effects were present and similar in both carriers and non-carriers of the?APOE?ε4 allele. |
33188132 |
| 3740 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Frailty |
RF |
|
33586645 |
| 1574 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Freezing of gait (FOG) |
RF |
|
36166069 |
| 3868 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Freezing of gait (FOG) |
RF |
|
33763009 |
| 2421 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Hearing loss (HL) |
RF |
|
35587456 |
| 1368 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Hearing loss (HL) |
RF |
|
35532912 |
| 1473 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Hearing loss (HL) |
RF |
increase the risk of dementia |
34305572 |
| 1909 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Hearing loss (HL) |
RF |
|
36342675 |
| 1548 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Hearing loss (HL) |
RF |
|
32959064 |
| 3772 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
hemodynamic deficits |
RF |
|
34953303 |
| 3584 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
high blood lipids and insulin resistance |
RF |
|
21033433 |
| 3888 |
Tuberous sclerosis complex |
Sign or Symptom |
|
|
Human |
high reported seizure frequency(HRSF) |
RF |
|
33225634 |
| 3456 |
Tuberous sclerosis complex |
Sign or Symptom |
|
|
Human |
high tuber burden |
RF |
|
28721058 |
| 3472 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Insulin resistance (IR) |
RF |
|
20031276 |
| 3735 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Insulin resistance (IR) |
RF |
In non-diabetic AD |
33597002 |
| 3597 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Insulin resistance (IR) |
RF |
|
30112972 |
| 3890 |
Tuberous sclerosis complex |
Sign or Symptom |
|
|
Human |
intellectual disability(ID) |
RF |
|
33225634 |
| 3729 |
Alzheimer's Disease |
Sign or Symptom |
|
|
mice |
liver dysfunction |
RF |
|
33681678 |
| 2731 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
lobar Cerebral microbleeds (MBs) |
RF |
|
33782518 |
| 3861 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
long-standing cervical dystonia |
RF |
|
34015516 |
| 2979 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
medication difficulty |
RF |
|
33037589 |
| 2615 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
medication difficulty |
RF |
|
33037589 |
| 1742 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
olfactory dysfunction |
RF |
|
34014391 |
| 3489 |
Parkinson disease |
Sign or Symptom |
|
|
rat |
Peripheral inflammation |
RF |
|
20584104 |
| 2425 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Phlegm-Dampness |
RF |
|
33907404 |
| 1886 |
Tuberous sclerosis complex |
Sign or Symptom |
|
|
Human |
prolonged duration of IS |
RF |
per 1-month interval |
16043792 |
| 1881 |
Tuberous sclerosis complex |
Sign or Symptom |
|
|
Human |
prolonged time from treatment initiation until the cessation of IS |
RF |
|
16043792 |
| 1379 |
Amyotrophic Lateral Sclerosis |
Sign or Symptom |
|
|
Human |
SAH(subarachnoid haemorrhage) |
RF |
Transient ischaemic attack |
26260352 |
| 3682 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
severe hypoglycaemia |
RF |
|
32870568 |
| 3504 |
Tuberous sclerosis complex |
Sign or Symptom |
|
|
Human |
severe mental retardation |
RF |
|
28721058 |
| 3829 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Vestibular dysfunction |
RF |
|
32942935 |
| 1688 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Sleep disturbance |
RF |
Model 2: Main effects adjusted for sex, education, age, and race. |
29077487 |
| 1687 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Sleep disturbance |
RF |
Model 3: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status |
29077487 |
| 1560 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Sleep disturbance |
RF |
|
35013056 |
| 1696 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Sleep disturbance |
RF |
Model 1: Main effect unadjusted |
29077487 |
| 1686 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Sleep disturbance |
RF |
Model 4: Main effects adjusted for adjusted for sex, age, education, race, e4 carrier status, the presence of hypertension and hypercholesterolemia |
29077487 |
| 4039 |
Alzheimer's Disease |
Sign or Symptom |
|
|
Human |
Sleep disturbance |
RF |
|
29077487 |
| 1514 |
Parkinson disease |
Sign or Symptom |
|
|
Human |
Sleep disturbance |
RF |
|
35013056 |
