Saleem Iqbal
Position: Senior Postdoctoral Fellow
E-mail: saleemiqbal550@gmail.com, saleem.iqbal.1@ulaval.ca
Research Interests: X-Ray Crystallography, Systems Pharmacology, Structural and Translational Bioinformatics, Oncology, Neurobiology, Drug Discovery, Protein folding, Biomarkers- non-coding ncRNAs, personalized medicine
Biography
Dr. Saleem Iqbal is an award recipient for Structural Virology-SARS-CoV-2 project. He currently works as Senior Postdoctoral fellow here at Institutes for Systems Genetics, Frontiers Science Centre for Disease-related Molecular Network, West China Hospital. His current work focusses on AI guided drug discovery therapeutics and multi-omics of Oncology. As a Neuroscientist, Biophysicist, Crystallographer and structural bioinformatician, he uses his expertise in protein folding, System Biology, Molecular modelling, Ligand design, SAR, Molecular dynamics simulations to understand and study important human diseases such as Alzheimer’s Disease, Parkinson’s disease, COVID-19 therapeutics and Cancer at different interfaces. He has been Visiting Professor at the School of Pharmaceutical Education and Research at Jamia Hamdard University and School of Biotechnology at Bennett University. He earned his Ph.D., in Bioinformatics-Crystallography and Biophysics-Interdisciplinary from prestigious Biophysics Department, University of Madras- which is home of pioneering discoveries viz., Triple Helical Structure of Collagen, the famous Ramachandran plot for the protein structure and application of anomalous scattering methods. He worked as Research Associate for Prostate Cancer therapeutics at Bioinformatics Lab funded by Department of Biotechnology, India. He also worked as Senior Research Associate at Prestigious Department of Computational and Data Sciences (CDS), Indian Institute of Science, Bangalore., where his publication on secretase biology "Discovery of microRNAs as biomarkers targeting the delta secretases" is a key finding in Alzheimer’s Disease. He is recipient of various travel awards. Dr. Saleem Iqbal major projects have been funded by Alzheimer’s Association, EMBO, DBT and CIHR.
Activities
Work Experience and Employment
Institute of System Genetics, West China Hospital
2024-08 to Present |
Postdoctoral Fellow. (Systems Oncology)
Indian Institute of Sciences: Bangalore, Karnataka, IN
2023-06 to 2024-08 | Research Associate- Systems Biology (Department of Computational & Data Sciences (CDS), Indian Institute of Sciences (IISc).
Centre de recherche du CHUL-Faculty de Medicine : Quebec, QC, CANADA
2021-09 to 2023-06 | Senior Post-doctoral Fellow (Structural Virology of SARS-CoV-2 therapeutics)
Indian Institute of Sciences: Bangalore, Karnataka, IN
2020-04 to 2021-09-12 | Research Associate-Systems Medicine (Bioinformatics Centre, CDS & Supercomputer Education and Research Centre)
Jamia Hamdard: NEW DELHI, IN
2018-12 to 2020-03| Prostate Cancer therapeutics
Research Associate (Molecular medicine)
Education and qualifications
UNIVERSITY OF MADRAS: CHENNAI, TAMIL NADU, IN
2015-01-10 to 2019-08-05 | Ph.D. in BIOINFORMATICS- CRYSTALLOGRAPHY & BIOPHYSICS-Interdisciplinary)
UNIVERSITY OF MADRAS: CHENNAI, TAMIL NADU, IN
2011-06-05 to 2013-06-03 | M S BIOINFORMATICS (DEPARTMENT OF BIOCHEMISTRY)
Professional Research and Achievements
Visiting Professor
Bennett University: Greater Noida, NEW DELHI, IN
2020-01 to 2021-09 | (SCHOOL OF ENGINEERING AND APPLIED SCIENCES-BIOTECHNOLOGY)
Professional Teaching
Visiting Professor
Jamia Hamdard University: NEW DELHI, IN
2019-2020 | (SCHOOL OF PHARMACEUTICAL EDUCATION AND RESEARCH (SPER).
Professional Mentorship
Mentored 10 PhD Students and various Masters students in Bioinformatics and (molecular simulations of biological macromolecules of high scientific interests) during 2019-2023 at (CASCB) University of Madras, (SPER) Jamia Hamdard University, School of Biotechnology, Bennett University & Chu de Quebec Hospital, Canada.
Funding (1)
‘Innovative therapeutic approaches for the 2019-novel coronavirus’
2021-09 to 2023-09 | Received Prestigious CIHR Award.
Canadian Institutes of Health Research (ON, CA)
Funding (2)
Department of Biotechnology-(DBT-RA) Fellowship Award
2018 to 2020 | Received Research Associateship Award for Drug Discovery therapeutics
Publications
Deep Drug Discovery of Mac Domain of SARS-CoV-2 (WT) Spike Inhibitors: Using Experimental ACE2 Inhibition TR-FRET Assay, Screening, Molecular Dynamic Simulations and Free Energy Calculations
Bioengineering
2023-08-14 | Journal article| First and Co-Corresponding author.
DOI: 10.3390/bioengineering10080961
Contributors: Saleem Iqbal; Sheng-Xiang Lin
Design, crystal structure determination, molecular dynamic simulation and MMGBSA calculations of novel p38-alpha MAPK inhibitors for combating Alzheimer’s disease
Journal of Biomolecular Structure and Dynamics
2022-09-02 | Journal article | First author
DOI: 10.1080/07391102.2021.1877197
Contributors: Saleem Iqbal; Raju Potharaju; S. Naveen; N. K. Lokanath; Arasambattu K. Mohanakrishnan; Krishnasamy Gunasekaran
Insights in the structural understanding of amyloidogenicity and mutation-led conformational dynamics of amyloid beta (Aβ) through molecular dynamics simulations and principal component analysis
Journal of Biomolecular Structure and Dynamics
2022-08-13 | Journal article | First author
DOI: 10.1080/07391102.2021.1871955
Contributors: Saleem Iqbal, Sriram Srinivasa Raghavan; Niraikulam Ayyadurai; Krishnasamy Gunasekaran
In Silico Identification of Potential Inhibitors of the SARS-CoV-2 Nucleocapsid Through Molecular Docking-Based Drug Repurposing
Dr. Sulaiman Al Habib Medical Journal
2022-05-31 | Journal article | First and Corresponding author.
DOI: 10.1007/s44229-022-00004-z
Contributors: Ruksar A; Iqbal S; Rauf S; Heena A, Lata V; Shkir M
Heliyon
2021-12 | Journal article | First and Co-Corresponding author
DOI: 10.1016/j.heliyon.2021.e08502
Contributors: Saleem Iqbal; Md. Zubbair Malik; Debnath Pal
Development of a Lung Cancer Model in Wistar Rat and In Silico Screening of its Biomarkers
Current Computer-Aided Drug Design
2021-07-15 | Journal article
DOI: 10.2174/1574893615999200505075713
Contributors: Nisat Alam; Hasina Najnin; Maidul Islam; Saleem Iqbal; Rana Zaidi
Divergent Synthesis and Evaluation of the in vitro Cytotoxicity Profiles of 3,4‐Ethylenedioxythiophenyl‐2‐propen‐1‐one Analogues
ChemMedChem
2019-08-06 | Journal article
CONTRIBUTORS : Jayachandran Karunakaran; Nachiappan Dhatchana Moorthy; Somenath Roy Chowdhury; Saleem Iqbal; Hemanta K. Majumder; Krishnasamy Gunasekaran; Elangovan Vellaichamy; Arasambattu K. Mohanakrishnan
SAUSSUREA LAPPA AND SAFFRON‐POLYPHENOLS AS SOURCE FOR ALZHEIMER'S DISEASE THERAPEUTICS
Alzheimer's & Dementia
2019-07 | Journal Article-Proceedings | First and Corresponding author
DOI: 10.1016/j.jalz.2019.06.1230
Contributors: Saleem Iqbal
Crystal structures and Hirshfeld surface analyses of 4,4′-{[1,3-phenylenebis(methylene)]bis(oxy)}bis(3-methoxybenzaldehyde) and 4,4′-{[(1,4-phenylenebis(methylene)]bis(oxy)}bis(3-methoxybenzaldehyde)
Acta Crystallographica Section E Crystallographic Communications
2019-06-01 | Journal article | First Author
DOI: 10.1107/s2056989019006662
Identification of potential PKC inhibitors through pharmacophore designing, 3D-QSAR and molecular dynamics simulations targeting Alzheimer’s disease
Journal of Biomolecular Structure and Dynamics
2018-11-18 | Journal article; | First and Corresponding author
DOI: 10.1080/07391102.2017.1406824
Contributors: Saleem Iqbal; Dhanabalan Anantha Krishnan; Krishnasamy Gunasekaran
Novel isothiacalothrixin B analogues exhibit cytotoxic activity on human colon cancer cells in vitro by inducing irreversible DNA damage
PLOS ONE
2018-09-06 | Journal article ; DOI: 10.1371/journal.pone.0202903
CONTRIBUTORS : Dhatchana Moorthy N, Muthu Ramalingam B, Iqbal S, Mohanakrishnan AK, Gunasekaran K, Vellaichamy E.
poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3b cell line
European Journal of Nanomedicine
2017-10-26 | Journal article; DOI: 10.1515/ejnm-2017-0013
THERAPEUTIC ROLE OF QUERCETIN IN TREATING TYPE 3 DIABETES (T3D) AS EVIDENCED BY SYSTEM PHARMACOLOGY
Alzheimer's & Dementia | First and Corresponding author
2017-07 | Journal article ; DOI: 10.1016/j.jalz.2017.06.711
Contributors: Saleem Iqbal
Antioxidant and Anticancer Activities of Methanol Extract of Seeds of Datura stramonium l
Free Radicals and Antioxidants 7(2), 184–189. | First and Corresponding author
2017-07 | Journal article | https://doi.org/10.5530/fra.2017.2.28
Contributors: Saleem Iqbal; Sivaraj C; Gunasekaran K.
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
Journal of Médicinal Chemistry;
2017-07 | Journal article; DOI: 10.1016/j.jalz.2017.06.711
Contributors: Muthu Ramalingam B, Dhatchana Moorthy N, Chowdhury SR, Mageshwaran T, Vellaichamy E, Saha S, Ganesan K, Rajesh BN, Iqbal S, Majumder HK, Gunasekaran K, Siva R, Mohanakrishnan AK.
Book Chapter(s)
microRNA Isolation, Expression Profiling, and Target Identification for Neuroprotection Alzheimer’s Disease. In: Ray, S.K. (eds) Neuroprotection. Methods in Molecular Biology, vol 2761. Humana, New York, NY.
2024 | Journal- Neuroprotection. Methods in Molecular Biology | First Author
https://doi.org/10.1007/978-1-0716-3662-6_20
Contributors: Saleem Iqbal; Debnath Pal
Scientific Presentations
❖ Presented a Poster entitled “Network-based identification of miRNAs and transcription factors and in silico drug screening targeting δ-secretase involved in Alzheimer's disease” at Alzheimer’s Association International Conference (AAIC), July 31st -Aug 04, 2022, San Diego, California, USA.
❖ Presented a Poster entitled “Efficacy in binding mechanism of staurosporine inhibitors against Cyclin dependent kinases using molecular modelling and dynamic simulations approaches” at Alzheimer’s Association International Conference (AAIC), 22-28 July 2016 Toronto, CANADA.
❖ Presented a Poster entitled: “Therapeutic role of quercetin in treating Type 3 Diabetes(T3D) as evidenced by System Pharmacology” at Alzheimer’s Related Disorders Society Of India, on 10- 11 December, 2016.
❖ Presented a poster entitled “Comparision of Antioxidant activities of Saussurea lappa and Datura Stramonium” - International Conference on Medicinal plants and herbal drugs for Human Welfare (ICMP-2015).
❖ Presented a poster in Current Trends in Drug discovery and research (CTDDR-2016), head at lucknow (25th -28th feb 2016) India .
❖ Presented a poster entitled “Molecular Docking Studies and 3DQSAR modeling of Piperazine Derivatives of Xanthone as Adrenergic inhibitors for Cardiovascular Diseases” - International Congress on “Friedreich’s Ataxia and DNA Structure in Health & Disease- (DSHD 2015)