13 Sultana A, Alam MS, Liu X, Sharma R, Singla RK, Gundamaraju R, Shen B. Single-cell RNA-seq analysis to identify potential biomarkers for diagnosis, and prognosis of non-small cell lung cancer by using comprehensive bioinformatics approaches. Transl Oncol. 2022 Nov 16;27:101571. doi: 10.1016/j.tranon.2022.101571. Epub ahead of print. PMID: 36401966.

12 Lin Y, Qi X, Chen J, Shen B. Multivariate competing endogenous RNA network characterization for cancer microRNA biomarker discovery: a novel bioinformatics model with application to prostate cancer metastasis. Precis Clin Med. 2022 Jan 10;5(1):pbac001. doi: 10.1093/pcmedi/pbac001. PMID: 35821682; PMCID: PMC9267254.

11 Lin Y, Wang L, Ge W, Hui Y, Zhou Z, Hu L, Pan H, Huang Y, Shen B. Multi-omics network characterization reveals novel microRNA biomarkers and mechanisms for diagnosis and subtyping of kidney transplant rejection. J Transl Med. 2021 Aug 13;19(1):346. doi: 10.1186/s12967-021-03025-8. PMID: 34389032; PMCID: PMC8361655.

10 Qian F, Wang J, Wang Y, Gao Q, Yan W, Lin Y, Shen L, Xie Y, Jiang X, Shen B. MiR-378a-3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation. Clin Transl Med. 2021 Feb;11(2):e307. doi: 10.1002/ctm2.307. PMID: 33634974; PMCID: PMC7882078.

9 Lin Y, Miao Z, Zhang X, Wei X, Hou J, Huang Y, Shen B. Identification of Key MicroRNAs and Mechanisms in Prostate Cancer Evolution Based on Biomarker Prioritization Model and Carcinogenic Survey. Front Genet. 2021 Jan 15;11:596826. doi: 10.3389/fgene.2020.596826. PMID: 33519899; PMCID: PMC7844321.

8 Qi X, Lin Y, Liu X, Chen J, Shen B. Biomarker Discovery for the Carcinogenic Heterogeneity Between Colon and Rectal Cancers Based on lncRNA-Associated ceRNA Network Analysis. Front Oncol. 2020 Oct 30;10:535985. doi: 10.3389/fonc.2020.535985. PMID: 33194594; PMCID: PMC7662689.

7 Singla RK, Sultana A, Alam MS, Shen B. Regulation of Pain Genes-Capsaicin vs Resiniferatoxin: Reassessment of Transcriptomic Data. Front Pharmacol. 2020 Oct 29;11:551786. doi: 10.3389/fphar.2020.551786. PMID: 33192502; PMCID: PMC7658921.

6 Qi X, Lin Y, Chen J, Shen B. The landscape of emerging ceRNA crosstalks in colorectal cancer: Systems biological perspectives and translational applications. Clin Transl Med. 2020 Aug;10(4):e153. doi: 10.1002/ctm2.153. PMID: 32898321; PMCID: PMC7426901.

5 Hu H, He X, Zhang Y, Wu R, Chen J, Lin Y, Shen B. MicroRNA Alterations for Diagnosis, Prognosis, and Treatment of Osteoporosis: A Comprehensive Review and Computational Functional Survey. Front Genet. 2020 Mar 3;11:181. doi: 10.3389/fgene.2020.00181. PMID: 32194637; PMCID: PMC7063117.

4 Wu R, Lin Y, Liu X, Zhan C, He H, Shi M, Jiang Z, Shen B. Phenotype-genotype network construction and characterization: a case study of cardiovascular diseases and associated non-coding RNAs. Database (Oxford). 2020 Jan 1;2020:baz147. doi: 10.1093/database/baz147. PMID: 31942979; PMCID: PMC6964217.

3 Qi X, Yu C, Wang Y, Lin Y, Shen B. Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer. Clin Transl Med. 2019 Oct 29;8(1):28. doi: 10.1186/s40169-019-0245-6. PMID: 31664600.

2 Qi X, Lin Y, Chen J, Shen B. Decoding competing endogenous RNA networks for cancer biomarker discovery. Brief Bioinform. 2019 Jan 30;10.1093/bib/bbz006. doi: 10.1093/bib/bbz006. [Epub ahead of print]. PMID: 30715152.

1 Lin Y, Chen F, Shen L, Tang X, Du C, Sun Z, Ding H, Chen J, Shen B. Biomarker microRNAs for prostate cancer metastasis: screened with a network vulnerability analysis model. <i>J Transl Med</i>. 2018 May 21;16(1):134. doi: 10.1186/s12967-018-1506-7. PMID: 29784056; PMCID: PMC5963164.

28 Liu K, Xu X, Sun L, Li H, Jin Y, Ma X, Shen B, Martin C. Proteomics profiling reveals lipid metabolism abnormalities during oogenesis in unexplained recurrent pregnancy loss. Front Immunol. 2024 Aug 8;15:1397633. doi: 10.3389/fimmu.2024.1397633. PMID: 39176081; PMCID: PMC11339622.

27 Xie W, Sharma A, Kaushik H, Sharma L, Nistha, Anwer MK, Sachdeva M, Elossaily GM, Zhang Y, Pillappan R, Kaur M, Behl T, Shen B, Singla RK. Shaping the future of gastrointestinal cancers through metabolic interactions with host gut microbiota. Heliyon. 2024 Jul 27;10(15):e35336. doi: 10.1016/j.heliyon.2024.e35336. PMID: 39170494; PMCID: PMC11336605.

26 Xue L, He S, Singla RK, Qin Q, Ding Y, Liu L, Ding X, Bediaga-Bañeres H, Arrasate S, Durado-Sanchez A, Zhang Y, Shen Z, Shen B, Miao L, González-Díaz H. Machine learning guided prediction of warfarin blood levels for personalized medicine based on clinical longitudinal data from cardiac surgery patients: a prospective observational study. Int J Surg. 2024 Jun 4. doi: 10.1097/JS9.0000000000001734. Epub ahead of print. PMID: 38833337.

25 Wang D, Chen Y, Li J, Wu E, Tang T, Singla RK, Shen B, Zhang M. Natural products for the treatment of age-related macular degeneration. Phytomedicine. 2024 Jul 25;130:155522. doi: 10.1016/j.phymed.2024.155522. Epub 2024 Mar 16. PMID: 38820665.

24 Ritu, Goyal RK, Narwal S, Bhatt A, Sehrawat R, Devi P, Gulati M, Singla RK. Role of MMP-9 and NF-κB in Diabetic Retinopathy: Progression and Potential Role of Bioflavonoids in the Mitigation of Diabetic Retinopathy. Curr Med Chem. 2024 May 30. doi: 10.2174/0109298673316493240527113707. Epub ahead of print. PMID: 38818917.

23 Zhang C, Singla RK, Tang M, Shen B. Natural products act as game-changer potentially in treatment and management of sepsis-mediated inflammation: A clinical perspective. Phytomedicine. 2024 May 3;130:155710. doi: 10.1016/j.phymed.2024.155710. Epub ahead of print. PMID: 38759311.

22 Ullah A, Chen Y, Singla RK, Cao D, Shen B. Pro-inflammatory Cytokines and CXC Chemokines as Game-Changer in Age-Associated Prostate Cancer and Ovarian Cancer: Insights from Preclinical and Clinical Studies' Outcomes. Pharmacol Res. 2024 May 13:107213. doi: 10.1016/j.phrs.2024.107213. Epub ahead of print. PMID: 38750677.

21 Ullah A, Jiao W, Shen B. The role of proinflammatory cytokines and CXC chemokines (CXCL1-CXCL16) in the progression of prostate cancer: insights on their therapeutic management. Cell Mol Biol Lett. 2024 May 14;29(1):73. doi: 10.1186/s11658-024-00591-9. PMID: 38745115; PMCID: PMC11094955.

20 Ullah A, Singla RK, Batool Z, Cao D, Shen B. Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases). Rev Endocr Metab Disord. 2024 May 6. doi: 10.1007/s11154-024-09884-y. Epub ahead of print. PMID: 38709387.

19 Zhou Y, Duan L, Zeng Y, Song X, Pan K, Niu L, Pu Y, Li J, Khalique A, Fang J, Jing B, Zeng D, Shen B, Ni X. The panda-derived Lactiplantibacillus plantarum BSG201683 improves LPS-induced intestinal inflammation and epithelial barrier disruption in vitro. BMC Microbiol. 2023 Sep 6;23(1):249. doi: 10.1186/s12866-023-02928-4. PMID: 37674107; PMCID: PMC10481503.

18 Characterization of site-specific N-glycosylation signatures of isolated uromodulin from human urine

17 Ullah A, Wang MJ, Wang YX, Shen B. CXC chemokines influence immune surveillance in immunological disorders: Polycystic ovary syndrome and endometriosis. Biochim Biophys Acta Mol Basis Dis. 2023 Mar 30;1869(5):166704. doi: 10.1016/j.bbadis.2023.166704. Epub ahead of print. PMID: 37001703.

16 Kapoor B, Gulati M, Gupta R, Singla RK. Microbiota dysbiosis and myasthenia gravis: Do all roads lead to Rome? Autoimmun Rev. 2023 May;22(5):103313. doi: 10.1016/j.autrev.2023.103313. Epub 2023 Mar 12. PMID: 36918089.

15 Singla RK, Behzad S, Khan J, Tsagkaris C, Gautam RK, Goyal R, Chopra H, Shen B. Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies. Front Pharmacol. 2022 Feb 21;13:801733. doi: 10.3389/fphar.2022.801733. PMID: 35264951; PMCID: PMC8899191.

14 Singla RK, He X, Chopra H, Tsagkaris C, Shen L, Kamal MA, Shen B. Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources. Front Pharmacol. 2021 Dec 1;12:758159. doi: 10.3389/fphar.2021.758159. PMID: 34925017; PMCID: PMC8671886.

13 Singla RK, Sai CS, Chopra H, Behzad S, Bansal H, Goyal R, Gautam RK, Tsagkaris C, Joon S, Singla S, Shen B. Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies. Front Cell Dev Biol. 2021 Nov 5;9:745177. doi: 10.3389/fcell.2021.745177. PMID: 34805155; PMCID: PMC8602797.

12 Singla RK, Ashraf GM, Ganash M, Bhat G V, Shen B. Physicochemical, Interaction & Topological Descriptors vs. hMAO-A Inhibition of Aplysinopsin Analogs: A Boulevard to the Discovery of Semi-Synthetic Anti-Depression Agents. Curr Drug Metab. 2021 Oct 15. doi: 10.2174/1389200222666211015155014. Epub ahead of print. PMID: 34779368.

11 Singla RK. Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling - Part 3. Curr Drug Metab. 2021;22(6):412-414. doi: 10.2174/138920022206210708103019. PMID: 34455943.

10 Joon S, Singla RK, Shen B, Kamal MA. QSCR Analysis of Cytotoxicity of 6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-4(1H)-ones on Chinese Hamster Ovary Cell Line: Design of REPUBLIC1986. Curr Med Chem. 2021 Jun 23. doi: 10.2174/0929867328666210623150552. Epub ahead of print. PMID: 34165404.

9 Li Y, Shen L, Huang C, Li X, Chen J, Li SC, Shen B. Altered nitric oxide induced by gut microbiota reveals the connection between central precocious puberty and obesity. Clin Transl Med. 2021 Feb;11(2):e299. doi: 10.1002/ctm2.299. PMID: 33634977; PMCID: PMC7842634.

8 Singla RK, Guimarães AG, Zengin G. Editorial: Application of Plant Secondary Metabolites to Pain Neuromodulation. Front Pharmacol. 2021 Jan 14;11:623399. doi: 10.3389/fphar.2020.623399. PMID: 33519489; PMCID: PMC7841409.

7 Shen B, Singla RK. Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases & their Metabolic Profiling-Part 2. Curr Drug Metab. 2020;21(14):1070-1071. doi: 10.2174/138920022114201230142204. PMID: 33413055.

6 Sultana A, Singla RK, He X, Sun Y, Alam MS, Shen B. Topical Capsaicin for the Treatment of Neuropathic Pain. Curr Drug Metab. 2020 Nov 16. doi: 10.2174/1389200221999201116143701. Epub ahead of print. PMID: 33198614.

5 Singla RK. Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling: Part 1. Curr Drug Metab. 2020;21(7):480-481. doi: 10.2174/138920022107200925101631. PMID: 33172364.

4 Shen B, Singla RK, Agarwal T, Xuefei H. Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder - Parkinson's Disease. Curr Drug Targets. 2020 Oct 13. doi: 10.2174/1389450121999201013155202. Epub ahead of print. PMID: 33050857.

3 Shen L, Shen K, Bai J, Wang J, Singla RK, Shen B. Data-driven microbiota biomarker discovery for personalized drug therapy of cardiovascular disease. Pharmacol Res. 2020 Sep 29;161:105225. doi: 10.1016/j.phrs.2020.105225. Epub ahead of print. PMID: 33007417.

2 Singla RK, Shen B. In Silico ADME-T Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes. Curr Drug Metab. 2020 Sep 1. doi: 10.2174/1389200221999200901202945. Epub ahead of print. PMID: 32875983.

1 Zhou J, Oldfield CJ, Yan W, Shen B, Dunker AK. Identification of Intrinsic Disorder in Complexes from the Protein Data Bank. ACS Omega. 2020 Jul 14;5(29):17883-17891. doi: 10.1021/acsomega.9b03927. PMID: 32743159; PMCID: PMC7391252.

2 Yu C, Qi X, Lin Y, Li Y, Shen B. iODA: An Integrated Tool for Analysis of Cancer Pathway Consistency from Heterogeneous Multi-omics Data. J Biomed Inform. 2020 Oct 20:103605. doi: 10.1016/j.jbi.2020.103605. Epub ahead of print. PMID: 33096244.

1 Zhou J, Oldfield CJ, Yan W, Shen B, Dunker AK. Intrinsically disordered domains: Sequence ➔ disorder ➔ function relationships. Protein Sci. 2019 Sep;28(9):1652-1663. doi: 10.1002/pro.3680. Epub 2019 Aug 9. PMID: 31299122; PMCID: PMC6699093.

46 Li JK, Tang T, Zong H, Wu EM, Zhao J, Wu RR, Zheng XN, Zhang H, Li YF, Zhou XH, Zhang CC, Zhang ZL, Zhang YH, Feng WZ, Zhou Y, Wang J, Zhu QY, Deng Q, Zheng JM, Yang L, Wei Q, Shen BR. Intelligent medicine in focus: the 5 stages of evolution in robot-assisted surgery for prostate cancer in the past 20 years and future implications. Mil Med Res. 2024 Aug 21;11(1):58. doi: 10.1186/s40779-024-00566-z. PMID: 39164787; PMCID: PMC11337898.

45 Batool Z, Kamal MA, Shen B. Advancements in triple-negative breast cancer sub-typing, diagnosis and treatment with assistance of artificial intelligence : a focused review. J Cancer Res Clin Oncol. 2024 Aug 6;150(8):383. doi: 10.1007/s00432-024-05903-2. PMID: 39103624; PMCID: PMC11300496.

44 Duan J, Li P, Shao A, Hao X, Zhou R, Bi C, Liu X, Li W, Zhu H, Chen G, Shen B, Zhu T. PPCRKB: a risk factor knowledge base of postoperative pulmonary complications. Database (Oxford). 2024 Jul 19;2024:baae054. doi: 10.1093/database/baae054. PMID: 39028753; PMCID: PMC11259045.

43 Ren S, Yang L, Du J, He M, Shen B. DRGKB: a knowledgebase of worldwide diagnosis-related groups' practices for comparison, evaluation and knowledge-guided application. Database (Oxford). 2024 Jun 6;2024:baae046. doi: 10.1093/database/baae046. PMID: 38843311; PMCID: PMC11155695.

42 Zheng M, Kumar A, Sharma V, Behl T, Sehgal A, Wal P, Shinde NV, Kawaduji BS, Kapoor A, Anwer MK, Gulati M, Shen B, Singla RK, Bungau SG. Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions. Front Cell Dev Biol. 2024 Mar 27;12:1353860. doi: 10.3389/fcell.2024.1353860. PMID: 38601081; PMCID: PMC11004261.

41 Yu C, Zong H, Chen Y, Zhou Y, Liu X, Lin Y, Li J, Zheng X, Min H, Shen B. PCAO2: an ontology for integration of prostate cancer associated genotypic, phenotypic and lifestyle data. Brief Bioinform. 2024 Mar 27;25(3):bbae136. doi: 10.1093/bib/bbae136. PMID: 38557678; PMCID: PMC10982949.

40 Li J, Tang T, Wu E, Zhao J, Zong H, Wu R, Feng W, Zhang K, Wang D, Qin Y, Shen Z, Qin Y, Ren S, Zhan C, Yang L, Wei Q, Shen B. RARPKB: A knowledge-guide decision support platform for personalized robot-assisted surgery in prostate cancer. Int J Surg. 2024 Mar 18. doi: 10.1097/JS9.0000000000001290. Epub ahead of print. PMID: 38498357.

39 Xue L, Singla RK, He S, Arrasate S, González-Díaz H, Miao L, Shen B. Warfarin-A natural anticoagulant: A review of research trends for precision medication. Phytomedicine. 2024 Jun;128:155479. doi: 10.1016/j.phymed.2024.155479. Epub 2024 Feb 23. PMID: 38493714.

38 Gautam RK, Tripathi SM, Akash S, Sharma S, Sharma K, Goyal S, Behzad S, Gundamaraju R, Mishra DK, Zhang Y, Shen B, Sundriyal S, Singla RK. Unlocking the Immunomodulatory Potential of Rosmarinic Acid Isolated from Punica granatum L. Using Bioactivity-Guided Approach: In Silico, In Vitro, and In Vivo Approaches. Curr Med Chem. 2024 Mar 5. doi: 10.2174/0109298673291064240227094654. Epub ahead of print. PMID: 38445701.

37 Zong H, Li J, Wu E, Wu R, Lu J, Shen B. Performance of ChatGPT on Chinese national medical licensing examinations: a five-year examination evaluation study for physicians, pharmacists and nurses. BMC Med Educ. 2024 Feb 14;24(1):143. doi: 10.1186/s12909-024-05125-7. PMID: 38355517; PMCID: PMC10868058.

36 Wang S, Shen B, Guo L, Shang M, Liu J, Sun Q, Shen B. scFed: federated learning for cell type classification with scRNA-seq. Brief Bioinform. 2023 Nov 22;25(1):bbad507. doi: 10.1093/bib/bbad507. PMID: 38221903; PMCID: PMC10788680.

35 Wu E, Fan X, Tang T, Li J, Wang J, Liu X, Zungar Z, Ren J, Wu C, Shen B. Biomarkers discovery for endometrial cancer: A graph convolutional sample network method. Comput Biol Med. 2022 Nov;150:106200. doi: 10.1016/j.compbiomed.2022.106200. Epub 2022 Oct 13. PMID: 37859290.

34 Li J, Fan X, Tang T, Wu E, Wang D, Zong H, Zhou X, Li Y, Zhang C, Zhang Y, Wu R, Wu C, Yang L, Shen B. An artificial intelligence method for predicting postoperative urinary incontinence based on multiple anatomic parameters of MRI. Heliyon. 2023 Sep 20;9(10):e20337. doi: 10.1016/j.heliyon.2023.e20337. PMID: 37767466; PMCID: PMC10520312.

33 Li J, Zhang Z, Zhang C, Zhu Q, Zhao J, Zong H, Deng Q, Zheng J, Wu E, Wu R, Tang T, Zhang Y, Dong Q, Li Y, Wang J, Yang L, Qiu S, Shen B, Wei Q. Association Between Urinary Bisphenols and Body Composition Among American Adults: Cross-Sectional National Health and Nutrition Examination Survey Study. JMIR Public Health Surveill. 2023 Sep 19;9:e49652. doi: 10.2196/49652. PMID: 37615638; PMCID: PMC10548327.

32 Zhang C, Zhang X, Sun Z, Liu X, Shen B. MetaSepsisBase: a biomarker database for systems biological analysis and personalized diagnosis of heterogeneous human sepsis. Intensive Care Med. 2023 Jun 17. doi: 10.1007/s00134-023-07126-4. Epub ahead of print. PMID: 37329364.

31 Zhan C, Liu K, Zhang Y, Zhang Y, He M, Wu R, Bi C, Shen B. Myocardial infarction unveiled: Key miRNA players screened by a novel lncRNA-miRNA-mRNA network model. Comput Biol Med. 2023 Apr 28;160:106987. doi: 10.1016/j.compbiomed.2023.106987. Epub ahead of print. PMID: 37141653.

30 Shen K, Din AU, Sinha B, Zhou Y, Qian F, Shen B. Translational informatics for human microbiota: data resources, models and applications. Brief Bioinform. 2023 May 4:bbad168. doi: 10.1093/bib/bbad168. Epub ahead of print. PMID: 37141135.

29 Singla RK, Joon S, Sinha B, Kamal MA, Simal-Gandara J, Xiao J, Shen B. Current trends in natural products for the treatment and management of dementia: Computational to clinical studies. Neurosci Biobehav Rev. 2023 Apr;147:105106. doi: 10.1016/j.neubiorev.2023.105106. Epub 2023 Feb 23. PMID: 36828163.

28 Xue L, Ding Y, Qin Q, Liu L, Ding X, Zhou Y, Liu K, Singla RK, Shen K, Din AU, Zhang Y, Shen Z, Shen B, Miao L. Assessment of the impact of intravenous antibiotics treatment on gut microbiota in patients: Clinical data from pre-and post-cardiac surgery. Front Cell Infect Microbiol. 2023 Jan 19;12:1043971. doi: 10.3389/fcimb.2022.1043971. PMID: 36741975; PMCID: PMC9896080.

27 Liu K, Zhang Y, Martin C, Ma X, Shen B. Translational Bioinformatics for Human Reproductive Biology Research: Examples, Opportunities and Challenges for a Future Reproductive Medicine. Int J Mol Sci. 2022 Dec 20;24(1):4. doi: 10.3390/ijms24010004. PMID: 36613446.

26 Singla RK, De R, Efferth T, Mezzetti B, Sahab Uddin M, Sanusi, Ntie-Kang F, Wang D, Schultz F, Kharat KR, Devkota HP, Battino M, Sur D, Lordan R, Patnaik SS, Tsagkaris C, Sai CS, Tripathi SK, Găman MA, Ahmed MEO, González-Burgos E, Babiaka SB, Paswan SK, Odimegwu JI, Akram F, Simal-Gandara J, Urquiza MS, Tikhonov A, Mondal H, Singla S, Lonardo SD, Mulholland EJ, Cenanovic M, Maigoro AY, Giampieri F, Lee S, Tzvetkov NT, Louka AM, Verma P, Chopra H, Olea SP, Khan J, Alvarez Suarez JM, Zheng X, Tomczyk M, Sabnani MK, Medina CDV, Khalid GM, Boyina HK, Georgiev MI, Supuran CT, Sobarzo-Sánchez E, Fan TP, Pittala V, Sureda A, Braidy N, Russo GL, Vacca RA, Banach M, Lizard G, Zarrouk A, Hammami S, Orhan IE, Aggarwal BB, Perry G, Miller MJ, Heinrich M, Bishayee A, Kijjoa A, Arkells N, Bredt D, Wink M, Fiebich BL, Kiran G, Yeung AWK, Gupta GK, Santini A, Lucarini M, Durazzo A, El-Demerdash A, Dinkova-Kostova AT, Cifuentes A, Souto EB, Zubair MAM, Badhe P, Echeverría J, Horbańczuk JO, Horbanczuk OK, Sheridan H, Sheshe SM, Witkowska AM, Abu-Reidah IM, Riaz M, Ullah H, Oladipupo AR, Lopez V, Sethiya NK, Shrestha BG, Ravanan P, Gupta SC, Alzahrani QE, Dama Sreedhar P, Xiao J, Moosavi MA, Subramani PA, Singh AK, Chettupalli AK, Patra JK, Singh G, Karpiński TM, Al-Rimawi F, Abiri R, Ahmed AF, Barreca D, Vats S, Amrani S, Fimognari C, Mocan A, Hritcu L, Semwal P, Shiblur Rahaman M, Emerald M, Akinrinde AS, Singh A, Joshi A, Joshi T, Khan SY, Balla GOA, Lu A, Pai SR, Ghzaiel I, Acar N, Es-Safi NE, Zengin G, Kureshi AA, Sharma AK, Baral B, Rani N, Jeandet P, Gulati M, Kapoor B, Mohanta YK, Emam-Djomeh Z, Onuku R, Depew JR, Atrooz OM, Goh BH, Andrade JC, Konwar B, Shine VJ, Ferreira JMLD, Ahmad J, Chaturvedi VK, Skalicka-Woźniak K, Sharma R, Gautam RK, Granica S, Parisi S, Kumar R, Atanasov AG, Shen B. The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis. Phytomedicine. 2022 Oct 22;108:154520. doi: 10.1016/j.phymed.2022.154520. Epub ahead of print. PMID: 36334386.

25 Tang T, Liu X, Wu R, Shen L, Ren S, Shen B. CTRR-ncRNA: A Knowledgebase for Cancer Therapy Resistance and Recurrence Associated Non-coding RNAs. Genomics Proteomics Bioinformatics. 2022 Oct 17:S1672-0229(22)00131-0. doi: 10.1016/j.gpb.2022.10.003. Epub ahead of print. PMID: 36265769.

24 Bi C, Zhou S, Liu X, Zhu Y, Yu J, Zhang X, Shi M, Wu R, He H, Zhan C, Lin Y, Shen B. NDDRF: A risk factor knowledgebase for personalized prevention of neurodegenerative diseases. J Adv Res. 2022 Sep;40:223-231. doi: 10.1016/j.jare.2021.06.015. Epub 2021 Jun 20. PMID: 36100329; PMCID: PMC9481935.

23 Singla RK, Joon S, Shen L, Shen B. Translational Informatics for Natural Products as Antidepressant Agents. Front Cell Dev Biol. 2022 Jan 20;9:738838. doi: 10.3389/fcell.2021.738838. PMID: 35127696; PMCID: PMC8811306.

22 Ren S, Jin Y, Chen Y, Shen B. CRPMKB: a knowledge base of cancer risk prediction models for systematic comparison and personalized applications. Bioinformatics. 2021 Dec 20:btab850. doi: 10.1093/bioinformatics/btab850. Epub ahead of print. PMID: 34927675.

21 Okoh MP, Singla RK, Madu C, Soremekun O, Adejoh J, Alli LA, Shen B. Phytomedicine in Disease Management: In-Silico Analysis of the Binding Affinity of Artesunate and Azadirachtin for Malaria Treatment. Front Pharmacol. 2021 Nov 30;12:751032. doi: 10.3389/fphar.2021.751032. PMID: 34916935; PMCID: PMC8669099.

20 Zhan C, Zhang Y, Liu X, Wu R, Zhang K, Shi W, Shen L, Shen K, Fan X, Ye F, Shen B. MIKB: A manually curated and comprehensive knowledge base for myocardial infarction. Comput Struct Biotechnol J. 2021 Nov 16;19:6098-6107. doi: 10.1016/j.csbj.2021.11.011. PMID: 34900127; PMCID: PMC8626632.

19 Yang L, Liu X, Chen Y, Shen B. An update on the CHDGKB for the systematic understanding of risk factors associated with non-syndromic congenital heart disease. Comput Struct Biotechnol J. 2021 Oct 13;19:5741-5751. doi: 10.1016/j.csbj.2021.10.017. PMID: 34765091; PMCID: PMC8556603.

18 Singla RK, Sharma P, Dubey AK, Gundamaraju R, Kumar D, Kumar S, Madaan R, Shri R, Tsagkaris C, Parisi S, Joon S, Singla S, Kamal MA, Shen B. Natural Product-Based Studies for the Management of Castration-Resistant Prostate Cancer: Computational to Clinical Studies. Front Pharmacol. 2021 Oct 19;12:732266. doi: 10.3389/fphar.2021.732266. PMID: 34737700; PMCID: PMC8560712.

17 Singla RK, Gupta R, Joon S, Gupta AK, Shen B. Isolation, Docking and In silico ADME-T Studies of Acacianol: Novel Antibacterial Isoflavone Analogue Isolated from Acacia leucophloea Bark. Curr Drug Metab. 2021 Oct 4. doi: 10.2174/1389200222666211005091417. Epub ahead of print. PMID: 34636294.

16 Miao Z, Bai J, Shen L, Singla RK. The Combination of Tradition and Future: Data-Driven Natural-Product-Based Treatments for Parkinson's Disease. Evid Based Complement Alternat Med. 2021 Jul 14;2021:9990020. doi: 10.1155/2021/9990020. PMID: 34335855; PMCID: PMC8294954.

15 He H, Shi M, Lin Y, Zhan C, Wu R, Bi C, Liu X, Ren S, Shen B. HFBD: a biomarker knowledge database for heart failure heterogeneity and personalized applications. Bioinformatics. 2021 Jun 23:btab470. doi: 10.1093/bioinformatics/btab470. Epub ahead of print. PMID: 34164644.

14 Yan W, Yu C, Chen J, Zhou J, Shen B. ANCA: A Web Server for Amino Acid Networks Construction and Analysis. Front Mol Biosci. 2020 Nov 19;7:582702. doi: 10.3389/fmolb.2020.582702. PMID: 33330622; PMCID: PMC7711068.

13 Chen Y, Yu C, Liu X, Xi T, Xu G, Sun Y, Zhu F, Shen B. PCLiON: An Ontology for Data Standardization and Sharing of Prostate Cancer Associated Lifestyles. Int J Med Inform. 2020 Nov 7;145:104332. doi: 10.1016/j.ijmedinf.2020.104332. Epub ahead of print. PMID: 33186790.

12 Liu X, Zhang X, Chen J, Ye B, Ren S, Lin Y, Sun XF, Zhang H, Shen B. CRC-EBD: Epigenetic Biomarker Database for Colorectal Cancer. Front Genet. 2020 Oct 6;11:907. doi: 10.3389/fgene.2020.00907. PMID: 33133126; PMCID: PMC7573234.

11 Yang L, Yang Y, Liu X, Chen Y, Chen Y, Lin Y, Sun Y, Shen B. CHDGKB: a knowledgebase for systematic understanding of genetic variations associated with non-syndromic congenital heart disease. Database (Oxford). 2020 Jan 1;2020:baaa048. doi: 10.1093/database/baaa048. PMID: 32608479; PMCID: PMC7327432.

10 Pei Z, Shi M, Guo J, Shen B. Heart Rate Variability Based Prediction of Personalized Drug Therapeutic Response: The Present Status and the Perspectives. Curr Top Med Chem. 2020;20(18):1640-1650. doi: 10.2174/1568026620666200603105002. PMID: 32493191.

9 Shi M, He H, Geng W, Wu R, Zhan C, Jin Y, Zhu F, Ren S, Shen B. Early Detection of Sudden Cardiac Death by Using Ensemble Empirical Mode Decomposition-Based Entropy and Classical Linear Features From Heart Rate Variability Signals. Front Physiol. 2020 Feb 25;11:118. doi: 10.3389/fphys.2020.00118. PMID: 32158399; PMCID: PMC7052183.

8 Lin Y, Zhao X, Miao Z, Ling Z, Wei X, Pu J, Hou J, Shen B. Data-driven translational prostate cancer research: from biomarker discovery to clinical decision. J Transl Med. 2020 Mar 7;18(1):119. doi: 10.1186/s12967-020-02281-4. PMID: 32143723; PMCID: PMC7060655.

7 Chen Y, Liu X, Yu Y, Yu C, Yang L, Lin Y, Xi T, Ye Z, Feng Z, Shen B. PCaLiStDB: a lifestyle database for precision prevention of prostate cancer. Database (Oxford). 2020 Jan 1;2020:baz154. doi: 10.1093/database/baz154. PMID: 31950190; PMCID: PMC6966110.

6 Shen B, Lin Y, Bi C, Zhou S, Bai Z, Zheng G, Zhou J. Translational Informatics for Parkinson's Disease: from Big Biomedical Data to Small Actionable Alterations. Genomics Proteomics Bioinformatics. 2019 Aug;17(4):415-429. doi: 10.1016/j.gpb.2018.10.007. Epub 2019 Nov 28. PMID: 31786313; PMCID: PMC6943761.

5 Zhan C, Shi M, Wu R, He H, Liu X, Shen B. MIRKB: a myocardial infarction risk knowledge base. Database (Oxford). 2019 Jan 1;2019:baz125. doi: 10.1093/database/baz125. PMID: 31688939; PMCID: PMC6830040.

4 Shi M, Zhan C, He H, Jin Y, Wu R, Sun Y, Shen B. Renyi Distribution Entropy Analysis of Short-Term Heart Rate Variability Signals and Its Application in Coronary Artery Disease Detection. Front Physiol. 2019 Jun 26;10:809. doi: 10.3389/fphys.2019.00809. PMID: 31293457; PMCID: PMC6606792.

3 Zhu F, Ye F, Fu Y, Liu Q, Shen B. Electrocardiogram generation with a bidirectional LSTM-CNN generative adversarial network. Sci Rep. 2019 May 1;9(1):6734. doi: 10.1038/s41598-019-42516-z. PMID: 31043666; PMCID: PMC6494992.

2 Lin Y, Wu W, Sun Z, Shen L, Shen B. MiRNA-BD: an evidence-based bioinformatics model and software tool for microRNA biomarker discovery. RNA Biol. 2018;15(8):1093-1105. doi: 10.1080/15476286.2018.1502590. Epub 2018 Sep 17. PMID: 30081733; PMCID: PMC6161673.

1 Qian F, Guo J, Jiang Z, Shen B. Translational Bioinformatics for Cholangiocarcinoma: Opportunities and Challenges. Int J Biol Sci. 2018 May 22;14(8):920-929. doi: 10.7150/ijbs.24622. PMID: 29989102; PMCID: PMC6036745.

19 Zong H, Wu R, Cha J, Feng W, Wu E, Li J, Shao A, Tao L, Li Z, Tang B, Shen B. Advancing Chinese biomedical text mining with community challenges. J Biomed Inform. 2024 Aug 27;157:104716. doi: 10.1016/j.jbi.2024.104716. Epub ahead of print. PMID: 39197732.

18 Wang J, Goyal R, Gautam RK, Garg K, Husain S, Chopra H, Dubey AK, Rayan RA, Kamal MA, Mishra DK, Gundamaraju R, Shen B, Singla RK. Decoding and Unravelling Mpox, Herpes, and Syphilis Infections: A State of Art Review. Curr Pharm Biotechnol. 2024 Jul 19. doi: 10.2174/0113892010293479240709074020. Epub ahead of print. PMID: 39039685.

17 Ritu, Xiong Y, Sharma HP, Goyal RK, Narwal S, Berwal A, Jain S, Priya M, Singh M, Agarwal G, Wang X, Shen B, Singla RK. Bioflavonoid combination attenuates diabetes-induced nephropathy in rats via modulation of MMP-9/TIMP-1, TGF-β, and GLUT-4-associated pathways. Heliyon. 2024 Jun 22;10(13):e33217. doi: 10.1016/j.heliyon.2024.e33217. PMID: 39027501; PMCID: PMC11255568.

16 Li J, Zong H, Wu E, Wu R, Peng Z, Zhao J, Yang L, Xie H, Shen B. Exploring the potential of artificial intelligence to enhance the writing of english academic papers by non-native english-speaking medical students - the educational application of ChatGPT. BMC Med Educ. 2024 Jul 9;24(1):736. doi: 10.1186/s12909-024-05738-y. PMID: 38982429; PMCID: PMC11232216.

15 Wang D, Tang T, Li P, Zhao J, Shen B, Zhang M. The global burden of cataracts and its attributable risk factors in 204 countries and territories: a systematic analysis of the global burden of disease study. Front Public Health. 2024 Jun 12;12:1366677. doi: 10.3389/fpubh.2024.1366677. PMID: 38932770; PMCID: PMC11199524.

14 Dubey AK, Kaur I, Madaan R, Raheja S, Bala R, Garg M, Kumar S, Lather V, Mittal V, Pandita D, Gundamaraju R, Singla RK, Sharma R. Unlocking the potential of oncology biomarkers: advancements in clinical theranostics. Drug Metab Pers Ther. 2024 Mar 12. doi: 10.1515/dmpt-2023-0056. Epub ahead of print. PMID: 38469723.

13 Wang J, Behl T, Rana T, Sehgal A, Wal P, Saxena B, Yadav S, Mohan S, Anwer MK, Chigurupati S, Zaheer I, Shen B, Singla RK. Exploring the pathophysiological influence of heme oxygenase-1 on neuroinflammation and depression: A study of phytotherapeutic-based modulation. Phytomedicine. 2024 Feb 19;127:155466. doi: 10.1016/j.phymed.2024.155466. Epub ahead of print. PMID: 38461764.

12 Ullah A, Zhao J, Singla RK, Shen B. Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus. Front Cell Dev Biol. 2023 Oct 19;11:1272536. doi: 10.3389/fcell.2023.1272536. PMID: 37928902; PMCID: PMC10620730.

11 Wang J, Rani N, Jakhar S, Redhu R, Kumar S, Kumar S, Kumar S, Devi B, Simal-Gandara J, Shen B, Singla RK. Opuntia ficus-indica (L.) Mill. - anticancer properties and phytochemicals: current trends and future perspectives. Front Plant Sci. 2023 Oct 4;14:1236123. doi: 10.3389/fpls.2023.1236123. PMID: 37860248; PMCID: PMC10582960.

10 Gautam RK, Mittal P, Goyal R, Dua K, Mishra DK, Sharma S, Singla RK. Nanomedicine: Innovative Strategies and Recent Advances in Targeted Cancer Therapy. Curr Med Chem. 2023 Oct 11. doi: 10.2174/0109298673258987231004092334. Epub ahead of print. PMID: 37828674.

9 Dong X, Lu Y, Guo L, Li C, Ni Q, Wu B, Wang H, Yang L, Wu S, Sun Q, Zheng H, Zhou W, Wang S. PICOTEES: a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts. J Genet Genomics. 2023 Sep 13:S1673-8527(23)00187-X. doi: 10.1016/j.jgg.2023.09.003. Epub ahead of print. PMID: 37714454.

8 Yang R, Li X, Ying Z, Zhao Z, Wang Y, Wang Q, Shen B, Peng W. Prematurely delivering mothers show reductions of lachnospiraceae in their gut microbiomes. BMC Microbiol. 2023 Jun 15;23(1):169. doi: 10.1186/s12866-023-02892-z. PMID: 37322412; PMCID: PMC10268532.

7 Goyal R, Gautam RK, Chopra H, Dubey AK, Singla RK, Rayan RA, Kamal MA. Comparative highlights on MERS-CoV, SARS-CoV-1, SARS-CoV-2, and NEO-CoV. EXCLI J. 2022 Sep 29;21:1245-1272. doi: 10.17179/excli2022-5355. PMID: 36483910; PMCID: PMC9727256.

6 Sharma R, Jadhav M, Choudhary N, Kumar A, Rauf A, Gundamaraju R, AlAsmari AF, Ali N, Singla RK, Sharma R, Shen B. Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and <i>in vivo</i> validation. Front Nutr. 2022 Nov 16;9:1063118. doi: 10.3389/fnut.2022.1063118. PMID: 36466417; PMCID: PMC9709420.

5 Singla RK, Sharma P, Kumar D, Gautam RK, Goyal R, Tsagkaris C, Dubey AK, Bansal H, Sharma R, Shen B. The role of nanomaterials in enhancing natural product translational potential and modulating endoplasmic reticulum stress in the treatment of ovarian cancer. Front Pharmacol. 2022 Oct 26;13:987088. doi: 10.3389/fphar.2022.987088. PMID: 36386196; PMCID: PMC9643842.

4 Singla RK, Dhonchak K, Sodhi RK, Arockia Babu M, Madan J, Madaan R, Kumar S, Sharma R, Shen B. Bergenin ameliorates cognitive deficits and neuropathological alterations in sodium azide-induced experimental dementia. Front Pharmacol. 2022 Sep 29;13:994018. doi: 10.3389/fphar.2022.994018. PMID: 36249784; PMCID: PMC9556967.

3 Mondal H, Parvanov ED, Singla RK, Rayan RA, Nawaz FA, Ritschl V, Eibensteiner F, Siva Sai C, Cenanovic M, Devkota HP, Hribersek M, De R, Klager E, Kletecka-Pulker M, Völkl-Kernstock S, Khalid GM, Lordan R, Găman MA, Shen B, Stamm T, Willschke H, Atanasov AG. Twitter-based crowdsourcing: What kind of measures can help to end the COVID-19 pandemic faster? Front Med (Lausanne). 2022 Sep 16;9:961360. doi: 10.3389/fmed.2022.961360. PMID: 36186802; PMCID: PMC9523003.

2 Singla RK, Wang X, Gundamaraju R, Joon S, Tsagkaris C, Behzad S, Khan J, Gautam R, Goyal R, Rakmai J, Dubey AK, Simal-Gandara J, Shen B. Natural products derived from medicinal plants and microbes might act as a game-changer in breast cancer: a comprehensive review of preclinical and clinical studies. Crit Rev Food Sci Nutr. 2022 Jul 15:1-45. doi: 10.1080/10408398.2022.2097196. Epub ahead of print. PMID: 35838143.

1 Singla RK, Dhir V, Madaan R, Kumar D, Singh Bola S, Bansal M, Kumar S, Dubey AK, Singla S, Shen B. The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives. Front Pharmacol. 2022 Apr 11;13:769111. doi: 10.3389/fphar.2022.769111. PMID: 35479320; PMCID: PMC9036189.